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| 1 | Proteomic Analysis of Macrophages:A Potential Way to Identify Novel Proteins Associated with Activation of Macrophages for Tumor Cell Killing显示文摘One major mechanism through which macrophages effectively kill tumor cells requires cell to cell contact,indicating that certain molecules expressed on cell surface of activated macrophages may mediate the tumoricidal capability. Tumor necrosis factor (TNF) and nitric oxide (NO) are the two classical mediators of tumor cell death. However,evidence of discrepancy is accumulating indicating these known mediators do not appear to account for the broad and potent tumoricidal activity of macrophages. To obtain a full repertoire of tumoricidal activation-associated membrane proteins,we combined one-dimensional SDS-PAGE with capillary liquid chromatography-tandem mass spectrometry (LC-MS/MS). Using this technique,we identified 454 activated macrophage specifically expressed proteins with extremely high confidence,including most known activation markers of macrophages,such as NO synthase (iNOS),Ym1,cyclooxygenase,etc. Membrane bound TNF-α was also identified on activated macrophages. However,it was also detected on thioglycolate elicited macrophages,indicating this molecule may not play a key role in conjugation-dependent tumor cell killing. In contrast,although NO has not been assigned as an effector molecule of conjugation-dependent tumoricidal pathway,iNOS was identified from membrane fraction of activated macrophages,suggesting NO may be involved in conjugation-dependent tumoricidal mechanism,because iNOS association with plasma membrane is ideally suited to deliver NO directly into the contacted tumor cells. This research provides not only new insights into macrophage conjugation-dependent tumoricidal mechanisms,but also a valuable data set of macrophage activation associated membrane proteins,thus providing better understanding of the functional mechanisms of macrophages in anti-tumor and other biological processes. | Lingbing Zhang Haoxuan Zhu Yanni Lun Dongmei Yan Leyang Yu Bairong Du Xun Zhu | 2007 | Cellular & Molecular Immunology2007，4，5： | 7 |
| 2 | Histopathology and Ultrastructural Pathology of Cyprinid Herpesvirus Ⅱ(CyHV-2) Infection in Gibel Carp, Carassius auratus gibelio显示文摘Cyprinid herpesvirus II(Cy HV-2) infection is identified in cultured gibel carp, Carassius auratus gibelio, with high mortality in China in recent years. Histological pathology includes acute hepatocellular necrosis, splenic necrosis, kidney necrosis, hyperplasia of the secondary lamellae with focal necrosis. Acute necrotic myocarditis and granulocytes are prominent within the cardiac lumen in infected fish. In addition, necrosis is observed in the submucosa and mucosa epithelium of intestinal tract. Edemas are observed in renal glomerulus, submucosa and mucosa epithelium of intestinal tract, myocardial cells and neurons. Transmission electron microscopy indicates the cytoplasmic inclusions in splenocytes, glomerulus cells and hematopoietic tissue cells of kidney, epithelial cells of gills and brain cells. The histopathology and ultrastructural pathology in Cy HV-2 infected gibel carp are characterized with extensive necrosis and cytoplasmic inclusions in spleen, kidney, gill and brain, which suggests that Cy HV-2 may mainly infect the spleen, kidney, gill and brain of fish. | JIANG Nan XU Jin MA Jie FAN Yuding ZHOU Yong LIU Wenzhi ZENG Lingbing | 2015 | Wuhan University Journal of Natural Sciences2015，20，5： | 6 |
