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| 1 | A high-resolution climatic change since Holocene inferred from multi-proxy of lake sediment in westerly area of China显示文摘Multi-proxy data are presented and a discuss is made of paleoclimatic and paleoenvironmental changes during Holocene from a 225-cm-long sediment core from Wulungu Lake, located in westerly area of China. The chronology is constructed from six AMS radiocarbon dates on the bulk organic matter. Analyses of pollen, TOC, TN, δ 13Corg, ostracod assemblages and the shell stable isotopes, suggest Holocene climate pattern as follows: temperate and dry (10.0―7.6 cal. ka BP)-warm and wet (7.6―5.3 cal. ka BP) -warm and moist (5.3―3.6 cal. ka BP) -temperate and dry (3.6―2.1 cal. ka BP)-temperate and moist (2.1―1.3 cal. ka BP) -cool and dry (1.3 cal. ka BP―present). With the climatic change, Wulungu Lake experienced two large-scale retreat (5.3―3.6 cal. ka BP and 1.3 cal. ka BP―present) and an obvious transgression (7.6―5.3 cal. ka BP). The records of climatic and environmental evolution of Wulungu Lake were in good accordance with those of adjacent areas. It responded to regional environmental change, global abrupt climate events and followed the westerly climate change mode. | JIANG QingFeng SHEN Ji LIU XingQi ZHANG EnLou XIAO XiaYun | 2007 | Chinese Science Bulletin2007，52，14： | 28 |
| 2 | The effect of surface roughness on thermal-elasto-hydrodynamic model of contact mechanical seals显示文摘In this paper,the effect of surface roughness on sealing clearance,pressure distribution,friction torque and leakage is studied by the thermal-elasto-hydrodynamic mixed lubrication model.A convergent nominal clearance is formed by the pressure deformation and thermal deformation of the seal faces.This causes more serious wear in the inner side than that of the outer side of the contact area.Mass leakage increases with the growing of the surface roughness.The temperature and thermal deformation on the seal surface increases substantially if the roughness is reduced.The contact mechanical seals have consistent performance when the standard deviation of surface roughness is approximately 0.2μm.In order to validate the theoretical analysis model,a method combining the measurement of three-dimensioned profile and Raman spectrum is proposed. | WEN QingFeng LIU Ying HUANG WeiFeng SUO ShuangFu WANG YuMing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 13 |
| 3 | Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales显示文摘The Serling Co region is located at the transitional zone of the interaction between the Indian monsoon and the westerlies over the Tibetan Plateau. The Serling Co lake covers a water area of2,389 km2(June 2017) in a 45,530 km2drainage basin. Under the dramatic hydro-meteorological changes on the Tibetan Plateau in recent decades, and complex hydrological compositions of rivers and lakes in the basin, the lake area expanded by 43%, from1,667 km2in 1976, to 2,389 km2in 2017 (1)In 2014 it surpassed Nam Co as the largest lake on the Tibetan Plateau [2], and exerts significant effect on regional environmental conditions. | Liping Zhu Junbo Wang Jianting Ju Ning Ma Yinsheng Zhang Chong Liu Boping Han Linshan Liu Mingda Wang Qingfeng Ma | 2019 | Science Bulletin2019，64，7： | 13 |
| 4 | Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores显示文摘Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing.The effects of sintering temperature on microstructure and physical and mechanical properties were investigated.The results show that the average particle size,shrinkage,bulk density,crystallite size,flexural strength,Vickers hardness,and nanoindentation hardness increased with the increase in sintering temperature,whereas the open porosity decreased with increasing sintering temperature.No change was observed in phase composition,chemical bond,atomic ratio,and surface roughness.For the sintered samples,the shrinkage in Z direction is much greater than that in X or Y direction.The optimum sintering temperature in argon atmosphere is 1350℃with a shrinkage of 3.0%,3.2%,and 5.5%in X,Y,and Z directions,respectively,flexural strength of 26.7 MPa,Vickers hardness of 198.5 HV,nanoindentation hardness of 33.1 GPa,bulk density of 2.5 g/cm^3,and open porosity of 33.8%.The optimum sintering temperature was 70℃higher than that sintering in air atmosphere when achieved the similar properties. | He LI Yongsheng LIU Yansong LIU Qingfeng ZENG Kehui HU Zhigang LU Jingjing LIANG | 2020 | Journal of Advanced Ceramics2020，9，2： | 13 |
