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| 1 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 2 | Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 prototypic 自体免疫的疾病。天生、适应的免疫合作地贡献 SLE 的发展。介绍抗原的房间(APC ) 被建议了连接天生、适应的免疫。T 房间 immunoglobulin-domain-containing 和 mucin-domain-containing molecule-4 (Tim-4;另外作为 Timd4 知道) ,首先在 APC 的表面上表示了,是 TIM 家庭,的一个成员作为免疫系统的潜在的管理者收到了许多注意的分子的一个最近描述的组。在这研究,我们使用了量的即时反向的抄写聚合酶链反应从 SLE 病人在外部血 mononuclear 房间( PBMC )检验 Tim-4 的 mRNA 表示并且进一步在 PBMC 和浆液肿瘤坏死因素( TNF )分析了在 Tim-4 和 Tim-1 (为 Tim-4 的潜在的 ligand )的表示之间的关联-伪层次。结果证明在 PBMC 的那个 Tim-4 mRNA 表达式比在健康控制在 SLE 病人是显著地更高的,特别在疾病的活跃阶段的那些病人。而且, Tim-4 mRNA 层次密切在 SLE 病人然而并非在控制组在 PBMC 并且与浆液 TNF- 伪层次与 Tim-1 mRNA 层次被相关。一起拿,这些结果证明 Tim-4 可以涉及 SLE 的致病。 | Peiqing Zhao Liyun Xu Piming Wang Xiaohong Liang Jianni Qi Peng Liu Chun Guo Lining Zhang Chunhong Ma Lifen Gao | 2010 | Cellular & Molecular Immunology2010，7，2： | 11 |
| 3 | Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice显示文摘可观的证据显示那种类型 1 个 T 助手(Th1 )- 并且当时,调停 Th17 的有免疫力的回答支持动脉粥样硬化患者匾的形成那 CD4 + CD25 + 规章的 T 房间(Tregs ) 有的 Foxp3 + 保护的效果。然而,因为令人满意的匾破裂模型的缺乏,在匾破裂遗体的多样的 CD4 + 淋巴细胞子集的功能糟糕理解。这里,我们在颈动脉动脉上用一本高脂肪的食谱和领子放置建立了动脉粥样硬化患者匾破裂的一个鼠科的模型,并且在 apolipoprotein 电子大美人与 lipopolysaccharide, phenylephrine 注射和寒冷的联合由短期的刺激触发了匾破裂(ApoE −/−) 老鼠。我们由 PCR,流动 cytometry, ELISA 和 immunohistochemistry 调查了在 Th1 房间, Th17 房间和 Tregs 和匾破裂之间的协会。总共, 75 %(18/24 ) 脆弱的匾,而是没有稳定的匾,显示出的破裂特征。Th17 房间的比例在处理以后在 splenocytes 之中被增加,但是在 Th1 房间和 Tregs 的层次的变化不与破裂有关。而且,处理在浆液并且在匾破裂的区域导致了 interleukin-17 (IL-17 ) 的高水平。在 vitro, IL-17 增加了 apoptosis 的水平,与匾破裂联系的一个主要因素,在有教养的鼠科的脉管的光滑的肌肉房间。Th17 房间和 IL-17 可以涉及短期的刺激在 ApoE −/− 老鼠。 | Tian Ma Qi Gao Faliang Zhu Chun Guo Qun Wang Fei Gao Lining Zhang | 2013 | Cellular & Molecular Immunology2013，10，4： | 9 |
| 4 | Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries显示文摘Soft tissue injury is very common and associated with pain,tissue swelling and even malformation if not treated on time.Treating methods include cryotherapy,electrical therapy,ultrasound therapy and anti-inflammatory drug,but none of them is completely satisfying.In this work,for a better therapeutic effect,drug therapy and pulsed electromagnetic field(PEMF)therapy were combined.We constructed a drug delivery system using the tetra-PEG/agar hydrogel(PA).By incorporating Fe3O4 NPs into the hydrogel network,a magnetism-responsive property was achieved in the system.The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel.A magnetism-controlled release was attained by the incorporation of Fe3O4.Finally,in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue.Therefore,this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury. | Lining Zhang Xiuqin Zuo Shengjie Li Mi Sun Huimin Xie Kai Zhang Jikun Zhou Liyun Che Junxuan Ma Zishan Jia Fei Yang | 2019 | Bioactive Materials2019，4，1： | 7 |
| 5 | Study on contrast test of PPC pre-oxidation and coagulation for algae removal and deodorization显示文摘The effect of treating algae-bearing water and induced odor by use of permanganate potassium composite (PPC) pre-oxidation was investigated, and was compared with the effect of treatments by pre-chlorination, permanganate potassium pre-oxidation and simple coagulation. The results showed that simple coagulation and pre-chlorination were less effective in removing algae and its odor, whereas PPC pre-oxidation was the most effective in algae removal and deodorization. Upon oxidation with PPC, the cells of Oscillatoria agardhic were inactivated and some intra-cellular and extra-cellular components were released into the water, which may help the coagulation by their bridging effect. The efficient removal of algae by PPC pre-oxidation is believed to be the joint contribution of several mechanisms. | Chen Zhonglin(陈忠林) Wang Lining Ma Jun Li Xueyan Fang Jingyun | 2005 | High Technology Letters2005，11，3： | 3 |
