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| 1 | Collapse simulation of a super high-rise building subjected to extremely strong earthquakes显示文摘In recent years, super high-rise buildings (>500 m) are developing very quickly and become an important frontier of civil engineering. The collapse resistance of super high-rise buildings subjected to extremely strong earthquake is a critical problem that must be intensively studied. This paper builds up a nonlinear finite element model of the tallest building in China, Shang- hai Tower (632 m), and proposes the modeling method and failure criteria for different structural elements. The dynamic char- acters of this building are then analyzed, and the possible failure modes and collapse processes due to earthquakes are pre- dicted, as well as the corresponding collapse mechanism. This work will be helpful in collapse prevention and the seismic design of super high-rise buildings. | LU Xiao LU XinZheng ZHANG WanKai YE LiePing | 2011 | Science China(Technological Sciences)2011，54，10： | 49 |
| 2 | Engineering practice of seismic isolation and energy dissipation structures in China显示文摘The concepts of seismic isolation and energy dissipation structures emerged in the early 1970s.In China,the first seismic isolation structure was finished in 1993,and the first energy dissipation structure was built at about the same time.Up to 2007,China had more than 600 seismic isolation and about 100 energy dissipation building structures.In 2008,the huge Wenchuan earthquake hit the southwest of China,which triggered a bloom of new seismic isolation and energy dissipation structures.This paper presents the development history and representative applications of seismic isolation and energy dissipation structures in China,reviews the state-of-the-practice of Chinese design,and discusses the challenges in the future applications.Major findings are as follows:Basic design procedures are becoming standardized after more than ten years of experiences,which mainly involve determination of design earthquake forces,selection of ground motions,modeling and time-history analyses,and performance criteria.Nonlinear time-history analyses using multiple ground motions are the characteristic of the design of seismic isolation and energy dissipation structures.Regulations,standardization and quality control of devices,balance between performance and cost,comparison with real responses,and regular inspection are identified as the issues that should be improved to further promote the application of seismic isolation and energy dissipation structures in China. | PAN Peng YE LiePing SHI Wei CAO HaiYun | 2012 | Science China(Technological Sciences)2012，55，11： | 10 |
| 3 | An improved ground motion intensity measure for super high-rise buildings显示文摘Ground motion intensity measure (IM) is an important part in performance-based seismic design. A reasonable and efficient IM can make the prediction of the structural seismic responses more accurate. Therefore, a more reasonable IM for super high-rise buildings is proposed in this paper. This IM takes into account the significant characteristic that higher-order vibration modes play important roles in the seismic response of super high-rise buildings, as well as the advantages of some existing IMs. The key parameter of the proposed IM is calibrated using a series of time-history analyses. The collapse simulations of two super high-rise buildings are used to discuss the suitability of the proposed IM and some other existing IMs. The results indicate that the proposed IM yields a smaller coefficient of variation for the critical collapse status than other existing IMs and performs well in reflecting the contribution of higher-order vibration modes to the structural response. Hence, the proposed IM is more applicable to seismic design for super high-rise buildings than other IMs. | LU Xiao YE LiePing LU XinZheng LI MengKe MA XiaoWei | 2013 | Science China(Technological Sciences)2013，56，6： | 9 |
| 4 | Evaluation of collapse resistance of RC frame structures for Chinese schools in seismic design categories B and C显示文摘According to the Code for Seismic Design of Buildings (GB50011-2001), ten typical reinforced concrete (RC) frame structures, used as school classroom buildings, are designed with different seismic fortification intensities (SFIs) (SFI=6 to 8.5) and different seismic design categories (SDCs) (SDC=B and C). The collapse resistance of the frames with SDC=B and C in terms of collapse fragility curves are quantitatively evaluated and compared via incremental dynamic analysis (IDA). The results show that the collapse resistance of structures should be evaluated based on both the absolute seismic resistance and the corresponding design seismic intensity. For the frames with SFI from 6 to 7.5, because they have relatively low absolute seismic resistance, their collapse resistance is insufficient even when their corresponding SDCs are upgraded from B to C. Thus, further measures are needed to enhance these structures, and some suggestions are proposed. | Tang Baoxin Lu Xinzheng Ye Lieping Shi Wei | 2011 | Earthquake Engineering and Engineering Vibration2011，10，3： | 8 |
