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| 1 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 2 | Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p 15^INK4B, p 16^INK4A, and p57^KIP2 transcription显示文摘 | Qingping Zheng Hongjia Fan Zhenzhen Meng Lin Yuan Cuicui Liu You Peng Weiwei Zhao Lulu Wang Jing Li Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 3 | Boosting single-band red upconversion luminescence in colloidal NaErF_4 nanocrystals:Effects of doping and inert shell显示文摘Single-band red upconversion luminescence(UCL) is vital to in vivo bioimaging as well as 'see and treat' biomedicines. Herein, starting with the previously reported β-NaErF4:Tm UCNPs, we examined the effects of both Yb^(3+) doping and inert shell coating on the red-to-green(R/G) ratio for Er3+ based UCL. The doping of Yb^(3+) into the β-NaErF4:Tm3+ core not only enhances the whole UCL intensity, but also raises the R/G ratio by 1.25 times. In addition, the coating of an inert NaYF4 shell, which is usually adopted for the enhancement of UCL intensity, further boosts the R/G value up to as high as 77.92. This work may benefit the potential bioimaging application of single-band red UCL. | Xiangshui Cui Yao Cheng Hang Lin Qingping Wu Ju Xu Yuansheng Wang | 2019 | Journal of Rare Earths2019，37，6： | 2 |
| 4 | Integrated Wide Area Protection and Control for Power Grid Security显示文摘The traditional“three defense lines”for power systems are based on local information and static protection&control strategy,which are not suitable to modern large-scale power systems.In order to improve the security of UHV hybrid power grids,the Integrated Wide Area Protection&Control(IWAPC)is proposed in this paper by applying the new technologies of synchronized high-speed communication,which integrates“three defense lines”and promotes existing wide area protection only for security control.The IWAPC is the hierarchical protection and control system which provides the protection and control for wide area power networks to improve their reliability and security.It is divided into three levels,the local bay level,the substation integrated protection level and the wide area protection level.The wide area real-time protection and control information platform is the most important part of the IWAPC,which is based on a synchronized wide area communication network.The key technologies and new development trends include network topology analysis,wide area backup protection,wide area intelligent reclosing,wide area load shedding,wide area auto-switching,overload cutoff and transfer,transmission section protection,intelligent system splitting and dynamic stability control.It cannot only integrate three lines of defense for power system protection and control,but also improve security of the power grid. | Qingping Wang Zhiqian Bo Yingke Zhao Xiaowei Ma Ming Zhang Hao Zheng Lin Wang | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 2 |
| 5 | Analysis of a consensus fragment in ERIC-PCR fingerprinting of Enterobacter sakazakii显示文摘 | Yingwang Ye Qingping Wu Lin Yao Xiaohui Dong Kui Wu Jumei Zhang | 2009 | International Journal of Food Microbiology2009，，2： | 1 |
| 6 | Adsorption of phenol from aqueous solutions by organomontmorillonite显示文摘 | Su Jin Lin Hongfu Wang Qingping | | 0，，1： | 1 |
| 7 | A compari- son of polymerase chain reaction and international organization for standardization methods for determination of Enterobacter sakazakii contamination of infant formulas from Chinese mainland markets显示文摘 | YE YINGWANG WU QINGPING LIN YAO | 2009 | Foodlorne Pathogens Disease2009，6，10： | 1 |
| 8 | Errorminimized extreme learning machine with growth of hiddennodes and incremental learning 显示文摘 | FENG Guorui HUANG Guangbin LIN Qingping | 2009 | IEEE Transactions onNeural Networks/a Publication of the IEEE NeuralNetworks Council2009，20，8： | 1 |
| 9 | Some remarks on general systems显示文摘 | Hu Qingping Lin Yi | 1996 | International Journal of Systems Science1996，，4： | 1 |
| 10 | Subsystems of general systems显示文摘 | Hu Qingping Li Dan Lin Yi | 1996 | Kybernetes1996，，3： | 1 |
| 11 | Error minimized extreme learning machine with growth of hidden nodes and incremental learning 显示文摘 | FENG Guorui HUANG Guangbin LIN Qingping | 2009 | IEEE Transactions on Neural Networks2009，20，8： | 1 |
