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| 1 | Energy metabolism disorders and potential therapeutic drugs in heart failure显示文摘Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy supply.This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of heart.Current HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the disease.Drugs aimed at cardiac energy metabolism have not yet been developed.In this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy metabolism.Finally,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF. | Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 11 |
| 2 | Low-dose intravenous tissue plasminogen activator for acute ischaemic stroke: an alternative or a new standard?显示文摘Background:With the recent publication of a large clinical trial on the use of a lower dose of intravenous(IV)tissue plasminogen activator(tPA)for acute ischaemic stroke(AIS),the concept of using a different dose has been debated.We intend to review the literature on using a lower dose of IV tPA and gain a better understanding of the impact of different IV doses on the treatment of patients with AIS.Methods:A comprehensive literature search of the related topics in PubMed,EMBASE,Web of Science and MEDLINE was carried out.Key words used include low dose IV tPA,thrombolysis,Alteplace and tPA for AIS.Findings were tabulated according to the size of the cohort studied,outcome,adverse event and level of evidence.The results of all studies using lower doses were analysed for efficacy and adverse events.Results:From 1992 to 2016,there were 23 trials that included 10950 patients published on the use of lower doses of IV tPA for AIS.Doses ranged from 0.5,0.6,0.75 to 0.85 mg/kg.Most were observational,retrospective and registry studies.One was a prospective open-label randomised controlled trial.13 trials combined lower doses of IV tPA with a glycoprotein IIb/IIIa inhibitor or thrombectomy.Patients treated with lower doses of IV tPA showed a trend of lower rate of symptomatic intracranial haemorrhage and mortality at 3 months but slightly more disability.Conclusions:Lower doses of IV tPA showed less haemorrhagic events but were not more effective compared with the standard dose.The optimal low dose of IV tPA remains unclear.Patients with AIS with a high risk of developing sypmtomatic intracranial haemorrhage might benefit from lower dose IV tPA,such as 0.6 mg/kg. | Yi Dong Wenjie Cao Xin Cheng Kun Fang Fei Wu Lumeng Yang Yanan Xie Qiang Dong | 2016 | Stroke & Vascular Neurology2016，1，3： | 2 |
| 3 | Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight显示文摘Neuropeptide Y(NPY) is widely expressed in the central nervous system and influences many physiological processes.It is located within the rat quantitative trait locus(QTL) for alcohol preference on chromosome 4.Alcohol-nonpreferring(NP) rats consume very little alcohol,but have significantly higher NPY expression in the brain than alcohol-preferring(P) rats.We capitalized on this phenotypic difference by creating an Npy knockout(KO) rat using the inbred NP background to evaluate NPY effects on alcohol consumption.Zinc finger nuclease(ZNF) technology was applied,resulting in a 26-bp deletion in the Npy gene.RT-PCR,Western blotting and immunohistochemistry confirmed the absence of Npy mRNA and protein in KO rats.Alcohol consumption was increased in Npy^(+/-) but not Npy^(-/-) rats,while Npy^(-/-) rats displayed significantly lower body weight when compared to Npy^(+/+) rats.In whole brain tissue,expression levels of Npy-related and other alcohol-associated genes,Npy1 r,Npy2r,Npy5 r,Agrp,Mc3 r,Mc4r,Crh and CrMr,were significantly greater in Npy^(-/-) rats,whereas Pome and Crhr2 expressions were highest in Npy^(+/-) rats.These findings suggest that the NPY-system works in close coordination with the melanocortin(MC) and corticotropin-releasing hormone(CRH) systems to modulate alcohol intake and body weight. | Bin Qiu Richard L.Bell Yong Cao Lingling Zhang Robert B.Stewart Tamara Graves Lawrence Lumeng Weidong Yong Tiebing Liang | 2016 | Journal of Genetics and Genomics2016，43，7： | 2 |
| 4 | Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis显示文摘 | William R Kessler Oscar W Cummings George Eckert Naga Chalasani Lawrence Lumeng Paul Y Kwo | 2004 | Clinical Gastroenterology and Hepatology2004，，7： | 2 |
