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| 1 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 2 | Characteristics and sedimentary processes of lamina-controlled sand-particle imbricate structure in deposits on Lingshan Island, Qingdao, China显示文摘Imbricate structure is a common sedimentary structure and is well developed in sandy sediments.Here,we report a laminacontrolled fine-sand-particle imbricate structure in a set of very fine grained sedimentary rocks(fine sandstone,siltstone,and mudstone)at the Dockyard and Qianceng Cliff areas of Lingshan Island,Qingdao,Shandong,China.Sets of up to 300 laminae are found in stratigraphic profiles in these areas.The laminae are generally less than 1 mm thick,with most being 0.3–0.4 mm thick and the thinnest being<0.1 mm.The dip angle of the imbricate structure varies widely,between 0°and 90°,with an average dip angle of about 40°–50°,which is higher than that of imbricate riverbed gravels(about 34°).The dip angle is a function of the shape and sorting of the particles,as well as the hydrodynamic conditions under which these fine-grained sediments were deposited.Several profiles show well-developed multiscale,soft-sediment deformation structures.Flute casts,load casts,and groove casts are also common.Fragments of carbon remains occur widely and commonly constitute stringers several millimeters thick and up to 10 cm long,together with fine clasts.Vitrain lenticles are also common.Based on the imbricate structure of the Lingshan Island deposits,it is shown that in addition to paleocurrent analysis,the imbricate structure can be used to infer information about fluid properties,transport characteristics,and sedimentary processes of the depositional environment.A near-bottom underflow,either of authigenic origin or derived from cold river water in winter in a delta interdistributary bay or delta-front environment,is inferred to have provided the hydrodynamic setting in which this imbricate structure formed.The imbricate structure,together with other sedimentary structures and features,shows that the sedimentary rocks on Lingshan Island were deposited in an inland,shallow-water environment,such as a delta,and not in a deep-water or submarine continental-slope environment. | SHAO ZhuFu ZHONG JianHua LI Yong MAO Cui LIU ShengXin NI LiangTian TIAN Yuan CUI XinYing LIU YunTian WANG XiaoNan LI WeiHua LIN GangShan | 2014 | Science China Earth Sciences2014，57，5： | 11 |
| 3 | Abnormal Rich-Club Organization Associated with Compromised Cognitive Function in Patients with Schizophrenia and Their Unaffected Parents显示文摘Schizophrenia is considered to be a disorder of brain connectivity, which might result from a disproportionally impaired rich-club organization. The rich-club is composed of highly interconnected hub regions that play crucial roles in integrating information between different brain regions. Few studies have yet investigated whether the structural rich-club organization is impaired in patients and their first-degree relatives. In this study, we established a weighted network model of white matter connections using diffusion tensor imaging of 19 patients and 39 unaffected parents, 22 young healthy controls for the patients, and 25 old healthy controls for the parents. Feeder edges between rich-club nodes and non-rich-club nodes were significantly decreased in both schizophrenic patients and their unaffected parents compared with controls.Furthermore, the feeder edges showed significant positive correlations with the scores in Category Fluency Test—animal naming in the unaffected parents. Specific feeder edges exhibited discriminative power with accuracy of 84.4% in distinguishing unaffected parents from old healthy controls. Our findings suggest that impaired richclub organization, especially impaired feeder edges, may be related to familial vulnerability to schizophrenia,possibly reflecting a genetic predisposition for schizophrenia. | Xin Zhao Lin Tian Jun Yan Weihua Yue Hao Yan Dai Zhang | 2017 | Neuroscience Bulletin2017，33，4： | 8 |
