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| 1 | What does complement do in Alzheimer’s disease? Old molecules with new insights显示文摘Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease(AD)and anti-inflammatory and immunotherapeutic approaches may be amenable to AD treatment.It is known that complement activation occurs in the brain of patients with AD,and contributes to a local inflammatory state development which is correlated with cognitive impairment.In addition to the complement’s critical role in the innate immune system recognizing and killing,or targeting for destruction,complement proteins can also interact with cell surface receptors to promote a local inflammatory response and contributes to the protection and healing of the host.On the other hand,complement activation also causes inflammation and cell damage as an essential immune function to eliminate cell debris and potentially toxic protein aggregates.It is the balance of these seemingly competing events that influences the ultimate state of neuronal function.Our mini review will be focusing on the unique molecular interactions happening in the AD development,the functional outcomes of those interactions,as well as the contribution of each element to AD. | Yong Shen Libang Yang Rena Li | 2013 | Translational Neurodegeneration2013，2，1： | 3 |
| 2 | Structure and governance model of rural social space quality:A case study of Longxi County in the Loess Hilly Area of China显示文摘The rural social space quality is an important indicator to measure the living standard and thinking ideas and so forth of rural residents in a certain region.In this paper,213 administrative villages in Longxi County of the Loess Hilly Area,China are taken as evaluation units to construct the evaluation model of the rural social space quality.This paper deeply analyzed the variation patterns and their formation mechanism of the rural social space quality at a village scale,and proposed a governance model based on the rural social space quality.The results show that:(1)the social space quality levels of individual administrative villages show a gradually decreasing trend from the township seats to outward.The eastern part of Longxi County has a relatively high education level and living standard,and the western part has a relatively high population stability level and income level.(2)The rural social space quality is mainly in a ring structure,supplemented by the interlaced structure.The core area is the towns and their surrounding areas,while the transition area,marginal area,and other areas are expanded around the core area.(3)Social forces and spatial effects jointly shape the variation of the rural social space quality.Social organizations provide a driving force for the allocation of elements,and interweaving with the spatial effects lead to the differences in the social space quality.(4)The governance models of the rural social space quality are constructed based on the principles of retaining the rural“people”,optimizing the rural“land”,and developing the rural“industry”,so as to improve the rural centripetal force,core force,inner thrust,and source power. | WU Shanshan MA Libang TAO Tianmin DOU Haojian | 2022 | Journal of Geographical Sciences2022，32，7： | 2 |
| 3 | Reliability Assessment of Interconnected Power Systems with HVDC Links Considering Frequency Regulation Process显示文摘With various components and complex topologies,the applications of high-voltage direct current(HVDC)links bring new challenges to the interconnected power systems in the aspect of frequency security,which further influence their reliability performances.Consequently,this paper presents an approach to evaluate the impacts of the HVDC link outage on the reliability of interconnected power system considering the frequency regulation process during system contingencies.Firstly,a multi-state model of an HVDC link with different available loading rates(ALRs)is established based on its reliability network.Then,dynamic frequency response models of the interconnected power system are presented and integrated with a novel frequency regulation scheme enabled by the HVDC link.The proposed scheme exploits the temporary overload capability of normal converters to compensate for the imbalanced power during system contingencies.Moreover,it offers frequency support that enables the frequency regulation reserves of the sending-end and receiving-end power systems to be mutually available.Several indices are established to measure the system reliability based on the given models in terms of abnormal frequency duration,frequency deviation,and energy losses of the frequency regulation process during system contingencies.Finally,a modified two-area reliability test system(RTS)with an HVDC link is adopted to verify the proposed approach. | Chengjin Ye Libang Guo Yi Ding Ming Ding Peng Wang Lei Wang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，2： | 2 |
