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| 1 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 2 | Surrogate-Assisted Particle Swarm Optimization Algorithm With Pareto Active Learning for Expensive Multi-Objective Optimization显示文摘For multi-objective optimization problems, particle swarm optimization(PSO) algorithm generally needs a large number of fitness evaluations to obtain the Pareto optimal solutions. However, it will become substantially time-consuming when handling computationally expensive fitness functions. In order to save the computational cost, a surrogate-assisted PSO with Pareto active learning is proposed. In real physical space(the objective functions are computationally expensive), PSO is used as an optimizer, and its optimization results are used to construct the surrogate models. In virtual space, objective functions are replaced by the cheaper surrogate models, PSO is viewed as a sampler to produce the candidate solutions. To enhance the quality of candidate solutions, a hybrid mutation sampling method based on the simulated evolution is proposed, which combines the advantage of fast convergence of PSO and implements mutation to increase diversity. Furthermore, ε-Pareto active learning(ε-PAL)method is employed to pre-select candidate solutions to guide PSO in the real physical space. However, little work has considered the method of determining parameter ε. Therefore, a greedy search method is presented to determine the value ofεwhere the number of active sampling is employed as the evaluation criteria of classification cost. Experimental studies involving application on a number of benchmark test problems and parameter determination for multi-input multi-output least squares support vector machines(MLSSVM) are given, in which the results demonstrate promising performance of the proposed algorithm compared with other representative multi-objective particle swarm optimization(MOPSO) algorithms. | Zhiming Lv Linqing Wang Zhongyang Han Jun Zhao Wei Wang | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，3： | 13 |
| 3 | Arab/c/opste N^(6)-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies显示文摘The biological functions of the epitranscriptomic modification N^(6)-methyladenosine(m^(6)A)in plants are not fully understood.CPSF30-L is a predominant isoform of the polyadenylation factor CPSF30 and consists of CPSF30-S and an m^(6)A-binding YTH domain.Little is known about the biological roles of CPSF30-L and the molecular mechanism underlying its m^(6)A-binding function in alternative polyadenylation.Here,we charac-terized CPSF30-L as an Arabidopsis m^(6)A reader whose m^(6)A-binding function is required for the floral tran-sition and abscisic acid(ABA)response.We found that the m^(6)A-binding activity of CPSF30-L enhances the formation of liquid-like nuclear bodies,where CPSF30-L mainly recognizes m*A-modified far-upstream elements to control polyadenylation site choice.Deficiency of CPSF30-L lengthens the 3'untranslated region of three phenotypes-related transcripts,thereby accelerating their mRNA degradation and leading to late flowering and ABA hypersensitivity.Collectively,this study uncovers a new molecular mechanism for m^(6)A-driven phase separation and polyadenylation in plants. | Peizhe Song Junbo Yang Chunling Wang Qiang Lu Linqing Shi Subiding Tayier Guifang Jia | 2021 | Molecular Plant2021，14，4： | 12 |
| 4 | Virus profile in children with acute respiratory infections with various severities in Beijing, China显示文摘 | Zhu Runan Song Qinwei Qian Yuan Zhao Linqing Deng Jie Wang Fang Sun Yu | 2014 | Chinese Medical Journal2014，，21： | 10 |
| 5 | An A-D-A′-D-A type unfused nonfullerene acceptor for organic solar cells with approaching 14%efficiency显示文摘In recent years,power conversion efficiency(PCE)of organic solar cells(OSCs)has made significant improvement.A large number of studies were reported to achieve high PCEs through exploring new active layer materials,especially the high efficiency fused ring acceptors(FRAs).Compared with FRAs,another type of so-called unfused-ring acceptors(UFAs),possessing some advantages such as simple synthesis and low cost,have attracted a lot of attention.Herein,a new UFA BTzO-4F,incorporating with a benzotriazole moiety and S···O intramolecular noncovalent interactions,has been successfully synthesized.The photovoltaic device based on PBDB-T:BTzO-4F achieved a record PCE of 13.8%for UFAs,which indicates that introducing the benzotriazole moiety is an effective strategy for high quality acceptors.Thus,these findings of this work demonstrate the great potential of UFAs for high performance OSCs. | Xingzheng Liu Yanan Wei Xin Zhang Linqing Qin Zhixiang Wei Hui Huang | 2021 | Science China Chemistry2021，64，2： | 7 |