| 4 | Multi-channel micro neural probe fabricated with SOI显示文摘Silicon-on-insulator(SOI) substrate is widely used in micro-electro-mechanical systems(MEMS).With the buried oxide layer of SOI acting as an etching stop,silicon based micro neural probe can be fabri-cated with improved uniformity and manufacturability.A seven-record-site neural probe was formed by inductive-coupled plasma(ICP) dry etching of an SOI substrate.The thickness of the probe is 15 μm.The shaft of the probe has dimensions of 3 mm×100 μm×15 μm with typical area of the record site of 78.5 μm2.The impedance of the record site was measured in-vitro.The typical impedance characteris-tics of the record sites are around 2 MΩ at 1 kHz.The performance of the neural probe in-vivo was tested on anesthetic rat.The recorded neural spike was typically around 140 μV.Spike from individual site could exceed 700 μV.The average signal noise ratio was 7 or more. | PEI WeiHua ZHU Lin WANG ShuJing GUO Kai TANG Jun ZHANG Xu LU Lin GAO ShangKai CHEN HongDa | 2009 | Science China(Technological Sciences)2009，52，5： | 6 |
| 5 | Evaluating Soil Dissolved Organic Matter Extraction Using Three-Dimensional Excitation-Emission Matrix Fluorescence Spectroscopy显示文摘Soil dissolved organic matter(DOM) consists of many organic compounds and plays an important role in contaminant transport in the ecosystem. However, the effects of different extraction conditions on contents of different DOM components are poorly understood.We extracted DOM from three soils using different extraction times, solid to liquid ratios(SLR), and extraction solution(KCl)concentrations, and evaluated the extractions using three-dimensional excitation-emission matrix(EEM) fluorescence spectroscopy.The sum of the contents of the main DOM components(protein-, fulvic-, and humic-like compounds) increased by 0.6–3.5, 2.5–3.9,and 0.11–0.37 times(P < 0.05) when SLR decreased from 1:2 to 1:10, the extraction solution concentration increased from 0.01 to 1.5 mol L^(-1), and extraction time increased from 10 to 300 min, respectively. The three-dimensional EEM fluorescence spectroscopy is a useful tool to characterize the components of DOM and evaluate DOM extraction in soils. | XIE Wenming ZHANG Shanshan RUAN Lin YANG Mingyue SHI Weiming ZHANG Hailin LI Weihua | 2017 | Pedosphere2017，27，5： | 6 |
| 6 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 7 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 8 | One compound approach combining factor-analytic model with AMMI and GGE biplot to improve multi-environment trials analysis显示文摘To improve multi-environmental trial(MET)analysis,a compound method—which combines factor analytic(FA)model with additive main effect and multiplicative interaction(AMMI)and genotype main effect plus genotype-by-environment interaction(GGE)biplot—was conducted in this study.The diameter at breast height of 36 open-pollinated(OP)families of Pinus taeda at six sites in South China was used as a raw dataset.The best linear unbiased prediction(BLUP)data of all individual trees in each site was obtained by fitting the spatial effects with the FA method from raw data.The raw data and BLUP data were analyzed and compared by using the AMMI and GGE biplot.BLUP results showed that the six sites were heterogeneous and spatial variation could be effectively fitted by spatial analysis with the FA method.AMMI analysis identified that two datasets had highly significant effects on the site,family,and their interactions,while BLUP data had a smaller residual error,but higher variation explaining ability and more credible stability than raw data.GGE biplot results revealed that raw data and BLUP data had different results in mega-environment delineation,test-environment evaluation,and genotype evaluation.In addition,BLUP data results were more reasonable due to the stronger analytical ability of the first two principal components.Our study suggests that the compound method combing the FA method with the AMMI and GGE biplot could improve the analysis result of MET data in Pinus teada as it was more reliable than direct AMMI and GGE biplot analysis on raw data. | Weihua Zhang Jianlin Hu Yuanmu Yang Yuanzhen Lin | 2020 | Journal of Forestry Research2020，31，1： | 4 |