| 4 | Synthesis of SiO 2 /polystyrene hybrid particles via an esterification method显示文摘 | Libang Feng Hui Li Meijuan Yang Xinwei Wang | 2010 | Colloid and Polymer Science2010，，6： | 1 |
| 5 | Assessment of environmental and economic costs of rural household energy consumption in Loess Hilly Region,Gansu Province,China显示文摘 | Li Guozhu Niu Shuwen Ma Libang | 2009 | Renewable Energy2009，34，6： | 1 |
| 6 | Assessment of Environmental and Economic Costs of Rural Household Energy Consumption in Loess Hilly Region, Gansu Province, China 显示文摘 | Li Guozhu Niu Shuwen Ma Libang Zhang Xin | 2009 | Renewable Energy2009，34，6： | 1 |
| 7 | Fibers reinforced composite hydrogels with improved lubrication and load-bearing capacity显示文摘Hydrogels as one kind of soft materials with a typical three-dimensional(3D)hydrophilic network have been getting great attention in the field of biolubrication.However,traditional hydrogels commonly show poor tribology performance under high-load conditions because of their poor mechanical strength and toughness.Herein,pure chemical-crosslinking hydrogels mixed with different types of the micron-scale fibers can meet the requirements of strength and toughness for biolubrication materials,meanwhile the corresponding tribology performance improves significantly.In a typical case,three kinds of reinforcement matrix including needle-punched fibers,alginate fibers,and cottons are separately combined with Poly(n-vinyl pyrrolidone)-poly 2-hydroxyethyl methacrylate(PVP-PHEMA)hydrogels to prepare fibers reinforced composite hydrogels.The experimental results show that the mechanical properties of fibers reinforced composite hydrogels improve greatly comparable with pure PVP-PHEMA hydrogels.Among three kinds of fibers reinforced composite hydrogel,the as-prepared composite hydrogels reinforced with needle-punched fibers possess the best strength,modulus,and anti-tearing properties.Friction tests indicate that the fibers reinforced composite hydrogels demonstrate stable water-lubrication performance comparable with pure PVP-PHEMA hydrogels.Besides,the hydrogel-spunlace fiber samples show the best load-bearing and anti-wear capacities.The improved tribology performance of the composite hydrogels is highly related to mechanical property and the interaction between the fibers and hydrogel network.Finally,spunlace fibers reinforced hydrogel materials with high load-bearing and low friction properties are expected to be used as novel biomimetic lubrication materials. | Jiawei LI Luyao GAO Rongnian XU Shuanhong MA Zhengfeng MA Yanhua LIU Yang WU Libang FENG Meirong CAI Feng ZHOU | 2022 | Friction2022，10，1： | 1 |
| 8 | Grafting poly(methyl methacrylate) onto silica nanoparticle surfaces via a facile esterification reaction显示文摘 | Libang Feng Lin He Yingxia Ma Yulong Wang | 2009 | Materials Chemistry and Physics2009，，1： | 1 |
| 9 | Multi-cycle reconfigurable THz extraordinary optical transmission using chalcogenide metamaterials显示文摘Metamaterials composed of metallic antennae arrays are used as they possess extraordinary optical transmission(EOT)in the terahertz(THz)region,whereby a giant forward light propagation can be created using constructive interference of tunneling surface plasmonic waves.However,numerous applications of THz meta-devices demand an active manipula-tion of the THz beam in free space.Although some studies have been carried out to control the EOT for the THz region,few of these are based upon electrical modulation of the EOT phenomenon,and novel strategies are required for act-ively and dynamically reconfigurable EOT meta-devices.In this work,we experimentally present that the EOT resonance can be coupled to optically reconfigurable chalcogenide metamaterials which offers a reversible all-optical control of the THz