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| 1 | lncRNA NEAT1 promotes the Taxol resistance of breast cancer via sponging the miR-23a-3p-FOXA1 axis显示文摘Breast cancer is the most prevalent malignancy among women worldwide.Paclitaxel(Taxol)is a widely applied chemotherapeutic agent against breast cancer.Although Taxol therapy has achieved improvements recently,development of chemoresistance of breast cancer patients is a major obstacle,leading to therapeutic failure.Long non-coding RNAs(lncRNAs)play pivotal roles in tumorigenesis and progresses of breast cancer.However,the biological roles and molecular targets of lncRNA NEAT1 in Taxol-resistant breast cancer remain unclear.Here,we report that NEAT1 is significantly upregulated in breast tumors and cell lines.In addition,silencing NEAT1 effectively sensitizes breast cancer cells to Taxol.Bioinformatical analysis and luciferase assay demonstrated that miR-23a-3p could be sponged and downregulated by NEAT1.We demonstrated that miR-23a-3p was downregulated and functioned as a tumor suppressor in breast cancer.Furthermore,in the established Taxol-resistant MDA-MB-231 breast cancer cell line,we detected significantly increased NEAT1 expression and downregulated miR-23a-3p expression.Importantly,FOXA1 was identified and validated as a direct target of miR-23a-3p in breast cancer cells.Rescue experiments demonstrated that the restoration of miR-23a-3p in NEAT1-overexpressing Taxol-resistant breast cancer cells successfully overcame the NEAT1-promoted Taxol resistance.Taken together,our results revealed the clinical roles and molecular mechanisms for the NEAT1-mediated chemoresistance,providing new insights into the development of non-coding RNA-based therapeutic strategies for enhancing the anti-cancer effects of traditional chemotherapeutic drugs. | Lin Zhu Fengchun Wang Wenhui Fan Zhi Jin Chao Teng Jianxin Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 7 |
| 2 | Three-Dimensional TIN Algorithm for Digital Terrain Modeling显示文摘The problem of taking an unorganized point cloud in 3D space and fitting a polyhedral surface to those points is both important and difficult. Aiming at increasing applications of full three dimensional digital terrain surface modeling, a new algorithm for the automatic generation of three dimensional triangulated irregular network from a point cloud is pro- posed. Based on the local topological consistency test, a combined algorithm of constrained 3D Delaunay triangulation and region-growing is extended to ensure topologically correct reconstruction. This paper also introduced an efficient neighbor- ing triangle location method by making full use of the surface normal information. Experimental results prove that this algo- rithm can efficiently obtain the most reasonable reconstructed mesh surface with arbitrary topology, wherein the automati- cally reconstructed surface has only small topological difference from the true surface. This algorithm has potential applica- tions to virtual environments, computer vision, and so on. | ZHU Qing ZHANG Yeting LI Fengchun | 2008 | Geo-Spatial Information Science2008，11，2： | 6 |
| 3 | Use of infrared thermal imaging to diagnose health of Ammopiptanthus mongolicus in northwestern China显示文摘Population of the rare and endangered species Ammopiptanthus mongolicus(Maxim.) Cheng f. declined rapidly in China's arid region and Central Asia. There is an urgent need to protect this species, which is particularly important in maintaining biodiversity throughout the arid region of northwestern China. By analyzing the infrared thermal images based on plant-transpiration transfer coefficient(h_at) and photosynthetic parameters, we made quantitative and accurate diagnoses of the plant growth and health status of A. mongolicus. Using an LI-COR6400 photosynthesis system, we measured the net photosynthetic rate(P_n), stomatal conductance(G_s), and transpiration rate(T_r). Infrared thermal images obtained in the field were processed by ENVI4.8 software to calculate surface temperatures of the plant subjects. We found that the plant transpiration transfer coefficient of A. mongolicus was in the order of old plants [young plants [intermediate-aged plants. Declining health levels of young, intermediate, and old plants were divided into three categories:\0.4, 0.4–0.7,and [0.7. The coefficient showed a significant negative correlation with T_r, G_s, and P_n, indicating that they can simultaneously reflect the state of plant growth. By establishing h_at and photosynthetic parameters in regression model Y = a-blnx, we can accurately diagnose plant growth and decline of plant health conditions. | Weijie Yuan Yi Yu Yongde Yue Ji Wang Fengchun Zhang Xiaohong Dang | 2015 | Journal of Forestry Research2015，26，3： | 5 |
