|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Successful preimplantation genetic diagnosis for alpha- and beta-thalassemia in China 显示文摘 | Deng J Peng WL Li J | 2006 | Prenat Diagn2006，26，11： | 1 |
| 3 | NaoXinQing,anantistroke herbal medicine,reduces hydrogen peroxide-induced injury in NG108-15 cells显示文摘 | Bei WJ Peng WL Ma Y | | 0，，03： | 1 |
| 4 | Successful preimplantation genetic diagnosis for alpha-and beta-thalassemia in China显示文摘 | Deng J Peng wL Li J et a1 | 2006 | Prenat Diagn2006，26，11： | 1 |
| 5 | A novel method for separating the anodic voltammetric peaks of dopamine and ascorbie acid显示文摘 | Xu Y Peng WL | 2004 | Microchim Acta2004，146，： | 1 |
| 6 | Marital status and fertility of 185 male renal transplant recipients in China 显示文摘 | Xu LG Wang HW Peng WL | 2008 | J Androl2008，29，6： | 1 |
| 7 | High epitope density in a single recombinant protein molecule of the extracellular domain of influenza A virus M2 protein significantly enhances protective immunity显示文摘 | Liu WL Peng Z Liu ZQ | 2004 | Vaccine2004，23，3： | 1 |
| 8 | Successful preimplamation genetic diagnosis for alpha- and beta-thalassemia in China 显示文摘 | Deng J Peng WL Li J | 2006 | Prenat Diagn2006，26，11： | 1 |
| 9 | Facile Synthesis of trans-3,4-Diol Derivatives of Substituted Chromans via Catalytic Epoxidation显示文摘A praedcal opthesis of trans-3,4-aiol derivatives of subnituted chromans via epoxidation with combined use of mangenese (III) salen complex 3 and hydrgen perokide has been developed. These diol derivatives are key intermediates for the syntheis of a series of biologicallimportant chroman compounds. | Sun, HB Yan, Z Hua, WY Huang, WL Peng, SX | 1997 | Chinese Chemical Letters1997，8，1： | 1 |
| 10 | Extended vertical lower tra pezius (l)sland myocutaneous flap for reconstruction of craniomaxillo facial defects显示文摘 | Chen WL Deng YF Peng GG | | 0，，02： | 1 |
| 11 | Extended vertical lower trapezius island myocutaneous flap for reconstruction of cranio- maxillofacial defects显示文摘 | Chen WL Deng YF Peng GG | 2007 | Oral Maxillofac Surg2007，36，2： | 1 |
| 12 | Marital status and fertility of 185 male renal transplant recipients in China显示文摘 | Xu LG Wang HW Peng WL | | 0，，06： | 1 |
| 13 | Successful preimplantation genetic diagnosis for alpha- and beta-thalassemia in China显示文摘 | Deng J Peng WL Li J | 2006 | Prenat Diagn2006，26，11： | 1 |
| 14 | Design of β-carboline derivatives as DNA-targeting antitumor agents显示文摘 | Guan HJ Chen HS Peng WL | | 0，，10： | 1 |
| 15 | Flavanoids from leaves of Diospyros kaki protect primary neuron culture from injury induced by oxidative stress 显示文摘 | Bei W J Peng WL Xu AL | 2005 | Life Sciences2005，76，： | 1 |
| 16 | Studies on the electronic structures and related properties of ^2+(L=bpy,bpm,bpz) with DFT method显示文摘 | Zheng KC Wang JP Peng WL | 2002 | J Mol Struct (Theochem)2002，582，： | 1 |
| 17 | Successful preimplantation genetic diagnosis for alpha- and beta-thalassernia in china 显示文摘 | Deng J Peng WL Li J | 2006 | Prenat Diagn2006，26，11： | 1 |
| 18 | Extended vertical lower trapezius lsland myoeutaneous flap for reconstruction of cranio- maxillofacial defects 显示文摘 | Chen WL Deng YF Peng GG | 2007 | Int J Oral Maxillofae Surg2007，36，2： | 1 |
| 19 | NaoXinQing, an anti - stroke herbal medicine, reduces hydrogen peroxide - induced injury in NG108- 15 cells显示文摘 | Bei WJ Peng WL Ma Y et at | 2004 | Neurosci Lett2004，63，2： | 1 |
| 20 | Flavanoids from leaves of dio- spyros kakipmtect primary neuron culture from injury induced by oxidative stress显示文摘 | Bei W J Peng WL Ma Y | 2005 | Ufe Science2005，76，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员