| 9 | Modulation of HLA Expression in Human Cytomegalovirus Immune Evasion显示文摘Human cytomegalovirus (hCMV) has evolved multiple mechanisms to escape the host immune recognition and innate or adaptive immune responses. Among them, hCMV has developed strategies to modulate the expression and/or function of human leukocyte antigens (HLAs), including by encoding series of infection stage-dependent hCMV proteins to detain and destroy the expression of HLA molecules on the surface of infected cells. This disturbs the antigen presentation and processing, by encoding MHC class I homologues or selective up-regulation of particular HLA class I molecules binding to NK cell inhibitory receptors, and by encoding specific ligand antagonists to interfere with NK cell activating receptors. Here we discussed the molecular mechanisms utilized by the hCMV to alter the formation, transportation and expression of HLA antigens on the infected cell surface. The knowledge about hCMV modulating HLA expression could benefit us to further understand the pathogenesis of viral diseases and may eventually develop novel effective immunotherapies to counteract viral infections and viral associated diseases. | Aifen Lin Huihui Xu Weihua Yan | 2007 | Cellular & Molecular Immunology2007，4，2： | 4 |
| 10 | Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents显示文摘Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their firstdegree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands(19 patients and 41 unaffected parents) and two unrelated groups of normal controls(24 controls matched with patients and 26 controls matched with relatives). The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global effi ciency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology.We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that(1) the global effi ciency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and(2) genetic vulnerability to schizophrenia may influence the anatomical organization of an individual's brain networks. | Hao Yan Lin Tian Qifeng Wang Qiang Zhao Weihua Yue Jun Yan Bing Liu Dai Zhang | 2015 | Neuroscience Bulletin2015，31，3： | 4 |
| 11 | Surface Organic Modification of Fe_3O_4 Magnetic Nanoparticles显示文摘The surface organic modification of Fe_3O_4 nanoparticles with silane coupling reagent KH570 was studied. The modified and unmodified nanoparticles were characterized by FT-IR, XPS and TEM. The spectra of FT-IR and XPS revealed that KH570 was coated onto the surface of Fe3O4 nanoparticles to get Fe-O-Si bond and an organic coating layer also was formed. Fe3O4 nanoparticles were spheres partly with mean size of 18.8 nm studied by TEM, which was consistent with the result 17.9 nm calculated by Scherrer’s equation. KH570 was adsorbed on surface and formed chemistry bond to be steric hindrance repulsion which prevented nanoparticles from reuniting. Then glycol-based Fe_3O_4 magnetic liquids dispersed stably was gained. | CUI Sheng SHEN Xiaodong LIN Benlan JIANG Guodong ZHANG Weihua | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 4 |
| 12 | Electrochemical Studies of Lithium Intercalation into Graphite Film Electrode for Li^+-ion Batteries显示文摘To study the electrochemical kinetic properties of the Li/Graphite system, cycle voltammerty (CV), ac-impedance and chro- noamperometry (CA) techniques have been used. The results showed that the diffusion of lithium ions in LixC6 is the rate-determining step. The chemical diffusion coefficients of lithium (DLi) have been estimated for different x values. As for the same material, the value of DLi was calculated in order to compare the differences among the three techniques. | Chuangang Lin Weihua Qiu Qingguo Liu Material Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，1： | 4 |
| 13 | Detection of bursts in neuronal spike trains by the mean inter-spike interval method显示文摘Bursts are electrical spikes firing with a high frequency,which are the most important property in synaptic plasticity and information processing in the central nervous system. However,bursts are difficult to identify because bursting activities or patterns vary with phys-iological conditions or external stimuli. In this paper,a simple method automatically to detect bursts in spike trains is described. This method auto-adaptively sets a parameter (mean inter-spike interval) according to intrinsic properties of the detected burst spike trains,without any arbitrary choices or any operator judgment. When the mean value of several successive inter-spike intervals is not larger than the parameter,a burst is identified. By this method,bursts can be automatically extracted from different bursting patterns of cultured neurons on multi-electrode arrays,as accurately as by visual inspection. Furthermore,significant changes of burst variables caused by electrical stimulus have been found in spontaneous activity of neuronal network. These suggest that the mean inter-spike interval method is robust for detecting changes in burst patterns and characteristics induced by environmental alterations. | Lin Chen Yong Deng Weihua Luo Zhen Wang Shaoqun Zeng | 2009 | Progress in Natural Science:Materials International2009，19，2： | 3 |
