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| 1 | New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review显示文摘In this paper review we describe benefits and disadvantages of the established methods of cartilage regeneration that seem to have a better long-term effectiveness.We illustrated the anatomical aspect of the knee joint cartilage, the current state of cartilage tissue engineering, through mesenchymal stem cells and biomaterials,and in conclusion we provide a short overview on the rehabilitation after articular cartilage repair procedures.Adult articular cartilage has low capacity to repair itself,and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, result-ing in significant pain and disability. Numerous efforts have been made to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, and to date several researchers aim to implement clinical application of cell-based therapies for cartilage repair. A literature review was conducted on PubM ed, Scopus and Google Scholar using appropriate keywords, examining the current literature on the wellknown tissue engineering methods for the treatment of knee osteoarthritis. | Giuseppe Musumeci Paola Castrogiovanni Rosalia Leonardi Francesca Maria Trovato Marta Anna Szychlinska Angelo Di Giunta Carla Loreto Sergio Castorina | 2014 | World Journal of Orthopedics2014，5，2： | 10 |
| 2 | Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?显示文摘Aging is the most prominent risk factor contributing to the development of neurodegenerative disorders. In the United States, over 35 million of elderly people suffer from age-related diseases. Aging impairs the self-repair ability of neuronal cells, which undergo progressive deterioration.Once initiated, this process hampers the already limited regenerative power of the central nervous system, making the search for new therapeutic strategies particularly difficult in elderly affected patients. So far, mesenchymal stem cells have proven to be a viable option to ameliorate certain aspects of neurodegeneration, as they possess high proliferative rate and differentiate in vitro into multiple lineages. However, accumulating data have demonstrated that during longterm culture, mesenchymal stem cells undergo spontaneous transformation. Transformed mesenchymal stem cells show typical features of senescence, including the progressive shortening of telomers, which results in cell loss and, as a consequence, hampered regenerative potential. These evidences, in line with those observed in mesenchymal stem cells isolated from old donors, suggest that senescence may represent a limit to mesenchymal stem cells exploitation in therapy, prompting scholars to either find alternative sources of pluripotent cells or to arrest the age-related transformation. In the present review, we summarize findings from recent literature, and critically discuss some of the major hurdles encountered in the search of appropriate sources of mesenchymal stem cells, as well as benefits arising from their use in neurodegenerative diseases. Finally, we provide some insights that may aid in the development of strategies to arrest or, at least, delay the aging of mesenchymal stem cells to improve their therapeutic potential. | Alessandro Castorina Marta Anna Szychlinska Rubina Marzagalli Giuseppe Musumeci | 2015 | Neural Regeneration Research2015，10，6： | 8 |
| 3 | Recently highlighted nutraceuticals for preventive management of osteoarthritis显示文摘Osteoarthritis(OA) is a chronic degenerative disease of articular cartilage with limited treatment options. This reality encourages clinicians to suggest preventive measures to delay and contain the outbreak of the pathological conditions. Articular cartilage and synovium suffering from OA are characterised by an inflammatory state and by significant oxidative stress,responsible for pain,swelling and loss of mobility in the advanced stages. This review will focus on the ability of olive oil to exert positive effects on the entire joint to reduce pro-inflammatory cytokine release and increase lubricin synthesis,olive leaf extract,since it maintains lubrication by stimulating high molecular weight hyaluronan synthesis in synovial cells,curcumin,which delays the start of pathological cartilage breakdown,sanguinarine,which downregulates catabolic proteases,vitamin D for its capacity to influence the oxidative and proinflammatory environment,and carnosic acid as an inducer of heme oxygenase-1,which helps preserve cartilage degeneration. These molecules,considered as natural dietary supplements,appear like a cuttingedge answer to this tough health problem,playing a major role in controlling homeostatic balance loss and slowing down the pathology progression. Natural or food-derived molecules that are able to exert potential therapeutic effects are known as 'nutraceutical',resulting from the combination of the words 'nutrition' and 'pharmaceutical'. These compounds have gained popularity due to their easy availability,which represents a huge advantage for food and pharmaceutical industries. In addition,the chronic nature of OA implies the use of pharmacological compounds with proven longterm safety,especially because current treatments like nonsteroidal anti-inflammatory drugs and analgesicsimprove pain relief but have no effect on degenerative progression and can also cause serious side effects. | Silvia Ravalli Marta Anna Szychlinska Rosalia Maria Leonardi Giuseppe Musumeci | 2018 | World Journal of Orthopedics2018，9，11： | 5 |