| 12 | Synthesis of Poly(acrylic acid)-Grafted Carboxymethyl Cellulose for Efficient Removal of Copper Ions显示文摘Biocompatible and high content grafted carboxymethyl cellulose-g-poly(acrylic acid)powder was successfully synthesized in an aqueous system,and used as adsorbents for the removal of Cu(II)in aqueous solution.The copolymer was characterized by FT-IR and SEM techniques.Graft copolymerization introduced a large number of carboxyl groups in the polymer and caused the micro-surface of the material to be porous.The fundamental adsorption behaviors of the material were studied.The adsorption kinetics was well fitted with pseudo-second order equation,while the adsorption isotherm preferred to be described the Langmuir equation.The maximum adsorption capacity obtained from the Langmuir model was 154.32 mg/g,indicating that the adsorption capacity of carboxymethyl cellulose was improved remarkably after grafting poly(acrylic acid).Moreover,Fourier transform infrared spectroscopy(FT-IR)has been used to investigate the adsorption mechanisms at molecular levels,which revealed that carboxyl groups are facile to form bidentate carboxylates with metal ions.Thus,this environment friendly copolymer will be a promising candidate for application in removal of heavy metal ions. | Ying Lin Yihua Cao Qingping Song Jiangang Gao Puyou Jia Hamed Alsulami Marwan Amin Kutbi | 2019 | Journal of Renewable Materials2019，7，12： | 1 |
| 13 | Error Minimized Extreme Learning Machine with Growth of Hidden Nodes and Incremental Learning 显示文摘 | Feng Guorui Huang Guangbin Lin Qingping | 2009 | IEEE Transactions on Neural Networks2009，20，8： | 1 |
| 14 | Analysis of a consensus fragment in ERIC-PCR fingerprinting of Enter-obacter sakazakii 显示文摘 | Yingwang Y Qingping W Lin Y | 2009 | Food Microbiology2009，132，23： | 1 |
| 15 | Preparation and characterization of a collagen/chitosan/heparin matrix for an implantable bioartificial liver显示文摘 | Xiaohong Wang Yongnian Yan Feng Lin Zhuo Xiong Rendong Wu Renji Zhang Qingping Lu | 2005 | Journal of Biomaterials Science Polymer Edition2005，，9： | 1 |
| 16 | Integrated protection based on multifrequency domain information for UHV half-wavelength AC transmission line显示文摘Half-wavelength AC Transmission(HWACT)can improve capability of AC transmission significantly.According to the basic principle of HWACT,the electromagnetic transient model of HWACT is built to analyze the fault transient process of transmission line.Based on fault characteristics of HWACT,the adaptability of traditional protections for transmission lines is analyzed briefly,such as current differential protection,distance protection and over current protection.In order to solve the problems of conventional protection caused by HWACT,a novel integrated protection based on multi-frequency domain information is proposed in this paper,which uses both the power frequency information and transient information.The integrated protection based on multi-frequency domain information takes advantages of power frequency and transient protections,which can not only improve the performance of traditional protection of AC transmission line but also realize fast fault judgment by transient travelling wave protection. | Qingping Wang Zhiqian Bo Xiaowei Ma Ming Zhang Yingke Zhao Yi Zhu Lin Wang | 2016 | Protection and Control of Modern Power Systems2016，1，1： | 1 |
| 17 | A comparison of poly- merase chain reaction and international organization for standardization methods for determination of Enterobacter sakazakii contamination of infant formulas from Chinese mainland markets显示文摘 | YE Yingwang WU Qingping LIN Yao | 2009 | Foodborne Pathog Dis2009，6，10： | 1 |
| 18 | A Novel Highly Selective“Turn-On”Fluorescence Sensor for Silver Ions Based on Schiff Base显示文摘A novel optical chemical sensor L was designed and synthesized for the determination of silver ions.The sensor L was derived from 1-naphthaldehyde and 3,4,5-tris(hexadecyloxy)benzohydrazide.The sensor L shows high sensitivity and selectivity for Ag+detection in comparison to other metal cations(Mg^(2+),Ca^(2+),Al^(3+),Cr^(3+),Fe^(3+),Co^(2+),Ni^(2+),Cu^(2+),Zn^(2+),Cd^(2+),Hg^(2+),Pb^(2+))and has no significant response to other common metal cations.Upon addition of Ag+,the fluorescent emission of the sensor L was enhanced dramatically but other metal cations had no same response.The detection limit for Ag+was 1.2×10^(−7) mol/L.Therefore,the sensor L is useful for Ag+detection with some advantages including sensitivity,selectivity,simplicity and low-cost. | Qi Lin Qingping Yang Bin Sun Taibao Wei Youming Zhang | 2014 | Chinese Journal of Chemistry2014，32，12： | 1 |
| 19 | Computer Methods in Applied Mechanics and Engineering显示文摘 | Ping Lin Qingping Guo Xianqiao Chen | 2003 | 5 (192): 2555~25642003，5，192： | 1 |
| 20 | Analysis of a consensus fragment in ERIC PCR fingerprinting of Enterobacter sakazakii 显示文摘 | Yingwang Ye Qingping Wn Lin Yao | 2009 | Int J Food Microbiol2009，132，2： | 1 |
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