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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | 集合种群强物种种群的演化特性显示文摘大量的数值模拟研究表明:(1)集合种群里最强物种种群对栖息地占有率相对较少时,较小的栖息地毁坏率就可以导致该最强物种种群与其它奇数物种种群一起退化;(2)而最强物种种群对栖息地占有率相对较多则是导致集合种群里弱物种种群集体灭绝的内因;(3)当栖息地的毁坏率大于最强物种种群对栖息地的占有率时,最强物种种群将先灭绝而使得弱物种种群进化为强物种种群或新的更强的强物种种群。 | 林振山 Larry Li | 2003 | 生态学报2003，23，9： | 18 |
| 3 | A Facile Recovery Process for Cathodes from Spent Lithium Iron Phosphate Batteries by Using Oxalic Acid显示文摘A simplistic and novel leaching process is developed to dispose spent lithium iron phosphate(LiFePO_(4))batteries.In this paper,oxalic acid is selected as a leaching reagent to recover lithium as a resource and remove phosphorus from LiFePO_(4) batteries,benefiting from its low natural effects.The physical properties of spent cathode materials(before leaching)and residues(after leaching)are identified by X-ray diffraction(XRD)and scanning electronic microscopy(SEM)with energy dispersive X-ray spectroscopy(EDS).The total amounts of Li and Fe are analyzed by inductively coupled plasma-atomic emission spectroscopy(ICP-AES).The process occurs under conditions of a 0.3 mol·L^(-1) oxalic acid concentration,a temperature of 80℃,a reaction time of 60 min and a solid/liquid ratio of 60 g·L^(-1).It can effectively precipitate92%ferrum in terms of FeC_(2)O_(4)·2H_(2)O from LiFePO4,with the leaching efficiency of Li achieving up to 98%.This method demonstrates a new strategy for dealing with spent lithium iron phosphate batteries with a low cost and low environmental impact. | Li Li Jun Lu Longyu Zhai Xiaoxiao Zhang Larry Curtiss Yi Jin Feng Wu Renjie Chen Khalil Amine | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 12 |
| 4 | 物种灭绝的若干种可能的序显示文摘利用集合种群共存动力模式 ,研究了由于栖息地毁坏而导致物种灭绝的顺序问题 .研究结果表明 :在群落里各物种种群具有相等的死亡率的假设下 ,栖息地毁坏而导致物种的灭绝存在 3种最基本可能的顺序 ,既最弱物种与最强物种相伴灭绝 ,最强物种与最弱物种是强弱交替灭绝 ,以及由强而弱依次灭绝 .参 | 林振山 LI Larry | 2003 | 应用与环境生物学报2003，9，6： | 5 |
| 5 | IPR, Trade, FDI, and Technology Transfer显示文摘在这调查,我们讨论在南方的知识产权权利(IPR ) 保护怎么从诺思影响贸易流动,外国直接投资(FDI ) 流动,和技术转移到南方。我们也在革新上讨论最佳的 IPR 政策和他们的效果。我们的讨论盖住理论研究和实验证据。这调查全面、批评。它试图给读者 IPR 和全球化文学的当前的状态。一些问题更彻底地被学习了,而为其它表面仅仅被抓了在之上。这调查给读者文学的一幅更清楚的图画并且可以帮助他们发现未来研究话题。 | Tan Li Larry D. Qiu | 2014 | Frontiers of Economics in China-Selected Publications from Chinese Universities2014，9，4： | 3 |
| 6 | Rhubarb-based Chinese herbal formulae for hepatic encephalopa-thy:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the effectiveness and safety of rhubarb-based Chinese herbal formulae(RCHF), which are widely used to treat hepatic encephalopathy(HE) in China.METHODS: Nine online databases were searched from inception to November 22, 2016. Eligible studies were randomized controlled trials of Traditional Chinese Medicine(TCM) treatment for adult patients(≥ 18 years old) with HE. Outcomes such as mortality rate, clinical response rate, blood ammonia level, and alanine aminotransferase were evaluated between TCM group and control group.RESULTS: Thirty studies involving 2661 HE patients were analyzed. Most studies used RCHF treatment.Compared with conventional treatment as