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| 1 | Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis显示文摘AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes. | Mehdi Mohamadnejad Mehrnaz Namiri Mohamad Bagheri Seyed Masiha Hashemi Hossein Ghanaati Narges Zare Mehrjardi Saeed Kazemi Ashtiani Reza Malekzadeh Hossein Baharvand | 2007 | World Journal of Gastroenterology2007，13，24： | 74 |
| 2 | Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention显示文摘Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality worldwide.The disease has been traditionally a major health problem in industrial countries,however the CRC rates are increasing in the developing countries that are undergoing economic growth.Several environmental risk factors,mainly changes in diet and life style,have been suggested to underlie the rise of CRC in these populations.Diet and lifestyle impinge on nuclear receptors,on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis.In this respect,the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations.The data from these studies may have important implications for the global prevention and treatment of CRC. | Faraz Bishehsari Mahboobeh Mahdavinia Michele Vacca Reza Malekzadeh Renato Mariani-Costantini | 2014 | World Journal of Gastroenterology2014，20，20： | 18 |
| 3 | Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population显示文摘AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC)in Iranian patients as compared to normal controls.METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers.RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7gene (P = 0.71).CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world. | Mohammad Farhadi Zahra Tahmasebi Shahin Merat Farin Kamangar Dariush Nasrollahzadeh Reza Malekzadeh | 2005 | World Journal of Gastroenterology2005，11，8： | 16 |
| 4 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 5 | Oxidative Coupling of Methane over Lithium Doped (Mn+W)/SiO_2 Catalysts显示文摘李的修正和性能导致了硅石相变(Mn+W ) 在甲烷(OCM ) 的氧化联合的反应条件下面, /SiO2 催化剂被调查了组织上采用描述和氧化还原作用研究。稳定性和新鲜的李的 precrystalline 形式导致了硅石相变催化剂依靠装载的李。与装载的高锂,催化剂在 OCM 溪流上使动摇。这 destabilization 不由于以 OCM 反应条件的李蒸发,一方石英被建议是在进在导致 Li 的硅石相变过程的石英的非结晶的硅石的结晶化的中介。然而,晶体结构的类型被发现关于选择催化剂的形成不重要。金属金属相互作用描述, Li-W 和 Mn-W,它在硅石期间被影响分阶段执行结晶化,被发现是 trimetallic 的批评参数并且被 TPR 学习。在做的李(Mn+W ) 的锂的角色 /SiO2 催化剂被在硅石相变包含 W 描述为 Mn-W 相互作用的一个主考。这些相互作用在过渡金属元素氧化还原作用性质的改进帮助,特别 Mn 的,赞成 OCM 选择。给词调音:甲烷的氧化联合;硅石相变;锂;金属间化合的相互作用; | A. Malekzadeh A. Khodadadi A. K. Dalai M. Abedini | 2007 | Journal of Natural Gas Chemistry2007，16，2： | 10 |
| 6 | Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients显示文摘factors,such as cigarette smoking,in esophageal squamous cell carcinoma(ESCC)in northeastern Iran,a region with a high incidence of ESCC.METHODS:The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffinembedded blocks of adjacent normal specimens from the cases,along with normal esophageal tissue from 80 healthy subjects.RESULTS:Positive expression of p53 protein was detected in 56.2%(45/80)of ESCC cases,and in none of the normal esophageal tissue of the control group(P<0.001).Furthermore,73.8%(59/80)of ESCC cases and 43.8%(35/80)of controls had positive expression of p21 protein(P<0.001).Cigarette smoking was significantly associated with p53 over-expression in ESCC cases(P=0.010,OR=3.64;95%CI:1.32-10.02).p21 over-expression was associated with poorer clinical outcome among the ESCC patients(P=0.009).CONCLUSION:Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran.Furthermore,p21 over-expression was found to be associated with poor prognosis,specifically in the operable ESCC patients. | Noushin Taghavi Firouzeh Biramijamal Masoud Sotoudeh Omeed Moaven Hooman Khademi Mohammad Reza Abbaszadegan Reza Malekzadeh | 2010 | World Journal of Gastroenterology2010，16，39： | 10 |