| 6 | Gravitational wave astrophysics, data analysis and multimessenger astronomy显示文摘This paper reviews gravitational wave sources and their detection. One of the most exciting potential sources of gravitational waves are coalescing binary black hole systems. They can occur on all mass scales and be formed in numerous ways, many of which are not understood. They are generally invisible in electromagnetic waves, and they provide opportunities for deep investigation of Einstein's general theory of relativity. Sect. 1 of this paper considers ways that binary black holes can be created in the universe, and includes the prediction that binary black hole coalescence events are likely to be the first gravitational wave sources to be detected. The next parts of this paper address the detection of chirp waveforms from coalescence events in noisy data.Such analysis is computationally intensive. Sect. 2 reviews a new and powerful method of signal detection based on the GPUimplemented summed parallel infinite impulse response filters. Such filters are intrinsically real time alorithms, that can be used to rapidly detect and localise signals. Sect. 3 of the paper reviews the use of GPU processors for rapid searching for gravitational wave bursts that can arise from black hole births and coalescences. In sect. 4 the use of GPU processors to enable fast efficient statistical significance testing of gravitational wave event candidates is reviewed. Sect. 5 of this paper addresses the method of multimessenger astronomy where the discovery of electromagnetic counterparts of gravitational wave events can be used to identify sources, understand their nature and obtain much greater science outcomes from each identified event. | LEE Hyung Mok LE BIGOT Eric-Olivier DU ZhiHui LIN ZhangXi GUO XiangYu WEN LinQing PHUKON Khun Sang PANDEY Vihan BOSE Sukanta FAN Xi-Long HENDRY Martin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 5 |
| 7 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 8 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 9 | Efficient CO_(2) electroreduction over N-doped hieratically porous carbon derived from petroleum pitch显示文摘Developing of economic and efficient catalysts is critical for the application of electroreduction of carbon dioxide to highly valuable chemicals.Herein,we present a facile method to synthesize N-doped hieratically porous carbon through pyrolysis of petroleum pitch followed by ammonia etching.We found mesopores are favored formation by removing of asphaltene from petroleum pitch during the carbonation process.Simultaneously,ammonia etching can not only increase the pyridinic-N content,but also upgrade the ratio of meso-to micro-pores of carbon materials.Using the N-doped hieratically porous carbon as catalyst for carbon dioxide electroreduction,the Faradaic efficiency of carbon monoxide reaches 83%at-0.9 V vs.the reversible hydrogen electrode(RHE)in 0.1 M KHCO_(3).This superior performance is attributed to the synergistic effects of highly pyridinic-N content in conjunction with the hieratically porous architecture,rendering abundant exposed and accessible active sites for electroreduction of CO_(2).Our work provides a new strategy for the large-scale preparation of high-performance,low-cost catalysts for CO_(2) electroreduction. | Hui Ning Dianliang Guo Xiaoshan Wang Zhonghao Tan Wenhang Wang Zhongxue Yang Linqing Li Qingshan Zhao Jian Hao Mingbo Wu | 2021 | Journal of Energy Chemistry2021，30，5： | 3 |
