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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Phytosterols: physiologic and metabolic aspects related to cholesteol - lowering properties 显示文摘 | Gemma B Miguel A C Magda R | 2008 | Nutrition Research2008，，28： | 1 |
| 3 | Determination of the glycosylation site in flavonoid mono-O-glycosides by collision-induced dissociation of electrospray-generated deprotonatedand sodiated molecules显示文摘 | Filip C Magda C | 2005 | Journal of Mass Spectrometry2005，，40： | 1 |
| 4 | Conlonization preva- lence of susceptibility of streptococcus agalactiae in preg- nant women at husm显示文摘 | Veit AR Horner R Magda C | 2011 | Revista Safide(Santa Maria)2011，36，1： | 1 |
| 5 | Phytosterols:Physiologic and metabolic aspects related tocholesterol-lowering properties显示文摘 | Gemma B Miguel I A C Magda R | 2008 | Nutrition Research2008，28，： | 1 |
| 6 | Fully-automated quantifica- tion of regional brain volumes for improved detection of focal atrophy in Alzheimer disease显示文摘 | Brewer JB Magda S Airriess C | 2009 | AJNR Am J Neuroradiol2009，30，3： | 1 |
| 7 | Long-term efficacy of haloperidol in autistic children: continuous versus discontinuous drug administration显示文摘 | Richard P Magda C Phillip A | 1989 | Journal of the American Academy of Child & Adolescent Psychiatry1989，28，1： | 1 |
| 8 | Mass spectrometry in the structural analysis of flavonoids显示文摘 | CUYKENS F MAGDA C | 2004 | J Mass Spectrom2004，39，： | 1 |
| 9 | Intractable seizures in tuberous sclerosis complex:from molecular pathogenesis to the rationale for treatment显示文摘 | Paolo C Roberta B Magda V | 2005 | J Child Neurol2005，20，4： | 1 |
| 10 | Daphnia magna wastewater toxicity assays: an interlaboratory study显示文摘 | Magda C Andreja D Milenko R | | 0，，1： | 1 |
| 11 | High response rate and acceptable toxicity of a combination of rituximab, vinorelbine, ifosfamide, mitoxantrone and prednisone for the treatment of diffuse large B ‐cell lymphoma in first relapse: results of the R ‐ NIMP GOELAMS study显示文摘 | Emmanuel Gyan Diane Damotte Stéphane Courby Delphine Sénécal Philippe Quittet Aline Schmidt‐Tanguy Anne Banos Steven Gouill Thierry Lamy Jean Fontan Hervé Maisonneuve Magda Alexis Francois Dreyfus Olivier Tournilhac Kamel Laribi Philippe Solal‐Céligny Nin | 2013 | Br J Haematol2013，，2： | 1 |
| 12 | Stressful life events and psychosocial correlates of pediatric inflammatory bowel disease activity显示文摘AIM To investigate the association of psychiatric and psychosocial correlates with inflammatory bowel disease(IBD) activity in children and adolescents.METHODS A total of 85 pediatric IBD patients(in remission or active state of the disease) and their parents completed a series of questionnaires and semi-structured interviews measuring life events,depression,anxiety,family dysfunction,and parent mental health.Differences between the remission and the IBD active group and the association of any significant variable with the disease activity state were examined.RESULTS Parents of children being in active state of the disease reported more life events(P = 0.005) and stressful life events(P = 0.048) during the past year and more mental health symptoms(P < 0.001),while the childrenthemselves reported higher levels of anxiety symptoms(P = 0.017) compared to the remission group.In the logistic regression multivariate analysis,the only predictor which had a significant positive effect on the probability of the patients being in active state was parent mental health symptoms(OR = 4.8;95%CI:1.2-25.8).CONCLUSION Life events,child anxiety and parent mental health symptoms may be important correlates of pediatric IBD activity and targets of thorough assessment and treatment. | George Giannakopoulos George Chouliaras Daphne Margoni Sophia Korlou Vassiliki Hantzara Ioanna Panayotou Eleftheria Roma Magda Liakopoulou Dimitris C Anagnostopoulos | 2016 | World Journal of Psychiatry2016，6，3： | 0 |
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