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| 1 | Isolation and characterization of bipotent liver progenitor cells from adult mouse显示文摘 | Li WL Su J Yao YC Tao XR Yan YB Yu HY Wang XM Li JX Yang YJ Lau JT HuYP | 2006 | 中国生物学文摘2006，20，5： | 26 |
| 2 | Study on the expression of matrix metalloproteinase-2 mRNA in human gastric cancer显示文摘 | Ji F Wang WL Yang ZL Li YM Huang HD Chen WD | 1999 | World Journal of Gastroenterology1999，5，5： | 19 |
| 3 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 4 | Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus显示文摘 | Li WL Zheng HC Bukuru J | 2004 | J Ethnopharmacol2004，92，1： | 1 |
| 5 | Successful preimplantation genetic diagnosis for alpha- and beta-thalassemia in China 显示文摘 | Deng J Peng WL Li J | 2006 | Prenat Diagn2006，26，11： | 1 |
| 6 | Decreased C-reactive protein induced resistin production in human monocytes by simvastat 显示文摘 | Hu WL Qian SB Li JJ | 2007 | Cytokine2007，40，3： | 1 |
| 7 | Meta-analysis:pharmacologic treatmentof obesity显示文摘 | Li ZP Maglione M Tu WL | 2005 | Ann Intern Med2005，142，7： | 1 |
| 8 | Effect of stealthy liposomal topotecan plus amlodipine on the multi-drug resistant leukaemia cells in vitro and xenograft in mice 显示文摘 | Li X Lu WL Liang GW | 2006 | Eur J Clin Invest2006，36，6： | 1 |
| 9 | A modified method of ecological footprint calculation and its application显示文摘 | Zhao S Li ZZ Li WL | | 0，，1： | 1 |
| 10 | Improvement of succinate production by overexpression of a cyanobacterial carbonic anhydrase in Escherichia coli显示文摘 | Wang D Li Q Li WL | 2009 | Enzyme and Microbial Technology2009，45，67： | 1 |
| 11 | The clinical characteristics and prognosis of Chinese early stage breast cancer patients:a retrospec- tive study显示文摘 | Lu WL Li HX Qian BY | 2010 | Breast J2010，16，3： | 1 |
| 12 | Response of Antioxidant Activity and Sensory Quality in Fresh-cut Pear as Affected by High 02 Active Packaging in Comparison with Low 02 Packaging 显示文摘 | WL Li XH Li X Fan | 2012 | Food Science and Technology International2012，18，3： | 1 |
| 13 | Apoptosis of ATII cells in mice induced by phosgene显示文摘 | Li WL Hai CX Liang X | | 0，，01： | 1 |
| 14 | Biomolecular recognition with a sensitivity-enhanced nanowire transistor biosensor 显示文摘 | Li BR Chen CW Yang WL | 2013 | Biosens Bioelect2013，45，1： | 1 |
| 15 | Celastrol Prevents Atherosclerosis via Inhibi- ting LOX-1 and Oxidative Stress 显示文摘 | Gu L Bai WL Li S | 2013 | Plos One2013，8，6： | 1 |
| 16 | Anxiolytic-like effect of asiaticoside in mice显示文摘 | Chen SW Wang WL Li WJ | 2006 | Pharmacol Biochem Behav2006，85，2： | 1 |
| 17 | A modified restriction display PCR method in sample - labelling of DNA microarray 显示文摘 | Li L Ma WL Zhu J | 2003 | J Virol Meth2003，67，： | 1 |
| 18 | Reduced expression of survivin, the inhibitor of apoptosis protein correlates with severity of preeclam- psia显示文摘 | Li CF Gou WL Li XL | 2012 | Placenta2012，33，1： | 1 |
| 19 | Construction of a multi-plex allele-specific PCR-based universal array (ASPUA) and its application to hearing loss screening显示文摘 | Li CX Pan Q Guo YG Li Y Gao HF Zhang D Hu H Xing WL Mitchelson K Xia K Dai P Cheng J | | 0，，： | 1 |
| 20 | Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatoeyte-like cells in injured livers of SCID mice显示文摘 | Tao XR Li WL Su J | 2009 | J Cell Biochem2009，108，3： | 1 |
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