| 5 | Biliary tract complications after orthotopic liver transplantation with choledochocholedochostomy anastomosis: endoscopic findings and results of therapy显示文摘 | Rungsun Rerknimitr Stuart Sherman Evan L. Fogel Cem Kalayci Lawrence Lumeng Naga Chalasani Paul Kwo Glen A. Lehman | 2002 | Gastrointestinal Endoscopy2002，，2： | 2 |
| 6 | Degradation of micropolluants in flow-through VUV/UV/H2O2 reactors: Effects of H2O2 dosage and reactor internal diameter显示文摘The degradation of atrazine (ATZ),sulfamethoxazole (SMX) and metoprolol (MET) in flowthrough VUV/UV/H2O2reactors was investigated with a focus on the effects of H2O2dosage and reactor internal diameter (ID).Results showed that the micropollutants were degraded efficiently in the flow-through VUV/UV/H2O2reactors following the pseudo first-order kinetics (R2>0.92).However,the steady-state assumption (SSA) kinetic model being vital in batch reactors was found invalid in flow-through reactors where fluid mixing was less sufficient.With the increase of H2O2dosage,the ATZ removal efficiency remained almost constant while the SMX and MET removal was enhanced to different extents,which could be explained by the different reactivities of the pollutants towards HO·.A larger reactor ID resulted in lower degradation rate constants for all the three pollutants on account of the lower average fluence rate,but the change in energy efficiency was much more complicated.In reality,the electrical energy per order (EEO) of the investigated VUV/UV/H2O2treatments ranged between 0.14–0.20,0.07–0.14 and 0.09–0.26 k Wh/m3/order for ATZ,SMX and MET,respectively,with the lowest EEOfor each pollutant obtained under varied H2O2dosages and reactor IDs.This study has demonstrated the efficiency of VUV/UV/H2O2process for micropollutant removal and the inadequacy of the SSA model in flow-through reactors,and elaborated the influential mechanisms of H2O2dosage and reactor ID on the reactor performances. | Lumeng Zhan Wentao Li Li Liu Tao Han Mengkai Li Zhimin Qiang 无 | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 7 | Obesity in- duces a phenotypic switch in adipose tissue macrophage polarization 显示文摘 | LUMENG C N BODIZIN J L SALTIEL A R | 2007 | J Clin Invest2007，117，1： | 1 |
| 8 | Epidemiology of pediatric obstructive sleep apnea显示文摘 | Lumeng J C Chervin R D | 2008 | Proc Am Thorac Soc2008，5，2： | 1 |
| 9 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization 显示文摘 | Lumeng CN Bodzin JL Saltiel AR | 2007 | J Clin Invest2007，117，1： | 1 |
| 10 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization 显示文摘 | Lumeng CN Bodzin JL Saltiel AR | 2007 | J Clin Invest2007，117，1： | 1 |
| 11 | Inflammatory links between obesity and metabolic disease显示文摘 | Lumeng C N Saltiel A R | 2011 | J Clin Invest2011，121，6： | 1 |
| 12 | Obesity induces a phenotypic switch in adipose tissue macrophgge polarization显示文摘 | Lumeng CN Bodzin JL Saltiel AR | 2007 | J Clin Invest2007，117，1： | 1 |
| 13 | T -ing up inflam- mation in fat显示文摘 | LUMENG C N MAILLARD I SALTIEL A R | 2009 | Nat Med2009，15，8： | 1 |
| 14 | Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes 显示文摘 | Lumeng C N DelProposto J B Westcott D J | 2008 | Diabetes2008，57，12： | 1 |
| 15 | Obesity induces a phe- notypic switch in adiposetissue mcrophage polarization 显示文摘 | Lumeng CN Bodzin JL Sahiel AR | 2007 | J Clin Invest2007，117，1： | 1 |
| 16 | Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice显示文摘 | Usher Michael G Duan Sheng Zhong Ivaschenko Christine Y Frieler Ryan A Berger Stefan Schütz Günther Lumeng Carey N Mortensen Richard M | 2010 | Journal of Clinical Investigation2010，，9： | 1 |
| 17 | Obesity induces a phenotypie switch in adipose tissue macrophage polarization 显示文摘 | Lumeng CN Bodzin JL Sahiel AR | 2007 | J Clin Invest2007，117，1： | 1 |
| 18 | Inflammatory links between obesity and metabolic disease显示文摘 | Lumeng Carey N Saltiel Alan R | 2011 | Journal of Clinical Investigation2011，，6： | 1 |
| 19 | Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes 显示文摘 | Lumeng CN DelProposto JB Westcott DJ | 2008 | Diabetes2008，57，12： | 1 |
| 20 | Epidemiology of pediatric obstructive sleep apnea 显示文摘 | Lumeng JC Chervin RD | 2008 | Proc Am Thorac Soc2008，5，2： | 1 |
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