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| 1 | 石羊河流域早全新世湖泊孢粉记录及其环境意义显示文摘三角城剖面全新世早期地层中85个样(分辨率为40~50年)孢粉分析显示: 孢粉组合中针叶树含量高达50%以上, 以云杉属、圆柏属为主, 两者之和达40%~60%左右, 且含量互为消长. 同流域其他湖相地层也有类似现象. 通过对云杉属、圆柏属生态习性、传播性能、与其他组分的数量关系及表土花粉分析, 认为孢粉组合中的云杉属、圆柏属等主要成分并不指示当地的植被状况, 而指示流域上游祁连山山上的植被状况; 云杉属和圆柏属含量与区域有效湿度关系密切, 云杉属丰值指示湿润, 圆柏属丰值指示干旱. 并用该模式重建了石羊河流域全新世早期的环境演化过程. | 朱艳 陈发虎 B. D. Madsen | 2001 | 科学通报2001，46，19： | 38 |
| 2 | Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review显示文摘Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease(IBD).Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels,long standing disease,and frequent steroid exposures;as a result,it is well established that vitamin D supplementation in this population is important.There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD.The active form of vitamin D,1,25(OH)D3,acts on T cells to promote T helper(Th)2/regulatory T responses over Th1/Th17 responses;suppresses dendritic cell inflammatory activity;induces antibacterial activity;and regulates cytokine production in favor of an antiinflammatory response.Murine and human IBD studies support a therapeutic role of vitamin D in IBD.Risk factors for vitamin D deficiency in this population include decreased sunlight exposure,disease duration,smoking,and genetics.Vitamin D normalization is associated with reduced risk of relapse,reduced risk of IBD-related surgeries,and improvement in quality of life.Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes.However,further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects,and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission,as well as maintaining this improvement in patients’disease states. | Krista M Reich Richard N Fedorak Karen Madsen Karen I Kroeker | 2014 | World Journal of Gastroenterology2014，20，17： | 34 |
| 3 | Preliminary research on Megalake Jilantai-Hetao in the arid areas of China during the Late Quaternary显示文摘我们识别了 geomorphological,在通过地调查并且通过地区性的遥感的分析的当前的 Jilantai 盐湖附近的高湖层次的沉积、生物的证据想象。在约 1060, 1050, 1044 和 1035 m a.s.l 的举起有四组海岸线,是在当前的盐湖上面的 37, 27, 21 和 12 m 分别地出现。沙和石子的沿岸的存款在在 1070 和 1080 m a.s.l 之间的举起被发现,比水流高的 47 ~ 57 m 腌湖表面,尽管 palaeoshoreline 地形仅仅在几个地点被保存。在 Herimuxini,在 Ulan Buh 荒芜的、典型湖的沉积和沙石子的北边缘上,沿岸的存款也发生在 1080 m a.s.l 并且在下面的举起。典型吐痰扩大的 A 11-km-long 从逐渐地在它的大拐弯上沿着黄河的南部的银行在一些沙石子石场从 1050 ~ 1035 m a.s.l 在举起减少的这条海岸线东方海岸线特征例如在水文学计量器车站和 Shilazhao 镇附近定位的那些,被识别。沿岸的存款 overlying 冲积的洪水的层在 Hangjin 在 Balagong 附近发生在沙石场县。也有沙滩岩石和沿岸的存款,沿着 Langshan-Yinshan 山的南部的山麓在几个地点在 cut-and-built 平台上保存。另外,揭示水下的三角洲沉积的侧面在 Wuhai 附近被识别,在黄河进入盆的地方。典型的湖沉积也在 Hetao 平原的东方结束在 Togtoh 站台存在。水的软体动物壳在沿岸的存款是普通的,包括 Corbicula 的几种,根值 lagotis, R。xauricularia 和 Gyraulus convexiusculus。Ostracode 壳能也在更好的沉积被识别。典型垂直 prograding 序列在湖的沉积很好被保存的露头是明显的。滚动波浪的卵石和沙滩岩石很通常在更高的举起在堤在侧面的顶上被保存。所有这些证据建议曾经有一个巨大的palaeo湖,用到达我们指的 ∼1080 m a.s.l 的最高的湖水平盖住 Jilantai 区域和 Hetao 平原的大多数部分巨大的 paleolake ,比现代的湖贝加尔湖大,作为“ Megalake Jilantai-Hetao ”. OSL 标明日期结果显示大湖以前形成了 ∼60 —50 ka,和在在 1060 和 1035 m a.s.l 之间的举起的四条海岸线多半从 ∼60 ∼50 ka 代表湖水平变化到早 Holocene。Megalake Jilantai-Hetao 的发现将多半影响黄河的发展的理解在期间晚第四级, Ulan Buh 和 Kubq 的进化抛弃,在这个区域的 neotectonism,并且可能地区性的气候的变化。 | CHEN FaHu FAN YuXin CHUN Xi D.B. MADSEN C.G. OVIATT ZHAO Hui YANG LiPing SUN Yang | 2008 | Chinese Science Bulletin2008，53，11： | 23 |
| 4 | Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review显示文摘Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients. | Ammar Hassanzadeh Keshteli Vickie E Baracos Karen L Madsen | 2015 | World Journal of Gastroenterology2015，21，4： | 21 |