| 4 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 5 | Autoimmune pancreatitis:current concepts显示文摘Autoimmune pancreatitis(AIP) is a distinct type of chronic pancreatitis with unique clinical,pathological,serological,and imaging features.AIP usually presents with obstructive jaundice.Imaging studies often reveal enlargement of the pancreas with a pancreatic mass and strictures of the main pancreatic duct.Two subtypes of AIP have recently been identified.Type I AIP is more prevalent in elderly Asian males and is characterized by lymphoplasmacytic sclerosing pancreatitis,obliterative phlebitis,and infiltration of large numbers of IgG4-positive plasma cells.Type II AIP is more prevalent in Caucasians and is characterized by granulocyte epithelial lesions.Most patients with type I AIP have a significantly elevated serum IgG4 concentration,which is an important feature for diagnosis and for differentiating between AIP and other conditions such as pancreatic cancer.Extrapancreatic complications are common,such as sclerosing cholangitis,sclerosing sialadenitis,retroperitoneal fibrosis in type I AIP,and ulcerative colitis in type II AIP.A rapid response to glucocorticoids treatment is suggestive of AIP,but the relapse rate is high,warranting the use of immunosuppressant treatment.B-cell depletion with rituximab may be a promising therapy.The prognosis of AIP is generally benign if treated promptly,and spontaneous remission occurs in a proportion of patients. | WANG Qian ZHANG Xuan ZHANG FengChun | 2013 | Science China(Life Sciences)2013，56，3： | 4 |
| 6 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 7 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 8 | EXAFS and SR-XRD study on Cu occupation sites in Zn_(1-x)Cu_xO diluted magnetic semiconductors显示文摘ZnO films, doped with 2.9 atom% Cu, were prepared by radio frequency magnetron sputtering on sapphire substrate at different substrate temperatures. No magnetic impurities such as Fe, Co and Ni were found in the PIXE spectra. The ZnO:Cu films possessed the wurtzite ZnO structure. No precipitates such as CuO and Cu2O or Cu cluster, were observed by synchrotron radiation X-ray diffraction in the ZnO:Cu films. Extended X-ray absorption fine structure (EXAFS) analysis showed that Cu atoms were incorporated into ZnO crystal lattice by occupying the sites of Zn atoms. | YANG Chen ZHANG Bin WANG Jianzhong SHI Liqun CHENG Huansheng YANG Tieying WEN Wen HU Fengchun | 2012 | Nuclear Science and Techniques2012，23，2： | 4 |
| 9 | Surgery for oligometastasis of pancreatic cancer显示文摘The incidence of pancreatic adenocarcinoma(PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy(PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases. | Fengchun Lu Katherine E.Poruk Matthew J.Weiss | 2015 | Chinese Journal of Cancer Research2015，27，4： | 3 |
| 10 | A necessary and sufficient condition for a surface sum of two handlebodies to be a handlebody显示文摘The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,2.Suppose that S is incompressible in both H1 and H2.Then H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2. | Fengchun Lei He Liu Fengling Li Andrei Vesnin | 2020 | Science China Mathematics2020，63，10： | 2 |
| 11 | Asymmetricalπback-donation of hetero-dicationic Mo^(4+)-Mo^(6+)pairs for enhanced electrochemical nitrogen reduction显示文摘The breaking of nonpolar N≡N bond of dinitrogen is the biggest dilemma for electrocatalytic nitrogen reduction reaction(NRR)application,driving electron migration between catalysts and N≡N bond(termed“πback-donation”process)is crucial for attenuating interfacial energy barrier but still remains challenging.Herein,using density functional theory calculations,we revealed that constructing a unique hetero-dicationic Mo^(4+)-Mo^(6+)pair could effectively activate N≡N bond with a lying-down chemisorption configuration by an asymmetrical“πback-donation”process.As a proof-of-concept demonstration,we synthesized MoO_(2)@MoO_(3)heterostructure with double Mo sites(Mo^(4+)-Mo^(6+)),which are embedded in graphite,for electrochemical nitrogen reduction.Impressively,this hetero-dicationic Mo^(4+)-Mo^(6+)pair catalysts display