| 5 | Passive-source ocean bottom seismograph(OBS) array experiment in South China Sea and data quality analyses显示文摘Long-term passive source ocean bottom seismograph(OBS) observatory is challenging due to various technical difficulties. In order to gain experience in this field, and to reveal the lithospheric structure beneath the extinct ridge in the central South China Sea(SCS), we carried out a passive source OBS array experiment, which includes 18 OBSs, in the deep portion of SCS. Here we present the instrumentation, the OBS deployment and recovery of this experiment, and more importantly, the data quality evaluated by a number of approaches. Through processing and inspecting waveforms from global, regional and local earthquakes, we find that most of recovered OBSs have good data quality with discernible main phases. The ambient noise analyses of OBS recordings show that their noise is higher than the global average, and the horizontal component is noisier than the vertical, indicating current impacts on horizontal components are more severe. In the period range of 5–10 s, there is a noise notch for the SCS OBSs, and noise levels of horizontal components are comparable to the vertical. This feature, which is not seen at OBS stations in open ocean, suggests the distant sources for double frequency microseism in this marginal sea are not significant. In addition, we successfully determined the orientations for 7 OBSs by investigating their Rayleigh wave polarizations; and we demonstrated the dispersion feature of Rayleigh waves through the frequency-time analysis. Finally, we summarized lessons learned from this experiment regarding the passive source OBS investigations in SCS. | Chenguang Liu Qingfeng Hua Yanliang Pei Ting Yang Shaohong Xia Mei Xue Ba Manh Le Da Huo Fang Liu Haibo Huang | 2014 | Chinese Science Bulletin2014，59，33： | 11 |
| 6 | Application of customized augments fabricated by rapid prototyping for severe bone defects of the knee显示文摘With the population aging and an increasing desire for a high quality of life,millions of patients who suffered knee arthropathy have undergone total knee arthroplasty (TKA).Although the success rate for primary TKA has been quite high,the number of revision surgeries can not be ignored.Bone loss is one of the challenges confronting surgeons who perform revision TKAs as it can impair alignment accuracy and the long-term stability of the implant.Although several options are available for bone loss after TKA--cement,bone grafting,standard augments,and hinged implants--there is no single ideal option available for all patients with a severe bone defect because of the variety and severity of the defects.1 The burgeoning rapid prototyping (RP) technique,which has been used to fabricate components with complex and unique structures,may offer a novel option in these cases. | Yin Qingfeng Liu Wenguang Wang Shaojin | 2014 | Chinese Medical Journal2014，，15： | 10 |
| 7 | An experimental and numerical study on the charring rate of timber beams exposed to three-side fire显示文摘To investigate the charring rate of timber beams exposed to three-side fire, a total of fifteen new and used Douglas-Fir timber beams in four groups exposed to three-side fire were experimentally studied, together with the finite element analyses of the temperature distribution in the beam section. The durations of fire exposure were 0 (on a test piece), 10, 15, 20 and 30 min, according to the ISO 834 standard fire curve. The charring depth of each timber beam was calculated by averaging the values at one-third and two-thirds along each cross section to give the charring rate of timber beams. It was found that the timber beam's charring rate reduces as the duration of fire exposure increases and the vertical charring rate is slightly higher than the horizontal one. The areas of beam sections reduce due to charring and the strength and stiffness of the pyrolysis layer near the charring edge decrease owing to the high-temperature. The average horizontal and vertical charring rates are 0.98 and 1.08 mm/min, respectively. To take into account the difference between the test furnace temperature curve and the ISO 834 stand- ard fire curve, some corrections were made for these data to yield the solution for charring rate. With the help of the finite element software ANSYS, the temperature distribution of the wood's cross-section was analyzed. The longer the exposure time is, the greater the effect of density will impose on the distribution of temperature, but the moisture content has no effect. | ZHANG Jin LIU ZengHui XU YiXiang MA ShuWei XU QingFeng | 2012 | Science China(Technological Sciences)2012，55，12： | 8 |