| 5 | Test and simulation of full-scale self-centering beam-to-column connection显示文摘A new type of beam-to-column connection for steel moment frames,designated as a'self-centering connection,'is studied.In this connection,bolted top-and-seat angles,and post-tensioned(PT)high-strength steel strands running along the beam are used.The PT strands tie the beam flanges on the column flange to resist moment and provide self-centering force.After an earthquake,the connections have zero deformation,and can be restored to their original status by simply replacing the angles.Four full-scale connections were tested under cyclic loading.The strength,energy-dissipation capacity,hysteresis curve,as well as angles and PT strands behavior of the connections are investigated.A general FEM analysis program called ABAQUS 6.9 is adopted to model the four test specimens.The numerical and test results match very well.Both the test and analysis results suggest that:(1)the columns and beams remain elastic while the angles sustain plastic deformations for energy dissipation when the rotation of the beam related to the column equals 0.05 rad,(2)the energy dissipation capacity is enhanced when the thickness of the angle is increased,and(3)the number of PT strands has a significant influence on the behavior of the connections,whereas the distance between the strands is not as important to the performance of the connection. | Deng Kailai Pan Peng Alexandre Lam Pan Zhenhua Ye Lieping | 2013 | Earthquake Engineering and Engineering Vibration2013，12，4： | 8 |
| 6 | An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP^(+)mononuclear cells and PDGF-BB secretion显示文摘Osteoporosis(OP)is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures.Pharmaceutical therapies that promote anabolic bone formation in OP patients and OP-induced fracture are needed.We investigated whether a neutralizing antibody against Siglec-15 can simultaneously inhibit bone resorption and stimulate bone formation.We found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody treatment.The secretion of platelet-derived growth factor-BB(PDGF-BB),the number of tartrate-resistant acid phosphatase-positive(TRAP+)mononuclear cells,and bone formation were significantly increased in the SIGLEC-15 conditional knockout mice and antibody-treated mice.The anabolic effect of the Siglec-15 neutralizing antibody on bone formation was blunted in mice with Pdgfb deleted in TRAP-1'cells.These findings showed that the anabolic effect of the Siglec-15 neutralizing antibody was mediated by elevating PDGF-BB production of TRAP4 mononuclear cells.To test the therapeutic potential of the Siglec-15 neutralizing antibody,we injected the antibody in an ovariectomy-induced osteoporotic mouse model,which mimics postmenopausal osteoporosis in women,and in two fracture healing models because fracture is the most serious health consequence of osteoporosis.The Siglec-15 neutralizing antibody effectively reduced bone resorption and stimulated bone formation in estrogen deficiency-induced osteoporosis.Of note,the Siglec-15 neutralizing antibody promoted intramembranous and endochondral ossification at the damaged area of cortical bone in fracture healing mouse models.Thus,the Siglec-15 neutralizing antibody shows significant translational potential as a novel therapy for OP and bone fracture. | Gehua Zhen Yang Dan Ruomei Wang Ce Dou Qiaoyue Guo Melissa Zarr Linda N.Liu Lieping Chen Ruoxian Deng Yusheng Li Zengwu Shao Xu Cao | 2021 | Bone Research2021，9，4： | 6 |
| 7 | Uniform-risk-targeted seismic design for collapse safety of building structures显示文摘Seismic design should quantitatively evaluate and control the risk of earthquake-induced collapse that a building structure may experience during its design service life.This requires taking into consideration both the collapse resistant capacity of the building and the earthquake ground motion demand.The fundamental concept of uniform-risk-targeted seismic design and its relevant assessment process are presented in this paper.The risks of earthquake-induced collapse for buildings located in three seismic regions with the same prescribed seismic fortification intensity but different actual seismic hazards are analyzed to illustrate the engineering significance of uniform-risk-targeted seismic design.The results show that with China's current seismic design method,the risk of earthquake-induced collapse of buildings varies greatly from site to site.Additional research is needed to further develop and implement the uniform-risk-targeted seismic design approach proposed in this paper. | SHI Wei LU XinZheng YE LiePing | 2012 | Science China(Technological Sciences)2012，55，6： | 5 |
