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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 3 | The GW2-WG1-OsbZIP47 pathway controls grain size and weight in rice显示文摘Regulation of seed size is a key strategy for improving crop yield and is also a basic biological question.However,the molecular mechanisms by which plants determine their seed size remain elusive.Here,we report that the GW2-WG1-OsbZIP47 regulatory module controls grain width and weight in rice.WG1,which encodes a glutaredoxin protein,promotes grain growth by increasing cell proliferation.Interestingly,WG1 interacts with the transcription factor OsbZIP47 and represses its transcriptional activity by associating with the transcriptional co-repressor ASP1,indicating that WG1 may act as an adaptor protein to recruit the transcriptional co-repressor.In contrary,OsbZIP47 restricts grain growth by decreasing cell proliferation.Further studies reveal that the E3 ubiquitin ligase GW2 ubiquitinates WG1 and targets it for degradation.Genetic analyses confirm that GW2,WG1,and OsbZIP47 function in a comm on pathway to control grain growth.Taken together,ourfindi ngs reveal a genetic and molecular framework for the control of grain size and weight by the GW2-WG1-OsbZIP47 regulatory module,providing new targets for improving seed size and weight in crops. | Jianqin Hao Dekai Wang Yingbao Wu Ke Huang Penggen Duan Na Li Ran Xu Dali Zeng Guojun Dong Baolan Zhang Limin Zhang Dirk Inze Qian Qian Yunhai Li | 2021 | Molecular Plant2021，14，8： | 14 |
| 4 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 5 | MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ显示文摘 | Min He Zhenqun Xu Tong Ding Dong-Ming Kuang Limin Zheng | 2009 | Cellular & Molecular Immunology2009，6，5： | 12 |
| 6 | Adsorption of VOCs on reduced graphene oxide显示文摘A modified Hummer's method was adopted for the synthesis of graphene oxide(GO) and reduced graphene oxide(rGO). It was revealed that the modified method is effective for the production of GO and rGO from graphite. Transmission electron microscopy(TEM) images of GO and rGO showed a sheet-like morphology. Because of the presence of oxygenated functional groups on the carbon surface, the interlayer spacing of the prepared GO was higher than that of rGO. The presence of \OH and C_O groups in the Fourier transform infrared spectra(FTIR) spectrum and G-mode and 2D-mode in Raman spectra confirmed the synthesis of GO and rGO. rGO(292.6 m^2/g) showed higher surface area than that of GO(236.4 m^2/g). The prepared rGO was used as an adsorbent for benzene and toluene(model pollutants of volatile organic compounds(VOCs)) under dynamic adsorption/desorption conditions. rGO showed higher adsorption capacity and breakthrough times than GO. The adsorption capacity of rGO for benzene and toluene was 276.4 and 304.4 mg/g, respectively.Desorption experiments showed that the spent rGO can be successfully regenerated by heating at 150.0°C. Its excellent adsorption/desorption performance for benzene and toluene makes rGO a potential adsorbent for VOC adsorption. | Lian Yu Long Wang Weicheng Xu Limin Chen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 7 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 8 | Effects of impregnation sequence on the microstructure and performances of Cu-Co based catalysts for the synthesis of higher alcohols显示文摘支持硅石的 CuCo 催化剂被受精方法为更高的白酒合成与不同受精顺序作好准备。这些催化剂被 H 2-TPR, XRD, N 2 吸附, XPS 技术和公司描绘选择加氢反应测量。催化剂的结构和表演上的受精顺序的效果被调查,并且到更高的白酒的选择上有重要影响。为共同使妊娠的样品在铜和钴之间有强壮的 synergistic 效果。合作受精准备的 CuCo/SiO 2 催化剂显示了全部的白酒,和一种更高的选择的更好的收益总计到达了 51.5% 的白酒。 | Siyu Deng Wei Chu Huiyuan Xu Limin Shi Lihong Huang | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 10 |
