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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array显示文摘We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si technology.The structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the system.We show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright photoluminescence.These strong emissions are correlated on all length scales according to the refractive index fluctuations.The relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications. | Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci Cirino Salvatore Vasi Rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 3 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 4 | A genetic algorithm for the design of a fuzzy controller for active queue management 显示文摘 | Fatta D G Hoffmann F Re Lo G | 2003 | IEEE Trans on System Man and Cybernetic2003，33，3： | 2 |
| 5 | A Smad transcriptional corepressor显示文摘 | Wotton D Lo RS Lee S | | 0，，： | 2 |
| 6 | Application of highresolution thermal infrared remote sensing and GIS to assess the urban heat island effect 显示文摘 | Lo C P Quattrovhi D A and Luvall J C | 1997 | International Journal of Remote Sensing1997，18，2： | 2 |
| 7 | 14 MeV neutron yields from D-T operation of the MIT Cockcroft-Walton accelerator显示文摘 | Borras M C Lo D H Petrasso R D | 1993 | Journal of Fusion Energy1993，12，3： | 2 |
| 8 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 9 | Selective glucoeorticoid control of Rho kinase isoforms regulate cell-cell interactions 显示文摘 | Rubenstein N M Callahan J A Lo D H | 2007 | Biochem Biophys Res Commun2007，354，2： | 1 |
| 10 | Evaluation of pre- test clinical score (4T's) for the diagnosis of heparin-in- duced thrombocytopenia in two clinical settings 显示文摘 | Lo GK Juhl D Warkentin TE | 2006 | J Thromb Haemost2006，4，4： | 1 |
| 11 | Examination of the difference between radiative and aerodynamic surface temperatures over sparsely vegetated surface显示文摘 | Chehbouni A Lo Seen D Njoku E G | 1996 | Remote Sens Environ1996，58，： | 1 |
| 12 | Pre-B-cell-colony- enhancing factor is critically involved in thromhin-induced lung endothelial cell barrier dysregulation显示文摘 | Ye SO Zhang LO Adyshev D | 2005 | Microvasc Res2005，70，3： | 1 |
| 13 | Simulation of near-shore solitary wave mechanics by a incompressible SPH method显示文摘 | Lo EYM Shao S D | 2002 | Journal of Applied Ocean Research2002，24，： | 1 |
| 14 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 15 | Morphological variation and raman spec- troscopy of ZnO hollow microspheres prepared by a chemical colloidal process显示文摘 | Lo S S Huang D | 2010 | Langmuir2010，26，9： | 1 |
| 16 | Alternatively activated dendritic cells derived from systemic lupus erythematosus patients have tolerogenic pheuotype and function 显示文摘 | Wu HJ Lo Y Luk D | 2015 | Clin Immunol2015，156，1： | 1 |
| 17 | The effects of dietary supplementation of vitamins C and E on the a-tocopherol content of muscles, liver and kidney, on the stability of lipids, and on certain meat quality parameters of the longissimus dorsi of rabbits 显示文摘 | Lo Fiego D P Santoro P Macchioni P | 2004 | Meat Science2004，67，： | 1 |
| 18 | Evaluation of pretest clinical score (4Ts) for the diagnosis of heparin-induced thrombocytopenia in two clinical setting 显示文摘 | Lo GK Juhl D Warkentin TE | 2006 | J Thromb Haemost2006，4，： | 1 |
| 19 | Two new self-adaptive projection methods for variational inequality problems显示文摘 | Han D Lo H K | 2002 | Computer and Mathematics with Applications2002，43，： | 1 |
| 20 | Optimal control of execution costs显示文摘 | Bertsimas D Lo A W | 1998 | Journal of Financial Markets1998，1，1： | 1 |
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