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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy显示文摘 | Luuk J. Rijzewijk Rutger W. van der Meer Hildo J. Lamb Hugo W.A.M. de Jong Mark Lubberink Johannes A. Romijn Jeroen J. Bax Albert de Roos Jos W. Twisk Robert J. Heine Adriaan A. Lammertsma Johannes W.A. Smit Michaela Diamant | 2009 | Journal of the American College of Cardiology2009，，16： | 2 |
| 3 | Integrated product formation and recovery in fermentation 显示文摘 | Luuk A M Wielen V D Karel C A | 1992 | Current Opinion in Biotechnology1992，3，： | 1 |
| 4 | Sorption of tetracycline on organo-montmorillonites显示文摘 | Niu Liu Ming-xia Wang Ming-ming Liu Fan Liu Liping Weng Luuk K. Koopal Wen-feng Tan | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 5 | Long-term anal sphincter performance after surgery for Hirschsprung,s disease显示文摘 | Heikkinen M Rintala R Luuk konen P | | 0，，： | 1 |
| 6 | Innovation Performance and Innovation Policy: the Case of the Netherlands 显示文摘 | Luuk Klomp | 2004 | De Economist2004，152，3： | 1 |
| 7 | Spontaneous remodeling of the spinal canal after conservative management of thoracolumbar burst fracture显示文摘 | Luuk WL Fontijne WP Stijnen T | 1998 | Spine1998，23，： | 1 |
| 8 | Findings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients With Type 2 Diabetes Mellitus显示文摘 | Arnold C.T. Ng Victoria Delgado Matteo Bertini Rutger W. van der Meer Luuk J. Rijzewijk Miriam Shanks Gaetano Nucifora Johannes W.A. Smit Michaela Diamant Johannes A. Romijn Albert de Roos Dominic Y. Leung Hildo J. Lamb Jeroen J. Bax | 2009 | The American Journal of Cardiology2009，，10： | 1 |
| 9 | Competitive adsorption of nonionic surfactant and nonionic polymer on silica显示文摘 | Bart R P Frans A M L Luuk K K | 2007 | Langmuir2007，23，： | 1 |
| 10 | Minimization of chemicals use during adsorptive recovery of suceinic acid显示文摘 | Cagri Efe Mervin Pieterse Horge Gascon Freek Kapteijn Luuk A M van der Wielen Adrie J J Straathof | 2010 | Industrial and Engineering Chemistry Research2010，49，： | 1 |
| 11 | Zwitterions as alternative draw solutions in forward osmosis for application in wastewater reclamation显示文摘 | Kerusha Lutchmiah Lionel Lauber Kees Roest Danny J.H. Harmsen Jan W. Post Luuk C. Rietveld Jules B. van Lier Emile R. Cornelissen | 2014 | Journal of Membrane Science2014，，： | 1 |
| 12 | Optimization of azeotropic protein separations in gradient and isocratic ion-exchange simulated moving bed chromatography显示文摘 | Houwing Joukje Billiet Hugo A H Van DerWielen Luuk A M | 2002 | Journal of Chromatography A2002，944，12： | 1 |
| 13 | d-Asbll is an essential mediator of canonical Delta - Notch signaling显示文摘 | SanderHI) Maria A Sarlori Da Sliva Jan - luuk Hiilebrands | 2008 | Nature Cell Biology2008，10，10： | 1 |
| 14 | Devising renewable heat policy: Overview of support options显示文摘 | Peter Connor Veit Bürger Luuk Beurskens Karin Ericsson Christiane Egger | 2013 | Energy Policy2013，，： | 1 |
| 15 | Myocardial Steatosis and Biventricular Strain and Strain Rate Imaging in Patients With Type 2 Diabetes Mellitus显示文摘 | Arnold C.T. Ng Victoria Delgado Matteo Bertini Rutger W. van der Meer Luuk J. Rijzewijk See Hooi Ewe Hans-Marc Siebelink Johannes W.A. Smit Michaela Diamant Johannes A. Romijn Albert de Roos Dominic Y. Leung Hildo J. Lamb Jeroen J. Bax | 2010 | Circulation2010，，24： | 1 |
| 16 | Immobilised enzymes: carrier-bound or carrier-free?显示文摘 | Linqiu Cao Luuk van Langen Roger A Sheldon | 2003 | Current Opinion in Biotechnology2003，，4： | 1 |
| 17 | Devising renewable heat policy: Overview of support options显示文摘 | Peter Connor Veit Bürger Luuk Beurskens Karin Ericsson Christiane Egger | 2012 | Energy Policy2012，，： | 1 |
| 18 | The Heritage of the Productive Landscape:Landscape Design for Rural areas in the Netherlands,1954-1985显示文摘 | Janssen Joks Knippengerg Luuk | | 0，，01： | 1 |
| 19 | A new, mild cross‐linking methodology to prepare cross‐linked enzyme aggregates显示文摘 | CesarMateo José M.Palomo Luuk M.van Langen Fredvan Rantwijk Roger A.Sheldon | 2004 | Bioeng2004，，3： | 1 |
| 20 | Temperature-induced alterations of in vivo chlorophyll a fluorescence induction in cucumber as affected by DCMU显示文摘 | Luuk H. J. Janssen Philip R. Hasselt | 1988 | Photosynthesis Research1988，，2： | 1 |
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