| 10 | Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection显示文摘Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Children's Hospital Affiliated to the Capital Institute of Paediatrics in Beijing. To investigate whether this outbreak of HAdV was related to nosocomial infections or the result of community infections, we collected respiratory specimens from patients with acute respiratory infections in a respiratory ward during June to December 2018, and screened for respiratory viruses. Among 1,840 cases included, 95(5.2%, 95/1840) were positive for HAdV and 81 were genotyped based on phylogenetic analysis, including seven as HAdV-1(8.6%), 30 HAdV-3(37.0%), two HAdV-6(2.5%), and 42 HAdV-7(51.9%). More HAdV-positive samples were collected in August(4.7%, 12/255), September(15.0%, 41/274) and October(6.9%, 17/247), with a peak in September 2018. By combining the results of HAdV phylogenetic analysis with clinical data of patients, there were 77 cases(4.2%, 77/1840;81.1%, 77/95) excluded from nosocomial infections, eight cases representing possible infections transmitted by visitors or attending parents, three cases without sequences that might have been due to infection transmitted by roommates positive for HAdV, one case of a roommate without an HAdV sequence, and six cases that shared highly homologous sequences with those of their roommates, for which nosocomial infections might be considered. In conclusion, genotyping of HAdVs based on phylogenetic analysis combined with clinical information provides a powerful method to distinguish nosocomial infections from community acquired infection, especially when tracing the origins of nosocomial infections. | Chuanyu Yang Chunmei Zhu Yuan Qian Jie Deng Baoyuan Zhang Runan Zhu Fang Wang Yu Sun Dongmei Chen Qi Guo Yutong Zhou Lei Yu Ling Cao Linqing Zhao | 2021 | Virologica Sinica2021，36，3： | 3 |
| 11 | High-performance fiber-integrated multifunctional graphene-optoelectronic device with photoelectric detection and optic-phase modulation显示文摘In graphene-based optoelectronic devices,the ultraweak interaction between a light and monolayer graphene leads to low optical absorption and low responsivity for the photodetectors and relative high half-wave voltage for the phase modulator.Here,an integration of the monolayer graphene onto the side-polished optical fiber is demonstrated,which is capable of providing a cost-effective strategy to enhance the light–graphene interaction,allowing us to obtain a highly efficient optical absorption in graphene and achieve multifunctions:photodetection and optical phase modulation.As a photodetector,the device has ultrahigh responsivity(1.5×10^(7) A/W)and high external quantum efficiency(>1.2×10^(9)%).Additionally,the polybutadiene/polymethyl methacrylate(PMMA)film on the graphene can render the device an optical phase modulator through the large thermo-optic effect of the PMMA.As a phase modulator,the device has a relatively low half-wave voltage of 3 V with a 16 dB extinction ratio in Mach–Zehnder interferometer configuration. | LINQING ZHUO PENGPENG FAN SHUANG ZHANG YUANSONG ZHAN YANMEI LINYU ZHANG DONGQUAN LI ZHEN CHE WENGUO ZHU HUADAN ZHENG JIEYUAN TANG JUN ZHANG YONGCHUN ZHONG WENXIAO FANG GUOGUANG LU JIANHUI YU ZHE CHEN | 2020 | Photonics Research2020，8，12： | 3 |
| 12 | Where are the Volcanic Calderas in the Xiangshan Volcanic Basin of Jiangxi? Implications from Anisotropy of Magnetic Susceptibility显示文摘Objective As the world's third largest volcanic type uranium ore field,the Xiangshan volcanic basin has attracted much attention for its large industrial value.The ore hosting rocks are mainly the early Cretaceous rhyodacite and porphyroclastic lava,as well as small amounts of high level intrusive acidic rocks and metamorphic rocks.The vertical alteration of polymetallic | GUO Fusheng LI Guangrong LIU Linqing WU Zhichun YANG Qingkun XIE Caifu | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 2 |
| 13 | Responses of calcareous sand foundations to variations of groundwater table and applied loads显示文摘The long-term settlement of calcareous sand foundations caused by daily periodic fluctuations has become a significant geological hazard,but effective monitoring tools to capture the deformation profiles are still rarely reported.In this study,a laboratory model test and an in situ monitoring test were conducted.An optical frequency domain reflectometer(OFDR)with high spatial resolution(1 mm)and high accuracy(10-6)was used to record the soil strain responses to groundwater table and varied loads.The results indicated that the fiber-optic measurements can accurately locate the swelling and compressive zones.During the loading process,the interlock between calcareous sand particles was detected,which increased the internal friction angle of soil.The foundation deformation above the sliding surface was dominated by compression,and the soil was continuously compressed beneath the sliding surface.After 26e48 h,calcareous sand swelling occurred gradually above the water table,which was primarily dependent on capillary water.The swelling of the soil beneath