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| 1 | Deeper Chemical Perceptions for Better Traditional Chinese Medicine Standards显示文摘Traditional Chinese medicines (TCMs), a complex system of natural resources with many diverse components, are widely used as approved medicinal agents in China. Quality control of TCMs is a huge challenge for the government and for testing institutes and is associated with numerous scientific issues. Among these considerations include the following questions: How many components are in TCMs? How can the multiple components in TCMs be comprehensively delineated and subsequently characterized? What is the level and range of these (active) metabolites within these multiple-component TCMs, in order to recommend standards? and What are the qualities required for a marker constituent to be selected, and from a practical perspective, how can these components be assessed with low cost and in a short time? All of these factors require significant and deep thinking in order to understand the individualistic chemistry of TCM in order to develop enhanced TCM quality standards for improved and consistent patient care. In this review, the latest exploratory research in TCM chemistry analytical techniques and methods is summarized in order to begin to develop responses to these scientific issues. Advances in these methods have included multidimensional separation for liquid chromatography–high-resolution mass spectrometry (LC–HRMS), smart triggering data-dependent acquisition of LC–HRMS, target analysis with liquid chromatography–mass spectrometry (LC–MS), supercritical fluid chromatography, and data mining of large mass spectrometry (MS) datasets. In addition, two quality strategies have been introduced in order to save reference standards and the analysis time for a TCM quality standard, including the application of the single standard to determine multi-components (SSDMC) and monomethodheterotrait matrix methods. Finally, a series of future improvements for analytical methods for TCMs are proposed. | Jin-Jun Hou Jian-Qing Zhang Chang-Liang Yao Rudolf Bauer Ikhlas A. Khan Wan-Ying Wu De-an Guo | 2019 | Engineering2019，5，1： | 9 |
| 2 | 传统药物安全用药北京宣言显示文摘在人类历史进程中,不同国家和地区的传统药物为人类防病治病和繁衍生息做出了不可磨灭的贡献,其安全性和有效性均得到了历史的检验。但是,随着传统药物在全球范围内应用日益广泛,传统药物的安全用药问题也出现了新情况、新问题和新挑战。对此,我们要充分认识科学技术进步和药品安全监管制度不断完善及其对发现、披露和处置传统药物安全性问题的推动作用,与时俱进地看待传统药物安全性形势和问题,与时俱进地加强传统药物安全性研究与监管。 | 肖小河 Hervé Louet Victor Navarro Ikhlas Khan 李秀惠 王伽伯 无 | 2018 | 药学学报2018，53，11： | 3 |
| 3 | 白木香化学成分及其药理作用与质量控制的研究进展(英文)显示文摘白木香为瑞香科沉香属植物,广泛分布于中国南部。中药沉香为该植物含树脂的木材,可用于循环系统疾病、腹痛、呕吐及呼吸困难等多种疾病的治疗。目前,已从白木香的叶、花以及含树脂的木材中分离并鉴定了249个单体化合物。现代药理研究表明,白木香浸膏及其单体化合物具有抑制α-葡萄糖苷酶、抗炎、细胞毒性、神经保护、抗神经炎、抗菌和抑制乙酰胆碱酯酶等活性。此外,现代的分析色谱技术也被应用于该植物的质量控制研究,以确保其用药安全。本文对SciFinder、Web of Science、PubMed和谷歌学术等数据库中有关报道白木香植物化学、药理作用以及质量控制研究的文献进行了全面系统的总结和讨论,以期为充分利用该植物资源和阐明其药用物质基础提供理论参考。 | 袁汉文 赵建平 刘永蓓 邱伊星 谢青玲 李明姣 Ikhlas A. KHANa 王炜 | 2018 | Digital Chinese Medicine2018，1，4： | 2 |
| 4 | Analysis of edge-detec-tion techniques for crack identification in bridges 显示文摘 | IKHLAS A Q ABUDAYYEH 0 KELLY M E | 2003 | Journal ofComputing in Civil Engineer2003，17，4： | 1 |