usual,lactulose, and vinegar, RCHF were associated with significant improvement in clinical response rate[risk ratio(RR) = 1.33, 95% confidence interval(CI) =1.25, 1.43, I2= 0%; RR = 1.26, 95% CI = 1.14, 1.38, I2=22%; and RR = 1.19, 95% CI = 1.06, 1.33, I2= 0%, respectively] and significant reductions in levels of blood ammonia and alanine aminotransferase. Only minor RCHF-associated adverse events, such as abdominal pain(0.3%), anal tenesmus(0.3%), and diarrhea(2.3%), were reported, and there were no significant differences in these events between the treatment group and the three types of control group.CONCLUSION: The findings suggest that RCHF may be an alternative treatment option for HE patients. More rigorous multicenter studies with larger samples and longer observational periods are needed to confirm these findings. | Zhang Ning Zhou Shuangnan Xiao Xiaohe Wanq Zhen Bai Yunfeng He Tingting Zhou Chao Wang Yao Kun Zhou Wang Zhongxia Liu Bing Larry J.Prokop Matthew C.Hernandez Li Jun Gong Man | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 7 | 水生态食物链多平衡态问题的理论研究显示文摘生态食物链的多平衡态问题关系到生态多样性。由于生态食物链复杂的非线性过程 ,使得该问题的理论研究困难重重。建立了一个生态食物链的准三分子模型 ,并讨论了系统的定态解及其稳定性。研究结果表明 :(1 )在定态里 ,浮游植物的密度正比于溶解营养物的密度、光合作用过程的速率 ,而反比于游泳掠夺者的捕食速率 ;(2 )如果溶解营养物的密度和光合作用过程的速率都很小 ,或者掠夺者的捕食速率过大 ,系统将是不稳定的 ;(3)生态食物链系统是一空间有序的结构 。 | 林振山 Li Larry | 2003 | 生态学报2003，23，10： | 3 |
| 8 | 血小板糖蛋白Ⅰbα因子突变(A156V)导致其与血管性血友病因子相互作用缺陷显示文摘目的 研究在流体切应力作用下表达突变的细胞与固着的血管性血友病因子 (vWF)相互作用中GPⅠbα突变 (A15 6V)的意义。方法 在GPⅠbαcDNA中直接诱发的突变克隆到哺乳类表达载体pDX的EcoRⅠ位点 ,随后将突变的cDNA转染在CHOβⅨ细胞。人的vWF通过甘氨酸和氯化钠沉淀及在Sepharose 4B柱分离的方法从血液冷沉淀制剂中纯化。纯化的vWF固着在盖玻片上 ,在平行板液流室中进行细胞滚动研究 ,用相差电视显微镜观察。结果 表达GPⅠb Ⅸ Ⅴ复合物的CHO细胞能粘附于并滚动在固着的vWF表面 ,当用表达A15 6V突变的细胞进行试验时 ,这些细胞虽然能粘附于并滚动在固着的vWF表面 ,但是它们滚动的速度明显快于其野生型 ,这表明突变的GPⅠbα与vWF之间的受体配体键的解离速度受损 ,单克隆抗体AN5 1与突变的GPⅠbα结合明显减少 ,表明A15 6V突变产生了GPⅠbα氨基端配体结合区的构象改变。结论 突变致使A15 6V突变细胞与固着的vWF产生较快的解离速度。突变的多肽在GPⅠbα氨基端配体结合区发生构象改变。 | 董京飞 Chester Li Alicia J.Schade Lily Sun Larry V.McIntire Jose A.Lopez | 2000 | 中华血液学杂志2000，21，9： | 2 |
| 9 | How should we intervene in psychosis risk syndromes?显示文摘 | Jijun WANG Kaida JIANG Tianhong ZHANG Huijun LI Kristen WOODBERRY Larry SEIDMAN | 2013 | 上海精神医学2013，25，1： | 2 |
| 10 | RhizoVision Crown:An Integrated Hardware and Software Platform for Root Crown Phenotyping显示文摘Root crown phenotyping measures the top portion of crop root systems and can be used for marker-assisted breeding,genetic mapping,and understanding how roots influence soil resource acquisition.Several imaging protocols and image analysis programs exist,but they are not optimized for high-throughput,repeatable,and robust root crown phenotyping.The RhizoVision Crown platform integrates an imaging unit,image capture software,and image analysis software that are optimized for reliable extraction of measurements from large numbers of root crowns.The hardware platform utilizes a backlight and a monochrome machine vision camera to capture root crown silhouettes.The RhizoVision Imager and RhizoVision Analyzer are free,open-source software that streamline image capture and image analysis with intuitive graphical user