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| 1 | Recent progress of SiC UV single photon counting avalanche photodiodes显示文摘4H-SiC single photon counting avalanche photodiodes(SPADs)are prior devices for weak ultraviolet(UV)signal detection with the advantages of small size,low leakage current,high avalanche multiplication gain,and high quantum efficiency,which benefit from the large bandgap energy,high carrier drift velocity and excellent physical stability of 4 H-SiC semiconductor material.UV detectors are widely used in many key applications,such as missile plume detection,corona discharge,UV astronomy,and biological and chemical agent detection.In this paper,we will describe basic concepts and review recent results on device design,process development,and basic characterizations of 4 H-SiC avalanche photodiodes.Several promising device structures and uniformity of avalanche multiplication are discussed,which are important for achieving high performance of 4 HSiC UV SPADs. | Linlin Su Dong Zhou Hai Lu Rong Zhang Youdou Zheng | 2019 | Journal of Semiconductors2019，40，12： | 5 |
| 2 | Extreme Pressure Equipments显示文摘Pressure equipments in the process industries and the newly developing industries usually have extreme sizes and/or are subjected to extreme operating conditions such as high pressure,blast loading,cryogenic temperature,elevated temperature,complex corrosion,and so on.In order to understand,research and develop these equipments systematically,a concept of extreme pressure equipments(EPEs) is proposed.The applications and demands of EPEs in petrochemical industry,coal chemical industry,advanced energy,military,space technology,and environment protection are introduced.Basic scientific problems in material,design,inspection, and safety related to EPEs are discussed.Then,take chemical composition,manufacturing process,service duration,and operating conditions for example,main factors which affect material properties of EPEs are analyzed.New design concepts including design based on life cycle,dynamic design and light-weight design are introduced.EPEs with higher efficiency,lower cost and safer performance are in urgent demand in national major projects including ten million ton oil refinery,one million ton ethylene,liquefied natural gas transportation,and nuclear power plant.Thus,further research should be conducted on information acquisition, multi-mechanism damage coupling model,damage inspection,life prediction,online safety monitoring,maintenance strategy,safety pre-warning system,and emergency system. | ZHENG Jinyang WU Linlin SHI Jianfeng | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 4 |
| 3 | PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway显示文摘The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides.A previous study suggested that this enzyme acts as a regulator of neuropeptide activity;however,the metabolic function of this enzyme in the liver has not been explored.Here,we identified the novel role of PSA in hepatic lipid metabolism.Specifically,PSA expression was lower in fatty livers from NAFLD patients and mice(HFD,ob/ob,and db/db).PSA knockdown in cultured hepatocytes exacerbated diet-induced triglyceride accumulation through enhanced lipogenesis and attenuated fatty acid β-oxidation.Moreover,PSA mediated activation of the master regulator of antioxidant response,nuclear factor erythroid 2-related factor 2(NRF2),by stabilizing NRF2 protein expression,which further induced downstream antioxidant enzymes to protect the liver from oxidative stress and lipid overload.Accordingly,liver-specific PSA overexpression attenuated hepatic lipid accumulation and steatosis in ob/ob mice.Furthermore,in human liver tissue samples,decreased PSA expression correlated with the progression of NAFLD.Overall,our findings suggest that PSA is a pivotal regulator of hepatic lipid metabolism and its antioxidant function occurs by suppressing NRF2 ubiquitination.Moreover,PSA may be a potential biomarker and therapeutic target for treating NAFLD. | Bangliang Huang Xin Xiong Linlin Zhang Xiufei Liu Yuren Wang Xiaoli Gong Qian Sang Yongling Lu Hua Qu Hongting Zheng Yi Zheng | 2021 | Journal of Molecular Cell Biology2021，13，7： | 4 |