| 3 | Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol显示文摘Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple biological and clinically relevant effects,including anticancer and antimicrobial function.However,the antiviral activity of honokiol has not yet been well studied.Here we showed that honokiol had no effect on herpes simplex virus-1(HSV-1)entry,but inhibited HSV-1 viral DNA replication,gene expression and the production of new progeny viruses.The combination of honokiol and clinical drug acyclovir augmented inhibition of HSV-1 infection.Our results illustrate that honokiol could be a potential new candidate for clinical consideration in the treatment of HSV-1 infection alone or combination with other therapeutics. | Shuai Liu Long Li Lingbing Tan Xiaozhen Liang | 2019 | Virologica Sinica2019，34，3： | 4 |
| 4 | Nonlinear V-I property of Ag /BaTiO_3 composite materials显示文摘THE composites formed by mixing metal particles into matrices have special optical and electri-cal properties. Up to now, main work has been laid on the investigation of optical propertyof the composites, rather than on that of electrical property. As well known, the structure of ZnO varistors can be described as semiconducting grainssurrounded by a thin layer of insulator. The thin layer of insulator is of electrical tunneling ef-fect leading to function of varistors. Because the resistance of the semiconducting grains | KONG Lingbing, FAN Huiqing, ZHANG Liangying and YAO XiElectronic Materials Research Laboratory, Xi’an Jiaotong University, Xi’an 710049, China | 1997 | Chinese Science Bulletin1997，42，12： | 3 |
| 5 | High prevalence of pathogenic Leptospira in wild and domesticated animals in an endemic area of China显示文摘Objective:To assess the prevalence of Leptospira detected in wildlife and domesticated animals in Jiangxi Province,China,in 2009.Methods:Urine samples from 28 buffaloes and kidney samples from 50 pigs,50 dogs and 38 rats were collected from Fuliang and Shangrao County,Jiangxi Province,China,in October 2009.Polymerase chain reaction(PCR) and culture analyses were used to detect Leptospira.The cultured isolates were typed using the microscopic agglutination lest(MAT).Results:The results showed that rats potentially serve as the main reservoir of leptospiral infection,followed by dogs.Although 16%of rats(6/38) were positive using culture analysis,PCR analysis using the diagnostic primers G1/G2 and B64Ⅰ/B64Ⅱor lipLS2 showed identification as 50%and 24%,respectively,of the rat samples as positive for the presence of leptospiral DNA.Conclusions:PCR-based detection of leptospiral DNA in infected kidney tissues of reservoirs is more efficient when using G1/G2 primers than lipL32 primers. However,the latter primers have a potential application for detection in urine samples.The alarmingly high prevalence of leptospiral DMA in the wild rat population near human habitation underscores the utility of routine Leptospira surveillance,preferably using PCR methods,which are more sensitive than traditional culture-based methods. | Wang Yalin Zeng Lingbing Yang Hongliang Xu Jianmin Zhang Xiangyan Guo Xiaokui Pal Utpal Qin Jinhong | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 2 |
| 6 | MEB-YOLO: An Efficient Vehicle Detection Method in Complex Traffic Road Scenes显示文摘Rapid and precise vehicle recognition and classification are essential for intelligent transportation systems,and road target detection is one of the most difficult tasks in the field of computer vision.The challenge in real-time road target detection is the ability to properly pinpoint relatively small vehicles in complicated environments.However,because road targets are prone to complicated backgrounds and sparse features,it is challenging to detect and identify vehicle kinds fast and reliably.We suggest a new vehicle detection model called MEB-YOLO,which combines Mosaic and MixUp data augmentation,Efficient Channel Attention(ECA)attention mechanism,Bidirectional Feature Pyramid Network(BiFPN)with You Only Look Once(YOLO)model,to overcome this problem.Four sections make up this model:Input,Backbone,Neck,and Prediction.First,to