| 7 | Achalasia: A review of Western and Iranian experiences显示文摘Achalasia is a primary motor disorder of the eso-phagus, in which esophageal emptying is impaired. Diagnosis of achalasia is based on clinical fi ndings. The diagnosis is confirmed by radiographic, endoscopic, and manometric evaluations. Several treatments for achalasia have been introduced. We searched the PubMed Database for original articles and meta-analyses about achalasia to summarize the current knowledge regarding this disease, with particular focus on different procedures that are used for treatment of achalasia. We also report the Iranian experience of treatment of this disease, since it could be considered as a model for medium-resource countries. Myotomy, particularly laparoscopic myotomy with fundoplication, is the most effective treatment for achalasia. Compared to other treatments, however, the initial cost of myotomy is usually higher and the recovery period is longer. When performing myotomy is not indicated or not possible, graded pneumatic dilation with slow rate of balloon inflation seems to be an effective and safe initial alternative. Injection of botulinum toxin into the lower esophageal sphincter before pneumatic dilation may increase remission rates. However, this needs to be conf irmed in further studies. Due to lack of adequate information regarding the role of expandable stents in the treatment of achalasia, insertion of stents does not currently seem to be a recommended treatment. In summary, laparoscopic myotomy can be considered as the procedure of choice for treatment of achalasia. Graded pneumatic dilation is an effective alternative when the performance of myotomy is not possible for any reason. | Javad Mikaeli Farhad Islami Reza Malekzadeh | 2009 | World Journal of Gastroenterology2009，15，40： | 9 |
| 8 | Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors显示文摘AIM: The healthy ranges for serum alanine aminotransferase(ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were included.ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels werecomputed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately. | Mehdi Mohamadnejad Akram Pourshams Reza Malekzadeh Ashraf Mohamadkhani Afsaneh Rajabiani Ali Ali Asgari Seyed Meysam Alimohamadi Hadi Razjooyan Mansooreh Mamar-Abadi | 2003 | World Journal of Gastroenterology2003，9，10： | 6 |
| 9 | Overlapping gastroesophageal reflux disease and irritable bowel syndrome:Increased dysfunctional symptoms显示文摘AIM:To investigate the association of gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) in Iranian patients and examine the prevalence of functional symptoms of the gastrointestinal tract in patients presenting with either IBS, GERD or both.METHODS: Six thousand four hundred and seventy six patients presented to the Gastro-intestinal (GI) clinic with symptoms of functional dysfunction of GI tract, 1419 patients (62.0% women, 38.0% men; mean age: 37.4±11.5 years) met Rome or Rome criteria(depending on the year of diagnosis)for IBS.2658 patients were diagnosed with GERD based on clinical presentation and endoscopic findings.We assessed other functional symptoms(epigastric pain,nausea,vomiting,belching,constipation and diarrhea)in patients suffering from GERD,IBS or both.RESULTS: Among IBS subjects, 63.6% (69.0% women, 31.0% men; mean age: 36.4±10.3 years) also hadGERD, whereas 34.7% of the non-IBS patients had GERD [odds ratio (OR) =3.2, 95% confidence interval (CI): 2.9-3.7, P<0.0001]. Among patients with GERD, 33.9% of subjects met Rome criteria compared to 13.5% of non-GERD patients (OR=3.6, 95% CI: 3.1-4.3, P<0.0001). Prevalence of all functional symptoms was higher in overlapping GERD and IBS subjects, when compared with their prevalence in the IBS subjects without GERD or GERD only subjects (P<0.05).CONCLUSION: This finding shows that in overlapping GERD and IBS, other functional abnormalities of the GI tract are also highly prevalent, suggesting a common underlying dysfunction. | Shadi Sadeghi Yarandi Siavosh Nasseri-Moghaddam Pardis Mostajabi Reza Malekzadeh | 2010 | World Journal of Gastroenterology2010，16，10： | 5 |