| 5 | 制度性宗教VS分散性宗教--关于杨庆堃《中国社会中的宗教》的讨论显示文摘杨庆堃的《中国社会中的宗教》中译本问世后,产生了很大的影响。人们在阅读之后,有所消化和吸收,有些学者在学术上深入“反刍”,提出了许多值得进一步思考的问题。《世界宗教文化》编辑部特邀《中国社会中的宗教》的主译者、上海复旦大学的范丽珠教授,上海复旦大学新闻学院的陈纳教授,美国Boston大学的RobertP.Weller(魏乐博)教授和加州大学SanDiego分校的RichardMadsen教授进行笔谈,就其中一些问题发表了各自的看法。 | Weller 范丽珠 陈纳 Madsen 郑筱筠 刘芳 | 2010 | 世界宗教文化2010，，5： | 20 |
| 6 | Gestational diabetes: A clinical update显示文摘Gestational diabetes mellitus(GDM)is increasing in prevalence in tandem with the dramatic increase inthe prevalence of overweight and obesity in women of childbearing age.Much controversy surrounds the diagnosis and management of gestational diabetes,emphasizing the importance and relevance of clarity and consensus.If newly proposed criteria are adopted universally a significantly growing number of women will be diagnosed as having GDM,implying new therapeutic challenges to avoid foetal and maternal complications related to the hyperglycemia of gestational diabetes.This review provides an overview of clinical issues related to GDM,including the challenges of screening and diagnosis,the pathophysiology behind GDM,the treatment and prevention of GDM and the long and short term consequences of gestational diabetes for both mother and offspring. | Ulla Kampmann Lene Ring Madsen Gitte Oeskov Skajaa Ditte Smed Iversen Niels Moeller Per Ovesen | 2015 | World Journal of Diabetes2015，6，8： | 17 |
| 7 | 晚第四纪青海湖高湖面研究显示文摘中国西北地区众多封闭湖泊湖岸堤的光释光(OSL)测年结果表明,"大湖"存在于深海氧同位素第5阶段(MIS 5)或者更早,而不是MIS 3阶段。由于高湖面测年结果的变化,我们对中国西北以及青藏高原地区湖泊对晚第四纪冰期-间冰期旋回气候变化响应的认识也随之改变。本研究对青海湖周边的湖岸堤、湖相沉积物、冲积和风成沉积物进行光释光测年,重建了青海湖末次间冰期以来的高湖面演化历史,得到以下结论:1)最高湖面(拔湖26~66 m)出现在MIS 5时期;2) MIS 3c时期湖面高出现在约13~17 m,但是在MIS 3a阶段湖面下降至接近于中全新世湖面高度;3)全新世最高湖面出现在距今约5.1 ka,湖面至少高出现在9.1 m,之后在约2 ka前再一次出现高湖面,高出现在湖面约8 m。青海湖高湖面的拔湖高度从MIS 5a到MIS 3时期,再到全新世是依次降低的,使得早期的湖岸堤没有被后期高湖面破坏而较好的保存了下来。 | 刘向军 赖忠平 David B. Madsen 李国强 于禄鹏 黄昶 陈发虎 | 2018 | 第四纪研究2018，38，5： | 15 |
| 8 | The environmental signal of an early Holocene pollen record from the Shiyang River basin lake sediments, NW China显示文摘Pollen analyses of 85 samples from the San-jiaocheng section well along the margin of a palaeolake at the end of the Shiyang River, NW China, show that Picea and Sabina dominate the pollen assemblage. Together they reach as high as 40%-60%, with the percentage of Picea varying inversely with that of Sabina. Similar results were obtained from another section in the Shiyang River drainage. Using modern ecological habitat relationship analogues, pol-len transport characteristics, and the overall pollen assem-blage, we propose that both Picea and Sabina pollen were transported by the river from the mountains at the upper reaches of the Shiyang River, and that the assemblage is more indicative of changes in upland vegetation than of local conditions near the section. This interpretation is supported by pollen data derived from surface samples, water samples, and riverbed samples. Using a moisture indicator (the Picea to Sabina ratio) and calculated pollen concentrations, we identify a series of | ZHU Yan, CHEN Fahu & Madsen DavidCollege of geography and Environment, Northwest Normal University, Lanzhou 730070, China National Key Laboratory of West Environmental System, Lanzhou University, Lanzhou 730000, China Utah Geological Surv | 2002 | Chinese Science Bulletin2002，47，4： | 10 |
| 9 | 对话宗教与社会资本显示文摘宗教资本、宗教的社会资本、灵性资本、宗教市场等理论范畴,一时成为中国宗教社会科学研究领域的热门话题,很多人在不了解这些理论范畴的情况下,直接套用来分析中国宗教现状。那么,这些产生于西方的宗教理论其本源究竟是什么?它们是否适用于中国宗教研究的实际? | Weller 范丽珠 Madsen 陈纳 郑筱筠 | 2011 | 世界宗教文化2011，，5： | 9 |
