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| 1 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 2 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 3 | MICROSTRUCTURES OF A NOVEL HIGH STRENGTH AND WEAR-RESISTING ZINC ALLOY显示文摘MICROSTRUCTURESOFANOVELHIGHSTRENGTHANDWEAR-RESISTINGZINCALLOYLiYuanyuan;XiaWei;NgaiTungwaiLeo;LuoJunming;ZhengLingyi(Departme... | Li Yuanyuan Xia Wei Ngai Tungwai Leo Luo Junming Zheng Lingyi(Department of Mechanical Engineering,South China University of Technology, Guangzhou 51064) | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 7 |
| 4 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 5 | Sphericities of non-spherical objects显示文摘Sphericity, as one of the most important shape parameter for non-spherical objects, is extensively applied in evaluating the porosity or packing density of particles. In this paper, the sphericities of common non- spherical objects are deduced and investigated. Maximum sphericities and optimum shapes of these objects are presented as well. A decreasing order of sphericity from sphere (1.0) to regular tetrahedron (0.671) for objects with constant sphericity is given. Similar trends are found in most sphericity-aspect ratio relationships, which exhibit single peak and the sphericity increases with the growth of aspect ratio before the peak point and decreases afterward. The peak loci of aspect ratio are all around 1.0 which makes the shape approaching to a sphere. The information in the paper could be useful as literature for general application. | Teng Li Shuixiang Li Jian Zhao Peng Lu Lingyi Meng | 2012 | Particuology2012，10，1： | 4 |
| 6 | LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase显示文摘Limb and CNS expressed 1 like(LIX1L) is over-expressed in several types of tumors.However,the function of LIX1L in glucose metabolism and hepatocellular carcinoma(HCC) progression remains elusive.Here we report that LIX1L is over-expressed in human HCC tissues,which predicts unfavorable prognosis.LIX1L deficiency in vivo significantly attenuated liver cancer initiation in mice.Functional studies indicated that LIX1L overexpression elevated proliferation,migratory,invasive capacities of HCC cells in vitro,and promoted liver cancer growth and metastasis in vivo.LIX1L knockdown up-regulated fructose-1,6-bisphosphatase(FBP1) expression to reduce glucose consumption as well as lactate production.Mechanistically,LIX1L increased miR-21-3p expression,which targeted and suppressed FBP1,thereby promoting HCC growth and metastasis.MiR-21-3p inhibitor could abrogate LIX1L induced enhancement of cell migration,invasion,and glucose metabolism.Inhibition of miR-21-3p suppressed tumor growth in an orthotopic tumor model.Our results establish LIX1L as a critical driver of hepatocarcinogenesis and HCC progression,with implications for prognosis and treatment. | Jie Zou Xiaoyun Zhu Dejuan Xiang Yanqiu Zhang Jie Li Zhigui Su Lingyi Kong Hao Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 4 |
| 7 | Spirolindemers A and B,Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi显示文摘Spirolindemers A and B,unprecedented lindenane sesquiterpenoid dimer(1)and trimer(2)equipped with oxaspiro[4.5]decane unit,were discovered from the medicinal plant Chloranthus henryi.Their structures including absolute configurations were achieved by HRMS,NMR,ECD,X-ray diffraction analyses,and quantum chemical calculations.Biogenetically,hetero-and homo-Diels-Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5]decane skeletons,respectively.Compound 1 showed anti-inflammatory activity by inhibiting the expression of iNOS and COX-2. | Jixin Li Jun Chi Pengfei Tang Yunpeng Sun Weijia Lu Wenjun Xu Yongyue Wang Jun Luo Lingyi Kong | 2022 | Chinese Journal of Chemistry2022，40，5： | 4 |
| 8 | Packing properties of binary mixtures in disordered sphere systems显示文摘Mixtures of binary spheres are numerically simulated using a relaxation algorithm to investigate the effects of volume fraction and size ratio.A complete profile of the packing properties of binary spheres is given.The density curve with respect to the volume fraction has a triangular shape with a peak at 70%large spheres.The density of the mixture increases with the size ratio,but the growth becomes slow in the case of a large size disparity.The volume fraction and size ratio effects are reflected in the height and movement,respectively,of specific peaks in the radial distribution functions.The structure of the mixture is further analyzed in terms of contact types,and the mean coordination number is demonstrated to be primarily affected by 'large-small' contacts.A novel method for estimating the average relative excluded volume for binary spheres by weighting the percentages of contact types is proposed and extended to polydisperse packings of certain size distributions.The method can be applied to explain the density trends of polydisperse mixtures in disordered sphere systems. | Lingyi Meng Peng Lu Shuixiang Li | 2014 | Particuology2014，12，5： | 3 |
