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| 1 | 在裸鼠体内建立血管瘤模型显示文摘血管瘤是儿童最常见的良性肿瘤,大部分可自发消退,但其发病及消退机制仍不清楚。本文旨在建立人类血管瘤动物模型,为血管瘤发病机制及药物治疗的研究提供基础。方法:取6个月大儿童的血管瘤组织,证实肿瘤细胞雌激素受体阳性后,将肿瘤切成薄片,接种到16只裸鼠皮下,并随机分为2组,对照组给予正常进食,实验组在进食同时给予雌二醇.每周测量移植物的大小。实验小鼠在术后90d处死. | Peng Q Liu W Tang Y | 2005 | 中国口腔颌面外科杂志2005，3，3： | 12 |
| 2 | Super-resolution dipole orientation mapping via polarization demodulation显示文摘Fluorescence polarization microscopy(FPM)aims to detect the dipole orientation of fluorophores and to resolve structural information for labeled organelles via wide-field or confocal microscopy.Conventional FPM often suffers from the presence of a large number of molecules within the diffraction-limited volume,with averaged fluorescence polarization collected from a group of dipoles with different orientations.Here,we apply sparse deconvolution and least-squares estimation to fluorescence polarization modulation data and demonstrate a super-resolution dipole orientation mapping(SDOM)method that resolves the effective dipole orientation from a much smaller number of fluorescent molecules within a sub-diffraction focal area.We further apply this method to resolve structural details in both fixed and live cells.For the first time,we show that different borders of a dendritic spine neck exhibit a heterogeneous distribution of dipole orientation.Furthermore,we illustrate that the dipole is always perpendicular to the direction of actin filaments in mammalian kidney cells and radially distributed in the hourglass structure of the septin protein under specific labelling.The accuracy of the dipole orientation can be further mapped using the orientation uniform factor,which shows the superiority of SDOM compared with its wide-field counterpart as the number of molecules is decreased within the smaller focal area.Using the inherent feature of the orientation dipole,the SDOM technique,with its fast imaging speed(at sub-second scale),can be applied to a broad range of fluorescently labeled biological systems to simultaneously resolve the valuable dipole orientation information with super-resolution imaging. | Karl Zhanghao Long Chen Xu-San Yang Miao-Yan Wang Zhen-Li Jing Hong-Bin Han Michael Q Zhang Dayong Jin Jun-Tao Gao Peng Xi | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 3 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 4 | Toxic effects of crude-oil-contaminated soil in aquatic environment on Carassius auratus and their hepatic antioxidant defense system显示文摘Under the indoor simulant conditions, toxic effects of crude-oil-contaminated soil which was put into aquatic environment on the young fishes Carassius auratus and their hepatic antioxidant system after a 20-d exposure were investigated. Results showed that the relationship between the mortality of C. auratus and the exposed doses could be divided into 3 phases: fishes exposed to the low dose groups (0.5-5.0 g/L) were dead due to the ingestion of crude-oil-contaminated soils in aquatic environment; at the medium dose groups (5.0-25.0 g/L) fishes were dead due to the penetration of toxic substances; at the high dose groups (25.0-50.0 g/L) fishes were dead due to environmental stress. The highest mortality and death speed were found in the 1.0 g/L dose group, and the death speed was sharply increased in the 50.0 g/L dose group in the late phase of exposure. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) and the content of malaondialdehyde (MDA) in the hepatic tissues of C. auratus were induced significantly. The activity of SOD was increased and then decreased. It was significantly inhibited in the 50.0 g/L dose group. The activity of CAT was highly induced, and restored to a level which is little more than the control when the exposed doses exceeded 10.0 g/L. The activity of GST was the most sensitive, it was significantly induced in all dose groups, and the highest elevation was up to 6 times in the 0.5 g/L dose group comparing with the control. The MDA content was significantly elevated in the 50.0 g/L dose group, and the changes of the MDA content were opposite with the changes of GST activity. | WANG Yuanyuan ZHOU Qixing PENG Shengwei MA Lena Q NIU Xiaowei | 2009 | Journal of Environmental Sciences2009，21，5： | 3 |
| 5 | 查看详情显示文摘 | Peng X G Guan S Q Chai X D | | 0，，： | 2 |
| 6 | Pycnogenol inhibits tumor necrosis factoralpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells 显示文摘 | Peng Q Wei Z Lau BH | 2000 | Cell Mol Life Sci2000，57，5： | 2 |
| 7 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water 显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catal Lett2006，109，： | 1 |
| 8 | Neutral Pd(II) and Ni (II) aeetylide catalysts for the polymerization of methyl methaerylate 显示文摘 | SUN H M SHEN Q PENG X G | 2002 | Catalysis Letters2002，80，12： | 1 |
| 9 | A simple,rapid,high-fidelity and cost-effective PCR-based two-step DNA synthesismethod for long gene sequences显示文摘 | XIONG A S YAO Q H PENG R H | 2006 | Nucleic Acids Res2006，28，1： | 1 |
| 10 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catalysis Letters2006，109，12： | 1 |
| 11 | Studies on the phase separation of a polyetherlmide- modified epoxy Resin, 4: Kinetic effect on the phase separation mechanism of a blend at different cure rates 显示文摘 | Peng L Q Cui J Li S J | 2000 | Macromolecular Chemistry and Physics2000，201，6： | 1 |
| 12 | Effect of transforming growth factor beta-1 in endotoxin-induced uveitis 显示文摘 | Peng B Li Q Roberge FG | 1997 | Invest Ophthalmol Vis Sci1997，38，1： | 1 |
| 13 | Tissue distribution and maternal transfer of poly-and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) : implications for reproductive risk 显示文摘 | Peng H Wei Q W Wan Y | 2010 | Environ Sci Technol2010，44，5： | 1 |
| 14 | 显示文摘 | Li Y X Hu Y F Peng S Q | 2009 | J Phys Chem C2009，113，： | 1 |
| 15 | Low-complexity estimator for four-dimensional parameters under a reparameterized distributed source model显示文摘 | Wan Q Peng Y N | 2001 | IEE Proceedings-Radar Sonar Navigation2001，148，6： | 1 |
| 16 | Identification of Random amplified polymorphic DNA and single sequence re-peat markers linked to powdery mildew resistance in commen wheat cultivar Brock显示文摘 | Wang Z Y Zheng Q Peng Y K | 2004 | Plant Prod Sci2004，7，3： | 1 |
| 17 | Determination of the enantiomers of tamsulosin hydrochloride and its synthetic intermediates by chiral liquid chromatography显示文摘 | MEILING Q PENG W RUIHUA C | 2004 | J Chromatographia2004，59，： | 1 |
| 18 | 5-Aminolevulinic acid-based photodynamic therapy:Clinical research and future challenges显示文摘 | PENG Q WARLOE T BERG K | 1997 | Cancer1997，79，12： | 1 |
| 19 | A general chemical conversion method to various semiconductor hollow structures 显示文摘 | PENG Q xu s | 2005 | Small2005，1，2： | 1 |
| 20 | Cyclosporin A traps ABCA1 at the plasma membrane and inhibits ABCA1-mediated lipid efflux to apolipoprotein A-I显示文摘 | Goff W L Peng D Q Settle M | 2004 | Arterioscler Thromb Vasc Biol2004，24，11： | 1 |
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