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| 1 | 海洋立管-海床土体接触作用数值分析显示文摘钢悬链线立管(SCR)与海床土体的接触问题会使立管疲劳寿命急剧减少因而受到广泛关注。引入包含土体吸力效应的简化帽盖型P-y曲线,据此利用等效弹簧单元模拟土体并建立了立管与弹簧的有限元接触模型,计算并分析了不同立管竖向位移荷载和土体吸力最值下管道形态和弯矩的变化规律,讨论了着陆点(TDP)位置和着陆区(TDZ)深度与土体受力变化之间的关系。结果表明,立管弯矩在着陆点处变化最剧烈,在其两侧分别达到正负弯矩峰值,同时土体在相应位置出现吸力和承载力最大值,着陆区以后管土各变量基本无变化。 | 杜金新 Low Y M | 2008 | 工程地质计算机应用2008，，4： | 13 |
| 2 | Nonlinear Bend Stiffener Analysis Using A Simple Formulation and Finite Element Method显示文摘Flexible marine risers are commonly used in deepwater floating systems.Bend stiffeners are designed to protect flexible risers against excessive bending at the connection with the hull.The structure is usually analyzed as a cantilever beam subjected to an inclined point load.As deflections are large and the bend stiffener material exhibits nonlinear stress-strain characteristics,geometric and material nonlinearities are important considerations.A new approach has been developed to solve this nonlinear problem.Its main advantage is its simplicity;in fact the present method can be easily implemented on a spreadsheet.Finite element analysis using ABAQUS is performed to validate the method.Solid elements are used for the bend stiffener and flexible pipe.To simulate the near inextensibility of flexible risers,a simple and original idea of using truss elements is proposed.Through a set of validation studies,the present method is found to be in a good agreement with the finite element analysis.Further,parametric studies are performed by using both methods to identify the key parameters and phenomena that are most critical in design.The most important finding is that the common practice of neglecting the internal steel sleeve in the bend stiffener analysis is non-conservative and therefore needs to be reassessed. | TONG Dong Jin LOW Ying Min SHEEHAN John M | 2011 | China Ocean Engineering2011，25，4： | 6 |
| 3 | Renin-angiotensin system in the kidney: What is new?显示文摘The renin-angiotensin system(RAS)has been known for more than a century as a cascade that regulates body fluid balance and blood pressure.AngiotensinⅡ(AngⅡ)has many functions in different tissues;however it is on the kidney that this peptide exerts its main functions.New enzymes,alternative routes for AngⅡformation or even active AngⅡ-derived peptides have now been described acting on AngⅡAT1or AT2receptors,or in receptors which have recently been cloned,such as Mas and AT4.Another interesting observation was that old members of the RAS,such as angiotensin converting enzyme(ACE),renin and prorenin,well known by its enzymatic activity,can also activate intracellular signaling pathways,acting as an outside-in signal transduction molecule or on the renin/(Pro)renin receptor.Moreover,the endocrine RAS,now is also known to have paracrine,autocrine and intracrine action ondifferent tissues,expressing necessary components for local AngⅡformation.This in situ formation,especially in the kidney,increases AngⅡlevels to regulate blood pressure and renal functions.These discoveries,such as the ACE2/Ang-(1-7)/Mas axis and its antangonistic effect rather than classical deleterious AngⅡeffects,improves the development of new drugs for treating hypertension and cardiovascular diseases. | Fernanda M Ferr?o Lucienne S Lara Jennifer Lowe | 2014 | World Journal of Nephrology2014，3，3： | 5 |
| 4 | Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome显示文摘 | M. B. O. Lowén E. A. Mayer M. Sj?berg K. Tillisch B. Naliboff J. Labus P. Lundberg M. Str?m M. Engstr?m S. A. Walter | 2013 | Aliment Pharmacol Ther2013，，12： | 4 |
| 5 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 6 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 7 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 8 | Thymosin alpha 1: isolation and sequence analysis of an immunologically active thymic polypeptide显示文摘 | GOLDSTEIN A L LOW T L MCADOO M | 1977 | Proc Natl Acad Sci USA1977，74，2： | 2 |
| 9 | The reflection of guided waves from circumferential notches in pipes 显示文摘 | Alleyne D N Lowe M J S Cawley P | 1998 | Trans ASME J of Appl Mech1998，65，： | 2 |
| 10 | Nutrient removal from eutrophic lake water by wetland filtration显示文摘 | Stites D L Lowe E F | 2002 | Ecological Engineering2002，19，2： | 1 |
| 11 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | LOWE S E THEODOROU M K TRINCI A P J | 1985 | Journal of General Microbiology1985，131，： | 1 |
| 12 | The mode conversion of a guided wave by a part-circumferential notch in a pipe显示文摘 | Lowe M Alleyne N Cawley P | 1998 | Journal of Applied Mechanics1998，，65： | 1 |
| 13 | Coronary in-stent restenosis:current status and future strategies显示文摘 | LOWE H C OESTERLE S N KHACHIGIAN L M | 2002 | J Am Coll Cardiol2002，39，2： | 1 |
| 14 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen S M Low D E Henry B | 2003 | N Engl J Med2003，348，20： | 1 |
| 15 | Guided waves in curved pipes显示文摘 | DEMMA A CAWLEY P LOWE M J S | 2002 | Review of Progress in Quantitative Nondestructive Evaluation2002，21，： | 1 |
| 16 | Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53显示文摘 | Bacus SS Gudkov AV Lowe M | 2001 | Oncogene2001，20，2： | 1 |
| 17 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 18 | Infiltration and physical character istics of functionally graded alumina/ calcium- hexaluminate composites 显示文摘 | Asmi D Low I M | 2001 | Journal of Materials Processing Technology2001，118，： | 1 |
| 19 | A qualitative exploration of a respiratory distress symptom cluster in lung cancer: Cough, breathlessness and fatigue显示文摘 | Molassiotis A Lowe M Blackball F | 2011 | Lung Cancer2011，71，1： | 1 |
| 20 | Enhanced single copy integration events in corn via particle bombardment using low quantities of DNA显示文摘 | Lowe B A Shiva Prakash N Way M | 2009 | Transgenic Research2009，18，6： | 1 |
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