| 10 | Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases显示文摘AIM: To assess the impact of Helicobacter pylori(H. pylori) genotypes and patient age and sex on the development of gastric diseases.METHODS: H. pylori-infected patients(n = 233) referred to the endoscopy unit at Tehran University of Medical Sciences(Tehran,Iran) were diagnosed with chronic gastritis(CG),gastric ulcer(GU),or duodenal ulcer(DU). Brucella blood agar was used for biopsy cultures and H. pylori isolation under microaerobic conditions. H. pylori isolates were confirmed with biochemical tests and through amplification of the 16 S r RNA gene. DNA was extracted from fresh cultures of the H. pylori isolates and used for amplification of vac A alleles and the cag A gene. Statistical analysis was performed to determine the association between H. pylori genotypes,age(< 40 years vs > 40 years) and sex of the patient,and gastric diseases.RESULTS: CG was the most prevalent gastric disease(113/233; 48.5%),compared to GU(64/233; 27.5%)and DU(56/233; 24%). More patients were male,and gastric diseases were more frequent in patients > 40 years(P < 0.05). The percentage of CG and GU patients that were male and female did not show a significant difference; however DU was more common in males(P < 0.05). Interestingly,a diagnosis of CG in patients > 40 years was more common in females(18.5%) than males(11.6%)(P = 0.05),whereas a diagnosis of GU or DU in patients > 40 years was more frequent in males(14.6% vs 10.7% and 12.4% vs 4.3%,respectively). Overall,genotyping of the H. pylori isolates revealed that the vac A s1(82%),vac A m2(70%),and cag A+(72.5%) alleles were more frequent than vac A s2(18%),vac A m1(29.2%),and cag A-(all P < 0.05). The vac A s1m2 cag A+ genotype was the most prevalent within the three disease groups. vac A s1m2 frequency was 56.2% with a similar occurrence in all diagnoses,while vac A s1m1 appeared more often in DU patients(33.9%). A genotype of vac A s2m2 occurred in 15% of isolates and was more common in CG patients(21.2%); vac A s2m1 was the least common genotype(3%). The vac A s1 allele was found to be a risk factor for DU,vac A s2 for CG,and vac A s1 and vac A s2 for GU(all P < 0.05). The vac A s2m2 genotype was associated with the development of CG and GU compared to DU(P < 0.05). No correlation was found between vac A m or cag A and gastric diseases.CONCLUSION: The outcome of H. pylori infection is the result of interaction between bacterial genotypes and the age and sex of infected individuals. | Sahar Honarmand-Jahromy Farideh Siavoshi Reza Malekzadeh Taher Nejad Sattari Saeid Latifi-Navid | 2015 | World Journal of Gastroenterology2015，21，31： | 5 |
| 11 | Oxidative coupling of methane over (Na_2WO_4+Mn or Ce)/SiO_2 catalysts:In situ measurement of electrical conductivity显示文摘The effects of manganese oxide or ceria promoters on the performance of Na2WO4/SiO2 catalysts for oxidative coupling of methane (OCM) are reported. The OCM reaction was performed in a continuous-flow microreactor at 800 ℃, atmospheric pressure and under GHSV = 13200 ml gC-1at h-1. Catalysts were characterized by in situ conductivity measurement, FT-IR spectroscopy, XRD, SEM and temperature programmed reduction analysis. Manganese oxide promoted Na2WO4/SiO2 is considered as one of the active and selective catalysts for OCM reaction. Ceria with high oxygen storage capacity is selected as a proper oxygen activator, providing a higher concentration of the oxy-anion species which is suitable for OCM reaction and compared with manganese oxide. Electrical conductivity of the catalysts was measured in OCM reaction under oxidizing atmosphere, i.e. in the absence of methane. It was found that the trimetallic catalysts, i.e. the catalysts having sodium, tungsten and Mn or Ce species, exhibited similar crystalline structures and morphologies, which lead to suitable bulk properties for the formation of an active and selective catalyst. However, tungsten had significant effect on the texture and redox properties of the catalysts. It was also shown that the crystalline structure of the bimetallic (Na+Mn or Ce)/SiO2 samples was quite different. This reveals that the metal oxides have significant effect on the extent of crystallization, taking place in the course of interaction of sodium with silica support. Similar conductivities and catalytic performances of (Na2WO4+Mn or Ce)/SiO2 catalysts propose that the ability of Na2WO4/SiO2 for utilizing oxy-anions formed in presence of different metal oxides is limited. | Zeinab Gholipour Azim Malekzadeh Reza Hatami Yadollah Mortazavi Abasali Khodadadi | 2010 | Journal of Natural Gas Chemistry2010，19，1： | 3 |
