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| 1 | Effect of resveratrol and in combination with 5-FU on murine liver cancer显示文摘AIM: To study the anti-tumor effect of resveratrol and in combination with 5-FU on murine liver cancer. METHODS: Transplantable murine hepatoma22 model was used to evaluate the anti-tumor activity of resveratrol (RES) alone or in combination with 5-FU in vivo. H22 cell cycles were analyzed with flow cytometry. RESULTS: Resveratrol could inhibit the growth of murine hepatoma22, after the mice bearing H22 tumor were treated with 10 mg/kg or 15 mg/kg resveratrol for ten days, and the inhibition rates were 36.3% (n = 10) and 49.3% (n = 9), respectively, which increased obviously compared with that in control group (85+22 vs 68+17, P<0.01). RES could induce the S phase arrest of H22 cells, and increase the persentage of cells in S phase from 59.1% (n = 9) to 73.5% (n = 9) in a dose-dependent manner (P<0.05). The enhanced inhibition of tumor growth by 5-FU was also observed in hepatoma22 bearing mice when 5-FU was administered in combination with 10 mg/kg resveratrol. The inhibition ratesfor 20 mg/kg or 10 mg/kg 5-FU in combination with 10 mg/kg resveratrol were 77.4% and 72.4%, respectively, compared with the group of 20 mg/kg or 10 mg/kg 5-FU alone, in which the inhibition rates were 53.4% and 43.8%, respectively (n = 8). There was a statistical significance between the combination group and 5-FU group. CONCLUSION: RES could induce the S phase arrest of H22 cells and enhance the anti-tumor effect of 5-FU on murine hepatoma22 and antagonize its toxicity markedly. These results suggest that resveratrol, as a biochemical modulator to enhance the therapeutic effects of 5-FU, may be potentially useful in cancer chemotherapy. | Sheng-LiWu Zhong-Jiesun LiangYu Ke-WeiMeng Xing-LeiQin Cheng-EnPan Sheng-LiWu | 2004 | World Journal of Gastroenterology2004，10，20： | 24 |
| 2 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 3 | Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis显示文摘AIM: Based on the pathogenesis of severe acute pancreatitis and our experimental studies, to investigate the effect of dexamethasone and dextran in treatment of patients with severe acute pancreatitis.METHODS: Thirty-two patients with severe acute pancreatitis were treated with 0.5-1 mg/kg per day dexamethasone for 3-5 d, and 500-1 000 mL/d of dextran 40 for 7 d, besides the routine therapy.RESULTS: After 4-8 h of treatment, abdominal pain began to be relieved; range of tenderness began to be localized in 27 patients. They were cured with nonsurgical treatment.Five of them were deteriorated, and treated with surgery.Four patients in this group died.CONCLUSION: Dexamethasone and dextran 40 block the pathologic process of severe acute pancreatitis through inhibition of inflammatory mediators and improvement of microcirculation disorders respectively. | Zi-FaWang ChangLiu YiLu RuiDong ]unXu LiangYu Ying-MinYao Qing-GuangLiu Cheng-EnPan | 2004 | World Journal of Gastroenterology2004，10，9： | 11 |
| 4 | Estimation of inbreeding and identification of regions under heavy selection based on runs of homozygosity in a Large White pig population显示文摘Background: Runs of homozygosity(ROHs) are homozygous segments of the genome where the two haplotypes inherited from the parents are identical. The current availability of genotypes for a very large number of single nucleotide polymorphisms(SNPs) is leading to more accurate characterization of ROHs in the whole genome. Here,we investigated the occurrence and distribution of ROHs in 3,692 Large White pigs and compared estimates of inbreeding coefficients calculated based on ROHs(FROH), homozygosity(FHOM), genomic relationship matrix(FGRM)and pedigree(FPED). Furthermore, we identified genomic regions with high ROH frequencies and annotated their candidate genes.Results: In total, 176,182 ROHs were identified from 3,569 animals, and all individuals displayed at least one ROH longer than 1 Mb. The ROHs identified were unevenly distributed on the autosomes. The highest and lowest coverages of Sus scrofa chromosomes(SSC) by ROH were on SSC14 and SSC13, respectively. The highest pairwise correlation among the different