|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Research and Practice of Dynamic Network Security Architecture for IaaS Platforms显示文摘Network security requirements based on virtual network technologies in IaaS platforms and corresponding solutions were reviewed.A dynamic network security architecture was proposed,which was built on the technologies of software defined networking,Virtual Machine(VM)traffic redirection,network policy unified management,software defined isolation networks,vulnerability scanning,and software updates.The proposed architecture was able to obtain the capacity for detection and access control for VM traffic by redirecting it to configurable security appliances,and ensured the effectiveness of network policies in the total life cycle of the VM by configuring the policies to the right place at the appropriate time,according to the impacts of VM state transitions.The virtual isolation domains for tenants’VMs could be built flexibly based on VLAN policies or Netfilter/Iptables firewall appliances,and vulnerability scanning as a service and software update as a service were both provided as security supports.Through cooperation with IDS appliances and automatic alarm mechanisms,the proposed architecture could dynamically mitigate a wide range of network-based attacks.The experimental results demonstrate the effectiveness of the proposed architecture. | Lin Chen Xingshu Chen Junfang Jiang Xueyuan Yin Guolin Shao | 2014 | Tsinghua Science and Technology2014，19，5： | 6 |
| 2 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 3 | Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. | Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 4 | Synthesis of bacteriochlorind and their potential untility in photodynamic 显示文摘 | Chen Yihui Lin Guolin Pendey R K | 2004 | Current Org Chem2004，8，： | 1 |
| 5 | Synthesis of bac- teriochlorind and their potential untility in photodynamic 显示文摘 | Chen Yihui Lin Guolin Pendey R K | 2004 | Current Org Chem2004，8，12： | 1 |
| 6 | Synthesis of bacteriochlorind and their potential untility in photodynamic 显示文摘 | Chen Yihui Lin Guolin Pendey R K | 2004 | Current Org Chem2004，8，： | 1 |
| 7 | Synthesis of bacteriochlorind and their potential untility in photodynamic 显示文摘 | Chen Yihui Lin Guolin Pendey R K | 2004 | Current Org Chem2004，8，： | 1 |
| 8 | Engineering behaviors of reinforced gabion retaining wall based on laboratory test显示文摘 | LIN Yuliang YANG Guolin LI Yun | 2010 | Journal of Central South University of Teetmology2010，17，6： | 1 |
| 9 | Synthesis of bacteriochlorind and their potential untility in photodynamic 显示文摘 | Chen Yihui Lin Guolin Pendey R K | 2004 | Current Org Chem2004，8，： | 1 |
| 10 | Synthesis of bac- teriochlorind and their potential untility in photodynamic 显示文摘 | Chen Yihui Lin Guolin Pendey R K | 2004 | Current Org Chem2004，8，： | 1 |
| 11 | No tillage outperforms conventional tillage under arid conditions and following fertilization显示文摘Reduced tillage practices present a tool that could sustainably intensify agriculture.The existing literature,however,lacks a consensus on how and when reduced tillage practices should get implemented.We reanalyzed here an extensive dataset comparing how regular tillage practices(i.e.,conventional tillage)impacted yield of eight crops compared to stopping tillage altogether(i.e.,no-tillage practice).We observed that aridity and fertilization favored no tillage over conventional tillage whereas conventional tillage performed better under high fertility settings.We further show that the responses are consistent across the crops.Our reanalysis complements the original and fills a gap in the literature questioning the conditions under which reducing tillage presents a viable alternative to common tillage practices. | Stavros D.Veresoglou Junjiang Chen Xuheng Du Qi Fu QingLiu Geng Chenyan Huang Xilin Huang Nan Hu Yiming Hun Guolin C.Li Zhiman Lin Zhiyu Ma Yuyi Ou Shuo Qi Haitian Qin Yingbo Qiu Xibin Sun Ye Tao YiLing Tian Jie Wang Lingxiao Wu Ziwei Wu Siqi Xie Ao Yang Dan Yang Chen Zeng Ying Zeng RuJie Zhang | 2023 | Soil Ecology Letters2023，5，1： | 1 |
| 12 | Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats显示文摘Thienorphine(TNP)is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence.The pharmacokinetic profile and biliary excretion of TNP and its glucuronide conjugate(TNP-Glu)were investigated after oral administration of TNP in rats.The concentrations of TNP and TNP-Glu were simultaneously quantified using a LC-MS/MS method.A double peak phenomenon was observed in TNP plasma concentration–time curves with the secondary peak appeared at 6–8 h.A slower decline of plasma concentrations in the terminal phase was observed for TNP with T1/2 of 7.01 h.TNP-Glu was the predominant component in rat plasma and bile.Its plasma level was about 10 times higher than TNP and the 24 h accumulative bile excretion rate was 23%.Enterohepatic circulation of TNP and TNP-Glu was evaluated using a paired rat model.In