|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | Hepatic encephalopathy:Lessons from preclinical studies显示文摘Hepatic encephalopathy(HE) is a major complication that is closely related to the progression of end-stage liver disease.Metabolic changes in advanced liver failure can promote cognition impairment,attention deficits and motor dysfunction that may result in coma and death.HE can be subdivided according to the type of hepatic injury,namely,type A,which results from acute liver failure,type B,which is associated with a portosystemic shunting without intrinsic liver disease,and type C,which is due to chronic liver disease.Several studies have investigated the pathogenesis of the disease,and most of the mechanisms have been explored using animal models.This article aimed to review the use of preclinical models to investigate HE.The most used animal species are rats and mice.Experimental models of type A HE include surgical procedures and the administration of hepatotoxic medications,whereas models of types B and C HE are generally surgically induced lesions in liver tissue,which evolve to hepatic cirrhosis.Preclinical models have allowed the comprehension of the pathways related to HE. | Luiza Cioglia Dias Lima Aline Silva Miranda Rodrigo Novaes Ferreira Milene Alvarenga Rachid Ana Cristina Sim?es e Silva | 2019 | World Journal of Hepatology2019，11，2： | 4 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | Methodological aspects about in vitro evaluation of antioxidant properties显示文摘 | Luís M. Magalh?es Marcela A. Segundo Salette Reis José L.F.C. Lima | 2008 | Analytica Chimica Acta2008，，1： | 1 |
| 5 | Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest显示文摘在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。 | José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de Andrade Elcida de Lima Araújo | 2020 | Journal of Plant Ecology2020，13，3： | 1 |
| 6 | Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.显示文摘 | Gabrieli Penha Bezerra Roberto Wagner da Silva Góis Teresinha Silva de Brito Francisco José Batista de Lima Mary Anne Medeiros Bandeira Nirla Rodrigues Romero Pedro Jorge Caldas Magalh?es Gilvandete Maria Pinheiro Santiago | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 7 | Rapid, simple laser-light scattering method for HDL particle sizing in whole plasma显示文摘 | Lima ES Maranhao RC | 2004 | Clin Chera2004，50，6： | 1 |
| 8 | Assessing arsenic, cadmium, and lead contents in major crops in Brazil for food safety purposes显示文摘 | Ana Paula Branco Corguinha Guilherme Amaral de Souza Veridiana Cardoso Gon?alves Camila de Andrade Carvalho Willian Eduardo Amaral de Lima Fábio Aurélio Dias Martins Celso Hideto Yamanaka Eros Artur Bohac Francisco Luiz Roberto Guimar?es Guilherme | 2014 | Journal of Food Composition and Analysis2014，，： | 1 |
| 9 | DC conductivity and dielectric permittivity of collagen-chitosan films显示文摘 | Lima C Oliveira R Figueiró S Wehmann C Góes J Sombra A | 2006 | Materials Chemistry and Physics2006，99，23： | 1 |
| 10 | Determination of arsenic compounds in beverages by high - performance liquid chromatography - inductively coupled plasma mass spectrometry 显示文摘 | NMM Coelho LN Coelho ES de Lima | 2005 | Talanta2005，66，： | 1 |
| 11 | Xylitol dehydrogenase from Candida tropicalis: molecular cloning of the gene and structural analysis of the protein显示文摘 | Luanne Helena Augusto Lima Cristiano Guimar?es do Amaral Pinheiro Lídia Maria Pepe Moraes Sonia Maria Freitas Fernando Araripe Gon?alves Torres | 2006 | Applied Microbiology and Biotechnology2006，，3： | 1 |
| 12 | Effect of Estrogen–Progestogen Hormonal Replacement Therapy on Periurethral and Bladder Vessels显示文摘 | R. M. Endo M. J. B. C. Gir?o M. G. F. Sartori M. J. Sim?es E. C. Baracat G. Rodrigues de Lima | 2000 | International Urogynecology Journal2000，，2： | 1 |
| 13 | Experimental evaluation of extended endplate beam-to-column joints subjected to bending and axial force显示文摘 | L.R.O. de Lima L. Sim?es da Silva P.C.G.da S. Vellasco S.A.L. de Andrade | 2004 | Engineering Structures2004，，10： | 1 |
| 14 | Experimental evaluation of extended endplate beam-to-column joints subjected to bending and axial force显示文摘 | L.R.O. de Lima L. Sim?es da Silva P.C.G.da S. Vellasco S.A.L. de Andrade | 2004 | Engineering Structures2004，，10： | 1 |
| 15 | Oxidative stress in the pathogene- sis of nonalcoholic fatty liver disease, in rats fed with a choline-de- ficient diet显示文摘 | Oliveira CP da Costa Gayotto LC Tatai C Della Bina BI Janiszewski M Lima ES | 2002 | J Cell Mol Med2002，6，3： | 1 |
| 16 | Acute Improvement in Insulin Resistance After Laparoscopic Roux-en-Y Gastric Bypass: Is 3 Days Enough to Correct Insulin Metabolism?显示文摘 | Gil Faria John Preto Eduardo Lima Costa Jo?o Tiago Guimar?es Concei??o Calhau António Taveira-Gomes | 2013 | Obesity Surgery2013，，1： | 1 |
| 17 | Uterine volume and menstrual patterns in users of the levonorgestrel-releasing intrauterine system with idiopathic menorrhagia or menorrhagia due to leiomyomas B显示文摘 | Magalhes J Aldrighi JM de Lima GR | 2007 | Contraception2007，75，3： | 1 |
| 18 | Update of the management of venous thromboembolism显示文摘 | Rodrigues HL Brandao ES Lima BS | 2002 | Rev Port Cardiol2002，21，2： | 1 |
| 19 | Anti-inflammatory effect of atorvastatin(80mg) in unstable angina pectoris and non-Q-wave acute myocardial infarction显示文摘 | Correia LC Spósito AC Lima JC Magalh(o)es LP Passos LCS Argemiro RMS | 2003 | Am J Cardiol2003，92，3： | 1 |
| 20 | Determination of arsenic compounds in beverages by high-performance liquid chromatography inductively coupled plasma mass spectrometry 显示文摘 | Coelho NM Coelho LM Lima ES | 2005 | Talanta2005，66，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员