inbreeding coefficient estimates was 0.95 between FROH_totaland FHOM, while the lowest was-0.083 between FGRMand FPED. The correlations between FPEDand FROHusing four classes of ROH lengths ranged from 0.18 to 0.37 and increased with increasing ROH length, except for ROH > 10 Mb. Twelve ROH islands were located on four chromosomes(SSC1, 4, 6 and 14). These ROH islands harboured genes associated with reproduction, muscular development, fat deposition and adaptation, such as SIRT1, MYPN, SETDB1 and PSMD4.Conclusion: FROHcan be used to accurately assess individual inbreeding levels compared to other inbreeding coefficient estimators. In the absence of pedigree records, FROHcan provide an alternative to inbreeding estimates.Our findings can be used not only to effectively increase the response to selection by appropriately managing the rate of inbreeding and minimizing the negative effects of inbreeding depression but also to help detect genomic regions with an effect on traits under selection. | Liangyu Shi Ligang Wang Jiaxin Liu Tianyu Deng Hua Yan Longchao Zhang Xin Liu Hongmei Gao Xinhua Hou Lixian Wang Fuping Zhao | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 10 |
| 5 | New electrochemical energy storage systems based on metallic lithium anode the research status,problems and challenges of lithium-sulfur,lithium-oxygen and all solid state batteries显示文摘Li-ion batteries have played a key role in the portable electronics and electrification of transport in modern society. Nevertheless,the limited highest energy density of Li-ion batteries is not sufficient for the long-term needs of society. Since lithium is the lightest metal among all metallic elements and possesses the lowest redox potential of.3.04 V vs. standard hydrogen electrode, it delivers the highest theoretical specific capacity of 3860 mA h g^(-1) and a high working voltage of full batteries which causes a great interest in electrochemical energy storage systems. Lithium-sulfur, lithium-oxygen and corresponding all solid state batteries based on metal lithium anode have received widely attention owing to their high energy densities. However, the problems in the cathode,electrolyte and anode of these three systems restrict their practical application. In this review, the research status and problems of these three energy storage systems are summarized and the challenges and future perspectives are also outlined. | Liangyu Li Chunguang Chen Aishui Yu | 2017 | Science China Chemistry2017，60，11： | 8 |
| 6 | Activation of liver X receptors promotes inflammatory cytokine mRNA degradation by upregulation of tristetraprolin显示文摘肝 X 受体(LXR ) 有反煽动性的性质。LXR 是否在煽动性的 cytokine 表示的 post-transcriptional 控制起一个作用,不是清楚的。这里,我们第一鉴别合成 LXR 收缩筋 T0901317 支持了 IL-1, IL-6 和 TNF mRNA 降级。而且, T0901317 使动摇通过它的 3-untranslated 区域的 TNF mRNA。另外, T0901317 增加了 tristetraprolin (TTP ) 的表示,当与 siRNA 反对 TTP 废除了调停 T0901317 的煽动性的 cytokine mRNA 腐烂时。有趣地, T0901317 镇压了 ERK1/2 和 p38 的导致 LPS 的 phosphorylation 在 THP-1 巨噬细胞的激活 mitogen 的蛋白质 kinase (MAPK ) 。这里介绍的证据证实有 T0901317 的 LXR 激活禁止 ERK1/2 和 p38 MAPK 的 phosphorylation,在 TTP 的增加的表示和 LPS 导致煽动性的 cytokine mRNAs 的腐烂的可能的结果。 | Ji Xiao Quan Chen Dan Tang Weiwei OU Jiazheng Wang1 Zhongcheng Mo Chaoke Tang Liangyu Peng Deming Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 7 |
| 7 | Effects of emodin and double blood supplies on liver regeneration of reduced size graft liver in rat model显示文摘AIM: To study the influences of emodin and reconstruction of double blood supplies on liver regeneration of reduced size graft liver in rat model.METHODS: A total of 45 SD-SD rat reduced size liver transplantation models were randomly divided into three groups (A-C). The conventional reduced size liver transplantation was performed on rats in group A, while the hepatic artery blood supply was restored in groups B and C. The emodin (1.5 mg/kg/d) was given by intraperitoneal route in group C only. The recipients were killed on the seventh day after the operation. The proliferative cell nuclear antigen (PCNA), TBil and ALT of serum were detected, and the pathological changes of liver cell were observed. RESULTS: The numbers of the rats that survived in A, B, and C group on the seventh day after operation