| 9 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 10 | Cryo-EM structures of human pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)channel mediates adenosine-5’-triphosphate(ATP)release for purinergic signaling,1 playing important roles in multiple physiological and pathological processes including apoptotic clearance,2 inflammatory response,3 cancer progression,and metastasis.4 Diverse stimuli have been reported to activate PANX1 channel,such as voltage,membrane stretch,hypotonicity,elevated extracellular K+or intracellular Ca2+concentration,C-terminal cleavage and phosphorylation.1,5 It is perplexing that PANX1 has been demonstrated to exhibit different unitary channel properties depending on the mode of activation.1,5 Particularly,PANX1 undergoes a stepwise,quantized activation progress upon sequentially cleaving the C-terminal of each subunit. | Qiuheng Jin Bo Zhang Xiang Zheng Ningning Li Lingyi Xu Yuan Xie Fangjun Song Eijaz Ahmed Bhat Yuan Chen Ning Gao Jiangtao Guo Xiaokang Zhang Sheng Ye | 2020 | Cell Research2020，30，5： | 2 |
| 11 | A computational investigation on random packings of sphere-spherocylinder mixtures显示文摘Random packings of binary mixtures of spheres and spherocylinders with the same volume and the same diameter were simulated by a sphere assembly model and relaxation algorithm. Simulation results show that, independently of the component volume fraction, the mixture packing density increases and then decreases with the growth of the aspect ratio of spherocylinders, and the packing density reaches its maximum at the aspect ratio of 0.35. With the same volume particles, results show that the dependence of the mixture packing density on the volume fraction of spherocylinders is approximately linear. With the same diameter particles, the relationship between the mixture packing density and component volume fraction is also roughly linear for short spherocylinders, but when the aspect ratio of spherocylinders is greater than 1.6, the curves turn convex which means the packing of the mixture can be denser than either the sphere or spherocylinder packing alone. To validate the sphere assembly model and relaxation algorithm, binary mixtures of spheres and random packings of spherocylinders were also simulated. Simulation results show the packing densities of sphere mixtures agree with previous prediction models and the results of spherocylinders correspond with the simulation results in literature. | LU Peng, LI ShuiXiang , ZHAO Jian & MENG LingYi State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics & Aerospace Engineering, College of Engineering, Peking University, Beijing 100871, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 2 |
| 12 | Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction显示文摘 | Hongjie Liu Zhaoting Wu Xianle Shi Wenzhi Li Chang Liu Dekun Wang Xiaoying Ye Lin Liu Jie Na Hong Cheng Lingyi Chen | 2013 | Developmental Biology2013，，1： | 1 |
| 13 | Fabricationand evaluation of chiral monolithic column modified byβ-Cyclodextrin derivatives显示文摘 | Li Yingjie Song Chunhui Zhang Lingyi | 2010 | Talanta2010，80，3： | 1 |
| 14 | Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography显示文摘 | Renmin Liu Aifeng Li Ailing Sun Lingyi Kong | 2004 | Journal of Chromatography A2004，，1： | 1 |
