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| 1 | Daifan San intervenes in forkhead box P3 and the interleukin(IL)-23/IL-17A signaling pathway to help prevent and treat primary biliary cirrhosis显示文摘OBJECTIVE:To investigate the mechanism by which Daifan San(DFS)prevents and treats primary biliary cirrhosis(PBC)via the forkhead box P3(FoxP3)and interleukin(IL)-23/IL-17A signaling pathways.METHODS:Ninety C57BL/6 mice were randomly divided into the control,model,DFS low-dose,DFS middle-dose,DFS high-dose and ursodeoxycholic acid(UDCA)groups(n=15 per group).A mouse model of PBC was induced using polyinosinic polycytidylic acids(poly I:C).Lymphocyte subset expression in the peripheral blood was analyzed via flow cytometry.The inflammatory cytokines and antimitochondrial autoantibody(AMA)levels were detected via enzyme-linked immunosorbent assays.The expressions and location of typeⅠcollagen,typeⅢcollagen,cytokeratin 19 and FoxP3 in the liver tissue were evaluated via immunohistochemistry.FoxP3,IL-23 and IL-17 expressions in the peripheral blood and liver tissue were evaluated via real-time polymerase chain reaction and western blotting.RESULTS:IL-17,IL-23,IL-8,IL-33,TNF-α,and AMA expressions were significantly increased in the model group and decreased in the DFS and UDCA groups.Conversely,Treg cell and FoxP3 expressions were significantly decreased in the model group and increased in the DFS and UDCA groups.The IL-23/IL-17A signaling pathway was closely correlated with chronic inflammation of the bile duct in PBC and functional deletion of Treg cells,leading to reduced FoxP3 levels and mediating the loss of tolerance in PBC.CONCLUSION:DFS may delay the occurrence and relieve the symptoms of PBC by downregulating IL-23/IL-17A signaling pathway expression and upregulating FoxP3 expression. | Zhan Kai Xu Yan Han Mengling Cheng Liangbin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 2 | β-Cyclodextrin carbon-based nanoparticles with a core-shell-shell structure for efficient adsorption of crystal violet and bisphenol A显示文摘Textile wastewater contains highly toxic,nondegradable,carcinogenic organic pollutants,causing severe damage to the ecological environment.In this work,β-cyclodextrin carbon-sphere-based nanocomposite(CS/SiO_(2)@β-CD)with a core-shell-shell configuration was prepared by hydrothermal synthesis and subsequent sedimentation-azeotropic distillation with SiO_(2)as intermediate layer for the removal of crystal violet(CV)and bisphenol A(BPA).The chemical structure and morphology of the CS/SiO_(2)@β-CD were characterized by FT-IR,SEM and TEM.The effects of contact time,pH,temperature and initial concentration of the absorbates on the adsorption property were explored.The CS/SiO_(2)@β-CD showed excellent adsorption capacity on CV and BPA,and the maximum adsorption capacity was 87.873 mg g^(-1)and 165.095 mg g^(-1),respectively.Their adsorption process was in line with the pseudo-second-order and pseudo-first-order kinetic models,respectively.The adsorption thermodynamics could be better fitted by Langmuir model than by Freundlich model.The calculated thermodynamic parameters(-ΔG0,ΔS0 andΔH0)illustrated the adsorption of CV was endothermic,in contrast,the adsorption of BPA was exothermic process.Furthermore,the CS/SiO_(2)@β-CD showed excellent recovery performance,making it a potential adsorbent for the practical treatment of textile wastewater. | Tian Tian Mengling Liu Yinhui Li Jian Han Liang Ren Heike Lorenz Qing Wu Jianxin Chen | 2022 | Particuology2022，20，3： | 1 |
| 3 | Performance Prediction of an Optimized Centrifugal Pump with High Efficiency显示文摘The main structural parameters of the IR100-80-100A type chemical centrifugal pump have been optimized by means of an orthogonal test approach.The centrifugal pump has been modeled using the CFturbo software,and 16 sets of orthogonal-test schemes have been defined on the basis of 4 parameters,namely,the blade number,blade outlet angle,impeller outlet diameter,and impeller outlet width.Such analysis has been used to determine the influence of each index parameter on the pump working efficiency and identify a set of optimal combinations of such parameters.The internalflowfield in the centrifugal pump has been simulated by using the PumLinx software.These numerical results have shown that,compared with the prototype pump,the outlet pressure and shaft power of the optimized pump can be significantly reduced,and the pump working efficiency can be improved by 5.59%.In the present study,some arguments are also provided to demonstrate that,with respect to other optimization methods,the orthogonal test approach is more convenient,and requires less test times. | Yuqin Wang Luxiang Zhou Mengle Han Lixiang Shen | 2023 | Fluid Dynamics & Materials Processing2023，19，9： | 0 |
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