were 14, 13, 13, respectively. The levels of TBil (31.5±5.2 μmol/L,23.2±3.1 μmol/L vs38.6±6.8 μmol/L), and ALT (5 351±1 050 nKat, 1300±900 nKat vs5779±1202 nKat) in serum in groups B and C were lower than those in group A(P<0.05), while the expression of PCNA in groups B or C was higher than that in group A (22.0±3.5%, 28.2±4.2%vs18.6±3.2%, P<0.05). The deeper staining nuclei, double nuclei, multi-nuclei and much glycogen were observed in liver cells of groups B and C, especially in group C, while fewer were found in liver cells of group A. CONCLUSION: The reconstruction of arterial blood supply is very important for rat liver regeneration after reduced size liver transplantation. Emodin has the effect of promoting liver regeneration and improving liver function in rats after reduced size transplantation. The possible mechanism is improving proliferation of liver cell and protecting liver cells from injury. | Ke-WeiMeng YiLv LiangYu Sheng-LiWu Cheng-EnPan | 2005 | World Journal of Gastroenterology2005，11，19： | 7 |
| 8 | Variational method based robust adaptive control for a guided spinning rocket显示文摘In this paper,a robust adaptive controller is designed for a guided spinning rocket,whose dynamics presents the characteristics of pitch-yaw cross coupling,fast time-varying aerodynamics parameters and wide flight envelop.First,a coupled nonlinear six-degree-of-freedom equation of motion for a guided spinning rocket is developed,and the lateral acceleration motion is modeled as a control plant with time-varying matched uncertainties and unmodeled dynamics.Then,a robust adaptive control method is proposed by combining Bregman divergence and variational method to achieve fast adaption and maintain bounded tracking.The stability of the resulting closed-loop system is proved,and the ultimate bound and convergence rate are also analyzed.Finally,numerical simulations are performed for a single operating point and the whole flight trajectory to show the robustness and adaptability of the proposed method with respect to timevarying uncertainties and unmodeled dynamics. | Zhongjiao Shi Liangyu Zhao Zhijie Liu | 2021 | Chinese Journal of Aeronautics2021，34，3： | 6 |
| 9 | METHOD FOR PRECISE CALCULATION OF ROOT STRESS OF SPIRAL BEVEL GEARS显示文摘METHODFORPRECISECALCULATIONOFROOTSTRESSOFSPIRALBEVELGEARSMETHODFORPRECISECALCULATIONOFROOTSTRESSOFSPIRALBEVELGEARSChenLiangyu... | Chen Liangyu Wang Yanzhong Zheng Xijian E Zhongkai Cai Chunyuan(Northeastern University) | 1994 | Chinese Journal of Mechanical Engineering1994，7，4： | 5 |
| 10 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 11 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 12 | Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing显示文摘Differentially expressed genes are thought to regulate the development and progression of oral squamous cell carcinomas(OSCC).The purpose of this study was to screen differentially expressed mRNAs in OSCC and matched paraneoplastic normal tissues,and to explore the intrinsic mechanism of OSCC development and progression.We obtained the differentially expressed mRNA expression profiles in 10 pairs of fresh-frozen OSCC tissue specimens and matched paraneoplastic normal tissue specimens by high-throughput RNA sequencing.By using Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses,the functional significance of the differentially expressed genes were analyzed.We identified 1,120 significantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC,compared to normal tissue.The differentially expressed mRNAs were involved in 20 biological processes and 68 signal pathways.Compared to adjacent normal tissue,the expression of MAGEA11 was up-regulated;TCHH was down-regulated.These findings were verified by real-time PCR.These differentially expressed mRNAs may function as oncogenes or tumor suppressors in the development and progression of OSCC.This study provides novel insights into OSCC.However,further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic biomarkers and candidate therapeutic targets for OSCC. | Liangyu Ge Siyu Liu Long Xie Lei Sang Changyan Ma Hongwei Li | 2015 | The Journal of Biomedical Research2015，29，5： | 4 |