improve the detection dataset and strengthen the network,MixUp and Mosaic data improvement are used during the picture processing step.Second,an attention mechanism is introduced to the backbone network,which is Cross Stage Par-tial Darknet(CSPDarknet),to reduce the influence of irrelevant features in images.Third,to achieve more sophisticated feature fusion without increasing computing cost,the BiFPN structure is utilized to build the Neck network of the model.The final prediction results are then obtained using Decoupled Head.Experiments demonstrate that the proposed model outperforms several already available detection methods and delivers good detection results on the University at Albany DEtection and TRACking(UA-DETRAC)public dataset.It also enables effective vehicle detection on real traffic monitoring data.As a result,this technique is efficient for detecting road targets. | Yingkun Song Shunhe Hong Chentao Hu Pingan He Lingbing Tao Zhixin Tie Chengfu Ding | 2023 | Computers, Materials & Continua2023，，6： | 2 |
| 7 | CD95-CD95L interaction mediates the growth control of MHV68 immortalized B cells by cytotoxic T cells显示文摘Dear Editor,The main limitation of the viral pathogenesis study of human gammaherpesviruses Epstein-Barr virus(EBV)and Kaposi sarcoma-associated herpesvirus(KSHV)is the absence of animal model owing to the narrow host tropism of both EBV and KSHV.Murine gammaherpesvirus 68(MHV68)encodes several genes involved | Sihan Dong Lingbing Tan Guifang Chen Xiaozhen Liang | 2017 | Virologica Sinica2017，32，3： | 2 |
| 8 | Studies on the poly(lactic-co-glycolic) acid microspheres of cisplatin for lungtargeting显示文摘 | Huo Dongjie Deng Shuhai Li Lingbing | 2005 | International Journal of Pharmaceutics2005，289，12： | 1 |
| 9 | Grinding aid-assisted preparation of high-performance carbon-LiMnPO_4显示文摘 | RAN Lingbing LIU Xiaoyan TANG Qiwei | 2013 | Electrochim Acta2013，114，： | 1 |
| 10 | Sol-gel Glass-coated Zinc Oxide for Varistor Applications显示文摘 | Lingbing Kong Fengchun Li Liangying Zhang Xi Yao | 1998 | Journal of Materials Science Letters1998，，9： | 1 |
| 11 | Preparation and properties of hydroxycamptothecin-loaded nanoparticles made of amphiphilic copolymer and normal polymer显示文摘 | Wang Jinli Wang Rong Li Lingbing | 2009 | Colloid and Interface Science2009，336，2： | 1 |
| 12 | Germ cell sex prior to meiosis in the rainbow trout显示文摘Germ cells make two major decisions when they move from an indeterminate state to their final stage of gamete production.One decision is sexual commitment for sperm or egg production,and the other is to maintain mitotic division or entry into meiosis.It is unclear whether the two decisions are made as a single event or separate events,because there has been no evidence for the presence of germ cell sex prior to meiosis.Here we report direct evidence in the fish rainbow trout that gonia have distinct sexuality.We show that dazl expression occurs in both male and female gonia but exhibits differential intracellular distribution.More strikingly,we show that boule is highly expressed in male gonia but absent in female gonia.Therefore,mitotic gonia possess sex,sperm/egg decision and mitosis/meiosis decision are two independent events,and sperm/egg decision precedes mitosis/meiosis decision in rainbow trout,making this organism a unique vertebrate model for mechanistic understanding of germ cell sex differentiation and relationship between the two decisions. | Mingyou Li Qian Shen Foong Mei Wong Hongyan Xu Ni Hong Lingbing Zeng Lin Liu Qiwei Wei Yunhan Hong | 2011 | Protein & Cell2011，2，1： | 1 |
| 13 | Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo显示文摘 | Zhimei Song Runliang Feng Min Sun Chenyu Guo Yan Gao Lingbing Li Guangxi Zhai | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
