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| 1 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 2 | Fabrication of agarose hydrogel with patterned silver nanowiresfor motion sensor显示文摘In this work, a facile strategy is proposed to construct stretchable electronics based on agarose hydrogels. The hot agarose solution is casted onto a template with patterned Ag nanowires, endowing agarose hydrogel with patterned conductive surface. After further heating treatment, Ag nanowires can be embedded into the agarose hydrogel, which improves the stability of Ag pattern and has no obvious e ffect on the conductivity of hydrogels. The agarose hydrogel with patterned Ag nanowires is certi fied to be an e ffective stretchable electrode to record the motion of joints, which has great potential applications in the field of wearable devices. | Qingquan Han Yang Chen Wei Song Milin Zhang Shengtao Wang Peng Ren Linna Hao Anhe Wang Shuo Bai Jian Yin | 2019 | Bio-Design and Manufacturing2019，2，4： | 1 |
| 3 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://gffzzdf7d528e3a264cb9hxvfb0b09wc9n6q9c.ffgz.tsg.suse.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 4 | Electrochemical synthesis of dipyrazolo/dipyrimidine-fused pyridines via oxidative domino cyclization of C(sp^(3))–H bonds显示文摘An electrochemically oxidative domino cyclization reaction of methyl azaarenes/ketones with pyrazol-5-amines and 6-amino-pyrimidine-2,4-diones was developed, providing a variety of dipyrazolo[3,4-b:4’,3’-e]pyridines and dipyrimidine-fused pyridines with moderate to good yields. The reaction involved two C–C bond formations and one C–N bond formation in one pot. Moreover, the photoluminescence properties of the representative dipyrazolo[3,4-b:4’,3’-e]pyridines were investigated. | Peng Qian Linna Xu Wenyan Wang Lin Zhang Liang Tang Jiaojiao Liu Liangquan Sheng | 2022 | Organic Chemistry Frontiers2022，9，6： | 0 |
| 5 | Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma显示文摘Background:Pancreatic duct adenocarcinoma(PDAC)remains a major health problem because conventional can-cer treatments are relatively ineffective against it.Microarray studies have linked many genes to pancreatic cancer,but the available data have not been extensively mined for potential insights into PDAC.This study attempted to identify PDAC-associated genes and signaling pathways based on six microarray-based profiles of gene expression in pancre-atic cancer deposited in the gene expression omnibus database.Methods:Pathway network methods were used to analyze core pathways in six publicly available pancreatic cancer gene(GSE71989,GSE15471,GSE16515,GSE32676,GSE41368 and GSE28735)expression profiles.Genes potentially linked to PDAC were assessed for potential impact on survival time based on data in The Cancer Genome Atlas and International Cancer Genome Consortium databases,and the expression of one candidate gene(CKS2)and its association with survival was examined in 102 patients with PDAC from our hospital.Effects of CKS2 knockdown were explored in the PDAC cell lines BxPC-3 and CFPAC-1.Results:The KEGG signaling pathway called“pathway in cancer”may play an important role in pancreatic cancer development and progression.Five genes(BIRC5,CKS2,ITGA3,ITGA6 and RALA)in this pathway were significantly associated with survival time in patients with PDAC.CKS2 was overexpressed in PDAC samples from our hospital,and higher CKS2 expression in these patients was associated with shorter survival time.CKS2 knockdown substantially inhibited PDAC cell proliferation in vitro.Conclusions:Analysis integrating existing microarray datasets allowed identification of the“pathway in cancer”as an important signaling pathway in PDAC.This integrative approach may be powerful for identifying genes and pathways involved in cancer. | Jun Li Wenle Tan Linna Peng Jialiang Zhang Xudong Huang Qionghua Cui Jian Zheng Wen Tan Chen Wu Dongxin Lin | 2018 | Cancer Communications2018，38，1： | 0 |
| 6 | H3K4me2/3 modulate the stability of RNA polymerase II pausing显示文摘Dear Editor,Modifications of histones are intricately linked with the regulation of gene expression,having demonstrated roles in various physiological processes and pathogenesis.Methylation of histone H3 lysine 4(H3K4)implemented by the COMPASS family is enriched at promoters and associated cis-regulatory elements,with H3K4 trimethylation(H3K4me3)being a hallmark of active gene promoters.1 However,the relative contributions of the deposition and removal of H3K4 methylation to transcriptional control remain unclear.We found that rapid depletion of core COMPASS subunits led to a dynamic turnover of H3K4me2 and H3K4me3 that is mediated by KDM5 demethylases.Depleting H3K4me2 and H3K4me3 did not affect TFIID recruitment or initiating RNA polymerase II(Pol II)but instead reduced levels of paused Pol II,which could be attributed to increased enrichment of the Integrator-PP2A complex(INTAC). | Shibin Hu Aixia Song Linna Peng Nan Tang Zhibin Qiao Zhenning Wang Fei Lan Fei Xavier Chen | 2023 | Cell Research2023，33，5： | 0 |