| 5 | The antimicrobial effects of root canal irrigation and medication显示文摘 | Ikhlas E K John K David H | 2007 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2007，103，4： | 1 |
| 6 | Thidiazuron-induced high-frequency direct shoot organogenesis of Cannabis sativa L.显示文摘 | Lata Hemant Chandra Suman Khan Ikhlas ElSohly Mahmoud A | 2009 | In Vitro Cellular & Developmental Biology2009，，1： | 1 |
| 7 | Authentication of true cinnamon (Cinnamon verum) utilising direct analysis in real time (DART)-QToF-MS显示文摘 | Bharathi Avula Troy J. Smillie Yan-Hong Wang Jerry Zweigenbaum Ikhlas A. Khan | 2015 | Food Additives & Contaminants: Part A2015，，： | 1 |
| 8 | Biologically active cannabinoids from high-potency Cannabis sativa 显示文摘 | Mohamed M Radwan Mahmoud A Ahmed Ikhlas A | 2009 | Journal of Natural Products2009，72，5： | 1 |
| 9 | Fingerprinting and Estimation of the bioactive components of Clutia richardiana L as a potential hypoglycemic herbal tea显示文摘 | Abourashed EA Markus G Ikhlas A | 2003 | Phytother Res2003，17，6： | 1 |
| 10 | High Frequency Plant Regeneration from Leaf Derived Callus of High Δ9-Tetrahydrocannabinol Yielding Cannabis sativa L.显示文摘 | Hemant Lata Suman Chandra Ikhlas Khan Mahmoud ElSohly | 2010 | Planta Med2010，，14： | 1 |
| 11 | Cholestane steroid glycosides from the rhizomes of Dioscorea villosa(w ild yam)显示文摘 | ZULFIQAR A TROY J S IKHLAS A K | 2013 | Carbohydrate Research2013，370，： | 1 |
| 12 | Issues related to botanicals显示文摘 | Ikhlas AK | 2006 | Life Sciences2006，78，2： | 1 |
| 13 | Glycoside primers of Psittacanthus cucullaris显示文摘 | Sinha A William H T Ikhlas H K | 1999 | J Nat Prod1999，62，： | 1 |
| 14 | Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B显示文摘 | Guoyi Ma Li Chong Xing-Cong Li Ikhlas A. Khan Larry A. Walker Shabana I. Khan | 2010 | Journal of Cancer Research and Clinical Oncology2010，，9： | 1 |
| 15 | New constituents from Noni (Morinda citrifolia ) fruit juice 显示文摘 | Ikhlas A Khan James W Rushing ILias Muhammad | 2006 | J Agr Food Chemistry2006，54，： | 1 |
| 16 | Identification of xanthones from Swertia punicea using high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry显示文摘 | Xin‐Gang Du Wei Wang Qing‐Ying Zhang Jun Cheng Bharathi Avula Ikhlas A. Khan De‐An Guo | 2012 | Rapid Commun Mass Spectrom2012，，24： | 1 |
| 17 | Issues related to botanicals 显示文摘 | Ikhlas AK | 2006 | Life Sciences2006，78，2： | 1 |
| 18 | The anticancer potential of steroidal saponin, dioscin, isolated from wild yam ( Dioscorea villosa ) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro显示文摘 | Pranapda Aumsuwan Shabana I. Khan Ikhlas A. Khan Zulfiqar Ali Bharathi Avula Larry A. Walker Zia Shariat-Madar William G. Helferich Benita S. Katzenellenbogen Asok K. Dasmahapatra | 2015 | Archives of Biochemistry and Biophysics2015，，： | 1 |
| 19 | Chemical composition and physicochemical properties of meatballs prepared from mechanically deboned duck quail meat using various types of flour显示文摘 | IKHLAS B HUDA NORYATI I | 2011 | International Journal of Poultry Science2011，10，1： | 1 |
| 20 | Plant based products: Use and development as repellents against mosquitoes: A review显示文摘 | Junaid U. Rehman Abbas Ali Ikhlas A. Khan | 2014 | Fitoterapia2014，，： | 1 |
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