| 4 | Mechanism of phthalic acid collector in flotation separation of fluorite and rare earth显示文摘The mechanism of phthalic acid,a dicarboxylic acid collector,in flotation separation of fluorite and rare earth(RE)was studied in this paper.The experimental data of flotation show that phthalic acid,as the collector,can realize highly efficient separation of fluorite and rare earth under weakly acidic conditions.The adsorption mechanism of phthalic acid on the surface of fluorite and bastnaesite was analyzed in this paper by means of the zeta potential measurement,the Fourier transform infrared(FT-IR),the X-ray photoelectron spectroscopy(XPS)and the stability constant measurement of active metal ion and phthalic acid coo rdination complex.According to the zeta potential testing results,the surfaces of fluorite adsorb the collector phthalate ion with negative charge under weakly acidic conditions which,in turn,increases its electronegativity and results in the motion of its potential.After the reaction between phthalic acid and fluorite ores under weakly acidic conditions,the peak of the fluorite ores is found to have significant changes in the FT-IR results,indicating strong chemical adsorption on the surfaces of phthalic acid and fluorite ores.According to the XPS analysis,the peak of benzene ring of phthalic acid is as high as 2%on the surface of fluorite,while no obvious characteristic peak of benzene ring is found on the surface of bastnaesite.According to the pH potentiometric titration results,the stability constant Ktotal of calcium phthalate complex within the acid range is higher than the stability constant K’total of cerium phthalate complex,indicating that the complex generated between phthalic acid and Ca^(2+)is more stable than the complex generated between phthalic acid and Ce^(3+).The possible reason is that Ca^(2+),with the highest reticular density,plays a prevailing role in the octahedron structure of fluorite amidst the acidic media.As the active point of flotation,Ca^(2+)works with the carboxyl groups of the collector phthalic acid(-C=O-)to form polycyclic calcium phthalate complex. | Sheng Chang Mei Li Kai Gao Dongliang Zhang Haijun Duan Linlin Ma Zheng Ruan | 2022 | Journal of Rare Earths2022，40，1： | 4 |
| 5 | Can Ecological Product Win Consumers in China? A Study on the Effect of Product Attributes and Consumers' Face Consciousness on Ecological Product Preference显示文摘 | Zhuomin Shi Linlin Wen Wanyi Zheng | 2014 | Frontiers of Business Research in China2014，8，2： | 3 |
| 6 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 7 | CPTA treatment reveals potential transcription factors associated with carotenoid metabolism in flowers of Osmanthus fragrans显示文摘Osmanthus fragrans is one of the top ten traditional flowers in China.It is divided into three different groups according to its color.α-Carotene and β-carotene are the main determinants to distinguish the color differences between three groups.However,the dominant genes and transcription factors involved in carotenoid metabolism remain unclear.CPTA treatment(0.7mmol·L−1)remarkably promoted lycopene,α-carotene and β-carotene contents in flowers.Transcriptome sequencing analysis revealed that CPTA treatment could trigger chain reactions in carotenoid metabolism pathway genes.Four up-regulated and 10 down-regulated transcription factors which have close association with carotenoid variation were significantly induced by CPTA treatment.The up-regulated TFs such as MYB43,MYB123,HSF,were further subjected to transcript expression determination in different cultivars with drastic colors.Among them,transcript expression of four up-regulated TFs coincided with the carotenoid accumulation in different cultivars.We selected up-regulated OfMYB43 to verify its function,which is related to stress tolerance and transcriptional regulation.Transient overexpression of OfMYB43 in O.fragrans flowers showed that it could remarkably promote the expression of PDS,ZISO,LCYE and CCD4,leading to increased accumulation of β-branch carotenoids.OfMYB43 was a potential positive regulator of carotenoid biosynthesis in O.fragrans flowers.This study provides insight into the molecular mechanism of carotenoid metabolism in O.fragrans. | Wan Xi Yanhong He Linlin Zhu Shiyang Hu Shuyi Xiong Yi Zhang Jingjing Zou Hongguo Chen Caiyun Wang Riru Zheng | 2021 | Horticultural Plant Journal2021，7，5： | 3 |
| 8 | Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many countries.However,the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.Here,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune systems.The viral protein partially co-localized with activated Mac-2+macrophages throughout the body.Moreover,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal COVID-19.Particularly,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune dysregulation.Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation.Melatonin,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted medicine.Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers. | Zhiqi Song Linlin Bao Wei Deng Jiangning Liu Erjun Ren Qi Lv Mingya Liu Feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 9 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 10 | Modify Cd3As2 nanowires with sulfur to fabricate self-powered NIR photodetectors with enhanced performance显示文摘Cd_(3)As_(2)nanowires(NWs)have great potential in the near-infrared(NIR)photodetection field due to their excellent optoelectronic properties as a typical Dirac semimetal.However,the existence of surface oxidization limits their photoresponse performance for practical applications.Here,we modified the surface of Cd_(3)As_(2)NWs with sulfur to prevent surface oxidizing and optimize the bandgap structure to improve the photoresponse performance.The S-modified Cd_(3)As_(2)samples existed as core/shell Cd_(3)As_(2)/CdS NWs and the corresponding single NW device showed a responsivity of 0.95 A/W in the NIR band at a 0 V bias,which is three orders of magnitude higher than that of an unmodified NW.This study provides an efficient and universally applicable way to prevent semimetals nanostructures from oxidizing and promote their optoelectronic properties. | Yongxu Yan Wenhao Ran Zhexin Li Linlin Li Zheng Lou Guozhen Shen | 2021 | Nano Research2021，14，10： | 2 |
| 11 | Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA显示文摘Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP protein family consisting of IGF2BP1~3 with the capacity of binding to many transcripts and regulating RNA stability, localization, and translation. In this study, we discovered that expression of IGF2BP2 was upregulated and led to a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). IGF2BP2 protein was gradually elevated from normal pancreas, pancreatic intraepithelial neoplasia to PDAC in an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, we demonstrated that IGF2BP2 promoted aerobic glycolysis and PDAC cell proliferation through directly binding to and stabilizing GLUT1 mRNA. In summary, our study unveiled an important role of IGF2BP2 in PDAC development by modulating aerobic glycolysis and as a potential therapeutic target for PDAC treatment. | Shan Huang Zheng Wu Yunyun Cheng Wenzhen Wei Linlin Hao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 2 |
| 12 | Recent advanced applications of ion-gel in ionic-gated transistor显示文摘Diversified regulation of electrons have received much attention to realize a multi-functional transistor,and it is crucial to have a considerable control over the charge carriers in transistors.Ionic gel,as the dielectric material in transistors,facilitates a large capacitance,and high induced-carrier concentrations.This review presents the recent progress in ionic-gated transistors(IGTs)that have good mechanical stability as well as high physical and chemical stability.We first briefly introduce the various applications of IGTs in sensors,neuromorphic transistors,organic transistor circuits,and health detection.Finally,the future perspectives of IGTs are discussed and some possible solutions to the challenges are also proposed. | Depeng Wang Shufang Zhao Ruiyang Yin Linlin Li Zheng Lou Guozhen Shen | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 13 | Discovery of Marine-terrestrial Transitional Facies Shale Gas in Taiyuan Formation of Zhenjia 1 Well,Northern Shaanxi,Ordos basin显示文摘Objective At present,there is controversy regarding the existence of marine-terrestrial transitional facies that can act as a source of shale gas.This detailed study of CarboniferousPermian age geological data from the northern Shaanxi area(China)provides new insight for this type of shale gas.In addition,a new deposition and accumulation pattern for this type of shale gas is established.Thus,the objectives of this study were to identify high quality gasbearing shale intervals in the lithological column of | ZHANG Yongsheng ZHENG Mianping XING Enyuan LI Yangchi GUI Baoling SHI Lizhi HE Yongtao WANG Linlin PENG Yuan ZHAO Haitong | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 1 |
| 14 | Neuromorphic-computing-based adaptive learning using ion dynamics in flexible energy storage devices显示文摘High-accuracy neuromorphic devices with adaptive weight adjustment are crucial for high-performance computing.However,limited studies have been conducted on achieving selective and linear synaptic weight updates without changing electrical pulses.Herein,we propose high-accuracy and self-adaptive artificial synapses based on tunable and flexible MXene energy storage devices.These synapses can be adjusted adaptively depending on the stored weight value to mitigate time and energy loss resulting from recalculation.The resistance can be used to effectively regulate the accumulation and dissipation of ions in single devices,without changing the external pulse stimulation or preprogramming,to ensure selective and linear synaptic weight updates.The feasibility of the proposed neural network based on the synapses of flexible energy devices was investigated through training and machine learning.The results indicated that the device achieved a recognition accuracy of~95%for various neural network calculation tasks such as numeric classification. | Shufang Zhao Wenhao Ran Zheng Lou Linlin Li Swapnadeep Poddar Lili Wang Zhiyong Fan Guozhen Shen | 2022 | National Science Review2022，9，11： | 1 |