| 7 | Modulating surface cation vacancies of nickel-cobalt oxides as efficient catalysts for lithium-oxygen batteries显示文摘Rechargeable lithium-oxygen batteries(LOBs)have received incremental attention owing to their high energy density and applicability to mobile devices and electric vehicles.However,the lack of robust,low-cost,and environmentally benign bifunctional catalysts is a major impediment to the commercial application.The introduction of vacancies is one of the effective strategies to enhance the performance of cathode catalysts for lithium-oxygen batteries,but the preparation is complicated.In this work,needle-like microsphere cathode catalysts of nickel-cobalt oxide containing cationic vacancies are constructed by controlling the annealing temperature.It is demonstrated that the presence of cationic vacancies can modulate the electronic structure of the catalyst,reduce the energy barrier for the oxygen electrode re-action,meanwhile enhance the bifunctional catalytic activity.Impressively,the nickel-cobalt oxide-based LOB with cationic vacancies exhibits large specific capacity(12,205 mAh g^(-1)at 200 mA g^(-1))and good durability.This work provides worthwhile insight into the formation and catalytic enhancement mech-anism of transition metal oxide catalysts with cationic vacancies,and to some extent,the creation of efficient and low-cost oxygen electrocatalysts for LOBs. | Yuan Yang Linna Dai Jianwei Qiu Zhibiao Hu Peng Wang Yongtao Zhao Huanhuan Guo Pengchao Si Rui Song | 2023 | Journal of Materials Science & Technology2023，，8： | 0 |
| 8 | A cis-eQTL in NSUN2 promotes esophageal squamous-cell carcinoma progression and radiochemotherapy resistance by mRNA-m^(5)C methylation显示文摘Dear Editor,Esophageal squamous cell carcinoma(ESCC)has poor prognosis because of the difficulty in early detection and low sensitivity of advanced disease to radiochemotherapy.1,2 ESCC presents a high proportion of primary resistance to radiochemotherapy,2which may be due to certain individual genetic variations.Expression quantitative trait loci(eQTLs)as proximal and continuous cellular phenotypes have been shown to be helpful to determine how genetic variants may influence phenotype. | Xiangjie Niu Linna Peng Weiling Liu Chuanwang Miao Xinjie Chen Jiahui Chu Xinyu Yang Wen Tan Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 0 |
| 9 | 基因表达谱整合分析揭示胰腺导管腺癌相关特异信号转导途径显示文摘背景与目的因为常规癌症治疗对胰腺导管腺癌(pancreatic duct adenocarcinoma,PDAC)而言疗效不佳,所以胰腺癌严重威胁着人类的健康。微阵列研究报道许多与胰腺癌相关基因,但是并未对微阵列数据进行深入整合分析。本研究利用与胰腺癌相关的6个微阵列基因表达谱来探讨与PDAC相关的基因和信号转导途径。方法采用信号通路网络方法分析6个已经发表的胰腺癌基因表达谱数据(GSE71989、GSE15471、GSE16515、GSE32676、GSE41368和GSE28735)。根据癌症基因组图谱和国际癌症基因组联合会数据库中的数据来评估PDAC相关基因的表达对胰腺癌患者存活时间的潜在影响,在我们医院收集的102例PDAC患者中检测到了一种候选基因(CKS2)的表达,其与患者存活相关。在PDAC细胞系BxPC-3和CFPAC-1中检测CKS2敲低后的影响。结果称为'癌症途径'的KEGG信号途径可能在胰腺癌的发生和发展中有重要作用。该途径中的5个基因(BIRC5、CKS2、ITGA3、ITGA6和RALA)与PDAC患者的生存时间显著相关。CKS2在我们医院PDAC样本中过表达,这些患者CKS2的高表达与较短的生存时间相关。体外敲低CKS2能够抑制PDAC细胞的增殖。结论整合目前微阵列数据集的分析可以确定'癌症通路'是PDAC的一个重要信号途径。这种整合方法可能对鉴别癌症相关基因和途径非常有效。 | Jun Li Wenle Tan Linna Peng Jialiang Zhang Xudong Huang Qionghua Cui Jian Zheng Wen Tan Chen Wu Dongxin Lin | 2018 | 癌症2018，37，11： | 0 |
| 10 | Study progression in application of process analytical technologies on film coating显示文摘Film coating is an important unit operation to produce solid dosage forms,thereby,the monitoring of this process is helpful to find problems in time and improve the quality of coated products.Traditional methods adopted to monitor this process include measurement of coating weight gain,performance of disintegration and dissolution test,etc.However,not only do these methods cause destruction to the samples,but also consume time and energy.There have recently emerged the applications of process analytical technologies(PAT)on film coating,especially some novel spectroscopic and imaging technologies,which have the potential to real-time track the progress in film coating and optimize production efficiency.This article gives an overview on the application of such technologies for film coating,with the goal to provide a reference for the further researches. | Tingting Peng Ying Huang Liling Mei Linna Wu Longkai Chen Xin Pan Chuanbin Wu | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 0 |
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