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| 1 | Clinical outcomes of tricuspid valve repair accompanying left-sided heart disease显示文摘AIM To determine whether the need for additional tricuspid valve repair is an independent risk factor when surgery is required for a left-sided heart disease.METHODS One hundred and eighty patients(68 ± 12 years,79 males) underwent tricuspid annuoplasty.Cox proportionalhazards regression model for multivariate analysis was performed for variables found significant in univariate analyses.RESULTS Tricuspid regurgitation etiology was functional in 154 cases(86%),organic in 16 cases(9%),and mixed in10 cases(6%),respectively.Postoperative mortality at 30 days was 11.7%.Mean follow-up was 51.7 mo with survival at 5 years of 73.5%.Risk factors for mortality were acute endocarditis [hazard ratio(HR) = 9.22(95%CI:2.87-29.62),P < 0.001],ischemic heart disease requiring myocardial revascularization [HR = 2.79(1.26-6.20),P = 0.012],and aortic valve stenosis [HR = 2.6(1.15-5.85),P = 0.021].Significant predictive factors from univariate analyses were double-valve replacement combined with tricuspid annuloplasty [HR = 2.21(1.11-4.39),P = 0.003] and preoperatively impaired ejection fraction [HR = 1.98(1.04-3.92),P = 0.044].However,successful mitral valve repair showed a protective effect [HR = 0.32(0.10-0.98),P = 0.046].Additionally,in instances where tricuspid regurgitation required the need for concomitant tricuspid valve repair,mortality predictor scores such as Euroscore 2 could be shortened to a simple Euroscore-tricuspid comprised of only 7 inputs.The explanation may lie in the fact that significant tricuspid regurgitation following leftsided heart disease represents an independent risk factor encompassing several other factors such as pulmonary arterial hypertension and dyspnea.CONCLUSION Tricuspid annuloplasty should be used more often as a concomitant procedure in the presence of relevant tricuspid regurgitation,although it usually reveals an overly delayed correction of a left-sided heart disease. | Kasra Azarnoush Ahmad S Nadeemy Bruno Pereira Massoud A Leesar Céline Lambert Alaa Azhari Vedat Eljezi Nicolas Dauphin Etienne Geoffroy Lionel Camilleri | 2017 | World Journal of Cardiology2017，9，10： | 4 |
| 2 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | Effect of yeast-supplemented feed on Salmonella and Campylobacter populations in broilers显示文摘 | LINE J E BAILEY J S COX N A | 1998 | Poultry Science1998，77，3： | 1 |
| 5 | Time-dependent polymerization kinetic study and the properties of hybrid polymers with functional silsesquioxanes 显示文摘 | MYA K Y LINE M J GUDIPATI C S | 2010 | The Journal of Physical Chemistry B2010，114，28： | 1 |
| 6 | Smiles and frowns in migration/velocity analysis 显示文摘 | ZHU J LINES L R GRAY S | 1998 | Geophysics1998，63，： | 1 |
| 7 | Application of composted pulp and paper mill sludge to a young pine plantation 显示文摘 | Jackson M J Line MA Wilson S | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 8 | Watersheds Grass- AGNPS model tool显示文摘 | Line D E Coffey S W Osmond D L | 1997 | Transactions of the ASAE1997，40，4： | 1 |
| 9 | The use ofa thermostable signature amidase in the resolution of the bicyclic synthon (rac) ~/-lactam 显示文摘 | T~D H S BROWN R C LINE K | 2004 | Tetrahedron2004，60，3： | 1 |
| 10 | 显示文摘 | CARETTO S GIARDINA MC NI- COLODI C et aL Chlorsulfuron resis- tance in Daucus carotacell lines and plants: involvement of gene amplifica- tion | 1994 | Theor Appl Genet1994，88，： | 1 |
| 11 | Moisture distribution in a mature soft wheat grain by three-dimensional magentic reso- nance imaging显示文摘 | Song H P Delwice S R Line M J | 1998 | Journal of Food Cereal Science1998，，27： | 1 |
| 12 | Past, present and future of geophysical inversion: A new millennium analysis显示文摘 | Treitel S Lines L | 2001 | Geophysics2001，66，1： | 1 |
| 13 | Cooperative inversion of geophysical data 显示文摘 | Lines L Schultz A K Treitel S | 1987 | Expanded Abstracts of 57^th Annual International SEG Meeting1987，，： | 1 |
| 14 | Functional Toll-like receptors in primary first-trimester trophoblasts显示文摘 | Line H. Tanger?s Guro S. St?dle Guro D. Olsen Ann-Helen Leknes Astrid S. Gundersen Bente Skei Anne Jorunn Vikdal Liv Ryan Bj?rg Steinkjer Merete F. Myklebost Mette Langaas Rigmor Austgulen Ann-Charlotte Iversen | 2014 | Journal of Reproductive Immunology2014，，： | 1 |
| 15 | Development of a collection for genetic diversityand po pulation structure analysis 显示文摘 | PANG W X LI X N CHOI leafy Brassica rapa fixed line S R | 2015 | Molecular Breeding2015，35，： | 1 |
| 16 | Cooperative inversion of geophysical data显示文摘 | Lines L Schultz A K Treitel S | 1988 | Geophysics1988，53，1： | 1 |
| 17 | Lethal synthesis of methylglyoxal by Escherichia coli during unregulated glycerol metabolism 显示文摘 | Freedberg W B Kistler W S Line E C | 1971 | Bacteriology1971，108，： | 1 |
| 18 | Species substitution for carbon storage: Sessile oak versus Corsican pine in France as a case study显示文摘 | Patrick V Céline M Ingrid S | 2009 | Forest Ecology and Management2009，257，4： | 1 |
| 19 | Cooperative inversion of geophysical data显示文摘 | Lines L Schultz A K Treitel S | 1988 | Geophysics1988，53，1： | 1 |
| 20 | Does recombinant human bone morphogenetic protein-2use in adult spinal deformity increase complications and are complications associated with location of rhBMP-2use?A prospective,multicenter study of279consecutive patients显示文摘 | Bess S Line BG Lafage V | 2014 | Spine(Phila Pa 1976)2014，39，3： | 1 |
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