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| 1 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 2 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 3 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 4 | Nitric oxide in diabetic nephropathy显示文摘 | Craven P A DeRubektis F R Melhem M | 1997 | Kidney Int Suppl1997，52，60： | 1 |
| 5 | Performance of the submerged membrane electro-bioreactor(SMEBR) with iron electrodes for waste- water treatment and fouling reduction显示文摘 | Bani Melhem K Elektorowicz M | 2011 | Journal of Membrane science2011，379，12： | 1 |
| 6 | Nitric oxide in diabetic nephropathy显示文摘 | Derubertis FR Melhem M | 1997 | Kidrey Int1997，52，： | 1 |
| 7 | Devel- opment of a novel submerged membrane electrobioreactor ( SMEBR ) : performance for fouling reduction 显示文摘 | K Bani - Melhem M Elektorowiez | 2010 | Environ Sci Techno12010，44，： | 1 |
| 8 | An incremental approach to scheduling during overloads in real time systems显示文摘 | Alvarez P M Melhem R Daniel M | 2000 | IEEE RealTime Systems2000，10，1： | 1 |
| 9 | Functional analysis of genetic variation in catehol-O-Methyltransferase(COMT):Effects on mRNA,protein,and enzyme activity in postmortem human brain显示文摘 | Chen J.S Lipska B.K Halim N Ma Q.D Matsumoto M Melhem S | | 0，，05： | 1 |
| 10 | High-level antigen expression and sustained antigen presentation in dendritic cells nucleofected with wild-type viral mRNA but not DNA显示文摘 | Melhem N M Gleason S M Liu X D | 2008 | Clin Vaccine Immunol2008，15，9： | 1 |
| 11 | Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment 显示文摘 | SAR Shilbayeh SS Melhem M | 2015 | Clin Pharmacol Drug Dev2015，4，5： | 1 |
| 12 | Vascular access in hemodialysis : issues, management, emerging concepts 显示文摘 | P Roy-Chaudhury BS Kelly M Melhem | 2005 | Cardiol Clin2005，23，： | 1 |
| 13 | Diffusion tensor MR imaging of the brain and white matter tractography显示文摘 | Melhem Elias R Susumu M | 2002 | AJR2002，178，： | 1 |
| 14 | Perivascular paclitaxelwraps block arteriovenous graft stenosis in a pig model 显示文摘 | KELLY B MELHEM M ZHANG J | 2006 | Neph-rol Dial Transplant2006，21，9： | 1 |
| 15 | Perivascular paclitaxel polymers reduce neointimal hyperplasia and venous stenosis in PTTE arteriovenous grafts:a possible solution for hemodialysis vascular access dysfunction 显示文摘 | Kelly B Melhem M Desai P | 2004 | J Am Soc Nephrol2004，15，： | 1 |
| 16 | Nitric oxide in diabetic nephropathy显示文摘 | Craven P A DeRubektis F R Melhem M | 1997 | Kidney Int Suppl1997，52，60： | 1 |
| 17 | Pollen morphological studies in Rubiaceae 显示文摘 | Melhem T S Rossi C L D B Silvestre M S F | 1974 | Hoehnea1974，4，： | 1 |
| 18 | Nitric oxide in diabetic nephropathy显示文摘 | Craven PA De Rubertis FR Melhem M | 1997 | J Kidney Int1997，，： | 1 |
| 19 | Perivascular paclitaxel polymers reduce neointimal hyper-plasia and venous stenosis in PTFE arteriovenous grafts:A possible solution for hemodialysis vascular access dysfunction显示文摘 | Kelly B Melhem M Desai P | 2004 | J Am Soc Nephrol2004，15，： | 1 |
| 20 | Nitric oxide in diabetic nephropathy显示文摘 | Craven PA DeRubertis FR Melhem M | 1997 | Kidney Int Suppl1997，60，： | 1 |
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