| 14 | Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans显示文摘螺旋体 interrogans 染色体编码 cheR 基因的二个拷贝,他们中的每能为 Escherichia coli cheR 0 异种 RP1254 的聚集的有缺点的显型补充到某些程度,当他们的也的在表示上禁止趋化性的野类型的 E 聚集时。coli 紧张, RP437。因此, CheR1 和 CheR2 应该忍受 methyltransferase 活动,尽管 CheR1 有仅仅而不是位于 2 螺旋的断然控告的脸的二保存基本氨基酸残余。当象 CheR2 的 Lys48 和 Arg55 一样的这残余被变异时,任何一个 CheRs 都不能维持上述的互补功能,建议他们考虑到类似于 E 的接受甲基的趋化性蛋白质的关键角色。coli。由 microarray 试金示威了,在 L 的 cheR1 的表情。在 28 点有教养的 | Yunyi Zhang Ke Dong Lingbing Zeng Qingtian Li Chang Liu Jin Wang Xiaokui Guo Guo-Ping Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 1 |
| 15 | Studies on the poly (lactic-co-glycolic)acid microspheres of cisplatin for lungtargeting 显示文摘 | HUO DONGJIE DENG SHUHAI LI LINGBING | 2005 | International Jo-urnal of Pharmaceutics2005，289，12： | 1 |
| 16 | Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles显示文摘 | HouLi Li XiaoBin Zhao YuKun Ma GuangXi Zhai LingBing Li HongXiang Lou | 2008 | Journal of Controlled Release2008，，3： | 1 |
| 17 | Prepar- ation and properties of a humidity sensor based on LiC1- doped porous silica 显示文摘 | KONG Lingbing ZHANG Liangying YAO Xi | 1997 | Journal of Materials Science Letters1997，16，10： | 1 |
| 18 | Enhancing the performance of poly(3-hexylthiophene)/ZnO nanorod arrays based hybrid solar cells through incorporation of a third component显示文摘Sparse ZnO nanorod arrays(NRAs)are fabricated on transparent conducting oxide coated glass substrates by using a modified liquid phase epitaxial growth method.By adjusting the polymer concentrations and the spin-coating parameters,full infiltration of poly(3-hexylthiophene)(P3HT)into the as-prepared ZnO NRAs is achieved at 130°C in vacuum.A third component is incorporated into the P3HT/ZnO NRAs ordered bulk heterojunctions(BHJs)either through ZnO surface modification with N719dye or CdS shell layer or by inclusion of a fullerene derivative into the P3HT matrix.Experimental results indicate that performances of the hybrid solar cells are improved greatly with the incorporation of a third component.However,the working principles of these third components differ from one another,according to morphology,structure,optical property,charge transfer and interfacial properties of the composite structures.An ideal device architecture for hybrid solar cells based on P3HT/ZnO NRAs ordered BHJs is proposed,which can be used as a guidance to further increase the power conversion efficiency of such solar cells. | ZHONG Peng QUE WenXiu ZHANG Jin YUAN Yuan LIAO YuLong YIN XingTian KONG LingBing HU Xiao | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 1 |
| 19 | Enhancement on oral absorption of paclitaxel by multifunctional pluronic micelles显示文摘 | Yimu Li Yiling Bi Yanwei Xi Lingbing Li | 2013 | Journal of Drug Targeting2013，，2： | 1 |
| 20 | Learning to Complete Knowledge Graphs with Deep Sequential Models显示文摘Knowledge graph (KG) completion aims at filling the missing facts in a KG, where a fact is typically represented as a triple in the form of (head, relation, tail). Traditional KG completion methods compel two- thirds of a triple provided (e.g., head and relation) to predict the remaining one. In this paper, we propose a new method that extends multi-layer recurrent neural networks (RNNs) to model triples in a KG as sequences. It obtains state-of-the-art performance on the common entity prediction task, i.e., giving head (or tail) and relation to predict the tail (or the head), using two benchmark data sets. Furthermore, the deep sequential characteristic of our method enables it to predict the relations given head (or tail) only, and even predict the whole triples. Our experiments on these two new KG completion tasks demonstrate that our method achieves superior performance compared with several alternative methods. | Lingbing Guo Qingheng Zhang Wei Hu Zequn Sun Yuzhong Qu | 2019 | Data Intelligence2019，1，3： | 1 |
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