more excellent catalytic performance with a high NH_(3)yield(60.9μg·h^(-1)·mg^(-1))and Faradic efficiency(23.8%)as NRR catalysts under ambient conditions than pristine MoO_(2)and MoO_(3).Operando characterizations using synchrotron-based spectroscopic techniques identified the emergence of a key^(*)N_(2)Hy intermediate on Mo sites during NRR,which indicates that the Mo sites are active sites and the NRR process tends to follow an associative mechanism.This novel type of hetero-dicationic catalyst has tremendous potential as a new class of transition metal-based catalysts with promising applications in electrocatalysis and catalysts for energy conversion and storage. | Hao Tan Qianqian Ji Chao Wang Hengli Duan Yuan Kong Yao Wang Sihua Feng Liyang Lv Fengchun Hu Wenhua Zhang Wangsheng Chu Zhihu Sun Wensheng Yan | 2022 | Nano Research2022，15，4： | 2 |
| 12 | The impact of biofuel plantation on biodiversity: a review显示文摘Because plants convert solar energy into chemical energy stored in organisms, biomass production as an energy source can help to reduce the world's reliance on fossil energy and mitigate global warming. Biofuel production is a fast-growing industry that represents a new type of large-scale human disturbance on ecosystems. Thus, the benefits of biofuel production bring environmental risks that include its potential impact on biodiversity, which is still an open question. In this review, we start first with a brief overview of the evolution of biofuel concept; second, we review the state of biofuel production across the continents,with a major emphasis on the main species used and their major feedstock. For which, we found significant differences for land use and environmental cultural management of biofuel plantation between tropical and temperate regions.Third, we summarize the impacts of biofuel plantation on biodiversity at multiple scales, based on the case studied with respect to the corresponding issues. At the genetic level,introgression and contamination by aggressive genotypes are a primary risk. At the species level, habitat pollution, degradation, and disturbance caused by intensive managementof biofuel plantation significantly raise the risk of habitat fragmentation, native extinction, and bio-invasion. At the ecosystem level, the large-scale homogeneous landscape of biofuel plantation results in simplified community and food web that severely damage ecosystem services, including ecosystem diversity. Finally, we compare the current and potential benefits and risks of biofuel plantations for the practical application of a biofuel industry of China. We emphasize the land use constraint from food security and biodiversity conservation, and the need for scientific research and systematic monitoring as a critical support for the sustainable development of biofuel production in China. | Ye Liu Yue Xu Fengchun Zhang Jinqi Yun Zehao Shen | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 13 | Analysis of the Stability and Mechanical Characteristics of the Jointed Surrounding Rock and Lining Structure of a Deeply Buried Hydraulic Tunnel显示文摘On-site monitoring and numerical simulation have been combined to analyze the stability of the jointed surrounding rock and the stress inside the lining structure of a sample deeply buried hydraulic tunnel.We show that the deformation around the tunnel was mainly concentrated in the range 51.37 mm∼66.73 mm,the tunnel circumference was dominated by shear failure,and the maximum plastic zone was about 3.90 m.When the shotcrete treatment was performed immediately after the excavation,the deformation of the surrounding rock was reduced by 58.94%∼76.31%,and the extension of the plastic zone was relatively limited,thereby leading to improvements in terms of the stability of surrounding rock.When the support was provided at different time points,the stress of the surrounding rock in the shallow part of the tunnel was improved everywhere.In the tunnel section with high ground stress and joint development,when 10 cm steel fiber concrete spray layer and 40 cm C25 concrete secondary lining were used,the maximum tensile stress on the lining structure was 0.89 MPa,i.e.,it was less than the tensile strength of concrete,which indicates that the internal force of the lining can meet the overall requirements. | Changchang Li Zuguo Mo Haibo Jiang Fengchun Yang | 2022 | Fluid Dynamics & Materials Processing2022，18，1： | 2 |