light.A modulation efficiency of 88%in transmission at 0.85 THz is experimentally observed using the EOT metama-terials,which is composed of a gold(Au)circular aperture array sitting on a non-volatile chalcogenide phase change ma-terial(Ge2Sb2Te5)film.This comes up with a robust and ultrafast reconfigurable EOT over 20 times of switching,excited by a nanosecond pulsed laser.The measured data have a good agreement with finite-element-method numerical simula-tion.This work promises THz modulators with significant on/off ratios and fast speeds. | Tun Cao Meng Lian Xieyu Chen Libang Mao Kuan Liu Jingyuan Jia Ying Su Haonan Ren Shoujun Zhang Yihan Xu Jiajia Chen Zhen Tian Dongming Guo | 2022 | Opto-Electronic Science2022，1，1： | 1 |
| 10 | Assessment of environmental and economic costs of rural household energy consumption in Loess Hilly Region, Gansu Province, China显示文摘 | Li Guozhu Niu Shuwen Ma Libang | 2009 | Renewable Energy2009，34，6： | 1 |
| 11 | Preparation of poly(ethylene glycol)-grafted silica nanoparticles using a facile esterification condensation method显示文摘 | Libang Feng Yulong Wang Na Wang Yingxia Ma | 2009 | Polymer Bulletin2009，，3： | 1 |
| 12 | Research on Biomass Distribution in Counties and Comprehensive Utilization Layout of Biomass Energy in Jilin Province显示文摘Firstly,the distribution of main biomass resources(like straw,livestock manure and forestry residue) in counties of Jilin Province,and then according to the annual output of biomass in each county,the energy regeneration of biomass and project distribution of organic fertilizer were studied,finally the direct economic effect and environmental effect of biomass developed recently were calculated. | Weidong Xi Shuai Dong Yusheng Yao Libang Wei Zhenhua Wang | 2013 | Meteorological and Environmental Research2013，4，1： | 1 |
| 13 | Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism显示文摘Scope: Circadian disorder and high-fat diet(HFD)can disturb lipid metabolism homeostasis and may promote the development of various metabolic diseases. The relationship between them is of great concern. This study aimed to explore the effects of Per1/Per2 double knockout(DKO)on hepatic lipid metabolism in mice under HFD and HFD with docosahexaenoic acid(DHA)substitution. Methods and results: Both wild type(WT)and DKO male C57BL/6 mice were fed with normal chow diet(CON), HFD, or HFD with DHA substitution(AO)for 15 weeks. At the end of the experiment, mice were sacrificed at zeitgeber time(ZT)0(7:00 am)or ZT12(7:00 pm). Pathological indicators were determined using histological and biochemical methods. Hepatic transcriptome sequencing analysis showed that DKO mice exhibited multiple dysfunctions in diurnal rhythm, drug metabolism, cell cycle, cancer pathways, and lipid metabolism. HFD had greater effects on fatty acid oxidation and cholesterol synthesis and metabolism in Per1-/-Per2-/-mice, which was improved by DHA substitution. Conclusions: Per1/Per2 played an important role in the circadian regulation of hepatic lipid metabolism, and DKO mice were more sensitive to HFD. DHA can improve circadian-related lipid metabolism disruption induced by HFD in mice. | Yiran Bu Si Chen Mengcheng Ruan Libang Wu Hualin Wang Na Li Xiuju Zhao Xiaoli Yu Zhiguo Liu | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 14 | Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size显示文摘Insulin-like growth factor 2 m RNA-binding protein 2(IGF2 BP2,also called IMP2)plays an essential role in the development and maturation of germ cells and embryos and is a candidate gene for goat litter size,based on a previous genomewide selective sweep analysis.In this study,the m RNA expression level of IGF2 BP2 was found to be significantly higher in a single-lamb group than in a multi-lamb group.Insertions/deletions(indels)within the goat IGF2 BP2 gene,including P4-Ins-13 bp and P5-Del-12 bp,were verified in 918 Shaanbei White Cashmere(SBWC)female goats.The minor allelic frequencies(MAFs)of P4-Ins-13 bp and P5-Del-12 bp loci were 0.349 and 0.295,respectively.Analysis using the Chi-square(χ^(2))test showed that the genotype(χ^(2)=14.479,P=0.006)distribution of P4-Ins-13 bp was significantly different between the single-lamb and multi-lamb groups.Correlation analysis demonstrated that P4-Ins-13 bp was significantly associated with goat litter size(P=0.022),and individual goats with the homozygous deletion/deletion(DD)genotype produced more litters than other goats.Therefore,considered as a potential molecular marker significantly related to lambing traits,the P4-Ins-13 bp mutation of the goat IGF2 BP2 gene can be used in goat breeding with practical molecular marker-assisted selection(MAS)to optimize female reproduction and improve economic efficiency in the goat industry. | Dongyun XIN Yangyang BAI Yi BI Libang HE Yuxin KANG Chuanying PAN Haijing ZHU Hong CHEN Lei QU Xianyong LAN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 0 |
