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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Associations of leptin gene polymorphisms with production traits in pigs 显示文摘 | De Oliveira Peixoto J Facioni Guimar?es S E Savio Lopes P | 2006 | J Anita Breed Genet2006，123，6： | 1 |
| 4 | Is bacterial vaginosis associated with squamous intraepithelial le- sion of the uterine cervix? 显示文摘 | Discacciati MG Simoes JA Lopes ES | 2006 | Diagn Cytopathol2006，34，5： | 1 |
| 5 | Efficacy and safety of oxaliplatin and docetaxel in patients with locally advanced and meta- static non-small cell lung cancer ( NSCLC ) 显示文摘 | Raes LE Santos ES Lopes G | 2006 | Lung Cancer2006，53，3： | 1 |
| 6 | Efficacy and safety of oxaliplatin and docetaxel in patients with locally advanced and metastatic non-small cell lung cancer (NSCLC)显示文摘 | Raez LE Santos ES Lopes G | 2006 | Lung Cancer2006，53，3： | 1 |
| 7 | The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistance显示文摘 | Thiago l_S Costa ES Lopes DV | 2010 | Biomed Pharmacother2010，64，1： | 1 |
| 8 | Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum显示文摘 | Pimentel-Coelho PM Magalhaes ES Lopes LM | 2010 | Stem Cells Dev2010，19，3： | 1 |
| 9 | Molecular modeling study of the recognition mechanism and enantioseparation of 4-hydroxypropra-nolol by capillary electrophoresis using carboxymethyl-β-cyclodextrin as the chiral selector显示文摘 | Nascimento C S Lopes J F Guimara~es L | 2014 | Analyst2014，139，16： | 1 |
| 10 | Effectiveness of implant surface decontamination using a highpressure sodium bicarbonate protocol:an in vitro study显示文摘 | Nemer Vieira LF Lopes de Chaves e Mello Dias EC Cardoso ES | 2012 | Implant Dent2012，21，5： | 1 |
| 11 | Efficacy and safety of oxaliplatin and docetaxel in patients with advanced and metastatic non-small-cell lung cancer ( NSCLC ) 显示文摘 | Raez LE Santos ES Lopes G | 2006 | Lung Cancer2006，53，： | 1 |
| 12 | Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson’s disease显示文摘 | Camila Andrade Mendes Medeiros Pedro Felipe Carvalhedo de Bruin Lívia Ariane Lopes Maria Cecília Magalh?es Maria de Lourdes Seabra Veralice Meireles Sales de Bruin | 2007 | Journal of Neurology2007，，4： | 1 |
| 13 | Para-metric analysis of the latera-l torsional buckling resistance ofsteel beams in case of fire显示文摘 | P M M Vila Real N Lopes L Sim es da Silva | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 14 | Front pattern of invasion in squa- mous cell Carcinoma of the penis : new prognostic factor for predicting risk of lymph node metastases显示文摘 | Guimar~es GC Lopes A Campos RS | 2006 | Urology2006，68，1： | 1 |
| 15 | Efficacy and safety of oxaliplatin and docetaxel in patients with locally advanced and metastatic non-small-cell lung cancer(NSCLC)显示文摘 | Raez LE Santos ES Lopes G | 2006 | Lung Cancer2006，53，3： | 1 |
| 16 | Human cord blood transplantation in a neonatal rat model of hypoxic- ischemic brain damage : functional outcome related to neuroprotection in the striatum 显示文摘 | Pimentel-Coelho PM Magalhaes ES Lopes LM | 2010 | Stem Ceils Dev2010，19，3： | 1 |
| 17 | Pronuclear Embryo Yield in Caninde and Saanen Goats for DNA Microinjection 显示文摘 | Moura RR Lopes -Junior ES Teixeira DIA | 2010 | Reproduetion in Domes- tic Animals2010，，45： | 1 |
| 18 | Linkage disequilibrium and haplotype block structure in six commercial pig lines显示文摘 | VERONEZE R LOPES P S GUIMAR?ES S E | 2013 | J Anim Sci2013，91，8： | 1 |
| 19 | Green fluorescent protein extraction and LPS removal from Escherichia coli fermentation medium using aqueous two-phase micellar system显示文摘 | Lopes AndréM Magalhes Pérola O Mazzola Priscila G | 2011 | Separation and Purification Technology2011，81，3： | 1 |
| 20 | The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistance 显示文摘 | Thiago LS Costa ES Lopes DV | 2010 | Biomed Pharmacother2010，64，1： | 1 |
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