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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Correlation of calcium measurement with low dose 64-slice CT and angiographic stenosis in patients with suspected coronary artery disease显示文摘 | Ma ES Yang ZG Li Y | 2010 | Int J cardiol2010，140，2： | 1 |
| 5 | The importance of cardiac MRI as a diagnostic tool in viral myocarditis-induced cardiomyopathy 显示文摘 | Olimulder MA Van Es J Galjee MA | 2009 | Neth Heart J2009，17，12： | 1 |
| 6 | Postpartum thyroid dysfunction:A state of immunological dysregulation 显示文摘 | Swelam ES Bakr HG Mansour MA | 2011 | Clin Lab2011，57，910： | 1 |
| 7 | Degradation of the minor Fusarium mycotoxin beauvericin by intracellular enzymes of Saccharomyces cerevisiae显示文摘 | G. Meca A. Ritieni T. Zhou X.Z. Li J. Ma?es | 2013 | Food Control2013，，2： | 1 |
| 8 | Endothelial keratoplasty a simplified technique to minimize graft dislocation, iatrogenic graft failure, and pupillary block 显示文摘 | Terry MA Shamie N Chen ES Hoar KL Friend DJ | 2008 | Ophthalmology2008，115，7： | 1 |
| 9 | Reduction of the enniatins A, A 1 , B, B 1 by an in vitro degradation employing different strains of probiotic bacteria: Identification of degradation products by LC–MS–LIT显示文摘 | M. Roig G. Meca E. Ferrer J. Ma?es | 2013 | Toxicon2013，，： | 1 |
| 10 | Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial显示文摘 | ANTONARAKIS ES CARDUCCI MA EISENBERGER MA | 2012 | Cancer Chemother Pharmacol2012，69，3： | 1 |
| 11 | Endothelial cell loss after Descemet' s stripping endothelial keratoplasty in a large prospective series显示文摘 | Terry MA Chen ES Shamie N Hoar KL Friend DJ | 2008 | Ophthalmology2008，115，3： | 1 |
| 12 | Occurrence and legislation of mycotoxins in food and feed from Morocco 显示文摘 | Abdellah Zinedine Jordi Ma? es | 2009 | Food Control2009，20，4： | 1 |
| 13 | Self-efficacy, self-management, and glycemic contral in adults with type 2 diabetes mellitus显示文摘 | A1-Khawaldeh OA A1-Hassan MA Froelicher ES | 2012 | J Diabetes Complications2012，26，1： | 1 |
| 14 | Hematologic and genetic characterization of an MYH9-related disorder in a Chinese family 显示文摘 | Ma ES Wong CL Shek TW | 2006 | Haematologiea2006，91，： | 1 |
| 15 | Tuberculous Addison's disease : mor- phological and quantitative evaluation with muhidetector-row CT 显示文摘 | Ma ES Yang ZG Li Y | 2007 | Eur J Radiol2007，62，： | 1 |
| 16 | Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin显示文摘 | Ghetie MA Bright H Vitetta ES | 2001 | Blood2001，97，5： | 1 |
| 17 | Preparation and characterization of starch/carrageenan edible films显示文摘 | Abdou ES Sorour MA | 2014 | International Food Re- search Journal2014，21，1： | 1 |
| 18 | Hormone replace- ment therapy after a diagnosis of breast cancer in relation to re- currence and mortality 显示文摘 | OMeara ES Rossing MA Daling JR | 2001 | J Nat Cancer Inst2001，93，： | 1 |
| 19 | Phase I rapid dose-escalation study of AGS-IC4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial显示文摘 | Antonarakis ES Carducci MA Eisenberger MA | 2012 | Cancer Chemother Pharmacol2012，69，3： | 1 |
| 20 | Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma显示文摘 | Gadd MA Casper ES Woodruff JM | 1993 | Ann Surg1993，218，： | 1 |
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