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| 1 | Engineering Herbicide-Resistant Rice Plants through CRISPR/Cas9-Mediated Homologous Recombination of Acetolactate Synthase显示文摘 | Sun, Yongwei Zhang, Xin Wu, Chuanyin He, Yubing Ma, Youzhi Hou, Han Guo, Xiuping Du, Wenming Zhao, Yunde Xia, Lanqin | 2016 | Molecular Plant2016，9，4： | 94 |
| 2 | Programmed Self-Elimination of the CRISPR/Cas9 Construct Greatly Accelerates the Isolation of Edited and Transgene-Free Rice Plants显示文摘 | Yubing He Min Zhu Lihao Wang Junhua Wu Qiaoyan Wang Rongchen Wang Yunde Zhao | 2018 | Molecular Plant2018，11，9： | 18 |
| 3 | Numerical simulation of dynamic response of operating metro tunnel induced by ground explosion显示文摘To evaluate the effects of possible ground explosion on a shallow-buried metro tunnel, this paper attempts to analyze the dynamic responses of the operating metro tunnel in soft soil, using a widely applied explicit dynamic nonlinear finite element software ANSYS/LS-DYNA. The blast induced wave propagation in the soil and the tunnel, and the von Mises effective stress and acceleration of the tunnel lining were presented, and the safety of the tunnel lining was evaluated based on the failure criterion. Besides, the parametric study of the soil was also carried out. The numerical results indicate that the upper part of the tunnel lining cross-section with directions ranging from 0° to 22.5° and horizontal distances 0 to 7 m away from the explosive center are the vulnerable areas, and the metro tunnel might be safe when tunnel depth is more than 7 m and TNT charge on the ground is no more than 500 kg, and the selection of soil parameters should be paid more attentions to conduct a more precise analysis. | Yubing Yang Xiongyao Xie Rulu Wang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，4： | 16 |
| 4 | Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing显示文摘Development of tools for targeted modifications of specific DNA sequences in plants is of great importance to basic plant biology research as well as crop improvement.The ability to cut DNA at specific locations in the genome to generate doublestrand breaks(DSBs)in vivo is a prerequisite for any genome editing efforts.Several engineered nucleases including zinc finger nucleases(ZFNs)and transcriptional activator-like nucleases(TALENs)have been successfully used to edit genomes.However, | Yubing He Tao Zhang Ning Yang Meilian Xu Lang Yan Lihao Wang Rongchen Wang Yunde Zhao | 2017 | Journal of Genetics and Genomics2017，44，9： | 14 |
| 5 | The effect of dissolved oxygen concentration on long-term stability of partial nitrification process显示文摘Dissolved oxygen(DO)concentration is regarded as one of the crucial factors to influence partial nitrification process.However,achieving and keeping stable partial nitrification under different DO concentrations were widely reported.The mechanism of DO concentration influencing partial nitrification is still unclear.Therefore,in this study two same sequencing batch reactors(SBRs)cultivated same seeding sludge were built up with realtime control strategy.Different DO concentrations were controlled in SBRs to explore the effect of DO concentration on the long-term stability of partial nitrification process at room temperature.It was discovered that ammonium oxidation rate(AOR)was inhibited when DO concentration decreased from 2.5 to 0.5 mg/L.The abundance of Nitrospira increased from 1011.5 to 1013.7 copies/g DNA,and its relative percentage increased from 0.056%to 3.2%during 190 operational cycles,causing partial nitrification gradually turning into complete nitrification process.However,when DO was 2.5 mg/L the abundance of Nitrospira was stable and AOB was always kept at 1010.7 copies/g DNA.High AOR was maintained,and stable partial nitrification process was kept.Ammonia oxidizing bacteria(AOB)activity was significantly higher than nitrite oxidizing bacteria(NOB)activity at DO of 2.5 mg/L,which was crucial to maintain excellent nitrite accumulation performance. | Bin Cui Qing Yang Xiuhong Liu Siting Huang Yubing Yang Zhibin Liu | 2020 | Journal of Environmental Sciences2020，32，4： | 12 |
