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| 1 | Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization显示文摘AIM: To determine the role of interleukin (IL)-17 in gastric ulcerogenesis. METHODS: Thirty-six gastric ulcer (GU) patients and 29 non-ulcer (NU) patients were enrolled in this study. Mucosal biopsy samples were obtained from the gastric antrum and GU site during endoscopy. Samples were used in in situ stimulation for 48 h in the presence of 10 μg/mL phytohemagglutinin-P (PHA), histological examination, and Helicobacter pylori(H pylori) culture. IL-17 and IL-8 protein levels in culture supernatants were assayed by ELISA. IL-17 mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). H pylori cagA and vacA status was assessed by reverse hybridization using a line probe assay (LiPA). IL-8 levels in culture supernatants were assayed after AGS cells were co-cultured with H pylori strain 26 695 or recombinant human (rh) IL-17. RESULTS: All 36 GU patients and 15 of 29 NU patients were found to be H pylori-positive, while 14 NU patients were H pylori-negative. All 51 H pylori strains from both GU and NU patients were cagA- and vacAs1/m1-positive. Antral mucosal tissues from H pylori-positive patients contained significantly (H pylori-positive NU patients: median 467 pg/mg/protein, range 53-2 499; H pylori-negative NU patients: median 104 pg/mg/protein, range 16-312, P<0.0005) higher levels of IL-17 than those from uninfected patients. IL-17 levels at the ulcer site were significantly (ulcer site: median 1356 pg/mg/protein, range 121-1 3730; antrum: median 761 pg/mg/protein, range 24-7 620, P<0.005) higher than those at distant sites in the antrum. Biopsies from H pylori-positive GU and NU patients showed IL-17 mRNA expression in all samples whereas those from the antrum of the H pylori-negative controls showed no detectable expression. A significant correlation was seen between IL-17 and IL-8 levels at each biopsy site (ulcer: r= 0.62, P<0.0001; antrum: r = 0.61, P<0.0001) in GU patients. RhIL-17 and H pylori strain 26 695 each stimulated IL-8 production from AGS cells. CONCLUSION: IL-17 may play an important role in the inflammatory response to H pylori colonization, and may ultimately influence the outcome of H pylori-associated diseases that arise within the context of gastritis. | Tomokazu Mizuno Takafumi Ando Kazuo Nobata Tomoyuki Tsuzuki Osamu Maeda Osamu Watanabe Masaaki Minami Kenji Ina Kazuo Kusugami Richard M. Peek Hidemi Goto | 2005 | World Journal of Gastroenterology2005，11，40： | 18 |
| 2 | Prospective clinical study of endoscopic ultrasound-guided choledochoduodenostomy with direct metallic stent placement using a forward-viewing echoendoscope显示文摘 | K. Hara K. Yamao S. Hijioka N. Mizuno H. Imaoka M. Tajika S. Kondo T. Tanaka S. Haba O. Takeshi Y. Nagashio T. Obayashi A. Shinagawa V. Bhatia Y. Shimizu H. Goto Y. Niwa | 2013 | Endoscopy2013，，05： | 6 |
| 3 | ICRF Heated Long-Pulse Plasma Discharges in LHD显示文摘A long-pulse plasma discharge for more than 30 min.was achieved on the LargeHelical Device(LHD).A plasma of n_e=0.8×10^(19)m^(-3)and T_(iO)=2.0 keV was sustained withP_(ICH)=0.52 MW,P_(ECH)=0.1 MW and averaged P_(NBI)=0.067 MW.Total injected heatingenergy was 1.3 GJ,which was a quarter of the prepared RF heating energy.One of the keys to thesuccess of the experiment was a dispersion of the local plasma heat load to divertors,accomplishedby shifting the magnetic axis inward and outward. | R. KUMAZAWA T. SEKI T. MUTOH K. SAITO T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIHARA M. SHOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. ASHIKAWA K. NISHIMURA H. FUNABA H. CHIKARAISHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.NOMURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK H. YAMADA K. KAWAHATA N. OHYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA | 2006 | Plasma Science and Technology2006，8，1： | 4 |
