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| 1 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Association of C(-106)T Polymorphism in Aldose Reductase Gene with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus显示文摘Objective To identify the possible association between C(-106)T polymorphism of the aldose reductase(ALR) gene and diabetic retinopathy(DR) in a cohort of Chinese patients with type 2 diabetes mellitus(T2DM).Methods From November 2009 to September 2010,patients with T2DM were recruited and assigned to DR group or diabetic without retinopathy(DWR) group according to the duration of diabetes and the grading of 7-field fundus color photographs of both eyes.Genotypes of the C(-106)T polymorphism(rs759853) in ALR gene were analyzed using the MassARRAY genotyping system and an association study was performed.Results A total of 268 T2DM patients(129 in the DR group and 139 in the DWR group) were included in this study.No statistically significant differences were observed between the 2 groups in the age of diabetes onset(P=0.10) and gender(P=0.78).The success rate of genotyping for the study subjects was 99.6%(267/268),with one case of failure in the DR group.The frequencies of the T allele in the C(-106)T polymorphism were 16.0%(41/256) in the DR group and 19.4%(54/278) in the DWR group(P=0.36).There was no significant difference in the C(-106)T genotypes between the 2 groups(P=0.40).Compared with the wild-type genotype,odds ratio(OR) for the risk of DR was 0.7(95% CI,0.38-1.3) for the heterozygous CT genotype and 0.76(95% CI,0.18-3.25) for the homozygous TT genotype.The risk of DR was positively associated with microalbuminuria(OR=4.61;95% CI,2.34-9.05) and insulin therapy(OR=3.43;95% CI,1.94-6.09).Conclusions Microalbuminuria and insulin therapy are associated with the risk of DR in Chinese patients with T2DM.C(-106)T polymorphism of the ALR gene may not be significantly associated with DR in Chinese patients with T2DM. | Yu Deng Xiu-fen Yang Hong Gu Apiradee Lim Munkhtulga Ulziibat Torkel Snellingen Jun Xu Kai Ma Ning-pu Liu | 2014 | Chinese Medical Sciences Journal2014，29，1： | 4 |
| 4 | Amnion epithelial cells——a novel therapy for ischemic stroke?显示文摘Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells(h AECs), which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days poststroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that h AECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy. | Megan A.Evans Brad R.S.Broughton Grant R.Drummond Henry Ma Thanh G.Phan Euan M.Wallace Rebecca Lim Christopher G.Sobey | 2018 | Neural Regeneration Research2018，13，8： | 4 |
| 5 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 3 |
| 6 | Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years显示文摘 | Stephanos J. Hadziyannis Nicolaos C. Tassopoulos E. Jenny Heathcote Ting–Tsung Chang George Kitis Mario Rizzetto Patrick Marcellin Seng Gee Lim Zachary Goodman Jia Ma Carol L. Brosgart Katyna Borroto–Esoda Sarah Arterburn Steven L. Chuck | 2006 | Gastroenterology2006，，6： | 2 |
| 7 | Single-incision laparoscopic right colectomy:experience with 17 consecutive cases and comparison with multi-port laparoscopic right colectomy显示文摘 | Adair J Gromski MA Lim RB | 2010 | Dis Colon Rectum2010，53，11： | 1 |
| 8 | Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse 显示文摘 | Lim H Ma L Ma WG | 1999 | Mol Endocrinol1999，13，6： | 1 |
| 9 | Microstructural evolution in the phase mixtures of Ti(C,N)-Mo at 1600°C显示文摘 | Qian Ma Lim L C | 1999 | Materials Science and Engineering1999，264，5： | 1 |
| 10 | Role of muscle in the gene- sis and management of knee osteoarthritis显示文摘 | Bennell KL Hunt MA Lim BW | 2008 | Rheum Dis Clin North Am2008，34，3： | 1 |
| 11 | Effects of glia maturation factor over-expression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion显示文摘 | Heer A Yorek MA Lim R | 2001 | Neurochem Res2001，26，12： | 1 |
| 12 | Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation,transcription factor activation,and neurotrophin secretion显示文摘 | Zaheer A Yorek MA Lim R | 2001 | Neurochem Res2001，26，12： | 1 |
| 13 | Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats显示文摘 | Lim A K Ma F Y Nikolie-Paterson D J | 2011 | Am J Nephrol2011，34，4： | 1 |
| 14 | p53 controls autoimmune arthritis via STAT-mediated regulation of the Thl7 celL/Treg cell balance in mice显示文摘 | Park JS Lim MA Cho ML | 2013 | Arthritis Rheum2013，65，4： | 1 |
| 15 | Prevention of cardiac hypertrophy in miceby calcineurin inhibition显示文摘 | Sman MA Lim HW Gude N | 1998 | Science1998，281，1： | 1 |
| 16 | A survey of movement strategies for improving network coverage in wireless sensor networks 显示文摘 | Bang Wang Hock Beng Lim Di Ma | 2009 | Computer Communications2009，，32： | 1 |
| 17 | Abdominal B Hoxa genes:regulation in adult uterus by estrogen and progesterone andrepression in müllerian duct by the synthetic estrogendiethylstilbestrol(DES)显示文摘 | Ma L Benson GV Lim H | 1998 | Dev Biol1998，197，2： | 1 |
| 18 | AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300显示文摘 | Lim JY Oh MA Kim WH | 2012 | J Cell Physiol2012，227，： | 1 |
| 19 | The Kalman filter as the optimal linear minimum mean-squared error multiuser CDMA detec-tor显示文摘 | Lim T J Ma Y | | 0，，07： | 1 |
| 20 | Truck dock assignment prob- lem with operational time constraint within crossdocks 显示文摘 | MIAO Z W LIM A MA H | 2009 | European Journal of Operational Research2009，192，1： | 1 |
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