| 6 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 7 | Technological breakthroughs in generating transgene-free and genetically stable CRISPR-edited plants显示文摘CRISPR/Cas9 gene-editing technologies have been very effective in editing target genes in all major crop plants and offer unprecedented potentials in crop improvement.A major challenge in using CRISPR gene-editing technology for agricultural applications is that the target gene-edited crop plants need to be transgene free to maintain trait stability and to gain regulatory approval for commercial production.In this article,we present various strategies for generating transgene-free and target geneedited crop plants.The CRISPR transgenes can be removed by genetic segregation if the crop plants are reproduced sexually.Marker-assisted tracking and eliminating transgenes greatly decrease the time and labor needed for identifying the ideal transgene-free plants.Transgenes can be programed to undergo self-elimination when CRISPR genes and suicide genes are sequentially activated,greatly accelerating the isolation of transgene-free and target gene-edited plants.Transgene-free plants can also be generated using approaches that are considered non-transgenic such as ribonucleoprotein transfection,transient expression of transgenes without DNA integration,and nano-biotechnology.Here,we discuss the advantages and disadvantages of the various strategies in generating transgene-free plants and provide guidance for adopting the best strategies in editing a crop plant. | Yubing He Yunde Zhao | 2020 | aBIOTECH2020，1，1： | 5 |
| 8 | Effects of drought stress on antioxidant enzyme,photosynthetic pigment and flavonoid pathway in two desert shrubs显示文摘Antioxidant enzyme activity,photosynthetic pigment content,and free malondialdehyde(MDA),as well as flavonoid content and the key enzyme activity in the flavonoid pathway were determined in two desert shrubs,Caryopteris mongolica Bunge and Reaumuria soongorica(Pall.)Maxim.under drought stress.The free MDA content was enhanced during the experimental period,which may be an indicator of oxidative stress.Superoxide dismutase(SOD),peroxidase(POD),and ascorbate peroxidase(APX)activities in C.mongholica showed a significant increase during the experiment,but catalase(CAT)activity was slightly decreased.On the other hand,POD and APX activities showed a significant increase and SOD and CAT activity data had no significant changes in R.soongorica.APX,SOD,and CAT activities were higher in R.soongorica than in C.mongholica,but MDA content was lower,indicating that the lower values of MDA were attributed to higher activities of antioxidant enzyme in R.soongorica.Chlorophyll content decreased significantly in the two shrubs during the experiment,which indicated that there was a photopro-tection mechanism through reducing light absorbance by decreasing pigments content.Caretonoids content increased in C.mongholica and decreased in R.soongorica.The ratio of Chla/Chlb decreased significantly but caretonoids/Chl revealed a sig-nificant increase in the two shrubs,which could be explained as no decrease of peripheral light-harvesting complexes and a higher tolerance to drought.Total flavonoid content and the activities of phenylalanine ammonialyase(PAL)and chalcone isomerase(CHI)showed different changes between C.mongholica and R.soongorica after treatment.These values decreased in R.soongorica and increased in C.mongholica except for PAL activity.However,anthocyanin content increased in the two shrubs,indicating that there was a different regulation response in the flavonoid pathway in the two shrubs under drought stress,and an-thocyanin should be an important antioxidant both in the shrubs.Our results demonstrated the different responses of antioxidant defense and drought tolerance ability between the two shrubs. | YuBing Liu MeiLing Liu Bo Cao | 2011 | Research in Cold and Arid Regions2011，3，4： | 5 |