bile-donor rats,no double-peak was detected and the elimination half life of TNP was significantly shortened(3.71 h)when compared to intact rats(7.01 h,P<0.05).Both TNP and TNP-Glu were detected in bile-recipient rats.Their exposures in recipient rats due to enterohepatic circulation were 15.6%and 42.6%for the parent drug and the metabolite,respectively.The deconjugation of the glucuronide conjugate and the reabsorption of free TNP were further confirmed in in situ perfused rat intestinal preparations.These results indicate that the enterohepatic circulation has a significant influence on the systemic exposure of the parent drug and its glucuronide conjugate,particularly on the terminal elimination of TNP,which may result in the prolonged retention of the drug in body. | Jingting Deng Xiaomei Zhuang Guolin Shen Hua Lin Zehui Gong | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 0 |
| 13 | Digestive tract reconstruction in pancreaticoduodenectomy in University Hospitals of China: a national questionnaire survey显示文摘Background Pancreaticoduodenectomy(PD)has been widely applied in general hospitals in China;however,there is still a lack of unified standards for each surgical technique and procedure.This survey is intended to investigate the current status of digestive tract reconstruction after PD in university hospitals in China.Method A cross-sectional survey was conducted among the members of the Young Elite Pancreatic Surgery Club of China by using the Questionnaire for Digestive Tract Reconstruction after Pancreaticoduodenectomy.The questionnaire was disseminated and collected by point-to-point communication via WeChat public platforms.Results A total of 73 valid questionnaires were returned from 65 university hospitals in 28 provincial divisions of China's Mainland.The respondents who performed PD surgery with an annual volume of over 100 cases accounted for 63%.Generally,laparoscopic PD was performed less often than open PD.Child and Whipple reconstructions accounted for 70%and 26%,respectively.The sequence of pancreatoenteric,biliary-enteric,and gastrointestinal reconstruction accounted for 84%of cases.In pancreatoenteric anastomosis,double-layer anastomosis is the most commonly employed type,accounting for approximately 67%,while single-layer anastomosis accounts for 30%.Of the double-layer anastomoses,duct-to-mucosa/dunking(94%/4%)PJ was performed with duct-mucosa using the Blumgart method(39%)and Cattel-Warren(29%),with continuous/interrupted sutures in the inner layer(69%/31%)and continuous/interrupted sutures in the outer layer(53%/23%).In single-layer anastomosis,continuous/interrupted sutures accounted for 41%/45%.In hepatojejunostomy,single-layer/double-layer suture accounted for 79%/4%,and continuous/interrupted suture accounted for 75%/9%.Forty-six percent of the responding units had not applied double-layer biliary-intestinal anastomosis in the last 3 years,75%of the responding surgeons chose the anastomosis method according to bile duct diameter,with absorbable/non-absorbable suture accounting for 86%/12%.PD/pylorus-preserving PD accounted for 79%/11%of GJ cases,the distance between GJ and HJ<30 cm,30-50 cm and>50 cm were 11%,75%,and 14%,respectively.Antecolic/retrocolic GJ accounted for 71%/23%of cases.Twenty-two percent of GJ cases employed Braun anastomosis,while 55%and 19%of GJ cases used linear cutting staplers/tube-type staplers,respectively;60%/14%were reinforced/not reinforced via manual suturing after stapler anastomosis.Manual anastomosis in GJ surgery employed absorbable/non-absorbable sutures(91%/9%).Significant differences in reconstruction techniques were detected between different volumes of PD procedures(<100/year and>100/year),regions with different economic development levels,and between north and south China.Conclusion Digestive tract reconstruction following PD exists heterogeneity in Chinese university hospitals.Corresponding prospective clinical studies are needed to determine the consensus on pancreatic surgery that meets the clinical reality in China. | Jishu Wei Qiang Xu Yuhua Zhang Jiabin Jin Xiaodong Tian Qiaofei Liu Zipeng Lu Zheng Wang Shanmiao Gou Song Gao Xianlin Han Yefei Rong Niandong Ji Ye Lin Guolin Li Shi Chen Feng Cao Hua Chen Wenming Wu Yupei Zhao the Young Elite Pancreatic Surgery Club of China | 2022 | Journal of Pancreatology2022，5，3： | 0 |
| 14 | Carbon-based supports for the electrocatalysis under industrially relevant conditions显示文摘1 Introduction.Carbon materials are ideal catalyst supports for functional metal components due to their appropriate physicochemical characteristics,such as high surface areas,tunable pore structures,variable morphologies and versatile surface properties based on chemical modifications,low cost and facile preparations from diverse precursors[1,2]. | Xue Yang Xianrui Gu Yang Song Guolin Hou Cheng Wang Lichen Liu Wei Lin | 2024 | Science China Chemistry2024，67，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员