|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair显示文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair. | Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai | 2018 | Bone Research2018，6，4： | 12 |
| 2 | Helicobacter pylori γ-glutamyl transpeptidase:A formidable virulence factor显示文摘Helicobacter pylori(H.pylori)produce an enzyme known asγ-glutamyl transpeptidase(HpGGT)that is highly conserved and common to all strains.HpGGT has been gaining increasing attention as an important virulence factor of the bacterium,having been demonstrated to be an important colonization factor in several animal models and has also recently been strongly associated with the development of peptic ulcer disease.From the results of various independent researcher groups,it is clear that HpGGT acts through several pathways to damage gastric epithelial cells including the induction of apoptosis and cell cycle arrest,production of reactive oxygen species leading to DNA damage,promotion of inflammation by increasing cyclooxygenase-2 and interleukin-8 expression,and upregulation of heparin-binding epidermal growth factor-like growth factor resulting in cell survival and proliferation.In addition,the potential role of HpGGT in promoting gastric carcinogenesis will also be discussed in this review.Apart from affecting the gastric epithelium,HpGGT also has immunomodulatory actions on host immune cells where it displays an antiproliferative effect on T cells by inducing cell cycle arrest and also works with other H.pylori virulence factors to skew dendritic cells towards a tolerogenic phenotype,possibly contributing to the persistence of the pathogen in the gastric mucosa. | Samantha Shi Min Ling Khay Guan Yeoh Bow Ho | 2013 | World Journal of Gastroenterology2013，19，45： | 10 |
| 3 | 中草药对良性前列腺增生的疗效及安个性:随机对照试验的系统回顾显示文摘中草药经常被用于治疗良性前列腺增生,但其疗效及安全性仍有待证实。为了比较单用中草药和中药与西药联合治疗良性前列腺增生的疗效及副作用,两位独立的评审员在主要的电子数据库中检索了单用中草药或中草药与西药联用与安慰剂或单用西药之间比较的随机对照试验,于动检索了相关期刊和灰色文献。评估的结果包括泌尿系统症状、尿动力学检测、小草药的效果优于西药。中草药的副作用发生需要有大型的质量更高的随机对照试验。 | Chun Ho Ma Wai Ling Lin Sing Leung Lui Xun-Yuan Cai Vivian Taam Wong Kun-Yuan Cai Eric Zie Zhang-Jin Zhang | 2013 | Asian Journal of Andrology2013，15，4： | 6 |
| 4 | Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits显示文摘Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity.Fracture fixation with biodegradable magnesium(Mg)pins enhanced fracture healing.We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and histologically.Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits.The fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band wire.Samples were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and histology.Microarchitectural analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week 12.Tensile testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,respectively.At week 12,Mg group was 60.8%higher in ultimate strength than the control group.Microindentation showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,respectively.At week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven bone-like.Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group. | Dick Ho Kiu Chow Jiali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin | 2021 | Bioactive Materials2021，6，11： | 3 |
| 5 | Helicobacter pylori γ-Glutamyl Transpeptidase Is a Pathogenic Factor in the Development of Peptic Ulcer Disease显示文摘 | Min Gong Samantha Shi Min Ling Sook Yin Lui Khay Guan Yeoh Bow Ho | 2010 | Gastroenterology2010，，2： | 3 |
| 6 | Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib显示文摘 | Ling Li Lisheng Wang Liang Li Zhiqiang Wang Yinwei Ho Tinisha McDonald Tessa L. Holyoake WenYong Chen Ravi Bhatia | 2012 | Cancer Cell2012，，2： | 2 |
| 7 | Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds显示文摘 | Min‐Hsiung Pan Ching‐Shu Lai Mei‐Ling Tsai Chi‐Tang Ho | 2014 | Mol. Nutr. Food Res2014，，1： | 2 |
| 8 | 17-Beta Estradiol and Hydroxyestradiols Interact via the NFKappaB Pathway to Elevate Cyclooxygenase 2 Expression and Prostaglandin E2 Secretion in Human Bronchial Epithelial Cells显示文摘 | Ho C C Ling Y C Chang L W | | 0，，02： | 1 |
| 9 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 10 | Functionalized Hydrogels for Articular Cartilage Tissue Engineering显示文摘Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints.AC defects are common in the knees of young and physically active individuals.Because of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage adequately.With rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating behaviors.They can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of cartilage.This article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC repair.Finally,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation. | Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin | 2022 | Engineering2022，8，6： | 1 |
| 11 | Airway difficulties caused by improperly applied cricoid pressure显示文摘 | Wong W Ling E | 2001 | J Emerg Med2001，20，： | 1 |
| 12 | The influence of friction heat on material properties显示文摘 | Ho T L Peterson M B Ling F F | 1974 | Wear1974，30，10： | 1 |
| 13 | Enhancing the competitiveness and sustainability of social enterprises in Hong Kong: A three-dimensional analysis显示文摘Running a social enterprise(SE) is more difficult than running a small or medium-sized enterprise because SEs have to achieve both economic sustainability as business enterprises and their social mission for the benefit of society.After a few years of operation, many SEs fail or struggle for survival. In this study, we examine some of the factors that affect an SE’s profitability, financial management, and business planning and management. Based on in-depth interviews with 22 social enterprises in Hong Kong, we find that SEs with the dual investment objectives of social mission and financial return are more sustainable and competitive than SEs with social impact as their sole objective. Furthermore, SEs managed by non-owner managers have better financial planning and performance than those managed by owner managers. In addition, SEs with an oversight/advisory committee are more competitive and have better management practices than those without such a committee. Our findings have policy implications for government, SEs, funding bodies, and non-profit organizations to enhance and promote the development of the social enterprise sector. | Sidney Leung Phyllis Mo Howard Ling Yanto Chandra So Sum Ho | 2019 | China Journal of Accounting Research2019，，2： | 1 |
| 14 | Simulated Equilibrium Factor Studies in Radon Chamber显示文摘 | TIEH - CHI CHU HO - LING LIU | 1996 | Applied Radiation and Isotopes1996，47，56： | 1 |
| 15 | Low - density Lipoprotein Receptor - Related Protein 8 ( apolipoprotein E receptor 2) Gene Polymorphisms in Alzheimer's Disease 显示文摘 | Suk Ling Ma Ho Keung Ng Larry Baum | 2002 | Neuroscience Letters2002，，332： | 1 |
| 16 | Functional Anatomy of Syntactic and Semantic Processing in Language Comprehension显示文摘 | LUKE KK HO LING LIU YOYO WAI | 2002 | Human Brain Mapping(S1065-9471)2002，16，： | 1 |
| 17 | Structure–property relationships of polyimides: a molecular simulation approach显示文摘 | Jin Woo Kang Kyoungsei Choi Won Ho Jo Shaw Ling Hsu | 1998 | Polymer1998，，26： | 1 |
| 18 | The Analysis of Risk Perception with Fuzzy Means -end Approach显示文摘 | Ling - zhong Lin Tsuen - Ho Hsu | 2013 | Quality & Quantity2013，47，2： | 1 |
| 19 | Controlled release carder of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite显示文摘 | Mei Ling Ho Yin Chih Fu Gwo Jaw Wang | 2008 | Journal of Controlled Release2008，128，： | 1 |
| 20 | MDR1 and BCRP1 expression in leukemic progenitors corre- lates with chemotherapy response in acute myeloid leukemia显示文摘 | Ho M M HOGGE E D LING V | 2008 | Exp Hematol2008，36，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员