| 15 | Brassinosteroid and gibberellin coordinate rice seed germination and embryo growth by regulating glutelin mobilization显示文摘Seed germination is the beginning of a new lifecycle,and involves many complex physiological and biochemical reactions including seed reserve mobilization in the endosperm and nutrient transport and reuse in the embryo.Although glutelin is a dominant storage protein in rice,its contribution to seed germination and its regulatory mechanisms are mostly unknown.Gibberellin (GA) and brassinosteroid (BR),two major growth-promoting phytohormones,also play positive roles in controlling seed germination.However,how GA and BR interact and coordinate seed germination and facilitate glutelin mobilization remains unclear.In the present study,biochemical and physiological analyses of seed germination indicated that both GA and BR promote seed germination and post-germination growth.Exogenous application of GA restored germination defects caused by BR deficiency or insensitivity.Proteomic and q RT-PCR results showed that the expression of several glutelin proteins and their encoding genes was induced by BR and GA in the embryo.Expression assays suggested that the increased accumulation of glutelin protein in the embryo was due to the accelerated degradation of glutelin by a cysteine proteinase (REP-1) in the endosperm.The breakdown of glutelin in the endosperm showed a strict positive correspondence with the length of the shoot.The GluA2 mutation led to reduced degradation rate of glutelin and defects in seed germination,and the promotion effect of GA on seed germination was weakened in the glua2mutant.In vitro culture assay of rice embryos showed that glutelin mobilization functioned downstream of the GA and BR pathways to promote shoot elongation.These findings suggest a mechanism that mediates crosstalk between BR and GA in co-regulating rice seed germination and embryo growth. | Min Xiong Lingyi Chu Qianfeng Li Jiawen Yu Yihao Yang Peng Zhou Yong Zhou Changquan Zhang Xiaolei Fan Dongsheng Zhao Changjie Yan Qiaoquan Liu | 2021 | The Crop Journal2021，9，5： | 1 |
| 16 | Disordered packing density of binary and polydisperse mixtures of curved spherocylinders显示文摘 | Lingyi Meng Shuixiang Li | 2017 | Particuology2017，15，3： | 1 |
| 17 | Sarcaglarols A-D, Lindenane-Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks显示文摘Sarcaglarols A-D(1-4),two pairs of lindenane-monoterpene heterodimers fused by a 1,2-dioxane moiety,were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking-based strategy.Their planar structures,absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS,NMR spectroscopic data,ECD spectrum,and the X-ray diffraction study of isopropylidene derivatives.An intermolecular[2+2+2]cycloaddition may play a key role in the biosynthesis pathway of the 1,2-dioxane moiety fused lindenane-monoterpene heterodimer skeleton,which can be recognized as the biogenetic precursors of our previous reported lindenane-normonoterpene conjugates.In addition,compounds 1,3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid-exposed L02 cells. | Yongyue Wang Zhirong Cui Jun Chi Pengfei Tang Meihui Zhang Jixin Li Yongyi Li Hao Zhang Jun Luo Lingyi Kong | 2021 | Chinese Journal of Chemistry2021，39，1： | 1 |
| 18 | Study on difference between epidermis, phloem and xylem of Radix Ginseng with near-infrared and infrared spectroscopy coupled with principal component analysis显示文摘 | Yanhong Wu Yi Zheng Qingqing Li Jibran Iqbal Lingyi Zhang Weibing Zhang Yiping Du | 2010 | Vibrational Spectroscopy2010，，2： | 1 |
| 19 | Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities显示文摘Twenty-two new limonoids,mufolinoids A—V(1—22),including six rings A,B-seco limonoids(1—6),twelve ring A-seco limonoids(7—18),four ring-intact limonoids(19—22),together with thirteen known compounds(23—35)were isolated from Munronia unifoliolata.Their structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray diffraction and calculations of ECD and NMR technologies.Compounds 24,25,33,34 could be significantly reversed the multidrug resistance of MCF-7/doxorubicin(DOX)cells,and the reversal fold(RF)was much higher than that of positive drug Verapamil.Compounds 24,28,and 29 exhibited significant anti-inflammatory activity with the IC50 values in the range of 17.7—39.4μmol/L.Furthermore,compound 29 could markedly inhibit the release of IL-1βby inhibiting the initiation and assembly of NLRP3 inflammasome,which demonstrates the great potential of limonoids as an anti-inflammatory agent. | Yunpeng Sun Qiurong Li Letian Cui Pengfei Tang Yongyi Li Lingyi Kong Jun Luo | 2022 | Chinese Journal of Chemistry2022，40，1： | 1 |
| 20 | Effect of the interaction between carrageenan,gellan gum and flaxseed gum on quality attibutes of starch-free emulsion-type sausage显示文摘 | Weiwei Zhou Lingyi Meng Xingming Li | 2010 | J Muscle Food2010，21，2： | 1 |
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