| 12 | Hydrothermal Alteration Mapping in Northern Khur, Iran, Using ASTER Image Processing: a New Insight to the Type of Copper Mineralization显示文摘Eastern Iran has great potential for the discovery of different types of mineralization. The study area encompasses Tertiary magmatism in the northern Lut block located in northern Khur, South Khorasan, eastern Iran and is mostly covered by volcanic rocks, which are intruded by porphyritic subvolcanic intrusions in some places. Application of the spectral angle mapper (SAM) technique to Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) images detected sericitic, argillic, and propylitic alterations, silicification, and secondary iron oxides. The alteration is linear and associated within vein-type mineralization. Twelve prospective areas are selected for detailed exploration and based on our processing results, in addition to NW-SE faults, which are associated with Cu mineralization indications, NE-SW faults are also shown to be important. Based on the presence of subvolcanic rocks and numerous Cu ± Pb-Zn vein-type mineralizations, extensive alteration, high anomaly of Cu and Zn (up to 100 ppm), the age (43.6 to 31.4 Ma) and the initial 87Sr/86Sr ratio (0.7047 to 0.7065) of the igneous rocks, and the metallogenic epoch of the Lut block (middle Eocene-lower Oligocene) for the formation of porphyry Cu and epithermal deposits, the studied area shows great potential for porphyry copper deposits. | Azadeh Malekzadeh SHAFAROUDI Mohammad Hassan KARIMPOUR | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 3 |
| 13 | Randomized placebo‐controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis显示文摘 | Mehdi Mohamadnejad Kamran Alimoghaddam Mohammad Bagheri Mandana Ashrafi Leila Abdollahzadeh Shahram Akhlaghpoor Maryam Bashtar Ardeshir Ghavamzadeh Reza Malekzadeh | 2013 | Liver Int2013，，10： | 3 |
| 14 | Gluten sensitive enteropathy in patients with iron deficiency anemia of unknown origin显示文摘AIM: To determine the prevalence of gluten sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. METHODS: In this cross-sectional study, patients with IDA of obscure origin were screened for GSE. Anti- endomysial antibody (EMA) and tissue transglutamin- ase antibody (tTG) levels were evaluated and duodenal biopsies were taken and scored according to the Marsh classification. The diagnosis of GSE was based on a positive serological test and abnormal duodenal histol- ogy. Gluten free diet (GFD) was advised for all the GSE patients. RESULTS: Of the 4120 IDA patients referred to our Hematology departments, 206 (95 male) patients were found to have IDA of obscure origin. Thirty out of 206 patients (14.6%) had GSE. The mean age of GSE pa- tients was 34.6 ± 17.03 (range 10-72 years). The female to male ratio was 1.3:1. Sixteen patients had Marsh 3,12 had Marsh 2, and 2 had Marsh 1 lesions. The sever- ity of anemia was in parallel with the severity of duode- nal lesions. Twenty-two GSE patients (73.3%) had no gastrointestinal symptoms. Fourteen GSE patients who adhered to GFD without receiving iron supplementation agreed to undergo follow up visits. After 6 mo of GFD, their mean hemoglobin levels (Hb) increased from 9.9 ± 1.6 to 12.8 ± 1.0 g/dL (P < 0.01). Interestingly, in 6 out of 14 patients who had Marsh 1/2 lesions (e.g. no villous atrophy) on duodenal biopsy, mean Hb increased from 11.0 ± 1.1 to 13.1 ± 1.0 g/dL (P < 0.01) while they did not receive any iron supplementation. CONCLUSION: There is a high prevalence (e.g. 14.6%) of GSE in patients with IDA of obscure origin. Gluten free diet can improve anemia in GSE patients who have mild duodenal lesions without villous atrophy. | Farhad Zamani Mehdi Mohamadnejad Ramin Shakeri Afsaneh Amiri Safa Najafi Seyed Meysam Alimohamadi Seyed Mohamad Tavangar Ardeshir Ghavamzadeh Reza Malekzadeh | 2008 | World Journal of Gastroenterology2008，14，48： | 3 |