| 8 | Carbon-supported Fe/Co-N electrocatalysts synthesized through heat treatment of Fe/Co-doped polypyrrole-polyaniline composites for oxygen reduction reaction显示文摘In this paper,we synthesized cathode catalysts(PANI-PPYR,Fe/PANI-PPYR,Co/PANI-PPYR and Fe-Co/PANI-PPYR)with high performance oxygen reduction by using a simple heat treatment process.These catalysts were fabricated by directly calcining the Fe and/or Co doped polyaniline(PANI)-polypyrrole(PPYR)composites.Their electrocatalytic activity for ORR both in acidic and in alkaline media was investigated by voltammetric techniques.Among the prepared catalysts,Co/PANI-PPYR presents the most positive ORR onset potential of 0.62 V(vs.SCE)in 0.5 mol/L H2SO4 solution or?0.09 V(vs.SCE)in 1 mol/L NaOH solution.In addition,the Co/PANI-PPYR catalyst shows the largest limiting-diffusion current density for ORR,which is 4.3 mA/cm2@0.2 V(vs.SCE)in acidic and 2.3 mA/cm2@?0.3 V(vs.SCE)in alkaline media.In acidic media,a four-electron reaction of ORR on the Co/PANI-PPYR and Fe/PANI-PPYR catalysts is more dominant than a two-electron reaction.In alkaline media,however,a four-electron and a two-electron mechanisms are co-present for the ORR on all the prepared catalysts.Co/PANI-PPYR catalyst also presents good electrocatalytic activity stability for ORR both in acidic and in alkaline media. | YI QingFeng ZHANG YuHui LIU XiaoPing YANG YaHui | 2014 | Science China Chemistry2014，57，5： | 8 |
| 9 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 10 | The chimeric genes in the hybrid lineage of Carassius auratus cuvieri(♀)×Carassius auratus red var.(♂)显示文摘Hybridization can combine the genomes of different strains or species, which leads to changes of genotype and phenotype in the hybrids. In this study, we aimed to investigate the genetic variations of hybrids(WR-F1 and WR-F2) derived from the intraspecific hybridization of white crucian carp(Carassius auratus cuvieri, WCC, ♀) and red crucian carp(Carassius auratus red var., RCC, ♂). Here, we compared the orthologous genes in the liver transcriptomes of hybrids with those of WCC and RCC, and classified the orthologous genes into eight gene patterns within three categories(chimera, mutant, and biparental origin genes).The results revealed 19.04%, 4.17% chimeric genes and 6.90%, 5.05% mutations of orthologous genes in WR-F1 and WR-F2 respectively. Seventeen of twenty-three characterized genes(77%) were confirmed to be the chimeras at the genomic DNA level.The GO classification discovered that some chimeric and mutant genes were related to metabolic process, immune system and developmental process in WR-F1. Our results provide the new evidence that hybridization can combine the parental genomes,leading to changes in the genotype of the resultant hybrids. This is the first report on the formation of chimeric genes from fish intraspecific hybridization, which is potentially interesting from the context of both evolution and the genetic breeding of fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Xiujuan Xu Fangzhou Hu Jing Wang Jun Xiao Shi Wang Wuhui Li Min Tao Qinbo Qin Rurong Zhao Zhanzhou Yao Shaojun Liu | 2018 | Science China(Life Sciences)2018，61，9： | 6 |
| 11 | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1). | Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin | 2021 | Cell Research2021，31，10： | 6 |
| 12 | Hybrid Precoding for mm Wave Massive MIMO Systems with Different Antenna Arrays显示文摘In this paper, the performance of hybrid precoding is investigated for mmWave massive MIMO systems with different antenna arrays. The hybrid precoding with partially connected architecture (PCA) is adopted. The spectral efficiency (SE) and received energy efficiency (EE) are investigated by considering four types of antenna arrays, including uniform linear array (ULA), uniform rectangular planar array (URPA), uniform hexagonal planar array (UHPA), and uniform circular planar array (UCPA), respectively. We focus on analysis at the antenna response vector and utilize the idea of orthogonal matching pursuit algorithm to seek the optimal hybrid precoder. Furthermore, the trade-off of precoding architectures is studied between SE and received EE. Simulation results show that if the uniform planar array antenna is more concentrated, the SE and receive EE will be higher. Considering SE and received EE, the performance of planar arrays outperform linear array. There exist different optimal radio-frequency chain numbers to maximize the SE for planar array and linear array. In addition, the PCA can achieve relatively higher received EE while the SE is close to the fully connected architecture and the full digital architecture. | Qingfeng Ding Yuqian Deng Xinpeng Gao Mengxia Liu | 2019 | China Communications2019，16，10： | 6 |