| 15 | Advances in Electrocatalytic Semi-Hydrogenation of Acetylene in Aqueous Electrolyte: Progress, Challenges, and Opportunities显示文摘Catalytic hydrogenation is a foundational pillar of the chemical industry.Especially,semi-hydrogenation of acetylene(C_(2)H_(2))to ethylene(C_(2)H_(4))is an important industrial reaction to generate polymer-grade C_(2)H_(4) from crude streams for polyethylene production.The industrial C_(2)H_(2) semi-hydrogenation process is currently dominated by the thermocatalytic route that involves cost-prohibitive Pdbased catalysts,high operation temperature,and excess hydrogen feed.Thermocatalytic semi-hydrogenation of C_(2)H_(2) is also hindered by limited C_(2)H_(4) selectivity due to unwanted over-hydrogenation.Therefore,seeking strategies to improve the catalyst performance while reducing energy consumption and capital expenditure of the current hydrogenation schemes is essential to the petrochemical industry.Fortunately,recent advances in electrocatalytic C_(2)H_(2) semi-hydrogenation systems lead to a sustainable alternative to traditional thermocatalytic systems.Using renewable electricity as an energy source and water as a hydrogen source,electrocatalytic systems can operate under ambient conditions with tunable selectivity toward C_(2)H_(4).In this review,we first discuss the reactor design for electrocatalytic C_(2)H_(2) semi-hydrogenation.We then review the computational studies for understanding and predicting the catalytic behavior ofmetal catalysts.We also summarize advanced electrocatalysts categorized into Cu-based and non-Cu-based materials.Finally,we provide perspectives on the opportunities to overcome existing challenges for future practical application of electrocatalytic C_(2)H_(2) semihydrogenation. | Zihao Yan Libang Xu Huiyuan Zhu | 2023 | Renewables2023，1，3： | 0 |
| 16 | Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia显示文摘Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of it.Lacticaseibacillus rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine degradation rate reached 36.3%at 109 CFU/mL for 24 h.LC-MS analysis revealed that high concentrations of inosine could activate compensatory metabolic pathways of L.rhamnosus Fmb14 to catalyse inosine as an energy source and produce intracellular folic acid and riboflavin.The contents of folic acid and riboflavin were 6.0 and 4.3 fold increased after inosine treatment in the cell-free extracts(CFE).L.rhamnosus Fmb14 CFE treatment ameliorates hyperuricemia through xanthine oxidase(XOD)inhibition and ATP-binding cassette subfamily G member 2(ABCG2)promotion,both of which are responsible for uric acid(UA)synthesis and secretion in HepG2 and Caco2 cells,respectively.The in vivo results showed that the serum UA level decreased from 236.28 to 149.28μmol/L after 8 weeks of oral administration of L.rhamnosus Fmb14 in inosine-induced hyperuricemia model mice.Our results revealed that L.rhamnosus Fmb14 has a potential as a biological therapeutic agent in hyperuricemia prevention. | Hongyuan Zhao Xiaoyu Chen Fanqiang Meng Libang Zhou Xinyi Pang Zhaoxin Lu Yingjian Lu | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 17 | Ecological Land Suitability for Arid Region at River Basin Scale:Framework and Application Based on Minmum Cumulative Resistance(MCR) Model显示文摘As an important and typical arid inland region in China,Shiyang River Basin plays an important role in maintaining the sustainable development of eco-environment,whose ecological land suitability restricts the development of the local human activities.Therefore,Shiyang River Basin was selected as the case study,the minimum cumulative resistance(MCR)model and GIS technique were integrated to create land suitability evaluation map.We calculated the MCR value of ecological source and living