| 13 | Measurement of electric properties of the single supersaturated aerosol droplet显示文摘A system for measuring the electric properties of single aerosol droplet is designed and applied to the NaClO4 aerosol droplet in different relative humidity (RH). The conductance and capacitance are ob-tained within the whole RH range, especially in the supersaturated state which cannot be acquired from the bulk solution. These results reflect the situation of ions in the droplet macroscopically and supply useful information for other relative study fields, such as crystallogeny and aerography. | HE KeJuan CHENG Hua ZHU YanYing WANG LiangYu ZHANG YunHong | 2008 | Chinese Science Bulletin2008，53，11： | 3 |
| 14 | Effect of trace yttrium on the microstructure,mechanical property and corrosion behavior of homogenized Mg-2Zn-0.1Mn-0.3Ca-xY biological magnesium alloy显示文摘The effects of trace yttrium(Y)element on the microstructure,mechanical properties,and corrosion resistance of Mg-2Zn-0.1Mn-0.3Ca-xY(x=0,0.1,0.2,0.3)biological magnesium alloys are investigated.Results show that grain size decreases from 310 to 144µm when Y content increases from 0wt%to 0.3wt%.At the same time,volume fraction of the second phase increases from 0.4%to 6.0%,yield strength of the alloy continues to increase,and ultimate tensile strength and elongation decrease initially and then increase.When the Y content increases to 0.3wt%,Mg_(3)Zn_(6)Y phase begins to precipitate in the alloy;thus,the alloy exhibits the most excellent mechanical property.At this time,its ultimate tensile strength,yield strength,and elongation are 119 MPa,69 MPa,and 9.1%,respectively.In addition,when the Y content is 0.3wt%,the alloy shows the best corrosion resistance in the simulated body fluid(SBF).This investigation has revealed that the improvement of mechanical properties and corrosion resistance is mainly attributed to the grain refinement and the precipitated Mg_(3)Zn_(6)Y phase. | Mingfan Qi Liangyu Wei Yuzhao Xu Jin Wang Aisen Liu Bing Hao Jicheng Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 3 |
| 15 | Deformation mode-determined misorientation and microstructural characteristics in rolled pure Zr sheet显示文摘In this work, commercially pure Zr sheets were subjected to β air cooling and then rolled to different reductions(10% and 50%)at room temperature. Microstructures of both the β-air-cooled and the rolled specimens were well characterized by electron channelling contrast imaging and electron backscatter diffraction techniques, with special attentions paid to their misorientation characteristics. Results show that the β-air-cooled specimen owns a Widmanst?tten structure featured by lamellar grains with typical phase transformation misorientations. The 10% rolling allows prismatic slip and tensile twinning({11-21}<11-2-6> and{10-12}<10-11>) to be activated profusely, which produce new low-angle(~3°–5°) and high-angle(~35° and ~85°) misorientation peaks, respectively. After increasing the rolling reduction to 50%, twinning is suppressed and dislocation slip becomes the dominant deformation mode, with the lamellar grains highly elongated and aligned towards the rolling direction.Meanwhile, only one strong low-angle misorientation peak related to the prismatic slip is presented in the 50%-rolled specimen,with all other peaks disappeared. Analyses on local misorientations reveal that hardly any residual strains exist in the β-air-cooled specimen, which should be related to their sufficient relaxation during slow cooling. Residual strains introduced by 10% rolling are heterogeneously distributed near grain/twin boundaries while heavier deformation(50% rolling) produces much larger residual strains pervasively existing throughout the specimen microstructure. | CHAI LinJiang XIA JiYing ZHI Yan GOU YinNing CHEN LiangYu YANG ZhiNan GUO Ning | 2018 | Science China(Technological Sciences)2018，61，9： | 3 |