| 10 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 11 | Variance components and correlations of female fertility traits in Chinese Holstein population显示文摘Background: The objective of the present study was to estimate(co)variance components of female fertility traits in Chinese Holsteins, considering fertility traits in different parities as different traits. Data on 88,647 females with 215,632 records(parities) were collected during 2000 to 2014 from 32 herds in the Sanyuan Lvhe Dairy Cattle Center, Beijing, China. The analyzed female fertility traits included interval from calving to first insemination, interval from first to last insemination, days open, conception rate at first insemination, number of inseminations per conception and non-return rates within 56 days after first insemination.Results: The descriptive statistics showed that the average fertility of heifers was superior to that of cows. Moreover,the genetic correlations between the performances of a trait in heifers and in cows were all moderate to high but far from one, which suggested that the performances of a trait in heifers and cows should be considered as different but genetically correlated traits in genetic evaluations. On the other hand, genetic correlations between performances of a trait in different parities of cows were greater than 0.87, with only a few exceptions, but variances were not homogeneous across parities for some traits. The estimated heritabilities of female fertility traits were low; all were below 0.049(except for interval from calving to first insemination). Additionally, the heritabilities of the heifer interval traits were lower than those of the corresponding cow interval traits. Moreover, the heritabilities of the interval traits were higher than those of the threshold traits when measuring similar fertility functions. In general, estimated genetic correlations between traits were highly consistent with the biological categories of the female fertility traits.Conclusions: Interval from calving to first insemination, interval from first to last insemination and non-return rates within 56 days after first insemination are recommended to be included in the selection index of the Chinese Holstein population. The parameters estimated in the present study will facilitate the development of a genetic evaluation system for female fertility traits to improve the reproduction efficiency of Chinese Holsteins. | Aoxing Liu Mogens Sandø Lund Yachun Wang Gang Guo Ganghui Dong Per Madsen Guosheng Su | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 6 |
| 12 | Is regular physical activity a key to mental health? Commentary on 'Association between physical exercise and mental health in 1.2 million individuals in the USA between 2011 and 2015:A cross-sectional study',by Chekroud et al.,published in Lancet Psychiat显示文摘The recent publication by Chekroud et al . in Lancet Psychiatry focuses on the relationship between physical exercise and mental health.Mental health is defined as optimal personal functioning 'resulting in productive activities,fulfilling relationships with other people,and the ability to adapt to change and to cope with adversity'.(p.4) Recently,mental health has no longer been described as a dichotomous state but as a continuum,with personal mental states ranging from highly functional to mentally ill. | Anne-Marie Elbe Stine NylANDsted Lyhne Esben Elholm Madsen Peter Krustrup | 2019 | Journal of Sport and Health Science2019，8，1： | 6 |