interfaces.The RhizoVision Analyzer was physically validated using copper wire,and features were extensively validated using 10,464 groundtruth simulated images of dicot and monocot root systems.This platform was then used to phenotype soybean and wheat root crowns.A total of 2,799 soybean(Glycine max)root crowns of 187 lines and 1,753 wheat(Triticum aestivum)root crowns of 186 lines were phenotyped.Principal component analysis indicated similar correlations among features in both species.The maximum heritability was 0.74 in soybean and 0.22 in wheat,indicating that differences in species and populations need to be considered.The integrated RhizoVision Crown platform facilitates high-throughput phenotyping of crop root crowns and sets a standard by which open plant phenotyping platforms can be benchmarked. | Anand Seethepalli Haichao Guo Xiuwei Liu Marcus Griffiths Hussien Almtarfi Zenglu Li Shuyu Liu Alina Zare Felix B.Fritschi Elison B.Blancaflor Xue-Feng Ma Larry M.York | 2020 | Plant Phenomics2020，2，1： | 2 |
| 11 | Cross-layer Optimization for State Update in Mobile Gaming显示文摘 | Yu Yang Li Zhu Larry S | 2008 | IEEE Transactions on Multimedia2008，10，5： | 1 |
| 12 | Interregional protection: Implications of fiscal decentralization and trade liberalization显示文摘 | Li Jie Larry D Qiu Qunyan Sun | 2003 | China Economics Review2003，14，： | 1 |
| 13 | Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases显示文摘 | Pratima Nangia-Makker Tirza Raz Larry Tait Malathy P.V. Shekhar Hong Li Vitaly Balan Hemanckur Makker Rafael Fridman Krishnarao Maddipati Avraham Raz | 2013 | Cancer Biology & Therapy2013，，： | 1 |
| 14 | A threedimensional flow control concept for singlecell experiments on a micrechip:cell selection, cell retention, cell culture, cell balancing, and cell scanning显示文摘 | PENG XY(LARRY) LI PCH | 2004 | Anal Chem2004，76，18： | 1 |
| 15 | A simple method for clinical assay superoxide dismutate显示文摘 | Sun Y larry W Li OY | 1998 | Clin Chem1998，23，3： | 1 |
| 16 | A three-dimensional flow control concept for single-cell experiments on a microchip:cell selection,cell retention,cell culture,cell balancing,and cell scanning显示文摘 | Peng XY(Larry) Li PCH | 2004 | Anal Chem2004，76，18： | 1 |
| 17 | Characterization of the pathogenic KU-SHIV model of acquired immunodefieiency syndrome in macaques 显示文摘 | simian/ loss of J Virol Joag SV Li Z Larry Foresman L et 81 | 1997 | AIDS Res Human Betroviruses1997，13，8： | 1 |
| 18 | Understanding China's Foreign Trade Policy: A Literature Review显示文摘 | Tan Li Larry Qiu Ying Xue | 2016 | Frontiers of Economics in China-Selected Publications from Chinese Universities2016，11，3： | 1 |
| 19 | Understanding eco-complexity: Social-Economic-Natural Complex Ecosystem approach显示文摘 | Rusong Wang Feng Li Dan Hu B. Larry Li | 2010 | Ecological Complexity2010，，1： | 1 |
| 20 | Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B显示文摘 | Guoyi Ma Li Chong Xing-Cong Li Ikhlas A. Khan Larry A. Walker Shabana I. Khan | 2010 | Journal of Cancer Research and Clinical Oncology2010，，9： | 1 |
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