| 9 | Spatial and Temporal Variability of PM_(2.5) Concentration in China显示文摘PM_(2.5) has become an increasing public concern recently because of its visibility reduction and severe health risks. For the whole year of 2013, hourly PM_(2.5) data of 496 monitoring sites scattered in 74 cities of China are collected to analyze temporal and spatial variability of PM_(2.5) concentration. Different temporal scales(seasonal variation, monthly variation and daily variation) and spatial scales(urban versus rural, typical areas and national scale) are discussed. Results show that PM_(2.5) concentration changes significantly in both long-term and short-term scales. An apparent bimodal pattern exists in daily variation of PM_(2.5) concentration and the daytime peak appears around 10:00 am while the lowest concentration appears around 16:00 pm. Spatial autocorrelation analysis and Ordinary Kriging are used to characterize spatial variability. Moran's I of PM_(2.5) concentration in three typical regions, the Beijing-Tianjin-Hebei region, the Yangtze River Delta region and the Pearl River Delta region, is 0.906, 0.693, 0.746, respectively, which indicates that PM_(2.5) is strong spatial correlated. Spatial distribution of annual PM_(2.5) concentration simulated by Ordinary Kriging shows that 7.94 million km2(83%) areas fail in meeting the requirement of China's National Ambient Air Quality Standards Level-2(35 mg/m3) and there are at least three concentrated highly polluted areas across the country. | XU Gang JIAO Limin ZHAO Suli CHENG Jiaqi | 2016 | Wuhan University Journal of Natural Sciences2016，21，4： | 9 |
| 10 | Estimation of forest volumes by integrating Landsat TM imagery and forest inventory data显示文摘Accurate information about forest volumes is essential for forest management planning. The survey interval of the Forest Resource Inventory of China (FRIC) is too long to meet the demand for timely decision-making required for forest protection, management, and utilization. Analysis of satellite imagery provides good potential for more frequent reporting of forest parameters. In this study, we describe an application of the k-nearest neighbors (kNN) method to Landsat TM imagery for improving estimation of forest volumes. Several spectral features were tested and compared in forest volume estimations, including normalized difference vegetation index, environmental vegetation index, and the combination of the spectral features. The combined index resulted in the most accurate volume estimations. The kNN estimator and the combined index were then used in forest volume estimation. The estimation error (RMSE) of the total volume was44.2%, much lower than those for Larix forest (the RMSE was 51.7%) and those for the Korean pine and broadleaved forests (the estimation errors were over 71.7% and 88.19%,respectively). This preliminary study demonstrates the potential of forest volume estimations with remote sensing data to provide useful information for forest management if only limited ground information is available. | GU Huiyan, DAI Limin, WU Gang, XU Dong, WANG Shunzhong &WANG Hui Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China School of Forestry, Northeast Forestry University, Harbin 150040, China State Key Lab of Systems Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Graduate University of Chinese Academy of Sciences, Beijing 100039, China | 2006 | Science China(Technological Sciences)2006，49，z1： | 8 |
| 11 | Catalytic properties of Cu/Co/Zn/Zr oxides prepared by various methods显示文摘基于的新 Cu 公司(Cu/Co/Zn/Zr ) 为高白酒的合成的催化剂用一起沉淀方法被准备,血浆在超声照耀下面的提高的方法和反向的一起沉淀方法。催化剂被赌注, SEM, XRD, H 2-TPR 和 XPS 的工具调查。各种各样的方法准备的催化剂的催化性质用公司加氢反应被检验。血浆提高了方法,在超声照耀下面的反向的一起沉淀方法在提高 Cu/Co/Zn/Zr 的催化性质两个都是有效的,这被发现混合氧化物。小粒子尺寸,活跃部件的高分散,特定的表面区域的改进和活跃阶段的表面内容能说明试验性的 Cu/Co/Zn/Zr 催化剂的优秀表演。 | Limin Shi Wei Chu Siyu Deng Huiyuan Xu | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 8 |
| 12 | Trithorax Group Proteins Act Together with a Polycomb Group Protein to Maintain Chromatin Integrity for Epigenetic Silencing during Seed Germination in Arabidopsis显示文摘Polycomb 组(PcG ) 和蛋白质被给看了反对地行动 epigenetically 在优核质调整基因表示的 trithorax 组(trxG ) 。trxG 蛋白质在另外的发展过程在 Arabidopsis,而是他们的角色抵抗调停 PcG 的花的压抑糟糕被理解。我们调查了在 trxG 之间的相互作用基因, TRITHORAX1 (ATX1 ) 的 ARABIDOPSIS 相当或相同的事物和 ULTRAPETALA1 (ULT1 ) ,和 PcG 基因胚胎的花 1 (EMF1 ) 在早开发期间。出人意料地,我们发现在 trxG 基因的变化没能救 emf1 异种的早花的显型。相反, emf1 atx1 ult1 幼苗显示出新奇的肿的根显型和基因表示的巨大的解除管制。在 emf1 atx1 ult1 的规章的基因比在 emf1 单身者异种增加两倍的种子主人的更大的宫外的表示一起显示那 PcG 和 trxG 因素镇压在萌芽以后的种子基因表示。而且,我们发现普遍基因 derepression 与 H3K27me3 的减少的层次被联系, epigenetic 基因表示的压抑的标记,并且与全球性改变的染色质组织。EMF1, ATX1,和 ULT1 能绑种子基因的染色质, ULT1 能身体上与 ATX1 和 EMF1 交往,建议 trxG 和 EMF1 蛋白质直接在为调停 EMF1 的基因 silencing 的目标基因 loci 联系。因此,当 ATX1, ULT1,和 EMF1 反对地交往调整 flowering 时,他们一起工作维持染色质完整并且在萌芽以后阻止早熟的种子基因表示。 | Fan Xu Tony Kuo Yenny Rosli Mao-Sen Liu Limin Wu Long-Fang Oliver Chen Jennifer C. Fletcher Zinmay Renee Sung Li Pu | 2018 | Molecular Plant2018，11，5： | 8 |