| 6 | Evaluation of landfarm remediation of hydrocarbon-contaminated soil at the inveresk railyard,Launceston,Australia显示文摘 | Line MA Garlandh CD and Crowley M | 1996 | Waste Management1996，16，7： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Application of composted pulp and paper mill sludge to a young pine plantation 显示文摘 | Jackson M J Line MA Wilson S | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 9 | Transplantation of embryonic stem cells into the infarcted mouse heart:formation of multiple cell types 显示文摘 | Singla DK Hacker TA Lining MA | 2006 | J Molecular and Cellular Cardiology2006，40，： | 1 |
| 10 | Transplantation of embryonic stem cells into the infarcted mouse heart:formation of multiple cell types 显示文摘 | Singla DK Hacker TA Lining MA | 2006 | J Molecular and Cellular Cardiology2006，40，： | 1 |
| 11 | Force-controlled Compensation Scheme for P-Q Valve-controlled Asymmetric Cylinder used on Hydraulic Quadruped Robots显示文摘Under the requirement of the force controller of hydraulic quadruped robots,the goal of this work is to accurately track the force commands at the level of the hydraulic drive unit.The main contribution focuses on the development of a force-controlled compensation scheme,which is specifically aimed at the key issues affecting the hydraulic quadrupedal locomotion.With this idea,based on a P-Q valve-controlled asymmetric cylinder,we first establish a mathematical model for the hydraulic drive unit force control system.With the desired force commands,a force feed-forward algorithm is presented to improve the dynamic performance of the system.Meanwhile,we propose a disturbance compensation algorithm to reduce the influence induced by external disturbances due to foot-ground impacts.Afterwards,combining with a variable gain PI controller,a series of experiments are implemented on a force control performance test platform to verify the proposed scheme.The results demonstrate that the force-controlled compensation scheme has the ability to notably improve the force tracking accuracy,reduce the response time and redundant force. | Yapeng Shi Mantian Li Fusheng Zha Lining Sun Wei Guo Cong Ma Zhibin Li | 2020 | Journal of Bionic Engineering2020，17，6： | 1 |
| 12 | Gate underlap design for short channel effects control in cylindrical gate-all-around MOSFETs based on an analytical model显示文摘 | Zhang Lining Wang Shaodi Ma Chenyue | 2012 | Iete Technical Review2012，29，1： | 1 |
| 13 | Electrophysiologic and phenotypic features of an autosomal cone-rod dystrophy caused by a novel CRX mutation显示文摘 | Lines MA Hébert M McTaggart KE | | 0，，： | 1 |
| 14 | Behavioral and other pheno types in a cytoplasmic Dynein light intermediate chain 1 mutant mouse显示文摘 | Banks GT Haas MA Line S | 2011 | J Neurosci2011，31，54： | 1 |
| 15 | From state monopoly to renewable portfolio: Restructuring China’s electric utility显示文摘 | Chunbo Ma Lining He | 2008 | Energy Policy2008，，5： | 1 |
| 16 | Model of NBTI combined with mobility degradation显示文摘The mobility degradation induced by negative bias temperature instability(NBTI) is usually ignored in traditional NBTI modeling and simulation, resulting in overestimation of the circuit lifetime, especially after longterm operation. In this paper, the mobility degradation is modeled in combination with the universal NBTI model.The coulomb scattering induced by interface states is revealed to be the dominant component responsible for mobility degradation. The proposed mobility degradation model fits the measured data well and provides an accurate solution for evaluating coupling of NBTI with HCI(hot carrier injection) and SHE(self-heating effect), which indicates that mobility degradation should be considered in long-term circuit aging simulation. | Xuezhong Wu Chenyue Ma Shucheng Gao Xiangbin Li Fu Sun Lining Zhang Xinnan Lin | 2018 | Journal of Semiconductors2018，39，12： | 0 |
