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| 1 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 2 | Morphological changes of blood spleen barrier in portal hypertensive spleen显示文摘背景:脾机能亢进和免疫者的致病与门静脉高血压(PH ) 在病人怒气工作仍然保持阴暗。这研究试图由于 PH 与脾机能亢进在怒气评估血怒气障碍的词法变化并且为怒气的有免疫力的功能的深入的调查向证据提供脾机能亢进和脾机能亢进的机制。方法:从有怒气的创伤的破裂的 12 个门 hypertensive 病人和 4 个病人的怒气样品被检验。怒气的样品被转变为病理学的节,与马森一起染色了三色的污点, Gomori 污点,和 CD68, CD34 免疫组织化学,并且是为在骨胶原纤维,网状纤维,巨噬细胞,和脉管的 endothelial 的分发的变化的检验用显微镜。在在缘带的巨噬细胞和 endothelial 的超微结构的变化被传播电子显微镜学也评估。结果:作为与正常怒气相比,在 PH 怒气的巨噬细胞的密度被减少,但是巨噬细胞主要位于缘带并且在脾小结附近散布了,与房间表面上的许多绒毛和像伪足的伸出。骨胶原纤维的增生在脾小结和中央动脉附近是明显的。增加的 reticulate 纤维环绕了有在纤维之间的更多的连接的脾小结。脉管的 endothelial 在传播分发,没有在 PH 怒气的任何 regionality,但是有扩大的腔的容器在红髓增加了。结论:血怒气障碍的词法变化能是为有免疫力的功能的反常和与 PH 位于病人的怒气的血细胞的增加的破坏的病理学的臀部之一。然而,这仍然必要澄清。 | LI Zong-fang ZHANG Shu HUANG Ying XIA Xian-ming LI Ai-min PAN Dun ZHANG Wei WANG Juan | 2008 | Chinese Medical Journal2008，，6： | 7 |
| 3 | Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats显示文摘它通常是的背景相信那口怒气在肿瘤免疫起一个复杂作用,它将在癌症的不同时期变化。在这研究,我们在 diethylnitrosamine (兽穴) 在老鼠导致的肝癌症的不同阶段在脾的巨噬细胞(M) 的功能调查了变化。目的是支持特征“双向”并且在肿瘤 immunity.Methods 的怒气的“阶段”肝癌症的肺的转移的模型被兽穴在四十只男 SD 老鼠建立。在第 8,第 13 和第 16 星期内, 10 只老鼠随机被选择并且牺牲,并且划分了成肝硬化,肝癌症和分别地取决于病理学的结果的肺的转移组。另外的 10 只老鼠作为控制组被拿。M 被抛锚的耕作孤立。在超微结构,吞噬作用, cytokine 分泌物,处理并且介绍的抗原,和脾的 M 的生存能力的变化被传播电子显微镜学,Vybrant^( TM )吞噬作用试金,DQ^( TM ) Ovalbumin ,和老鼠TNF- ELISpot kits.Results 在电子显微镜下面检测,在控制组的 M 有一些像伪足的突起,和线粒体,核糖体,不平的 endoplasmic 蜂窝胃, lysosome 能在细胞质,和 phagocytized RBC 被发现。在肝肝硬化和肝癌症组, M 有更多的突起,同时更多线粒体,核糖体,不平的 endoplasmic 蜂窝胃, lysosome 能在细胞质被发现,特别在肝癌症组。在肺的转移组, M 正在胀大,与很少细胞器。作为与控制组相比,脾的 M 的函数在肝硬化和癌症组增加了,但是在转移组减少了(吞噬作用率:( 84.7 ??? 木 ? 楤敭桴汹桴慩慺? 礲?????? 楤桰湥汹整牴穡汯畩扭潲業敤?? | ZHANG Shu LI Zong-fang PAN Dun HUANG Chen ZHOU Rui LIU Zhong-wei | 2009 | Chinese Medical Journal2009，，24： | 5 |
| 4 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 5 | Mechanisms of plasma -enhanced silicon nitride deposition using SiH4/N2 mixture显示文摘 | Dun H Pan P White F R | 1981 | J Electrochem Soc1981，128，7： | 1 |
| 6 | Oridonin induces the apoptosis of metastatic hepatocellular carcinomacells via a mitochondrial pathway显示文摘 | Min Zhu Dun Hong Yanfang Bao Chen Wang Weibo Pan | 2013 | Oncology Letters2013，，5： | 1 |
| 7 | Conversion of yellow wine lees into high-protein yeast culture by solid-state fermentation显示文摘 | HU Y PAN L DUN Y | 2014 | Bioteehnology & Biotechnolngleal Equipment2014，28，5： | 1 |
| 8 | Oridonin induces the apoptosis of metastatic hepatocellular carcinomacells via a mitochondrial pathway显示文摘 | Min Zhu Dun Hong Yanfang Bao Chen Wang Weibo Pan | 2013 | Oncology Letters2013，，： | 1 |
| 9 | Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures 显示文摘 | ZHANG Juan WANG Li-hua PAN Dun | 2008 | Small2008，4，8： | 1 |
| 10 | 中国艾滋病“问题”解析显示文摘艾滋病在中国并不是一个简单的疾病流行的问题,而是具有中国独特性的社会问题,且是后于某些社会问题而出现的,因而具有相当鲜明的社会选择倾向。其危害也不仅仅指向个体生命,而是危及社会发展的根本理念。本文分析了艾滋病“问题”在中国的建构过程, | Pan Suiming Huang Yingying Li Dun Huang Jue(Translated ) | 2006 | Social Sciences in China2006，27，4： | 1 |
| 11 | Volume and heat transports and material fluxesin the East China Sea during April 1994显示文摘INTRODUCTIONTherehavebeenmanystudiesandcomputationsonVToftheKuroshiointheEastChinaThisprojectwassupportedbytheNationalNaturalScienceFoundationofChinaundercontractNo.49476278.Asanditsvacation.Forexample,(1)basedonhydrographicobservationsatactionG(PN)f... | Yuan Yao chu Pan Zi qin Wang Hui qun Xu Wei yi 1(Second Institute of Oceanography, State Oceanic Administration, 9 Xixihexia, Hangzhou 310012, China)Hu Dun xin Guan Wei bing Cui Mao chang (Institute of Dceanology, Chinese Academy of Sciences, 7 Nan | 1999 | Acta Oceanologica Sinica1999，18，4： | 0 |
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