| 15 | A Randomized,Double Blinded,Placebo-Controlled Clinical Trial of Silymarin in Ulcerative Colitis显示文摘Objective:To evaluate the clinical efficacy of silymarin in ulcerative colitis(UC) patients.Methods:A randomized double blinded placebo-controlled clinical trial was conducted in 80 UC patients whose disease had been documented and were in remission state between September 2009 and October 2010.Patients were assigned to silymarin group(42 cases) and placebo group(38 cases) using a random number table.Either silymarin(140 mg) or placebo(lactose mono-hydrate,corn starch magnesium stearate) tablets were given once daily for 6 months along with their standard therapy.The efficacies were assessed by disease activity index(DAI),frequency difference of the disease flare-up,and paraclinical data.Results:Ten patients(4 in the silymarin group due to nausea and 6 in the placebo group due to disease flare-up and abdominal pain)discontinued the study.An improvement in hemoglobin level(11.811.6 g/dL vs.13.4 ±1.2 g/dL,P<0.05)and erythrocyte sedimentation rate(23.7±11.5 mm/h vs.10.8±3.2 mm/h,P<0.05) was observed in the silymarin group but not in the placebo group.DAI significantly decreased in the silymarin group and reached from 11.3 ±3.5 to 10.7 ±2.8(P<0.05).Thirty-five out of 38 patients in the silymarin group were in complete remission with no flare-up after 6 months as compared to 21 out of 32 patients in the placebo group(P=0.5000).Conclusion:Silymarin as a natural supplement may be used in UC patients to maintain remission. | Mansoor Rastegarpanah Reza Malekzadeh Homayoun Vahedi Maryam Mohammadi Elham Elahi Meghedi Chaharmahali Tahereh Safarnavadeh Mohammad Abdollahi | 2015 | Chinese Journal of Integrative Medicine2015，21，12： | 2 |
| 16 | Ecologic study of serum selenium and upper gastrointestinal cancers in Iran显示文摘AIM: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations.Recent cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan,and Kerman. The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency.METHODS: We measured serum selenium in 300 healthy adults from ArdabU (n = 100), Mazandaran (n = 50), Golestan (n = 100), and Kerman (n = 50), using inductively coupled plasma, with dynamic reaction cell, mass spectrometry (ICP-DRC-MS) at the US Centers for Disease Control (Atlanta,Georgia).RESULTS: The median serum selenium concentrations were very different in the four Provinces. The medians (IQR) for selenium in Ardabil, Mazandarn, Golestan, and Kerman were 82 (75-94), 123 (111-132), 155 (141-173), and 119 (110-128) μg/L, respectively (P<0.001). The results of linear regression showed that the Province variable, by itself,explained 76% of the variance in log selenium (r^2 = 0.76).The proportion of the populations with a serum selenium more than 90μg/L (the concentration at which serum selenoproteins are saturated) was 100% in Golestan,Kerman, and Mazandaran but only 29% in ArdabU.CONCLUSION: Our findings suggest nat selenium defidency is not a major contributor to the high incidence of EC seen in northeastern Iran, but it may play a role in the high incidence of GC in Ardabil Province. | Mehdi Nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian C.Abnet Philip R.Taylor Reza Malekzadeh Sanford M.Dawsey | 2004 | World Journal of Gastroenterology2004，10，17： | 2 |
| 17 | Improved production of erythromycin by Saccharopolyspora erythraea by various plant oils显示文摘 | Hamedi J Malekzadeh F Niknam V | 2002 | Biotechnology Letters2002，24，： | 2 |
| 18 | Free vibration analysis of sandwich structures with a flexible functionally graded syntactic core 显示文摘 | RAHMANI O KHALILI S M R MALEKZADEH K | 2009 | Composite Structures2009，91，： | 1 |
| 19 | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India显示文摘 | Nikbakht M Malekzadeh K Kumar JA | | 0，，01： | 1 |
| 20 | Endo-scopic management of intratracheal ectopic thyroid 显示文摘 | Pritchyk K M Thompson L D Malekzadeh S | 2004 | Otolaryngol Head Neck Surg2004，130，5： | 1 |
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