| 13 | Financing Alternatives for Chinese Small and Medium Enterprises: The Case for a Small and Medium Enterprise Stock Market显示文摘在中国为小、中等的企业资助选择在现在的学习被讨论。特别地,我们分析重要变化,在中国 s 的开发第二上证券市场。地区性的财产和公平的广泛的网络交换的中国 s,它被设置便于私人公平转移,和非执行的贷款交易似乎部分为小、中等的企业充满虚空,它不能容易为在股票交易所列出获得赞同。外国投资者能通过这些地区性的财产和公平交换在非列出的国内国有、私人的企业识别投资机会。同时,外国证券市场现在正在吸引年轻中国企业在他们的交换上列出他们的股票。 | Hung-gay Fung Qingfeng Liu Jot Yau | 2007 | China & World Economy2007，15，1： | 6 |
| 14 | Frictional performance of silicon carbide under different lubrication conditions显示文摘The frictional performance of materials used in face seals is critical to the sealing performance.Silicon carbide is commonly used in hard rings because of its abrasion resistance,corrosion resistance,and thermal shock resistance.In this study,the frictional performance of silicon carbide,including graphite-added silicon carbide,under water and lubrication-absent conditions was studied by using a Falex-1506 tribotester and different working parameters.In addition,the morphology of the worn surfaces was observed using scanning electron microscopy and the damage was characterized to understand the tribological behavior of different silicon carbides.The results suggest that the friction coefficients decrease with increasing pressure under water lubrication conditions because of the water within the holes on the surface of the materials.The percentage of water lubrication increases,whereas the percentage of solid friction decreases when the pressure increases.Under dry contact conditions,the friction coefficients change negligibly with increasing pressure and graphite-added silicon carbide shows better frictional performance. | Xingyu ZHAO Ying LIU Qingfeng WEN Yuming WANG | 2014 | Friction2014，2，1： | 5 |
| 15 | Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/ photodynamic/radiation synergistic cancer therapy显示文摘联合治疗是通常基于复杂 nanostructures 的利用,多重部件为 photothermal 作为相片热的精力变换器, photo-sensitizers,或剂量 intensifiers 工作的有希望的癌症治疗策略治疗(PTT ) ,光力学的治疗(太平洋夏季时间) ,或放射治疗(RT ) 。在这研究, ultrathin 钨氧化物 nanowires (W 18 O 49) 用一条 solvothermal 途径被综合并且作为多功能的 theranostic nanoplatform 检验了。在 vitro 并且在 vivo,分析证明这些 nanowires 能导致广泛的热 -- 并且汗衫在 980 nm 在附近下面的癌症房间的调停氧的损坏红外线(NIR ) 激光刺激。他们也被显示作为加强在放射治疗期间局部地并且有选择地提高放热精力免职的代理人的放射剂量工作。独自比作导致 NIR 的 PTT/PDT 和 RT, W 18 O 49-based synergistic tri 形式的治疗根除了异种皮移植肿瘤和没有复发被观察在以内一 9 月列在后面起来。而且,钨元素的强壮的 X 光检查变细能力(Z = 74, 4.438 厘米 2???? ?? ?? 佦 ? 畳 ?? 猯扵￣?? | Jianjian Qiu Qingfeng Xiao Xiangpeng Zheng Libo Zhang Huaiyong Xing Dalong Ni Yanyan Liu Shengjian Zhang Qingguo Ren Yanqing Hua Kuaile Zhao Wenbo Bu | 2015 | Nano Research2015，8，11： | 5 |
| 16 | Comparative Analysis of Fractional Vegetation Cover Estimation Based on Multi-sensor Data in a Semi-arid Sandy Area显示文摘The estimation of fractional vegetation cover(FVC) is important for identifying and monitoring desertification, especially in arid and semiarid regions. By using regression and pixel dichotomy models, we present the comparison of Sentinel-2A(S2) multispectral instrument(MSI) and Landsat 8(L8) operational land imager(OLI) data regarding the retrieval of FVC in a semi-arid sandy area(Mu Us Sandland, China, in August 2016). A combination of unmanned aerial vehicle(UAV) high-spatial-resolution images and field plots were used to produce verified data. Based on a normalized difference vegetation index(NDVI) regression model, the results showed that, compared with that of L8, the coefficient of determination(R2) of S2 increased by 26.0%, and the root mean square error(RMSE) and the sum of absolute error(SAE) decreased by 3.0% and 11.4%, respectively. For the ratio vegetation index(RVI) regression model, compared with that of L8, the R2 of S2 increased by 26.0%, and the RMSE and SAE decreased by 8.0% and 20.0%, respectively. When the pixel dichotomy model was used, compared