| 16 | The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis显示文摘Oscillations in cytosolic free calcium determine the polarity of tip-growing root hairs.The Ca2+channel cyclic nucleotide gated channel 14(CNGC14)contributes to the dynamic changes in Ca^2+concentration gradient at the root hair tip.However,the mechanisms that regulate CNGC14 are unknown.In this study,we detected a direct interaction between calmodulin 7(CaM7)and CNGC14 through yeast two-hybrid and bimolecular fluorescence complementation assays.We demonstrated that the third EF-hand domain of CaM7 specifically interacts with the cytosolic C-terminal domain of CNGC14.A two-electrode voltage clamp assay showed that CaM7 completely inhibitsCNGC14-mediated Ca2+influx,suggesting that CaM7 neg-atively regulates CNGC14-mediated calcium signaling.Fur-thermore,CaM7 overexpressing lines phenocopy the short root hair phenotype of a cngc14 mutant and this phenotype is insensitive to changes in external Ca^2+concentrations.We,thus,identified CaM7-CNGC14 as a novel interacting module that regulates polar growth in root hairs by con-trolling the tip-focused Ca2+signal. | Qudsia Zeb Xiaohan Wang Congcong Hou Xiwen Zhang Mengqi Dong Sisi Zhang Qian Zhang Zhijie Ren Wang Tian Huifen Zhu Legong Li Liangyu Liu | 2020 | Journal of Integrative Plant Biology2020，62，7： | 3 |
| 17 | Real-Time Pricing of Smart Grid Based on Piece-Wise Linear Functions显示文摘In a power grid system, utility is a measure of the satisfaction of users’ electricity consumption;cost is a monetary value of electricity generated by the supplier. The utility and cost functions represent the satisfaction of different users and the supplier. Quadratic utility, logarithmic utility,and quadratic cost functions are widely used in social welfare maximization models of real-time pricing. These functions are not universal;they have to be discussed in detail for individual models. To overcome this problem, a piece-wise linear utility function and a piece-wise linear cost function with general properties are proposed in this paper. By smoothing the piece-wise linear utility and cost functions, a social welfare maximization model can be transformed into a differentiable convex optimization problem. A dual optimization method is used to solve the smoothed model. Through mathematical deduction and numerical simulations, the rationality of the model and the validity of the algorithm are verified as long as the elastic and cost coefficients take appropriate values. Thus, different user types and the supplier can be determined by selecting different elastic and cost coefficients. | Zhihong XU Liangyu GUO Yan GAO Muhammad HUSSAIN Panhong CHENG | 2019 | Journal of Systems Science and Information2019，10，4： | 3 |
| 18 | HIGH ORDER LOCAL DISCONTINUOUS GALERKIN METHODS FOR THE ALLEN-CAHN EQUATION: ANALYSIS AND SIMULATION显示文摘在这份报纸,我们在场为 Allen-Cahn 方程的一个本地不连续的 Galerkin (LDG ) 方法。我们证明精力稳定性,分析 k + 的最佳的集中率 1 在 L2 标准和现在(2k + 1 )-th 顺序为有光滑的答案的 Allen-Cahn 方程的 semidiscrete LDG 方法的否定标准的估计。为了放松严重时间,走行进方法的明确的时间的限制,我们构造第一基于分离 Allen-Cahn 精力的凸的切开原则订半含蓄的计划并且证明相应无条件的精力稳定性。为了高完成,命令时间的精确性,我们采用半含蓄光谱推迟的修正(SDC ) 方法。与无条件地稳定的凸的切开计划结合, SDC 方法能是在我们的数字测试精确、稳定的高顺序。提高建议方法的效率, multigrid 解答者被改编解决结果非线性的代数学的系统。数字研究被介绍证实我们能在 L2 标准完成 O (hk+1 ) 的最佳的精确性并且与精确性改进 processing 以后技术从 O (hk+1 ) 改进 LDG 答案到 O (h2k+1 ) 。 ' | Ruihan Guo Liangyue Ji Yan Xu | 2016 | Journal of Computational Mathematics2016，34，2： | 3 |
| 19 | Design of Distributed Information Systems for Agile Manufacturing Virtual Enterprises Using CORBA and STEP Standards显示文摘 | Liangyu Zhou Rakesh Nagi | 2002 | Journal of Manufacturing Systems2002，21，1： | 2 |
| 20 | Recent advances on the circadian gene PER2 and metabolic rhythm of lactation of mammary gland显示文摘Due to regulation by circadian rhythm, the lactation of the mammary gland has rhythmicity. As one of prominent members of period protein family which regulates biological rhythms, PER2 plays an important role in developing the milk duct and maintaining the polarity and the morphology of the mammary epithelium; at the same time, it is also closely related with the metabolism of milk protein and milk fat. This paper summarized recent researches on PER2 gene and related researches on mammary gland development and metabolism to provide some information for the studies of the theory and technology on physiological functions of the mammary gland and milk quality control. | Mengzhi Wang Yujia Jing Liangyu Hu Jian Gao Luyang Ding Jun Zhang | 2015 | Animal Nutrition2015，，4： | 2 |
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