| 9 | Multistage analysis method for detection of effective herb prescription from clinical data显示文摘为特定的疾病条件或特别的耐心的组决定有效繁体中文药(TCM ) 治疗是因为复杂个性化的表明,在真实世界的病人和在临床的背景规定的个性化的联合治疗要求调查的一个困难的问题。在这研究,集成倾向大小写匹配的一个多级式的分析方法,复杂网络分析,和植物给了丰富分析被建议为特别疾病识别有效植物药方(例如,失眠) 。首先,匹配的倾向大小写被使用匹配临床的盒子。然后,核心网络抽取和植物集合丰富被联合检测核心有效植物药方。基于有效性的相互的信息被用来检测强壮的 herbsymptom 关系。这个方法在一个 TCM 临床的数据集合上被使用, 955 个病人从设计得好的观察研究收集了。结果与更高的有效性率揭示了那组植物药方(76.9% 对 42.8% 为匹配的样品;94.2% 对 84.9% 为所有样品) 与原版相比,药方被发现。有症状表明的特别的耐心的组也被识别帮助调查有效植物药方的指示。 | Kuo Yang Runshun Zhang Liyun He Yubing Li Wenwen Liu Changhe Yu Yanhong Zhang Xinlong Li Yan Liu Weiming Xu Xuezhong Zhou Baoyan Liu | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 10 | Hybrid interference alignment and power allocation for multi-user interference MIMO channels显示文摘This paper proposes a hybrid interference alignment scheme which combines maximizing signal-toleakage-noise ratio(Max-SLNR) at transmitter and maximizing signal-to-interference-noise ratio(Max-SINR) at receiver.The proposed scheme gives the same sum rate as the existing method using Max-SINR at both transmitter and receiver by avoiding the operation of reversing channel,thus it provides a simpler solution.Furthermore,two power allocation procedures are devised based on game theory and water filling.The gain of these schemes over equal power allocation increases to 2 bit/s/Hz in correlated fading channels as large-scale fading becomes significant.Additionally,user fairness is solved by introducing weighting factors. | SHU Feng YOU XiaoHu WANG Mao HAN YuBing LI Yang SHENG WeiXing | 2013 | Science China(Information Sciences)2013，56，4： | 5 |
| 11 | A reporter for noninvasively monitoring gene expression and plant transformation显示文摘Reporters have been widely used to visualize gene expression,protein localization,and other cellular activities,but the commonly used reporters require special equipment,expensive chemicals,or invasive treatments.Here,we construct a new reporter RUBY that converts tyrosine to vividly red betalain,which is clearly visible to naked eyes without the need of using special equipment or chemical treatments.We show that RUBY can be used to noninvasively monitor gene expression in plants.Furthermore,we show that RUBY is an effective selection marker for transformation events in both rice and Arabidopsis.The new reporter will be especially useful for monitoring cellular activities in large crop plants such as a fruit tree under field conditions and for observing transformation and gene expression in tissue culture under sterile conditions. | Yubing He Tao Zhang Hui Sun Huadong Zhan Yunde Zhao | 2020 | Horticulture Research2020，7，1： | 4 |
| 12 | Predictions of mortality related to four major cancers in China,2020 to 2030显示文摘Background:Cancer has become a global health problem,and assessments of cancer mortality are important for effective public health policy-making and adequate resource allocation.In this study,we aimed to predict the mortality rates and numbers of deaths related to four common cancers(lung,liver,stomach,and esophagus)in China from 2020 to 2030 and to estimate the corresponding cancer burden caused by population aging and tobacco smoking.Methods:Cancer mortality data(2004-2017)were extracted from China’s death surveillance datasets,and China’s population figures(2020-2030)were obtained from the United Nations population projections.Smoking prevalence data were retrieved from a World Health Organization global report,and relative risks of smoking and cancers were derived from large-scale Asian studies.We predicted the deaths related to the four major cancers and age-standardized mortality rates using joinpoint regression and linear regression models.The tobacco smoking related burden of these four major cancers was estimated using the population attributable fraction.Results:Unlike lung cancer mortality which was predicted to continue to increase,the age-standardized mortality rates for digestive cancers(liver,stomach,and esophageal cancers)are predicted to decline over the next decade.The number of deaths caused by the four major cancers is predicted to increase from 1,490,304 in 2020 to 1,823,960 in 2030.The age-specific mortality rates of the four major cancers are predicted to increase with age after 