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| 1 | Titanium carbonitride thick coating prepared by plasma spray synthesis and its tribological properties显示文摘TiCN coating, owing to its superior wear-resistance, has been frequently applied in many fields. TiCN thick coating was first prepared by reactive plasma spraying. The phase composition, microstructure and tribological properties of the TiCN coating were investigated in this research. Experimental results show that the microstructure of the TiCN coating was quite dense, and there was also a little amount of titanium oxides within the coating. By XPS analysis, Ti-C and Ti-N bonds were detected in the coating. The TiCN coating exhibited superior wear-resistance. The failure mechanism was attributed to the ad-hesive wear, the grinding of TiCN hard-grain, as well as the coating failure by oxidation. There were more Fe, Cr, O, etc. in the failure zone, suggesting that the corrosion propagated gradually from sur-face to interior. | ZHU Lin HE JiNing YAN DianRan XIAO LiSong DONG YanChun XUE DingChuan MENG DeLiang | 2007 | Chinese Science Bulletin2007，52，13： | 6 |
| 2 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 3 | Multi-relaxation time lattice Boltzmann simulations of deep lid driven cavity flows at different aspect ratios显示文摘 | Lin Lisong Chen Yicheng Lin Chaoan | 2011 | Computers and Fluids2011，45，1： | 1 |
| 4 | Nanostructured TiN coating prepared by reactive plasma spraying in atmosphere显示文摘 | Lisong Xiao Dianran Yan Jining He Lin Zhu Yanchun Dong Jianxin Zhang Xiangzhi Li | 2007 | Applied Surface Science2007，，18： | 1 |
| 5 | Resveratrol reduces acute lung injury in a LPS?induced sepsis mousemodel via activation of Sirt1显示文摘 | Tongxun Li Jinglan Zhang Jiliang Feng Qiang Li Lisong Wu Qing Ye Jianping Sun Yi Lin Mengran Zhang Rui Huang Jun Cheng Yongmei Cao Guoan Xiang Jinqian Zhang Qinghua Wu | 2013 | Molecular Medicine Reports2013，，6： | 1 |
| 6 | Thermal degradation behavior and gas phase flame‐retardant mechanism of polylactide/PCPP blends显示文摘 | Haijuan Lin Lijing Han Lisong Dong | 2014 | J Appl Polym Sci2014，，13： | 1 |
| 7 | Regio-selective chlorination of vinca alkaloids catalyzed by Lewis acid显示文摘Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of Lewis acid.The catalyst Cp2TiCl2 plays a key role in the chlorination reaction. | FANG LiSong ZHANG Qiao DENG ChunLin LEI XinSheng LIN GuoQiang | 2011 | Science China Chemistry2011，54，7： | 0 |
| 8 | Comparative transcriptome analysis revealed the influence of sucrose on flavor and taste quality of Coffea arabica and C.canephora varieties显示文摘Coffea arabica(Arabica)and C.canephora(Robusta)are the most popular coffee species in the world,accounting for 99%of overall consumption of coffee beans.Arabica generally possesses better coffee quality than Robusta partly due its higher sucrose content.The flavor and taste(FT)of coffee,as important aspects of coffee quality,are mainly affected by the content of caffeine,phenolic acid and terpenoid compounds,which use sucrose as an important precursor.However,how sucrose affects the coffee FT remains unclear.In this study,coffee beans at different developmental stages from Arabica#161(A161,high-sucrose variety)and Robusta#6(R6,low-sucrose variety)were sampled to perform transcriptomic analysis.Most differentially expressed genes(DEGs)between them were enriched in sucrose-related metabolisms and the FTrelated metabolism processes:caffeine biosynthesis,phenylpropanoid and flavonoid pathway,terpenoid metabolism.Thirty-four candidate DEGs probably contributed to the higher content of sucrose,anthocyanin and linalool in A161,and higher content of caffeine and carotenoid in R6.Generally,sucrose-related metabolisms were strongly associated with FT-related substance accumulation.The content of sucrose and its influence on the downstream secondary metabolism probably play important roles in the FT quality of coffee beans.Our results provide efficient targets for investigation regarding the influence of sucrose on FT quality of coffee beans. | Lifang Huang Lisong Hu Yu Fan Xiaoyang Wang Yunping Dong Fupeng Li Yuzhou Long Lin Yan Jie Meng | 2021 | Beverage Plant Research2021，1，1： | 0 |
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