with that of L8, the RMSE of S2 decreased by 21.3%, and the SAE decreased by 26.9%. Overall, S2 performed better than L8 in terms of FVC inversion. Additionally, in this paper, we develop a verified scheme based on UAV data in combination with the object-based classification method. This scheme is feasible and sufficiently robust for building relationships between field data and inversion results from satellite data. Further, the synergy of multi-source sensors(especially UAVs and satellites) is a potential effective way to estimate and evaluate regional ecological environmental parameters(FVC). | LIU Qiuyu ZHANG Tinglong LI Yizhe LI Ying BU Chongfeng ZHANG Qingfeng | 2019 | Chinese Geographical Science2019，29，1： | 4 |
| 17 | Targeted disruption of tyrosinase causes melanin reduction in Carassius auratus cuvieri and its hybrid progeny显示文摘The white crucian carp(Carassius auratus cuvieri,WCC) not only is one of the most economically important fish in Asia,characterized by strong reproductive ability and rapid growth rates,but also represents a good germplasm to produce hybrid progenies with heterosis.Gene knockout technique provides a safe and acceptant way for fish breeding.Achieving gene knockout in WCC and its hybrid progeny will be of great importance for both genetic studies and hybridization breeding.Tyrosinase(TYR) is a key enzyme in melanin synthesis.Depletion of tyr in zebrafish and mice results in mosaic pigmentation or total albinism.Here,we successfully used CRISPR-Cas9 to target tyr in WCC and its hybrid progeny(WR) derived from the cross of WCC(♀) and red crucian carp(Carassius auratus red var.,RCC,♂).The level of TYR protein was significantly reduced in mutant WCC.Both the mutant WCC and the mutant WR showed different degrees of melanin reduction compared with the wild-type sibling control fish,resulting from different mutation efficiency ranging from 60% to 90%.In addition,the transcriptional expression profiles of a series of pivotal pigment synthesis genes,i.e.tyrp1,mitfa,mitfb,dct and sox10,were down-regulated in tyr-CRISPR WCC,which ultimately caused a reduction in melanin synthesis.These results demonstrated that tyr plays a key role in melanin synthesis in WCC and WR,and CRISPR-Cas9 is an effective tool for modifying the genome of economical fish.Furthermore,the tyr-CRISPR models could be valuable in understanding fundamental mechanisms of pigment formation in non-model fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Jia Song Junmei Liu Wuhui Li Yuqin Shu Min Tao Chun Zhang Qinbo Qin Jing Wang Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，9： | 4 |
| 18 | Influence of the symmetry energy on the balance energy of the directed flow显示文摘The influence of the density-dependent symmetry energy on the balance energy (E bal) of directed flow from heavy ion collisions (HICs) at incident energies covered by INDRA and MSU experiments is studied,using the updated version of the ultrarelativistic quantum molecular dynamics (UrQMD) model,especially adapted to low-energy heavy ion collisions (HICs).Four mass-symmetric reactions with total mass numbers between 192 and 394 are chosen for investigating the influence of the symmetry energy on the system-mass dependence of E bal.The results show that the uncertainty in the density dependence of the symmetry potential causes changes of E bal of the order of several MeV,depending on the type of particle considered.The E bal of neutrons from HICs is particularly sensitive to the density dependence of the symmetry potential energy,while the system-mass dependence of E bal of Z=1 particles is not. | GUO ChenChen WANG YongJia LI QingFeng TRAUTMANN W LIU Ling WU LiJuan | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 4 |
| 19 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 20 | Roles of intracellular fibroblast growth factors in neural development and functions显示文摘Fibroblast growth factors (FGFs) can be classified as secretory (FGF1-10 and FGF15-23) or intracellular non-secretory forms (FGF11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be explored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neurons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A recent study showed that FGF13 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases. | ZHANG Xu BAO Lan YANG Liu WU QingFeng LI Shuai | 2012 | Science China(Life Sciences)2012，55，12： | 4 |
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