40-45 years,peaking in the age groups of 80-84 and ≥85 years.In 2030,the combined number of deaths from the four examined cancers among adults aged ≥65 years is predicted to be 1,167,153,accounting for 64% of all deaths from these cancers.Tobacco smoking is predicted to contribute to nearly 29% of deaths fromthese cancers,corresponding to 527,577 deaths.Conclusions:The overall trend in the combined total mortality from four major cancers is predicted to decline over the next decade;however,the corresponding death toll is expected to surge,in the context of China’s population aging and high smoking prevalence.These estimates provide data-driven evidence for China to implement effective cancer control measures in the future. | Ning Li Peng Wu Yubing Shen Cuihong Yang Luwen Zhang Yali Chen Zixing Wang Jingmei Jiang | 2021 | Cancer Communications2021，41，5： | 4 |
| 13 | Metal-organic framework membranes: From synthesis to electrocatalytic applications显示文摘Metal-orga nic frameworks(MOFs),as an emerging family of porous inorga nic-organic crystal materials,exhibit widely applications in gas storage and separation,drug release,sensing,and catalysis,owing to easily adjustable pore sizes,uniformly distributed metal centers,high surface areas,and tunable functionalities.However,MOF crystal powders are usually difficult to be directly applied into specific devices because of their brittleness,insolubility and low compatibility.Therefore,to expand versatile MOF membranes with robustness and operational flexibility is urgent to satisfy practical applications.Although numerous reports have reviewed the synthesis and applications of MOF membranes,relatively few reports the electrocatalytic properties based on MOF membranes.Herein,this mini-review provides an overview of preparation of MOF membranes,including directed synthesis,secondary growth and electrochemical deposition method.Meanwhile,fabrication of ultrathin 2D MOF nanosheets those can be also defined as a kind of nanoscale MOF membranes is also mentioned.Electrocatalytic performance of oxygen reduction reaction(ORR),oxygen evolution reaction(OER),hydrogen evolution reaction(HER)and CO2 reduction reaction(CO2RR) for diverse MOF membranes/nanosheets and their derivatives are introduced. | Xiaobang Liu Ting Yue Kai Qi Yubing Qiu Bao Yu Xia Xingpeng Guo | 2020 | Chinese Chemical Letters2020，31，9： | 3 |
| 14 | AtPEPTIDE RECEPTOR_2 mediates the AtPEPTIDE1‐induced cytosolic Ca^(2+) trise, which is required for the suppression of Glutamine Dumper gene expression in Arabidopsis roots显示文摘AtPEPTIDE RECEPTOR2(AtPEPR2) is a member of leucine‐rich repeat receptor‐like kinase family and binds to a group of AtPROPEP gene‐encoded endogenous peptides,AtPeps. Previously, we found that AtPEPR2 plays a moderate role in the AtPep1‐mediated innate immunity responses in Arabidopsis leaf. In this study, we found that AtPEPR2promoter has strong activity in the vascular tissues of the roots and the atpepr2 mutants showed a moderate but significantly shorter root phenotype. AtPEPR2 partially mediated AtPep1‐induced root elongation inhibition. AtPep1‐triggered cytosolic Ca2ttransient rise in roots showed partial dependence on AtPEPR2 and fully on extracellular Ca2t([Ca2t]ext). Transcriptional profiling analysis found that expression of 75% of AtPep1‐modulated genes in roots was fully dependent on AtPEPR2, of which two dramatically induced genes showed partial dependence on the [Ca2t]ext.Arabidopsis genome contains seven Glutamine Dumpers genes(AtGDUs), encoding amino acid exporters. Three of them(AtGDU2, 3, 5) were among the top 10 genes that were downregulated by AtPep1 through AtPEPR2 fully dependent pathway. Treatment with AtPep1 strongly suppressed promoter activity of AtGDU3 in roots, which was relieved by chelating [Ca2t]ext. Arabidopsis overexpressing AtGDU3showed a shorter root phenotype and decreased sensitivity to the AtPep1‐mediated inhibition of root elongation. Taken together, this study demonstrated a significant role of AtPEPR2 in the AtPep1‐mediated signaling in the roots. | Chunli Ma Jie Guo Yan Kang Kohei Doman Anthony C.Bryan Frans E.Tax Yube Yamaguchi Zhi Qi | 2014 | Journal of Integrative Plant Biology2014，56，7： | 3 |