| 14 | China's battery electric vehicles lead the world:achievements in technology system architecture and technological breakthroughs显示文摘Developing new energy vehicles has been a worldwide consensus,and developing new energy vehicles characterized by pure electric drive has been China's national strategy.After more than 20 years of high-quality development of China's electric vehicles(EVs),a technological R&D layout of“Three Verticals and Three Horizontals”has been created,and technological advantages have been accumulated.As a result,China's new energy vehicle market has ranked first in the world since 2015.To systematically solve the key problems of battery electric vehicles(BEVs)such as“driving range anxiety,long battery charging time,and driving safety hazards”,China took the lead in putting forward a“system engineering-based technology system architecture for BEVs”and clarifying its connotation.This paper analyzes the research status and progress of the three core components of this architecture,namely,“BEV platform,charging/swapping station,and real-time operation monitoring platform”,and their key technological points.The three major demonstration projects of the 2008 Beijing Olympic Games,the 2022 Beijing Winter Olympics,and the intelligent and connected autonomous battery electric bus project are discussed to specify the applications of BEVs in China.The key research directions for upgrading BEV technologies remain to be further improving the vehicle-level all-climate environmental adaptability and all-day safety of BEVs,systematically solving the charging problem of BEVs and improving their application convenience,and safeguarding safety with early warning and implementing active/passive safety protection for the whole life cycle of power batteries on the basis of BEVs'operation big data.BEVs have acquired new technological features such as intelligent and networked technology empowerment,extensive integration of control-by-wire systems,a platform of chassis hardware,and modularization of functional software. | Hongwen He Fengchun Sun Zhenpo Wang Cheng Lin Chengning Zhang Rui Xiong Junjun Deng Xiaoqing Zhu Peng Xie Shuo Zhang Zhongbao Wei Wanke Cao Li Zhai | 2022 | Green Energy and Intelligent Transportation2022，1，1： | 2 |
| 15 | Numerical Investigation of Transient Temperature Distribution during Ti-6Al-4V Selective Laser Melting显示文摘The transient temperature field in the powder bed has a crucial effect on the quality of parts fabricated using Selective Laser Melting(SLM). In this study, a finite element model is established regarding the variance of temperature-dependent thermal properties and transformation latent heat. The temperature distribution and melt pool dimensions of a laser scan track were obtained by varying multiple parameters(layer thickness, laser power and scan speed). The effects of transition of material state and heat source model are also analyzed in this paper. The finite element simulation results show that an increased laser power and/or decreased scan speed results in an elevated maximum temperature of the powder layer and a larger melt pool size. Furthermore, it is found that the maximum temperature is significantly lowered due to the heat diffusion into the previous sintered zone. The heat source model has to be selected properly according to the element size. | XING Xiaodong ZHOU Qiuyu WANG Shiyuan WANG Liquan JIANG Fengchun | 2019 | Journal of Thermal Science2019，28，2： | 2 |
| 16 | Heegaard genera of high distance are additive under annulus sum 显示文摘 | Li Fengling Yang Guoqiu Lei Fengchun | 2010 | Topology and its Application2010，，： | 1 |
| 17 | Analysis of the dynamic responses for a pre-cracked three-point bend specimen 显示文摘 | FENGCHUN JIANG | 2004 | International Journal of Fracture2004，127，： | 1 |
| 18 | Re search of fuzzy logic control strategy for engine start/stop in dual-clutch hybrid electric vehicle显示文摘 | YANG Lianghui tie Hongwen SUN Fengchun | 2010 | Seventh International Con{erence on Fuzzy Systems and Knowledge Discovery2010，6，8： | 1 |
| 19 | Ferromagnetic Ordering of Silicon Vacancies in N-doped Silicon Carbide 显示文摘 | ZHAO Mingwen PAN Fengchun MEI Liangmo | 2010 | Appl Phys Lett2010，96，01： | 1 |
| 20 | Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells显示文摘 | Hongxia Wang Andrew Gillis Chunyan Zhao Eugene Lee Josephine Wu Fengchun Zhang Fei Ye David Y. Zhang | 2011 | -Genetic Toxicology and Environmental Mutagenesis2011，，2： | 1 |
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