| 4 | Dopamine: an immune transmitter显示文摘The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies. | Sarah Thomas Broome Krystal Louangaphay Kevin AKeay Gian Marco Leggio Giuseppe Musumeci Alessandro Castorina | 2020 | Neural Regeneration Research2020，15，12： | 5 |
| 5 | Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array显示文摘We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si technology.The structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the system.We show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright photoluminescence.These strong emissions are correlated on all length scales according to the refractive index fluctuations.The relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications. | Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci Cirino Salvatore Vasi Rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 6 | Complications of Native Arteriovenous Fistula: The Role of C olor D oppler U ltrasonography显示文摘 | Bianca Visciano Eleonora Riccio Vincenzo De Falco Antonino Musumeci Ivana Capuano Andrea Memoli Antonella Di Nuzzi Antonio Pisani | 2014 | Ther Apher Dial2014，，2： | 2 |
| 7 | Exercise as medicine to be prescribed in osteoarthritis显示文摘Inactivity contributes to chronic diseases, including diabetes, hypertension,cardiovascular disorders, and obesity. Sedentary habits can shorten life expectancy. Exercise has been widely proposed as a valuable approach to prevention. Regular physical activity, as part of one’s daily routine, may help to manage pathological conditions. This editorial especially addresses osteoarthritis(OA), a degenerative disease of the articular cartilage, which is one of the most common causes of disability worldwide. Standard treatments for this illness include surgical procedures and pharmacological management;behavioural approaches are also strongly recommended. Physical exercise represents a practical strategy to preserve function, decrease pain and fatigue, and increase muscle strength and flexibility. We suggest that physical activity be considered as an established form of treatment, which means including exercise in standard therapeutic guidelines. A growing number of patients suffer from preventable chronic conditions that impose a heavy social and economic burden on the healthcare system. Preventive exercise training should be prescribed in the same way as pharmaceuticals. | Silvia Ravalli Paola Castrogiovanni Giuseppe Musumeci | 2019 | World Journal of Orthopedics2019，10，7： | 2 |
| 8 | Persistent hiccup as presenting symptom in medulla oblongata cavernoma:a case report and review of the literature 显示文摘 | Musumeci A Cristofori L Bricolo A | 2000 | Clin Neurel Neurosurg2000，102，： | 1 |
| 9 | The microsur- gical anatomy of the cisternal segment of the trochlear nerve, as seen through different neurosurgical operative windows 显示文摘 | Ammirati M Musumeci A Bernardo A | 2002 | Acta Neurochir2002，144，： | 1 |
| 10 | PLA/PLGA Nanoparticles for Sustained Release of Docetaxel显示文摘 | MUSUMECI T VENTURA C A GIANNONE I | 2006 | International Journal of Pharmaceuties2006，325，： | 1 |
| 11 | Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs 显示文摘 | Lavitrano M Smolenski RT Musumeci A | 2004 | FASEB J2004，18，： | 1 |
| 12 | An innovative EMI reduction design technique in power converters显示文摘 | Consoli A Musumeci S Oriti G | 1996 | IEEE Transactions on Electromagnetic Compatibility1996，38，4： | 1 |
| 13 | Safety of clopidogrel and proton pump inhibitors in patients undergoing drug-eluting stent implantation显示文摘 | ROSSINI R CAPODANNO D MUSUMECI G | 2011 | Coron Artery Dis2011，22，3： | 1 |
| 14 | Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer 显示文摘 | Musumeci M Coppola V Addario A | 2011 | Oncogene2011，30，3： | 1 |
| 15 | Can epsilon-aminocaproic acid balance the off-pump bleeding advantage显示文摘 | Musumeci A Santise G | 2003 | Cardiovasc Surg2003，11，3： | 1 |
| 16 | The miR-15a-miR-16-1 cluster controls prostatecancer by targeting multiple oncogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 17 | The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities显示文摘 | Bonci D Coppola V Musumeci M | 2008 | Nat Med2008，14，11： | 1 |
| 18 | Molecular mechanisms of resistance in Pseudomonas aeruginosa to Fluoroquinolones显示文摘 | Speciale A Musumeci R Blandino G | 2000 | Int J Antimicrob Agents2000，14，2： | 1 |
| 19 | BTG2 loss and miR 21 upregulation contribute to prostate cell transformation by inducing l uminal markers expression and epithelial mesenchymal transition 显示文摘 | Coppola V Musumeci M Patrizii M | 2013 | Oncogene2013，32，14： | 1 |
| 20 | Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin显示文摘 | Musumeci G Lo Furno D Loreto C | | 0，，： | 1 |
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