| 13 | 膨胀岩石室内试验ISRM建议方法草案显示文摘 | Madsen F T 刘元高 | 2002 | 岩石力学与工程学报2002，21，4： | 5 |
| 14 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 15 | Air pollution effects on the gut microbiota显示文摘 | Saad Y Salim Gilaad G Kaplan Karen L Madsen | 2014 | Gut Microbes2014，，： | 3 |
| 16 | 巨噬细胞中缺氧诱导因子1α表达促进动脉粥样硬化的发展显示文摘粥样硬化病变包含缺氧区域,但缺氧病理生理的重要性未知。缺氧诱导因子1a(hypoxia-induciblefactor-1α,HIF-1α)是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。 | 刘莉 叶鹏 Aarup A Pedersen TX Junker N Christoffersen C Bartels ED Madsen M Nielsen CH Nielsen LB | 2016 | 中华高血压杂志2016，24，9： | 3 |
| 17 | Impact of dietary L-arginine supply during early gestation on myofiber development in newborn pigs exposed to intra-uterine crowding显示文摘Background: Intra-uterine crowding(IUC) observed in hyperprolific sows impairs myofiber hyperplasia and overall fetal growth. Arginine supplementation(ARG) in gestation diets has been shown to positively affect litter and muscle development. The study objective was to assess whether the effect of ARG on offspring characteristics, with special emphasis on myofiber hyperplasia, differs under IUC conditions from these responses,because in that situation growth retardation is particularly prevalent due to reduced fetal nutrient supply.Unilateral oviduct ligation(OL) was used as a model for an uncrowded and hyperprolificacy(IN) as a model for a crowded intra-uterine environment.Methods: Five OL and five IN sows were fed a diet supplemented daily with either 43 g L-alanine(Ctrl) or 25 g L-arginine from d 14 to 28 of gestation in a cross-over design(two periods: 5^( th) and 6^( th) parity). At farrowing, two male and two female offspring, respectively, with a low and intermediate birth weight(BtW) were selected. After euthanization, the Semitendinosus muscle(STM) was removed and weighed, and the light and dark portions(STM_d and STM_l) were prepared for myofiber histochemistry using ATPase staining and the entire STM for gene expression analysis of myogenesis-related genes using RT-qPCR. In addition, various organs were removed and weighed. Data were analyzed using the MIXED model in SYSTAT.Results: No effect of either IUC or dietary treatment was found in litter characteristics. Offspring of ARG sows displayed a greater muscle area in STM(P < 0.01) as a result of the greater myofiber hyperplasia(P < 0.01). The increase was more distinct in the STM_l(P < 0.05) than in the STM_d(P = 0.131). Offspring of OL sows were heavier at birth(P < 0.01), had a heavier STM(P < 0.05), liver(P < 0.01) and kidney(P < 0.05), but when expressed relative to birth weight, these differences were absent. In addition, IUC had an effect(P < 0.05) on the expression of one of the myogenesis-related genes investigated.Conclusions: Independent from the extent of IUC, ARG improved Bt W, muscle and organ weights and myofiber hyperplasia in offspring. | Johannes Gulmann Madsen Camilo Pardo Michael Kreuzer Giuseppe Bee | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 3 |
| 18 | Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function显示文摘 | Karen Madsen Anthony Cornish Paul Soper Conor McKaigney Humberto Jijon Christine Yachimec Jason Doyle Lawrence Jewell Claudio De Simone | 2001 | Gastroenterology2001，，3： | 2 |
| 19 | Wave reflection from a vertical permeable wave absorber 显示文摘 | Madsen P A | 1983 | Coastal Engineering1983，，7： | 2 |
| 20 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
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