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| 1 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia显示文摘Oxysterol binding protein like 2(OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the potential genotypephenotype associations, the OSBPL2-disrupted Bama miniature(BM) pig model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear transfer(SCNT) and embryo transplantation approaches, and then subjected to phenotypic characterization of auditory function and serum lipid profiles. The OSBPL2-disrupted pigs displayed progressive hearing loss(HL) with degeneration/apoptosis of cochlea hair cells(HCs) and morphological abnormalities in HC stereocilia, as well as hypercholesterolaemia. High-fat diet(HFD) feeding aggravated the development of HL and led to more severe hypercholesterolaemia. The dual phenotypes of progressive HL and hypercholesterolaemia resembled in OSBPL2-disrupted pigs confirmed the implication of OSBPL2 mutation in nonsydromic hearing loss(NSHL) and contributed to the potential linkage between auditory dysfunction and dyslipidaemia/hypercholesterolaemia. | Jun Yao Huasha Zeng Min Zhang Qinjun Wei Ying Wang Haiyuan Yang Yajie Lu Rongfeng Li Qiang Xiong Lining Zhang Zhibin Chen Guangqian Xing Xin Cao Yifan Dai | 2019 | Journal of Genetics and Genomics2019，46，8： | 7 |
| 2 | Comprehensive learning pigeon-inspired optimization with tabu list显示文摘Dear editor,During the last decade,population-based algorithms have been extensively used to solve multimodal,discontinuous,non-convex,and nondifferentiable optimization problems.These algorithms search for the best solution by applying some operators and strategies over a set(population)of potential solutions(individuals).All those operators or strategies follow one principle:balancing between exploration and exploitation,which are the two cornerstones of problem-solving by searching[1].Therefor,a good population-based algorithm needs to establish an appropriate ratio between exploration and exploitation[2]. | Shang XIANG Lining XING Ling WANG Kai ZOU | 2019 | Science China(Information Sciences)2019，62，7： | 4 |
| 3 | Data-Driven Heuristic Assisted Memetic Algorithm for Efficient Inter-Satellite Link Scheduling in the BeiDou Navigation Satellite System显示文摘Inter-satellite link(ISL)scheduling is required by the BeiDou Navigation Satellite System(BDS)to guarantee the system ranging and communication performance.In the BDS,a great number of ISL scheduling instances must be addressed every day,which will certainly spend a lot of time via normal metaheuristics and hardly meet the quick-response requirements that often occur in real-world applications.To address the dual requirements of normal and quick-response ISL schedulings,a data-driven heuristic assisted memetic algorithm(DHMA)is proposed in this paper,which includes a high-performance memetic algorithm(MA)and a data-driven heuristic.In normal situations,the high-performance MA that hybridizes parallelism,competition,and evolution strategies is performed for high-quality ISL scheduling solutions over time.When in quick-response situations,the data-driven heuristic is performed to quickly schedule high-probability ISLs according to a prediction model,which is trained from the high-quality MA solutions.The main idea of the DHMA is to address normal and quick-response schedulings separately,while high-quality normal scheduling data are trained for quick-response use.In addition,this paper also presents an easy-to-understand ISL scheduling model and its NP-completeness.A seven-day experimental study with 10080 one-minute ISL scheduling instances shows the efficient performance of the DHMA in addressing the ISL scheduling in normal(in 84 hours)and quick-response(in 0.62 hour)situations,which can well meet the dual scheduling requirements in real-world BDS applications. | Yonghao Du Ling Wang Lining Xing Jungang Yan Mengsi Cai | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，11： | 4 |
| 4 | Multi- objective flexible job shop schedule: design and evalu- ation by simulation modeling显示文摘 | Xing Lining Chen Ying-wu Yang Ke wei | 2009 | Applied Soft Com- puting2009，9，： | 1 |
| 5 | Double layer ACO algorithm for the multi-objective FJSS显示文摘 | XING Lining CHEN Yingwu YANG Kewei | 2008 | New Gen- eration Computing2008，26，4： | 1 |
| 6 | Design of task priority model and algorithm for imaging observation problem显示文摘In the imaging observation system, imaging task scheduling is an important topic. Most scholars study the imaging task scheduling from the perspective of static priority, and only a few from the perspective of dynamic priority. However,the priority of the imaging task is dynamic in actual engineering. To supplement the research on imaging observation, this paper proposes the task priority model, dynamic scheduling strategy and Heuristic algorithm. At first, this paper analyzes the relevant theoretical basis of imaging observation, decomposes the task priority into four parts, including target priority, imaging task priority, track, telemetry & control(TT&C)requirement priority and data transmission requirement priority, summarizes the attribute factors that affect the above four types of priority in detail, and designs the corresponding priority model. Then, this paper takes the emergency tasks scheduling problem as the background, proposes the dynamic scheduling strategy and heuristic algorithm. Finally, the task priority model,dynamic scheduling strategy and heuristic algorithm are verified by experiments. | WU Jian LU Fang ZHANG Jiawei YANG Jinghui XING Lining | 2020 | Journal of Systems Engineering and Electronics2020，31，2： | 1 |
| 7 | Multi-objective flexible job shop schedule: design and evaluation by simulation modeling显示文摘 | Xing Lining Chen Yingwu Yang Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 8 | Multi-objective flexible job shop schedule:Design and evaluation by simulation modeling显示文摘 | Xing Lining Chen Yingwu Yang Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 9 | Multi-objective flexible Job Shop schedule:design and evaluation by simulation modeling显示文摘 | XING Lining CHEN Yingwu YANG Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 10 | An effi- cient search method for multi-objective flexible job shop scheduling problems显示文摘 | Xing Lining Chen Yingwu Yang Kewei | 2009 | J Intell Manuf2009，，20： | 1 |
