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| 1 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 2 | The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population显示文摘The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder.Consequently,the norepinephrine transporter gene is an attractive candidate in major depressive disorder research.In the present study,we evaluated the depression symptoms of subjects with major depressive disorder,who were all from the North of China and of Han Chinese origin,using the Hamilton Depression Scale.We examined the rela-tionship between two single nucleotide polymorphisms in the norepinephrine transporter,rs2242446 and rs5569,and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program.rs5569 was associated with depressed mood,and the GG genotype may be a risk factor for this;rs2242446 was associated with work and interest,and the TT genotype may be a risk factor for loss of interest.Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Han Chinese population. | Xinrong Li Ning Sun Yong Xu Yanfang Wang Suping Li Qiaorong Du Juyi Peng Jinxiu Luo Kerang Zhang | 2012 | Neural Regeneration Research2012，7，25： | 3 |
| 3 | A Strategy for Merging Objective Estimates of Global Daily Precipitation from Gauge Observations, Satellite Estimates, and Numerical Predictions显示文摘This paper describes a strategy for merging daily precipitation information from gauge observations, satellite estimates(SEs), and numerical predictions at the global scale. The strategy is designed to remove systemic bias and random error from each individual daily precipitation source to produce a better gridded global daily precipitation product through three steps.First, a cumulative distribution function matching procedure is performed to remove systemic bias over gauge-located land areas. Then, the overall biases in SEs and model predictions(MPs) over ocean areas are corrected using a rescaled strategy based on monthly precipitation. Third, an optimal interpolation(OI)–based merging scheme(referred as the HL-OI scheme)is used to combine unbiased gauge observations, SEs, and MPs to reduce random error from each source and to produce a gauge—satellite–model merged daily precipitation analysis, called BMEP-d(Beijing Climate Center Merged Estimation of Precipitation with daily resolution), with complete global coverage. The BMEP-d data from a four-year period(2011–14) demonstrate the ability of the merging strategy to provide global daily precipitation of substantially improved quality.Benefiting from the advantages of the HL-OI scheme for quantitative error estimates, the better source data can obtain more weights during the merging processes. The BMEP-d data exhibit higher consistency with satellite and gauge source data at middle and low latitudes, and with model source data at high latitudes. Overall, independent validations against GPCP-1DD(GPCP one-degree daily) show that the consistencies between BMEP-d and GPCP-1DD are higher than those of each source dataset in terms of spatial pattern, temporal variability, probability distribution, and statistical precipitation events. | Suping NIE Tongwen WU Yong LUO Xueliang DENG Xueli SHI Zaizhi WANG Xiangwen LIU Jianbin HUANG | 2016 | Advances in Atmospheric Sciences2016，33，7： | 3 |
| 4 | Negotiated care improves fluidstatus in diabetic peritoneal dialysis patients显示文摘 | Quan L?i Xu Ying Luo SuPing | 2006 | Peril Dial Int2006，26，1： | 1 |
| 5 | Effects of Flooding Stress on Growth and Root Physiology and Biochemistry of Grafted Red-seed Watermelon Seedlings显示文摘[Objectives]This study was conducted to explore how to improve the waterlogging tolerance of red-seed watermelon through grafting,to provide a theoretical basis for its cultivation in rainy season.[Methods]The effects of flooding stress on the growth and root physiological and biochemical characteristics of grafted and own-rooted red-seed watermelon seedlings were studied using Luffa as rootstocks and'Zhongxin 1'red-seed watermelon as scions.[Results]After flooding stress,the biomass and root activity of grafted seedlings of red-seed watermelon were significantly higher than those of own-rooted seedlings.With the prolongation of flooding stress time,the soluble sugar and proline content showed a trend of first increasing and then decreasing,and the grafted seedlings had a larger increase and a smaller decrease,and were always significantly higher than own-rooted seedlings in the same period.The content of malondialdehyde in the root system of grafted seedlings increased first and then decreased,while it continued to increase in own-rooted seedlings,and the increase in own-rooted seedlings was significantly greater than that in grafted seedlings during the same period.[Conclusions]Grafting on Luffa rootstocks could improve waterlogging tolerance of red-seed watermelon. | Ke ZHANG Siliang LUO Tangjing LIU Wu QIN Suping WU | 2023 | Agricultural Biotechnology2023，12，2： | 1 |
| 6 | Self-assembly of three-dimensional CdS nanosphere/graphene networks for efficient photocatalytic hydrogen evolution显示文摘In this work, we report the construction of three-dimensional(3D) CdS nanosphere/graphene networks by a one-step hydrothermal self-assembly route. The 3D graphene networks not only enhance the light scattering, thanks to the interconnected 3D architecture, but also improve the crystallinity of deposited CdS nanospheres, and at the same time provide a direct electron pathway to quickly separate the photogenerated electron-hole pairs from CdS, which thus dramatically improve the photocatalytic activity.The optimized 3D CdS nanosphere/graphene networks with 2 wt% of graphene could produce molecular hydrogen at a rate of 2310 μmol gcatalyst^(-1) h^(-1) under visible-light illumination(λ > 400 nm). | Zhijian Wang Zhi Liu Jiazang Chen Hongbin Yang Jianqiang Luo Jiajian Gao Junming Zhang Cangjie Yang Suping Jia Bin Liu | 2019 | Journal of Energy Chemistry2019，28，4： | 1 |