| 15 | Effect of channel block on the collective spiking activity of coupled stochastic Hodgkin-Huxley neurons显示文摘Toxins, such as tetraethylammonium (TEA) and tetrodotoxin (TTX), can make potassium or sodium ion channels poisoned, respectively, and hence reduce the number of working ion channels and lead to the diminishment of conductance. In this paper, we have studied by numerical simulations the effects of sodium and potassium ion channel poisoning on the collective spiking activity of an array of coupled stochastic Hodgkin-Huxley (HH) neurons. It is found for a given number of neurons sodium or potas- sium ion channel block can either enhance or reduce the collective spiking regularity, depending on the membrane patch size. For a given smaller or larger patch size, potassium and sodium ion channel block can reduce or enhance the collective spiking regularity, but they have different patch size ranges for the transformation. This result shows that sodium or potassium ion channel block might have dif- ferent effects on the collective spiking activity in coupled HH neurons from the effects for a single neuron, which represents the interplay among the diminishment of maximal conductance and the in- crease of channel noise strength due to the channel blocks, as well as the bi-directional coupling be- tween the neurons. | GONG YuBing XU Bo MA XiaoGuang HAN JiQu | 2008 | Science China Chemistry2008，51，4： | 3 |
| 16 | Multiple resonances with time delays in scale-free networks of Hodgkin-Huxley neurons subjected to non-Gaussian noise显示文摘The spiking behavior with varying time delay in scale-free networks of Hodgkin-Huxley neurons with non-Gaussian noise has been studied,and the effect of non-Gaussian noise on the delay-induced spiking behavior is discussed. It was found that multiple spatio-temporal resonances occur when the delay lengths are integer multiples of the spiking periods,and the resonances may be strengthened when the non-Gaussian noise is appropriate. This result shows that time delays can optimize the spiking temporal regularity and spatial synchronization,and appropriate non-Gaussian noise may enhance the delay-induced spiking behaviors. Our findings may help to further understand the joint roles of non-Gaussian noise and time delays in the spiking activity of scale-free neuronal networks. | HAO YingHang GONG YuBing LIN Xiu WANG Li | 2011 | Science China Chemistry2011，54，5： | 2 |
| 17 | Simple and efficient delivery of cellimpermeable organic fluorescent probes into live cells for live-cell superresolution imaging显示文摘Numerous commercial organic fluorophores with excellent optical properties are precluded from live-cell superresolution imaging due to poor cell permeability.Here,we develop a simple but effective strategy that renders cells permeable to cell-impermeable,organic fluorescent probes by using a novel peptide vehicle,PV-1.By simple coincubation with PV-1,22 different cell-impermeable,organic fluorescent probes were efficiently delivered into live cells and specifically labeled a variety of organelles.Moreover,PV-1 can simultaneously transfer up to three different probes into live cells.By using PV-1 and these cell-impermeable fluorescent probes,we obtained multicolor,longterm,live-cell superresolution images of various organelles,which allowed us to study the dynamic interactions between them.PV-1,together with these organic fluorescent probes,will greatly broaden the applications of superresolution imaging technology in diverse live-cell studies and opens up a new avenue in the design and application of peptide vehicles. | Meng Zhang Meihua Li Wenting Zhang Yubing Han Yu-Hui Zhang | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 18 | Application of non-equilibrium dendrite growth model considering thermo-kinetic correlation in twin-roll casting显示文摘Upon non-equilibrium solidifications, dendrite growth, generally as precursor of as-solidified structures,has severe effects on subsequent phase transformations. Considering synergy