| 4 | Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms显示文摘 | K. Niimi M. Fujishiro S. Kodashima O. Goto S. Ono K. Hirano C. Minatsuki N. Yamamichi K. Koike | 2010 | Endoscopy2010，，09： | 3 |
| 5 | Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms显示文摘 | S. Ono M. Fujishiro K. Niimi O. Goto S. Kodashima N. Yamamichi M. Omata | 2009 | Endoscopy2009，，08： | 2 |
| 6 | Antioxidant properties of four edible algae harvested in the Noto Peninsula, Japan显示文摘 | T. Kuda M. Tsunekawa H. Goto Y. Araki | 2004 | Journal of Food Composition and Analysis2004，，7： | 2 |
| 7 | Mesoporous Material from Zeolite显示文摘 | Y. Goto Y. Fukushima P. Ratu Y. Imada Y. Kubota Y. Sugi M. Ogura M. Matsukata | 2002 | Journal of Porous Materials2002，，1： | 1 |
| 8 | Olivary enlargement: Chronological and morphometric analyses显示文摘 | N. Goto M. Kaneko | 1981 | Acta Neuropathologica1981，，4： | 1 |
| 9 | Calcium Requirement Estimated by Balance Study in Elderly Japanese People显示文摘 | K. Uenishi H. Ishida A. Kamei M. Shiraki I. Ezawa S. Goto H. Fukuoka T. Hosoi H. Orimo | 2001 | Osteoporosis International2001，，10： | 1 |
| 10 | Associations of TNF-A-1031TT and -857TT genotypes with Helicobacter pylori seropositivity and gastric atrophy among Japanese Brazilians显示文摘 | Yoshiko Atsuta Lucy S. Ito Sueli M. Oba-Shinjo Miyuki Uno Samuel Katsuyuki Shinjo Suely K.N. Marie Yasuyuki Goto Nobuyuki Hamajima | 2006 | International Journal of Clinical Oncology2006，，2： | 1 |
| 11 | Regions of homology shared by Rfp-Y and major histocompatibility B complex genes显示文摘 | Marcia M. Miller Ronald Goto Rima Zoorob Charles Auffray W. Elwood Briles | 1994 | Immunogenetics1994，，1： | 1 |
| 12 | A polymorphic system related to but genetically independent of the chicken major histocompatibility complex显示文摘 | W. Elwood Briles Ronald M. Goto Charles Auffray Marcia M. Miller | 1993 | Immunogenetics1993，，6： | 1 |
| 13 | Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications显示文摘 | M. Makino S. Horai Y. Goto I. Nonaka | 2000 | Journal of Human Genetics2000，，2： | 1 |
| 14 | A polymorphic system related to but genetically independent of the chicken major histocompatibility complex显示文摘 | W. Elwood Briles Ronald M. Goto Charles Auffray Marcia M. Miller | 1993 | Immunogenetics1993，，6： | 1 |
| 15 | Effect of green light wavelength and intensity on photomorphogenesis and photosynthesis in Lactuca sativa显示文摘 | M. Johkan K. Shoji F. Goto S. Hahida T. Yoshihara | 2011 | Environmental and Experimental Botany2011，，： | 1 |
| 16 | Overall burden of bloodstream infection and nosocomial bloodstream infection in N orth A merica and E urope显示文摘 | M. Goto M. N. Al‐Hasan | 2013 | Clin Microbiol Infect2013，，6： | 1 |
| 17 | Extraction of Rare Earth Metals Using Liquid Surfactant Membranes in a Mixco Extractor显示文摘 | K. Uezu S. Irie O. Yoshimura M. Goto F. Nakashio | 1997 | Chemical Engineering Research and Design1997，，5： | 1 |
| 18 | A solid electrolyte oxygen sensor for steelmaking slags of the basic oxygen converter显示文摘 | M. Kawakami K. S. Goto M. Matsuoka | 1980 | Metallurgical Transactions B1980，，3： | 1 |
| 19 | Experimental vaccine activities of recombinant E1 and E2 glycoproteins and hypervariable region 1 peptides of hepatitis C virus in chimpanzees显示文摘 | M. Esumi T. Rikihisa S. Nishimura J. Goto K. Mizuno Y.-H. Zhou T. Shikata | 1999 | Archives of Virology1999，，5： | 1 |
| 20 | Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): A correlative study of the clinical features and mitochondrial DNA mutation显示文摘 | Y. Goto S. Horai T. Matsuoka Y. Koga K. Nihei M. Kobayashi I. Nonaka | 1992 | Neurology1992，，： | 1 |
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