| 13 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 14 | Emission of organic carbon, elemental carbon and water-soluble ions from crop straw burning under flaming and smoldering conditions显示文摘 | Lei Hong Gang Liu Limin Zhou Jiuhai Li Hui Xu Dan Wu | 2017 | Particuology2017，15，2： | 7 |
| 15 | Jurassic Hornblende Gabbros in Dongga,Eastern Gangdese,Tibet:Partial Melting of Mantle Wedge and Implications for Crustal Growth显示文摘The Gangdese batholith, more than 2500 km in length, is composed mainly of JurassicMiocene igneous rocks. This batholith is one of the most important constituents of the Tibetan orogenesis and provides an ideal place for study of Neo-Tethyan ocean geodynamic evolution and plateau uplift. Recent studies on the Gangdese Jurassic felsic magmatism highlight its juvenile source. However, important aspects concerning the genesis of the juvenile magmatism and related deep geodynamic evolution are still unclear. Here, we report detailed petrological, geochronological, geochemical, whole-rock Sr-Nd isotopic, and in situ Sr-Hf isotopic data for a recently identified hornblende gabbro in the Dongga area, southern Lhasa sub-block. This hornblende gabbro is dominated by hornblende and plagioclase, dated at Early Jurassic(ca. 180–190 Ma), and characterized by a narrow compositional range in SiO_2(49.38wt%–52.27wt%), MgO(4.08wt%–7.00wt%), FeO(10.43wt%–11.77wt%), Na_2O(2.58wt%–3.51wt%), and K_2O(0.48wt%–1.53wt%). It has depleted isotopic signatures, with whole-rock(^(87)Sr/^(86)Sr)i ratios of 0.7033–0.7043, ε_(Nd)(t) values of +4.90 to +6.99, in situ plagioclase(^(87)Sr/^(86)Sr)i ratios of 0.7034–0.7042, and zircon ε_(Hf)(t) of +12.2 to +16.8. Our results integrated with published data suggest a model of Gangdese juvenile crustal growth by a subduction-related water-enriched mantle wedge. The hydrous partial melting of the lithosphere mantle was triggered by the dehydration of a Neo-Tethyan oceanic slab. This mafic magmatism emplaced in the middle-lower crust of intraoceanic arcs or active continental margins, leading to Jurassic juvenile crustal growth in southern Tibet. | XU Bo HOU Zengqian ZHENG Yuanchuan ZHOU Ye ZHOU Limin YANG Yu HAN Yanwei ZHEN Guo WU Changda | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 7 |
| 16 | Water-conserving mining influencing factors identification and weight determination in northwest China显示文摘Water-conserving mining is an effective way to alleviate the contradiction between fragile ecological environment and high-intensity coal mining in the arid and semi-arid region of northwest China. It needs to consider the engineering and geological conditions, hydrogeological conditions and mining methods of coal seams. From the three aspects, this paper systematically analyzes the influencing factors and establishes an identification model with multi-level structures. The model includes three primary factors (including the engineering and geological conditions, hydrogeological conditions and mining methods), nine secondary factors (including overlying strata thickness, aquiclude, mining parameters and etc.), sixteen third-tier factors (including the faults, aquiclude thickness and effective mining height and etc.) and twelve fourth-tier factors (including the fault throw exp on ent, aquiclude permeability and coal pillar sizes and etc.). On the basis, the analytic hierarchy process is used to build the judgment matrix and obtain the weight of each influencing factor. The results indicate that the overlying strata thickness, aquiclude and effective mining height are the most import a nt factors among the primary factors of engineering and geological conditions, hydrogeological conditions and mining methods, respectively. The research results could provide theoretical references for the water-conserving mining of coal resources in northwest China. | Limin Fan Liqiang Ma Yihe Yu Shuokang Wang Yujun Xu | 2019 | International Journal of Coal Science & Technology2019，6，1： | 7 |