of thermodynamics and kinetics controlling interface migration and following conservation of heat flux in solid temperature field, a more flexible modeling for the dendrite growth is herein developed for multi-component alloys,where, two inherent problems, i.e. correlation between thermodynamics and kinetics(i.e. the thermokinetic correlation), and theoretical connection between dendrite growth model and practical processing,have been successfully solved. Accordingly, both the thermodynamic driving force G and the effective kinetic energy barrier Qeffhave been found to control quantitatively the dendrite growth(i.e. especially the growth velocity, V), as reflected by the thermo-kinetic trade-off. Compared with previous models, it is the thermo-kinetic correlation that guarantees quantitative connection between the practical processing parameters and the current theoretical framework, as well as more reasonable description for kinetic behaviors involved. Applied to the vertical twin-roll casting(VTC), the present model, realizes a good prediction for kissing points, which influences significantly alloy design and processing optimization.This work deduces quantitatively the thermo-kinetic correlation controlling the dendrite growth, and by proposing the parameter-triplets(i.e. G-Qeff-V), further opens a new beginning for connecting solidification theories with industrial applications, such as the VTC. | Yubing Zhang Jinglian Du Kang Wang Huiyuan Wang Shu Li Feng Liu | 2020 | Journal of Materials Science & Technology2020，44，9： | 2 |
| 19 | Progress in the Application of X Zeolite in Adsorption显示文摘The application of X zeolite in the areas for producing para-xylene by adsorptive separation, N_2/O_2 separation,etc., was reviewed, and the framework SiO_2/Al_2 O_3 molar ratio, the cations and the water content of X zeolite significantly affected its selectivity and capacity. As the active component of para-xylene adsorbent, the X zeolite with a framework SiO_2/Al_2 O_3 molar ratio of 2.2—2.4 coupled with cations of Ba^(2+) and K^+, as well as a water content of 4.0%—5.0% exhibited higher para-xylene selectivity. For N_2/O_2 separation, higher N_2 capacity and N_2/O_2 separation factor were achieved when the X zeolite had a framework SiO_2/Al_2 O_3 molar ratio of 2.0 coupled with Li^+ cations. The introduction of another cation in X zeolite could further increase the N_2/O_2 separation factor, while the adsorption of water, however, could lead to a remarkable decrease of N_2 capacity. Besides, the X zeolite could be used in adsorptive separation of highly pure He and selective adsorption of CO_2, CO, CH_4, N_2, Ar,and H_2. | Wang Yubing Wang Huiguo | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 2 |
| 20 | Chemical synaptic coupling-induced delay-dependent synchronization transitions in scale-free neuronal networks显示文摘Chemical synaptic couplings are more common than electric(gap junction) connections in neurons.In this paper,the firing synchronizations induced by chemical synaptic coupling in chemically delayed scale-free networks of modified Hodgkin-Huxley neurons have been studied.It was found that the chemical coupling-induced synchronization transitions are delay-dependent and much different for various delay lengths.In the absence of delay,the neurons exhibit a transition from chaotic bursting(CB) to bursting synchronization(BS) with desynchronized spikes in each burst;for smaller delay lengths,the firing evolves from CB to spiking synchronization(SS),but for larger delay lengths,there are transitions from CB to intermittently multiple SS behaviors.These findings show that the chemical coupling-induced firing synchronization transitions strongly depend on the chemical delay lengths,and intermittently multiple SS can only occur for larger delay lengths.This result would be helpful for better understanding the joint roles of the chemical coupling and chemical delay in the firing activity of the neurons. | GONG YuBing LIN Xiu WANG Li HAO YingHang | 2011 | Science China Chemistry2011，54，9： | 2 |
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