| 8 | Collapse simulation of reinforced concrete high‐rise building induced by extreme earthquakes显示文摘 | Xiao Lu Xinzheng Lu Hong Guan Lieping Ye | 2012 | Earthquake Engng Struct Dyn2012，，5： | 5 |
| 9 | Influence of soil——structure interaction on seismic collapse resistance of super-tall buildings显示文摘Numerous field tests indicate that the soilestructure interaction(SSI) has a significant impact on the dynamic characteristics of super-tall buildings,which may lead to unexpected structural seismic responses and/or failure.Taking the Shanghai Tower with a total height of 632 m as the research object,the substructure approach is used to simulate the SSI effect on the seismic responses of Shanghai Tower.The refined finite element(FE) model of the superstructure of Shanghai Tower and the simplified analytical model of the foundation and adjacent soil are established.Subsequently,the collapse process of Shanghai Tower taking into account the SSI is predicted,as well as its final collapse mechanism.The influences of the SSI on the collapse resistance capacity and failure sequences are discussed.The results indicate that,when considering the SSI,the fundamental period of Shanghai Tower has been extended significantly,and the collapse margin ratio has been improved,with a corresponding decrease of the seismic demand.In addition,the SSI has some impact on the failure sequences of Shanghai Tower subjected to extreme earthquakes,but a negligible impact on the final failure modes. | Mengke Li Xiao Lu Xinzheng Lu Lieping Ye | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，5： | 4 |
| 10 | B7-DC (PD-L2) costimulation of CD4^(+) T-helper 1 response via RGMb显示文摘The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo.In addition to interacting with the coinhibitory receptor PD-1,B7-DC has also been shown to bind repulsive guidance molecule b(RGMb).The functional consequences of the B7-DC/RGMb interaction,however,remain unclear.More than a decade ago,we reported that replacement of a murine B7-DC mutant lysine with serine(K113S)at positive 113 resulted in a loss of binding capacity to PD-1.Nevertheless,K113S remained costimulatory for T cells in vitro,implicating a dual functionality for B7-DC in T-cell responses.Here we show that recombinant K113S protein interacts with RGMb with a similar affinity to wild-type B7-DC.More importantly,K113S costimulates CD4^(+)T-cell responses via RGMb and promotes Th1 polarization.RGMb is expressed on the surface of naive mouse T cells,macrophages,neutrophils and dendritic cells.Finally,K113S/RGMb costimulation suppresses Th2-mediated asthma and ameliorates small airway inflammation and lung pathology in an experimental mouse model.Our findings indicate that RGMb is a costimulatory receptor for B7-DC.These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses,but also a novel approach to investigate the B7-DC/PD-1/RGMb axis.Recombinant K113S or its derivatives could potentially be developed as an agonist for RGMb to costimulate the Th1 response without triggering PD-1-mediated T-cell inhibition. | Xinxin Nie Wenni Chen Ying Zhu Baozhu Huang Weiwei Yu Zhanshuai Wu Sizheng Guo Yiping Zhu Liqun Luo Shengdian Wang Lieping Chen | 2018 | Cellular & Molecular Immunology2018，15，10： | 3 |
| 11 | Evaluation of Modal and Traditional Pushover Analyses in Frame-Shear-Wall Structures显示文摘 | Zhiwei Miao Lieping Ye Hong Guan Xinzheng Lu | 2011 | Advances in Structural Engineering2011，，5： | 2 |
| 12 | Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future显示文摘 | Chen Lieping Han Xue | 2015 | Journal of Clinical Investigation2015，，9： | 2 |
| 13 | Identification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas显示文摘 | Wotschofsky Z Liep J Meyer H A | 2012 | Int J Biol Sci2012，8，10： | 1 |
| 14 | Experimental study on seismic strengthening of RC columns with wrapped CFRP sheets 显示文摘 | Ye Lieping Zhang Ke Zhao Shuhong | 2003 | Construction and Building Materials2003，17，： | 1 |
| 15 | Maximum Seismic Displacement of Inelastic Systems Based on Energy Concept显示文摘 | LIEPING YE SHUNSUKE OTANI | 1999 | Earthquake Engineering and Structural Dynamics1999，28，： | 1 |
| 16 | Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity显示文摘 | Lieping Chen | 2004 | Nat Rev Immunol2004，4，5： | 1 |
| 17 | Maximum seismic displacement of inelastic systems based on energy concept 显示文摘 | Ye Lieping Shunsuke Otani | 1999 | Earthquake Engineering and Structural Dynamics1999，28，12： | 1 |
| 18 | Combination of Bamboo Filling and FRP Wrapping to Strengthen Steel Members in Compression显示文摘 | Peng Feng Yanhua Zhang Yu Bai Lieping Ye | 2013 | Journal of Composites for Construction2013，，3： | 1 |
| 19 | Identification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas显示文摘 | Wotschofsky Z Liep J Meyer HA | 2012 | Int J Biol Sci2012，8，10： | 1 |
| 20 | B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity显示文摘 | Gabriel L Sica In-Hak Choi Gefeng Zhu Koji Tamada Sheng-Dian Wang Hideto Tamura Andrei I Chapoval Dallas B Flies Jürgen Bajorath Lieping Chen | 2003 | Immunity2003，，： | 1 |
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