| 17 | Quantum-Inspired Distributed Memetic Algorithm显示文摘This paper proposed a novel distributed memetic evolutionary model,where four modules distributed exploration,intensified exploitation,knowledge transfer,and evolutionary restart are coevolved to maximize their strengths and achieve superior global optimality.Distributed exploration evolves three independent populations by heterogenous operators.Intensified exploitation evolves an external elite archive in parallel with exploration to balance global and local searches.Knowledge transfer is based on a point-ring communication topology to share successful experiences among distinct search agents.Evolutionary restart adopts an adaptive perturbation strategy to control search diversity reasonably.Quantum computation is a newly emerging technique,which has powerful computing power and parallelized ability.Therefore,this paper further fuses quantum mechanisms into the proposed evolutionary model to build a new evolutionary algorithm,referred to as quantum-inspired distributed memetic algorithm(QDMA).In QDMA,individuals are represented by the quantum characteristics and evolved by the quantum-inspired evolutionary optimizers in the quantum hyperspace.The QDMA integrates the superiorities of distributed,memetic,and quantum evolution.Computational experiments are carried out to evaluate the superior performance of QDMA.The results demonstrate the effectiveness of special designs and show that QDMA has greater superiority compared to the compared state-of-the-art algorithms based on Wilcoxon’s rank-sum test.The superiority is attributed not only to good cooperative coevolution of distributed memetic evolutionary model,but also to superior designs of each special component. | Guanghui Zhang Wenjing Ma Keyi Xing Lining Xing Kesheng Wang | 2022 | Complex System Modeling and Simulation2022，2，4： | 0 |
| 18 | Multi-sensor control for precise assembly of optical components显示文摘In order to perform an optical assembly accurately, a multi-sensor control strategy is developed which includes an attitude measurement system, a vision system, a loss measurement system and a force sensor. A 3-DOF attitude measuring method using linear variable differential transformers(LVDT) is designed to adjust the relation of position and attitude between the spherical mirror and the resonator. A micro vision feedback system is set up to extract the light beam and the diaphragm, which can achieve the coarse positioning of the spherical mirror in the optical assembly process. A rapid self-correlation method is presented to analyze the spectrum signal for the fine positioning. In order to prevent the damage of the optical components and realize sealing of the resonator, a hybrid force-position control is constructed to control the contact force of the optical components. The experimental results show that the proposed multi-sensor control strategy succeeds in accomplishing the precise assembly of the optical components, which consists of parallel adjustment, macro coarse adjustment, macro approach, micro fine adjustment, micro approach and optical contact. Therefore, the results validate the multi-sensor control strategy. | Ma Li Rong Weibin Sun Lining | 2014 | Chinese Journal of Aeronautics2014，27，3： | 0 |
| 19 | Blockade of CD28 by a synthetical peptoid inhibits T-ce proliferation and attenuates graft-versus-host disease显示文摘 | Na Li Faliang Zhu Fei Gao Qun Wang Xiaoyan Wang Haiyan Li Chunhong Ma Wensheng Sun Wenfang Xu Chaodong Wang Lining Zhang | 2010 | Cellular & Molecular Immunology2010，7，2： | 0 |
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