| 14 | Study on Electromagnetic-Fluid-Temperature Multiphysics Field Coupling Model for Drum of Mine Cable Winding Truck显示文摘Aiming at solving problems of low efficiency,low cable capacity in current 300m open-pit mine cable winding truck,a 900 m cable winding plan was proposed.In this paper,the mechanism of the thermal effect of the cable was described,and a two-dimensional axisymmetric electromagnetic-fluid-temperature multiphysics coupling model of the cable reel was established regarding the 900m cable reel as independent system.Considering the structure of the drum,the number of cable winding layers,the factors of heat conduction,heat radiation and convective heat transfer in the actual working process,the steady state analysis of the multi-physical field coupling was carried out.The sum of the losses of each part of the cable was obtained through the calculation of electromagnetic field,which was used as a heat source to calculate and analyze the temperature distribution of different layers of cable winding,as well as the temperature distribution and heat dissipation characteristics of different structures of the drum.The results show that three layers of cable winding is the best design.The lowest temperature of closed cylindrical drum is 70℃after heat dissipation,which has obvious advantages compared with the lowest temperature of 85℃after heat dissipation of squirrel-cage cylindrical drum.The results provide a reliable theoretical basis for the research and development of a new type of mine cable winding truck with 900 m cable capacity. | Weihua Chen Mingliang Zhou Xiaoheng Yan Zhengxing Li Xiaoxue Lin | 2021 | CES Transactions on Electrical Machines and Systems2021，5，2： | 3 |
| 15 | The chimeric gene atp6c confers cytoplasmic male sterility in maize by impairing the assembly of the mitochondrial ATP synthase complex显示文摘Cytoplasmic male sterility(CMS)is a powerful tool for the exploitation of hybrid heterosis and the study of signaling and interactions between the nucleus and the cytoplasm.C-type CMS(CMS-C)in maize has long been used in hybrid seed production,but the underlying sterility factor and its mechanism of action remain unclear.In this study,we demonstrate that the mitochondrial gene atp6c confers male sterility in CMS-C maize.The ATP6C protein shows stronger interactions with ATP8 and ATP9 than ATP6 during the assembly of F1F0-ATP synthase(F-type ATP synthase,ATPase),thereby reducing the quantity and activity of assem-bled F_(1)F_(o)-ATP synthase.By contrast,the quantity and activity of the F1'component are increased in CMS-C lines.Reduced F1F0-ATP synthase activity causes accumulation of excess protons in the inner membrane space of the mitochondria,triggering a burst of reactive oxygen species(ROS),premature programmed cell death of the tapetai cells,and pollen abortion.Collectively,our study identifies a chimeric mitochondrial gene(ATP6C)that causes CMS in maize and documents the contribution of ATP6C to F1F0-ATP synthase assembly,thereby providing novel insights into the molecular mechanisms of male sterility in plants. | Huili Yang Yadong Xue Bing Li Yanan Lin Haochuan Li Zhanyong Guo Weihua Li Zhiyuan Fu Dong Ding Jihua Tang | 2022 | Molecular Plant2022，15，5： | 2 |
| 16 | Silencing myostatin gene by RNAi in sheep embryos显示文摘 | Dayun Tang Huabin Zhu Jianmin Wu Hanzhong Chen Yan Zhang Xueming Zhao Xiaoliang Chen Weihua Du Dong Wang Xiukun Lin | 2012 | Journal of Biotechnology2012，，3： | 2 |
| 17 | A reverse causal-effect modeling approach for signal control of an oversaturated intersection显示文摘 | Liu Hongchao Balke K N Lin WeiHua | 2008 | Transportation Re search Part C2008，，16： | 1 |
| 18 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 19 | Metabolites of arsenic and increased DNA damage of p 53 gene in arsenic plant workers显示文摘 | Weihua Wen Jinghua Wen Lin Lu Hua Liu Jun Yang Huirong Cheng Wangjun Che Liang Li Guanbei Zhang | 2011 | Toxicology and Applied Pharmacology2011，，1： | 1 |
| 20 | Increased damage of exon 5 of p53 gene in workers from an arsenic plant显示文摘 | Weihua Wen Wangjun Che Lin Lu Jun Yang Xufang Gao Jinghua Wen Zhengchang Heng Shuqiao Cao Huirong Cheng | 2008 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2008，，1： | 1 |
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