the groundwater table was completed rapidly within less than 2 h.When the groundwater table and load remain constant,the compression creep behavior can be described by the Yasong-Wang model with R2¼0.993.The daily periodically varying in situ deformation of calcareous sand primarily occurs between the highest and lowest groundwater tables,i.e.4.2e6.2 m deep.The tuff interlayers with poor water absorption capacity do not swell or compress,but they produce compressive strain under the influence of deformed calcareous sand layers. | Dingfeng Cao Sanjay Kumar Shukla Linqing Yang Chengchao Guo Jinghong Wu Fuming Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 2 |
| 14 | The immunophilin CYCLOPHILIN28 affects PSII-LHCII supercomplex assembly and accumulation in Arabidopsis thaliana显示文摘In plant chloroplasts,photosystem II(PSII)complexes,together with light-harvesting complex II(LHCII),form various PSII-LHCII supercomplexes(SCs).This process likely involves immunophilins,but the underlying regulatory mechanisms are unclear.Here,by comparing Arabidopsis thaliana mutants lacking the chloroplast lumen-localized immunophilin CYCLOPHILIN28(CYP28)to wildtype and transgenic complemented lines,we determined that CYP28 regulates the assembly and accumulation of PSII-LHCII SCs.Compared to the wild type,cyp28 plants showed accelerated leaf growth,earlier flowering time,and enhanced accumulation of high molecular weight PSII-LHCII SCs under normal light conditions.The lack of CYP28 also significantly affected the electron transport rate.Blue native-polyacrylamide gel electrophoresis analysis revealed more Lhcb6 and less Lhcb4 in M-LHCII-Lhcb4-Lhcb6 complexes in cyp28 versus wild-type plants.Peptidyl-prolyl cis/trans isomerase(PPIase)activity assays revealed that CYP28 exhibits weak PPIase activity and that its K113 and E187 residues are critical for this activity.Mutant analysis suggested that CYP28 may regulate PSIILHCII SC accumulation by altering the configuration of Lhcb6 via its PPIase activity.Furthermore,the Lhcb6-P139 residue is critical for PSII-LHCII SC assembly and accumulation.Therefore,our findings suggest that CYP28 likely regulates PSII-LHCII SC assembly and accumulation by altering the configuration of P139 of Lhcb6 via its PPIase activity. | Weining Zhu Linqing Xu Xiaoxia Yu Ying Zhong | 2022 | Journal of Integrative Plant Biology2022，64，4： | 2 |
| 15 | Latest Advances in High-Voltage and High-Energy-Density Aqueous Rechargeable Batteries显示文摘Aqueous rechargeable batteries(ARBs)have become a lively research theme due to their advantages of low cost,safety,environmental friendliness,and easy manufacturing.However,since its inception,the aqueous solution energy storage sys-tem has always faced some problems,which hinders its development,such as the narrow electrochemical stability window of water,poor percolation of electrode materials,and low energy density.In recent years,to overcome the shortcomings of the aqueous solution-based energy storage system,some very pioneering work has been done,which also provides a great inspiration for further research and development of future high-performance aqueous energy storage systems.In this paper,the latest advances in various ARBs with high voltage and high energy density are reviewed.These include aqueous rechargeable lithium,sodium,potassium,ammonium,zinc,magnesium,calcium,and aluminum batteries.Further chal-lenges are pointed out. | Xinhai Yuan Fuxiang Ma Linqing Zuo Jing Wang Nengfei Yu Yuhui Chen Yusong Zhu Qinghong Huang Rudolf Holze Yuping Wu Teunis van Ree | 2021 | Electrochemical Energy Reviews2021，4，1： | 2 |
| 16 | Visual comfort is affected by urban colorscape tones in hazy weather显示文摘 | Yang Liu Jian Kang Ying Zhang Dehua Wang Linqing Mao | 2016 | Frontiers of Architectural Research2016，5，4： | 2 |
| 17 | Henoch-Sch? nlein purpura with hypocom-plementemia显示文摘 | LinQ Min Y Li Y | 2012 | Pediatr Nephrol2012，27，5： | 1 |
| 18 | TheInstitutionalandPolicyDevelopmentofTeacherEducationinChina[J]显示文摘 | LinQ XunY | 2001 | 亚太教师教育发展学报2001，4，2： | 1 |
| 19 | OffaxisGaussianSchellmodelbeamandpartiallycoherentlaserarraybeaminaturbulentatmosphere显示文摘 | CaiYangjian LinQing BaykalY etal | 2007 | Optics Communicatons2007，278，1： | 1 |
| 20 | Geneticvariationsandpolymorphismsintheezringeneareassociatedwithagerelatedcataract显示文摘 | LinQ ZhouN ZhangN ZhuB HuS ZhouZ QiY | 2013 | MolVis2013，19，： | 1 |
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