| 11 | Multi- objective Flexible Job Shop Schedule: Design and Evaluation by Simulation Modeling 显示文摘 | Xing Lining Chen Yingwu Yang Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 12 | Multi-objec- tive flexible Job Shop schedule:design and evaluation by sim- ulation modeling显示文摘 | XING Lining CHEN Yingwu YANG Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 13 | Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment显示文摘Psoriasis is a common chronic immune-mediated skin disease characterized by hyperproliferation and aberrant differentiation of keratinocytes and massive infiltration of inflammatory immune cells.Recent studies showed that Signal Transducer and Activator of Transcription 3(STAT3),which plays an important role in cell survival,proliferation,differentiation,angiogenesis,and immune responses,is constitutively activated in epidermal keratinocytes of human psoriatic skin lesions.In addition,STAT3 promotes the differentiation and expansion of T cells and facilitates cytokine production,thereby exacerbating the condition of psoriasis.Alantolactone(ALT)is a sesquiterpene lactone compound that could selectively suppress STAT3 activation,but its effectiveness and application in psoriasis treatment have not been determined.In this study,we developed ALT loaded chitosan/hyaluronic acid nanoparticles(CHALT),and investigated its therapeutic potential for psoriasis therapy.CHALT effectively abrogated the hyperproliferation by inducing ROS-mediated apoptosis with loss of mitochondrialmembrane potential,and also inhibited IL-6-induced STAT3 signaling activation and inflammatory reaction in HaCaT cell line.In an Imiquimod(IMQ)-induced psoriasis model,the topical treatment of psoriasis lesions with CHALT effectively attenuated the STAT3 hyperactivation within keratinocytes and ameliorated the symptoms of psoriasis.In addition,it was found that CHALT restricted the recruitment of immune cells.These results indicated that ALT-based nanoformulation CHALT holds great potential for psoriasis therapy. | Ruijie Chen Yuan-Yuan Zhai Lining Sun Zeqing Wang Xing Xia Qing Yao Longfa Kou | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 1 |
| 14 | Multi objective flexible Job Shop schedule:design and evaluation by simulation modeling显示文摘 | XING Lining CHEN Yingwu YANG Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 15 | Multi-objective flexible job shop schedule: design and evaluation by simulation modeling显示文摘 | XING Lining CHEN Yingwu YANG Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 16 | Multi-objective flexible job shop schedule: design and evaluation by simulation modeling 显示文摘 | Xing Lining Chen Yingwu Yang Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 17 | Multi- objective flexible job shop scheduling: design and evaluation by simulation modeling 显示文摘 | Xing Lining Chen Yingwu Yang Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 18 | Satellite scheduling engine: The intelligent solver for future multi-satellite management显示文摘With the rapid development and popularization of worldwide aerospace industries over the recent decades,the optimization requirements of multi-satellite management have exploded significantly.The latest data show 4852 operational satellites orbiting the earth,of which the US,China,and Russia own 2944,499,and 169,respectively.Therefore,how to manage and schedule effectively hundreds of satellites to conform to the developing and popularizing aerospace tendency emerges as a worldwide problem. | Yonghao DU Lining XING Yingguo CHEN | 2022 | Frontiers of Engineering Management2022，9，4： | 1 |
| 19 | Multi-objective flexible Job Shop scheduling: design and evaluation by simula- tion modeling 显示文摘 | XING Lining CHEN Yingwu YANG Kewei | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 20 | Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid malignancies:a prospective single-arm phase Ⅱ study显示文摘Post-transplantation cyclophosphamide(PT-Cy)alone or in combination with other immunosuppressive drugs has emerged as a promising strategy in the setting of allogeneic hematopoietic stem cell transplantation.Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloid disease in non-myeloablative bone marrow transplant setting.Thus,we aimed to evaluate the safety and efficacy of PT-Cy combined with cyclosporine as graft-versus-host disease(GVHD)prophylaxis after myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoid malignancies.This single-arm phase Ⅱ clinical trial(NCT01435447)involving 31 adult patients was conducted from January 2013 to June 2018.The donor-type neutrophil engraftment rate was 100%,and the overall incidence of grade Ⅱ to Ⅳ and grade Ⅲ to Ⅳ acute GVHD was 39%and 24%,respectively.The cumulative incidence rates of chronic GVHD(35%),including moderate to severe forms(10%),were reduced compared with those of the historical group(P=0.03 and P=0.04,respectively).With a median follow-up of 18 months,the estimated 2-year overall and event-free survival was 64.8%(95%confidence interval:47.8%–86.7%)and 58.4%(95%CI:41.9%–81.7%),respectively.The 2-year cumulative incidence rate of relapse was 19.5%(95%CI:9.0%–35.8%),whereas the non-relapse mortality rate was 21.8%(95%CI:11.3%–38.1%).These results demonstrated the feasibility of PT-Cy as GVHD prophylaxis in this clinical setting.This strategy could significantly reduce the incidence of chronic GVHD and its moderate to severe forms but not of acute GVHD and results in similar survival outcomes compared with the historical group.A prospective study with additional patients is warranted to confirm the role of PT-Cy in lymphoid malignancy. | Ling Wang Lining Wang Xing Fan Wei Tang Jiong Hu | 2021 | Frontiers of Medicine2021，15，1： | 0 |
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