| 15 | Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid显示文摘Liver injury caused by acetaminophen(AP)overdose is a leading public health problem.Although APinduced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone(NAPQI),a toxic metabolite of AP,resulting in cell damage,emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota.However,the gut microbiota-involved mechanism remains largely unknown.In our study,we found that vancomycin(Vac)pretreatment(100 mg/kg,twice a day for 4 days)attenuated AP-induced liver injury,altered the composition of gut microbiota,and changed serum metabolic profile.Moreover,we identified Vac pretreatment elevated cecum and serum 2-hydroxybutyric acid(2-HB),which ameliorated AP-induced cell damage and liver injury in mice by reducing AP bioavailability and elevating GSH levels.Our current results revealed the novel role of 2-HB in protecting AP-induced liver injury and add new evidence for gut microbiota in affecting AP toxicity. | Ningning Zheng Yu Gu Ying Hong Lili Sheng Linlin Chen Feng Zhang Jie Hou Weidong Zhang Zean Zhang Wei Jia Houkai Li | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 1 |
| 16 | The p38-MAPK Pathway Is Involved in Neuroprotection of Artemisinin against H2O2-induced Apoptosis in PC12 Cells显示文摘 | Liu Linlin Zhiwen Zeng Uma Gaur Fengxia Yan Wenhua Zheng | 2017 | Journal of Pharmacy and Pharmacology2017，5，7： | 1 |
| 17 | Analysis of the temporal and spatial distribution of water quality in China's major river basins, and trends between 2005 and 2010显示文摘 | Jinjian LI Xiaojie MENG Yan ZHANG Juan LI Linlin XIA Hongmei ZHENG | 2015 | Frontiers of Earth Science2015，9，3： | 1 |
| 18 | Detec- tion of QRS Complexes Based on Biorthogonal Spline Wavelet 显示文摘 | ZHENG XIUYU LI ZHEN SHEN LINLIN | 2008 | IEEE Information Science and Engineering2008，2008，2： | 1 |
| 19 | Magnesium ion-implantation-based gallium nitride p-i-n photodiode for visible-blind ultraviolet detection显示文摘In this work, a GaN p-i-n diode based on Mg ion implantation for visible-blind UV detection is demonstrated.With an optimized implantation and annealing process, a p-GaN layer and corresponding GaN p-i-n photodiode are achieved via Mg implantation. As revealed in the UV detection characterizations, these diodes exhibit a sharp wavelength cutoff at 365 nm, high UV/visible rejection ratio of 1.2 × 10~4, and high photoresponsivity of 0.35 A/W, and are proved to be comparable with commercially available GaN p-n photodiodes. Additionally, a localized states-related gain mechanism is systematically investigated, and a relevant physics model of electricfield-assisted photocarrier hopping is proposed. The demonstrated Mg ion-implantation-based approach is believed to be an applicable and CMOS-process-compatible technology for GaN-based p-i-n photodiodes. | WEIZONG XU YATING SHI FANGFANG REN DONG ZHOU LINLIN SU QING LIU LIANG CHENG JIANDONG YE DUNJUN CHEN RONG ZHANG YOUDOU ZHENG HAI LU | 2019 | Photonics Research2019，7，8： | 1 |
| 20 | An Extreme Gale Event in East China under the Arctic Potential Vorticity Anomaly through the Northeast China Cold Vortex显示文摘Arctic changes influence not only temperature and precipitation in the midlatitudes but also contribute to severe convection.This study investigates an extreme gale event that occurred on 30 April 2021 in East China and was forced by an Arctic potential vorticity(PV)anomaly intrusion.Temperature advection steered by storms contributed to the equatorward propagation of Arctic high PV,forming the Northeast China cold vortex(NCCV).At the upper levels,a PV southward intrusion guided the combination of the polar jet and the subtropical jet,providing strong vertical wind shear and downward momentum transportation to the event.The PV anomaly cooled the upper troposphere and the northern part of East China,whereas the lower levels over southern East China were dominated by local warm air,thus establishing strong instability and baroclinicity.In addition,the entrainment of Arctic dry air strengthened the surface pressure gradient by evaporation cooling.Capturing the above mechanism has the potential to improve convective weather forecasts under climate change.This study suggests that the more frequent NCCV-induced gale events in recent years are partly due to high-latitude waviness and storm activities,and this hypothesis needs to be investigated using more cases. | Wei TAO Linlin ZHENG Ying HAO Gaoping LIU | 2023 | Advances in Atmospheric Sciences2023，40，12： | 1 |
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