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您的检索式：作者名="Libang Yang"
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| 1 | What does complement do in Alzheimer’s disease? Old molecules with new insights显示文摘Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease(AD)and anti-inflammatory and immunotherapeutic approaches may be amenable to AD treatment.It is known that complement activation occurs in the brain of patients with AD,and contributes to a local inflammatory state development which is correlated with cognitive impairment.In addition to the complement’s critical role in the innate immune system recognizing and killing,or targeting for destruction,complement proteins can also interact with cell surface receptors to promote a local inflammatory response and contributes to the protection and healing of the host.On the other hand,complement activation also causes inflammation and cell damage as an essential immune function to eliminate cell debris and potentially toxic protein aggregates.It is the balance of these seemingly competing events that influences the ultimate state of neuronal function.Our mini review will be focusing on the unique molecular interactions happening in the AD development,the functional outcomes of those interactions,as well as the contribution of each element to AD. | Yong Shen Libang Yang Rena Li | 2013 | Translational Neurodegeneration2013，2，1： | 3 |
| 2 | Synthesis of SiO 2 /polystyrene hybrid particles via an esterification method显示文摘 | Libang Feng Hui Li Meijuan Yang Xinwei Wang | 2010 | Colloid and Polymer Science2010，，6： | 1 |
| 3 | Fibers reinforced composite hydrogels with improved lubrication and load-bearing capacity显示文摘Hydrogels as one kind of soft materials with a typical three-dimensional(3D)hydrophilic network have been getting great attention in the field of biolubrication.However,traditional hydrogels commonly show poor tribology performance under high-load conditions because of their poor mechanical strength and toughness.Herein,pure chemical-crosslinking hydrogels mixed with different types of the micron-scale fibers can meet the requirements of strength and toughness for biolubrication materials,meanwhile the corresponding tribology performance improves significantly.In a typical case,three kinds of reinforcement matrix including needle-punched fibers,alginate fibers,and cottons are separately combined with Poly(n-vinyl pyrrolidone)-poly 2-hydroxyethyl methacrylate(PVP-PHEMA)hydrogels to prepare fibers reinforced composite hydrogels.The experimental results show that the mechanical properties of fibers reinforced composite hydrogels improve greatly comparable with pure PVP-PHEMA hydrogels.Among three kinds of fibers reinforced composite hydrogel,the as-prepared composite hydrogels reinforced with needle-punched fibers possess the best strength,modulus,and anti-tearing properties.Friction tests indicate that the fibers reinforced composite hydrogels demonstrate stable water-lubrication performance comparable with pure PVP-PHEMA hydrogels.Besides,the hydrogel-spunlace fiber samples show the best load-bearing and anti-wear capacities.The improved tribology performance of the composite hydrogels is highly related to mechanical property and the interaction between the fibers and hydrogel network.Finally,spunlace fibers reinforced hydrogel materials with high load-bearing and low friction properties are expected to be used as novel biomimetic lubrication materials. | Jiawei LI Luyao GAO Rongnian XU Shuanhong MA Zhengfeng MA Yanhua LIU Yang WU Libang FENG Meirong CAI Feng ZHOU | 2022 | Friction2022，10，1： | 1 |
| 4 | Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage显示文摘Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation. | Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li | 2021 | International Journal of Oral Science2021，13，4： | 0 |
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