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| 1 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 2 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 3 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 4 | Dynamic deformation behavior of a FeCrNi medium entropy alloy显示文摘Deformation behavior of a FeCrNi medium entropy alloy(MEA)prepared by powder metallurgy(P/M)method was investigated over a wide range of strain rates.The FeCrNi MEA exhibits high strain-hardening ability,which can be attributed to the multiple deformation mechanisms,including dislocation slip,deformation induced stacking fault and mechanical twinning.The shear localization behavior of the FeCrNi MEA was also analyzed by dynamically loading hat-shaped specimens,and the distinct adiabatic shear band cannot be observed until the shear strain reaches~14.5.The microstructures within and outside the shear band exhibit different characteristics:the grains near the shear band are severely elongated and significantly refined by dislocation slip and twinning;inside the shear band,the initial coarse grains completely disappear,and transform into recrystallized ultrafine equiaxed grains by the classical rotational dynamic recrystallization mechanism.Moreover,microvoids preferentially nucleate in the central areas of the shear band where the temperature is very high and the shear stress is highly concentrated.These microvoids will coalesce into microcracks with the increase of strain,which eventually leads to the fracture of the shear band. | Ao Fu Bin Liu Zezhou Li Bingfeng Wang Yuankui Cao Yong Liu | 2022 | Journal of Materials Science & Technology2022，，5： | 2 |
| 5 | Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains显示文摘The worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 4.5 million deaths.Although coronaviruses have a proofreading mechanism to maintain the stability of their long genomic RNAs,mutations emerge continuously,and new variants conferring advantages rapidly become the dominant lineages[1].Strategies to fight the COVID-19 pandemic using either vaccines or nonpharmaceutical interventions have specifically been threatened by the emergence of SARS-CoV-2 variants of concern(VOCs)[2]. | Ting Pan Zhongwei Hu Fengyu Hu Yiwen Zhang Bingfeng Liu Changwen Ke Qiumin She Xin He Xiaoping Tang Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 6 | Electricity generation from food wastes and microbial community structure in microbial fuel cells显示文摘 | Jianna Jia Yu Tang Bingfeng Liu Di Wu Nanqi Ren Defeng Xing | 2013 | Bioresource Technology2013，，： | 1 |
| 7 | Biological hydrogen production from organic wastewater by dark fermentation in China: Overview and prospects显示文摘 | Ren Nanqi Guo Wanqian Liu Bingfeng | 2009 | Frontiers of Environmental Science and Engineering in China2009，3，4： | 1 |
| 8 | A Review of Magnetic Refrigerator and Heat Pump Prototypes Built Before the Year 2010 显示文摘 | Yu Bingfeng Liu Min Peter W E | 2010 | International Journal of Refrig- eration2010，33，： | 1 |
| 9 | Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19显示文摘COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness. | Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu Jianfang Tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 10 | The effect of hutyrate concentration on photo-hydrogen production from acetate by Rhodopseudornonas faecalis RLD-53 显示文摘 | Ren Nanqi Liu Bingfeng Ding Jie Guo Wanqian Cao Guangli Xie Guojun | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 11 | A review of magnetic refrigerator and heat pump prototypes built be- fore the 2010显示文摘 | Bingfeng Yu Min Liu Peter W Egolf | 2010 | Int J Refrigeration2010，33，： | 1 |
| 12 | The kinetic characterization of photofermentative bacterium Rhodopseudomonas faecalis RLD- 53 and its application for enhancing continuous hydrogen pmduciion 显示文摘 | Xie Guojun Liu Bingfeng Xing Defeng | 2012 | International Journal of Hydrogen Energy2012，37，13： | 1 |
| 13 | Magnetic Properties and Microstructure of Graded Fe/FePt Films显示文摘 | TSAI J TZENG H LIU Bingfeng | 2010 | J Appl Phys2010，107，11： | 1 |
| 14 | Ligand-controlled synthesis of high density and ultra-small Ru nanoparticles with excellent electrocatalytic hydrogen evolution performance显示文摘Ultra-small size metal nanoparticles(u-MNPs)have broad applications in the fields of catalysis,biomedicine and energy conversion.Herein,by means of a ligand-controlled synthesis strategy,series of Ru-based NPs with high dispersity and ultra-small size(marked as u-Ru/C),or sparse and aggregated state(marked as a-Ru/C)anchored on the surface of hollow porous carbon shells are prepared.Systematical in-situ thermogravimetry-mass spectrometry-Fourier transform infrared spectra tests suggest that the different ligands in these Ru-based precursors can regulate the nucleation,growth and fixation of metal sites during the pyrolysis process,thus contributing to Ru NPs with various size and dispersity.As a result,when applied to hydrogen evolution reaction,the u-Ru-1/C catalyst displays a low Tafel slope of 26 mV dec-1,overpotential of 31 mV(at 10 mA cm^(-2))and a large exchange current density of 1.7 mA cm^(-2) in 1.0 M KOH,significantly better than that of the a-Ru-2/C,hollow carbon and even commercial 20%Pt/C.This is mainly because that the u-Ru-1/C sample owns both smaller particle size,more electrochemical active sites,higher intrinsic activity and optimized surface H adsorption ability than that of the a-Ru-2/C counterpart.Such ligand-modulated growth strategy is not only applicable to Ru,but also can be extended to other similar metals,offering a step forward in the design and synthesis of highly dispersed u-MNPs. | Zhiwen Che Xuyun Lu Bingfeng Cai Xiangxing Xu Jianchun Bao Ying Liu | 2022 | Nano Research2022，15，2： | 1 |
| 15 | Enhanced photo-hydrogen production of Rhodopseudomonas Faecalis RLD-53 by EDTA addition显示文摘 | REN Hongyu LIU Bingfeng DING Jie | 2012 | International Journal of Hydrogen Energy2012，37，： | 1 |
| 16 | Enhanced hydrogen production from waste activated sludge by cascade utilization of organic matter in microbial显示文摘 | LU Lu XING Defeng LIU Bingfeng | 2012 | Water Research2012，46，4： | 1 |
| 17 | Feasibility studies on continuous hydrogen production using photo-fermentative sequencing batch reactor显示文摘 | XIE Guojun LIU Bingfeng GUO Wanqian | 2012 | International Journal of Hydrogen Energy2012，37，13： | 1 |
| 18 | Biological hydrogen production by dark fermentation: challenges and prospects towards scaled-up production显示文摘 | Nanqi Ren Wanqian Guo Bingfeng Liu Guangli Cao Jie Ding | 2011 | Current Opinion in Biotechnology2011，，3： | 1 |
| 19 | The kinetic characterization of photoermentative bacterium Rhodopseudomonas faecalis RLD-53 and its application for enhancing continuous hydrogen production显示文摘 | Xie Guojun Liu Bingfeng Xing Defeng | 2012 | International Journal of Hydrogen Energy2012，37，18： | 1 |
| 20 | Enhanced photo-H2 production by Rhodopseudomonas faecalis RLD-53 immobilization on activated carbon fibers显示文摘 | XIE Guojun LIU Bingfeng DING Jie | 2012 | Biomass and Bioenergy2012，44，： | 1 |
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