| 7 | KPNB1 , XPO7 and IPO8 Mediate the Translocation of NF‐κB /p65 into the Nucleus显示文摘 | Peizhou Liang Haiyan Zhang Guoxin Wang Suping Li Shujie Cong Yingyun Luo Biliang Zhang | 2013 | Traffic2013，，11： | 1 |
| 8 | Characterizing the maturity of highly evolved organic matter based on aromatic hydrocarbons and optimization with pyrobitumen reflectance and Raman spectral parameters显示文摘Maturity evaluation of highly evolved organic matter is an important problem in oil and gas geochemistry,because conventional organic geochemical proxies are not applicable due to hydrocarbon generation and expulsion.In this study,we investigated the pyrobitumen in the reservoirs of the Sinian Dengying Formation in the Sichuan Basin,China.We focused on aromatic hydrocarbon biomarkers,and the calibration and application of aromatic maturity proxies using pyrobitumen reflectance and Raman spectral parameters.Our results show that only the thiophene compounds are effective maturity indicators,such as MDR(4-/1-MDBT),MDR′(4-MDBT/(1-MDBT+4-MDBT)),MDR1(1-MDBT/DBT),4,6-/(1,4+1,6)-DMDBT,(2,6+3,6)-/(1,4+1,6)-DMDBT,and[2,1]BNT/([2,1]BNT+[1,2]BNT),as these are largely independent of the optical anisotropy of pyrobitumen.The condensation and incorporation of thiophene compounds can lead to an increase in the reflectance of pyrobitumen,which means the thiophene compound parameters are positively or negatively correlated with pyrobitumen reflectance.New potential maturity parameters were proposed,including DMDBTs/MDBTs,TeMDBTs/(DBT+MDBTs+DMDBTs+TMDBTs+TeMDBTs),1-MDBT/MDBTs,and[2,1]BNT/BNTs.This method and these parameters are universally applicable to maturity characterization,especially in rocks that lack vitrinite,contain strongly anisotropic organic matter,and have high contents of thiophene compounds. | Zhaoxi ZUO Jian CAO Wenxuan HU Chunhua SHI Xiaolin WANG Suping YAO Bing LUO | 2022 | Science China Earth Sciences2022，65，12： | 0 |
| 9 | Research on Drug-Patent Linkage System under the New Situation显示文摘Objective To explore the extent to which the drug-patent linkage system should be implemented in China. Methods The present situation of drug-patent linkage system internationally was analyzed. Then the practices of drug-patent linkage system were discussed through such methods as literature reviews and quantitative scoring methods in combination of selecting the representative countries. Finally the extent to which the drugpatent linkage system should be implemented in China was explored through comparative analysis. Results and Conclusion Compared with the United States, China should establish a drug-patent linkage system that will weaken the protection of original patented drugs and promote the timely marketing of high-quality generic drugs and appropriately prevent the patent abuse. | Huang Yufeng Luo Suping Yuan Hongmei | 2019 | Asian Journal of Social Pharmacy2019，14，1： | 0 |
| 10 | Research on Protection of the Interests of Generic Drug Companies in the Drug-Patent Linkage System Based on Cournot Model显示文摘Objective To establish a system conducive to generic drug companies based on the facts that although China has promised to implement the data monopoly system and patent term extension system for pharmaceutical companies that hold the patents, yet China is a country that manufactures a large number of generic drugs each year which are closely related to citizens’ healthcare. Methods The US drug patent linkage system was studied through literature review methods and then the protection of the interests of generic drug companies in the drug-patent linkage system was explored based on the Cournot model. Results and Conclusion The policy of improving the quality of generic drugs and increasing the spillover effect of technology is more beneficial to generic drug companies. Based on the results, some policy suggestions are put forward, such as the implementation of the simplified application system for generic drugs and the consistency evaluation of generic drugs. | Ding Wenqing Luo Suping Yuan Hongmei Zhang Dawei | 2019 | Asian Journal of Social Pharmacy2019，14，1： | 0 |
| 11 | Heritability of Main Yield Traits in Red-seed Watermelon and Their Correlation Analysis显示文摘[Objectives]This study was conducted to provide a reliable theoretical basis for the correct formulation of breeding programs for red-seed watermelon and the effective breeding of hybrid offspring.[Methods]With local varieties and inbred lines of red-seed watermelon as test materials,the generalized heritability of fruit number per plant,single-fruit weight,single-fruit seed number,single-fruit seed weight,seed kernel weight,1000-seed weight,kernel-producing ratio,seed production ratio and seed volume were estimated by variance analysis;and the heritability,genetic variation coefficients,and correlation of the nine yield traits in 43 red-seed watermelon varieties were studied.[Results]The generalized heritability of fruit number per plant,single-fruit weight,single-fruit seed number,single-fruit seed weight,seed kernel weight,1000-seed weight,kernel-producing ratio,seed production ratio and seed volume were 12.86%,80.14%,75.96%,74.39%,48.01%,17.12%,24.97%,18.60%,and 37.07%,respectively.The heritability of single-fruit weight,single-fruit seed number and single-fruit seed weight was higher,and early-generation individual selection could achieve a better effect on them;and 1000-seed weight and kernel-producing ratio had a higher coefficient of genetic variation,indicating a high selection potential.[Conclusions]Indirect selection could be achieved for traits such as the single-fruit seed number,single-fruit seed weight,seed kernel weight,and seed volume by selecting the single-fruit weight.In the process of red-seed watermelon breeding,traits with high heritability can be selected in early generations of hybrids,thus playing the role of early-generation orientation. | Tangjing LIU Siliang LUO Ke ZHANG Yanhong QIU Wu QIN Suping WU | 2023 | Agricultural Biotechnology2023，12，3： | 0 |
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