source,and divided the whole basin into five partitions according to the difference between ecological source and living source,and analyzed the patterns and characteristics of the ecological land suitability evaluation(ELSE)regions,respectively.The results showed that:1)The suitable ecological land includes prohibited development region and restricted development region,which accounts for 15.45%and 23.35%of the total land area of the Shiyang River Basin,respectively.These two regions mainly distributed high altitude region in the southern Qilian Mountain and low altitude region where had high density of rivers.2)The protection of ecological land requires not only conserving existing ecological land but also focusing on ecological buffer belts around ecological sources and improving ecological land service ability.3)Ecological networks should be constructed through artificial planting trees around the boundary of oasis and ecological restoration region.Buffer greenbelts should also be established between optimized development region and ecological restoration region. | WEI Wei LIU Congying MA Libang ZHANG Xueyuan XIE Binbin | 2022 | Chinese Geographical Science2022，32，2： | 0 |
| 18 | Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage显示文摘Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation. | Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li | 2021 | International Journal of Oral Science2021，13，4： | 0 |
| 19 | Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by Bacillus amyloliquefaciens显示文摘Bacillomycin D is a cyclic lipopeptide produced by Bacillus amyloliquefaciens fmbJ.At present,no relevant report has described the combinatorial biosynthesis of bacillomycin D.Due to the strong biosynthetic potential of the communication-mediating(COM)domains,its crosstalk between NRPS subunits has been studied to some extent,but the interaction of COM domain between modules is rarely reported.Therefore,in this study,we conducted the combinatorial biosynthesis of bacillomycin D through the deletion of the COM donor and acceptor domains between the modules and elucidated the interaction between the NRPS modules.The results showed that the deletion of the donor domain between modules 2 and 3 did not affect catalysis by upstream modules,but prevented downstream modules from catalysing the extension of the lipopeptide product,ultimately resulting in mutant complexes that could form linear dipeptides with the sequenceβ-NH_(2)FA-Asn-Tyr.However,the engineered hybrid bacillomycin D NRPSs lacking the donor domains between modules 3 and 4 and modules 6 and 7 could form multiple assembly lines that produced bacillomycin D and its analogs(linear tripeptides,cyclic hexapeptides and linear hexapeptides).In addition,all the acceptor domain deletion strains failed to produce bacillomycin D,only truncated peptides produced by module interruption(except for the acceptor domain deletion strains between modules 3 and 4,which also produced cyclic hexapeptides).In conclusion,deletion of the inter-module donor domains led to a more flexible hybrid biosynthetic system for the production of diverse peptide products;compared with the inter-subunit donor domain deletion strains that could only produce truncated peptides,the former had a greater biosynthetic capacity.Meanwhile,the acceptor domains between modules were an important part of module-module interactions and efficient communication within bacillomycin D synthetase. | Ziyan Lv Wenjie Ma Ping Zhang Zhaoxin Lu Libang Zhou Fanqiang Meng Zuwei Wang Xiaomei Bie | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 0 |
| 20 | NUMERICAL MODEL FOR COMPUTING WAVE LOADS ON ARBITRARY SHAPED STRUCTURES显示文摘A Modified Hybrid Element Method (MHEM) for computing wave loads on arbitrary geometric bodies is presented in this paper. The additional unknowns in Mei’s method are eradicated. Water depth varies in space. The MHEM adopts simple functionals to simplify the numerical scheme and the ICCG method to save CPU and storage; thus computing wave loads for a large flow domain or short waves can be carried out on small-sized computers or even microcomputers. Numerical results are compared with analytical solutions and experimental data. Good agreement is observed. | Zhang, Libang | 1989 | China Ocean Engineering1989，4，4： | 0 |
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