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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 3 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 4 | Satellite sensor image classification using cascaded architecture of neural fuzzy network显示文摘 | Lin C T Lee Y C Pu P H | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，38，2： | 2 |
| 5 | 显示文摘 | Lin Y H Tang Z L Zhang Z T | 2003 | J European Ceram Soc2003，23，： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 8 | Study of Self-Crimp Polyester Fibers 显示文摘 | RWEI S P LIN Y T SU Y Y | 2005 | Polymer Engineering and Science2005，45，6： | 1 |
| 9 | Predictors for extraintestinal infectiom of non-typhoidal Salmonella in patients without AIDS 显示文摘 | Chiu C H Lin T Y Qu J T | 1999 | Hat J Clin Pract1999，53，： | 1 |
| 10 | Sensitive and specific detection of strains of Japanese encephalitis virus using a onestep TaqMan RT-PCR technique显示文摘 | Huang J L Lin H T Wang Y M | 2004 | J Med Virol2004，74，4： | 1 |
| 11 | Acetyl danshenxinkun a from Salvia miltiorrhiza 显示文摘 | Lin Y L Liu C Y Chen T H etal | 2003 | J Chin Med2003，14，： | 1 |
| 12 | Structure of the channel catfish (Ictalurus punctatus) growth hormone gene and its evolutionary implication显示文摘 | Lin C M Chen T T | 1993 | Mol Mar Bio Biotechnol1993，2，： | 1 |
| 13 | Effect of brain e dema on infarct volume in a focal cerebral ischemia model in rats显示文摘 | Lin T N He Y Y Wu G Khan M Hsu C Y | 1993 | Stroke1993，24，： | 1 |
| 14 | Modeling and Performance of a Static Frequency Converter Starting a 300MV·A Synchronous Machine显示文摘 | LIU T H LIN C Y | 1996 | Electric Power Systems Research1996，，37： | 1 |
| 15 | Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua County in Taiwan 显示文摘 | LIN Y P TENG T P CHANG T K | 2002 | Landscape and Urban Planning2002，62，1： | 1 |
| 16 | Silicon-containing anionic water- borne polyurethane with covalently bonded reactive dye 显示文摘 | H H Wang Y T Lin | 2003 | Journal of Applied Polymer Science2003，90，8： | 1 |
| 17 | Chemical composition and antifungal activity of essential oils from different tissues of Japanese Cedar (Cryptomeria japonica)显示文摘 | Cheng S S Lin H Y Chang S T | 2005 | J Agrie Food Chem2005，53，3： | 1 |
| 18 | Multimedia evidence fusion for video concept detection via OWA operator 显示文摘 | Li M Zheng Y T Lin S X | 2009 | Lecture Notes in Computer Science: Advances in Multimedia Model ing2009，5371，： | 1 |
| 19 | Genetic diversity and biogeography of Cunninghamia konishii ( Cupressaeeae ) , an island species in Taiwan:a comparison with Cunninghamia lanceolata, a mainland species in China显示文摘 | Chung J D Lin T P Tan Y C | 2004 | Molecular Phy- logeneties and Evolution2004，33，： | 1 |
| 20 | Unusual effects of counterion to surfactant concentration ratio on viscoelasticity of a cationic surfactant drag reducer显示文摘 | Lin Z Zheng Y Davis H T | 2000 | J Non-Newtonian Fluid Mech2000，93，2： | 1 |
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