| 17 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 18 | Systematic Identification of the Light-quality Responding Anthocyanin Synthesis-related Transcripts in Petunia Petals显示文摘Previous studies have shown that high light intensity can induce anthocyanin synthesis(AS)in petunia plants.To identifywhich kind of light quality plays a role in inducing such metabolic process,and what transcripts participate in controlling it,we carried out whole-transcriptome sequencing and analysis of petunia petals treated with different light-quality conditions.Among the red and white light treatments,a total of 2205 differentially expressed genes and 15,22,and 20 differentially expressed circRNAs,miRNAs,and lncRNAs,were identified respectively.The AS-related genes,including the structural genes CHSj,F3H,F35H,DFR,and ANS,and the regulatory genes AN4,DPL,PHZ and MYBx were found to be downregulated under red light condition compared with their levels under white light condition.Furthermore,the light photoreceptor Cryptochrome 3(CRY3)and a series of light-dependent genes,such as PIF,HY5,andBBXs,were also determined to respond to the light treatments.The anthocyanin contents in early petunia petals under red light were significantly lower than that under white and blue light.The results of qRT-PCR further confirmed the expression pattern of some AS-related and light-response genes in response to different light quality.Yeast two-hybrid results showed that the key elements in the light signal pathway,HY5 can interact with BBX19,BBX24 and BBX25.And PHZ,the important AS regulator can induce anthocyanin synthesis in response to blue light quality fromtransient expression analysis in petunia petals.These findings presented here not only deepen our understanding of how light quality controls anthocyanin synthesis,but also allow us to explore potential target genes for improving pigment production in petunia flower petals. | Zhenzhu Fu Hongquan Shang Hui Jiang Jie Gao Xiaoyu Dong Huijuan Wang Yanmin Li Limin Wang Jing Zhang Qingyan Shu Yacong Chao Menglan Xu Rui Wang Liangsheng Wang Hechen Zhang | 2020 | Horticultural Plant Journal2020，6，6： | 7 |
| 19 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 20 | Digitally determining forest inventory units with an ecological classification system显示文摘Management-level forest resource data in China were obtained with a combination of two forest inventories. However, inconsistencies in the spatial attributes of forest data vary between the two inventory types and between two inventories of the same type. The inconsistencies make it inconvenient for long-term forest management planning with digital technologies. Ecological Land Types (ELTs) and Ecological Land Type Phases (ELTPs) have been mapped in selected forestry regions in northeast China, where important forest industries are located. The boundaries of ELTs are determined by geomorphic conditions, which are quantified by Digital Elevation Models (DEM); ELTPs are classified by overlaying ELTs with forest vegetation data layers that are obtained with both remotely sensed and ground data. The ELTPs represent the divisions of land in terms of both natural and human-induced forest conditions, and therefore they are reliable units for forest inventories and management. This paper introduces a case study for digitally determining forest inventory units in Benxi City, Liaoning Province, northeast China. The general objective of the study was to explain how a compatible forest inventory system should be designed and why the compatible forest inventory system was significant to digital forestry in China. | TANG Una, WANG Qingli, Guofan Shao, DAI Limin, WANG Shunzhong, LI Xiufen & XU Dong Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate University of Chinese Academy of Sciences, Beijing 100101, China Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA | 2006 | Science China(Technological Sciences)2006，49，z1： | 6 |
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