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| 1 | 中国19个狂犬病病毒街毒分离株N基因的序列分析显示文摘测定了 30年来从不同动物中分离的 19个中国狂犬病病毒街毒株N基因的部分核酸序列 ,并对其核苷酸差异做了比较分析。可将中国狂犬病病毒街毒株分为 4个组群 ,各组间的同源性为 83 45 %~ 88 6 2 %。除广西地区分离的狂犬病病毒街毒株彼此差异较大外 ,其余街毒株的地理分布与其N基因核酸序列差异的距离是密切相关的 ,基本上可按其地理分布分为东。 | 徐葛林 Li Ku 吴杰 C.A.De Mattos 郑新雄 薛经刚 胡巧玲 刘锦彦 朱家鸿 C.C.De Mattos J S.Smith | 2002 | 病毒学报2002，18，1： | 46 |
| 2 | The characteristics of CO_2 assimilation of photosynthesis and chlorophyll fluorescence in transgenic PEPC rice显示文摘With PEPC, PPDK, NADP-ME and PEPC+ PPDK transgenic and untransformed rice (Orysa sativa L.), the activities of related C4 photosynthesis enzymes, the chlorophyll fluorescence parameters, CO2 exchange and other physiological indexes were compared, in which the physiological characteristics of PEPC transgenic rice were mainly studied. The results were as follows: (i) The activities of PEPC in PEPC transgenic rice were 20-fold higher than those in untransformed rice; the light-saturation photosynthetic rates and the carboxylation efficiency of PEPC transgenic rice were increased by 55% and 50% more than those of untransformed rice, respectively, while the CO2 compensation point decreased by 27%. (ii) The PS II photochemical efficiency (Fv/Fm) and photochemical quenching (qp) of transgenic PEPC rice decreased less in comparison with those of untransformed rice after the treatment with high light intensity (3 h) or methyl viologen (MV), a photooxidative reagent, which demonstrated that the tolerance of PEPC | JIAO Demao, LI Xia, HUANG Xueqing, CHI Wei, KUANG Tingyun & Ku SB Maurice1. Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences, Nangjing 210014, China 2. Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China 3. Botany Department, Washington State University, Pullman, WA 99164-4236, USA | 2001 | Chinese Science Bulletin2001，46，13： | 29 |
| 3 | On linking climate to Chinese dynastic change: Spatial and temporal variations of monsoonal rain显示文摘The causal correlation or linkage between the East Asian Monsoon (EAM) intensity and rise/fall of Chinese dynasties recently proposed by high-resolution paleoclimate reconstructions is examined in detail. Aside from many exceptions to the correlation, both instrumental and historical climate records show strong spatial variations of rainfall on annual-to-decadal scales over eastern China. The relationship between rainfall and EAM intensity also exhibits regional disparity. These observations suggest: (1) Tak-ing paleo-proxy records from a single locality in eastern China to imply changes in drought/wetness as to affect the cultural and political history of China is fraught with uncertainty. (2) On annual-to-decadal scales, the thesis that δ18O in speleothems can be used as a proxy for the EAM strength lacks empirical underpinnings. | ZHANG DeEr1, LI Hong-Chun2,3, KU Teh-Lung2,4 & LU LongHua5 1 National Climate Center, Beijing 100081, China 2 Department of Earth Sciences & Research Center of Ocean Environment and Technology, Cheng-Kung University, Tainan 70101, Taiwan, China 3 School of Geographical Sciences, Southwest University of China, Chongqing 400715, China 4 Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089, USA 5 Chinese Academy of Meteorological Sciences, Beijing 100081, China | 2010 | Chinese Science Bulletin2010，55，1： | 19 |
| 4 | Environmental Factors Affecting Temporal and Spatial Dynamics of Soil Erosion in Xingguo County, South China显示文摘By using soil erosion maps of four different time periods and a digital elevation model (DEM), in combination withthe remote sensing and GIS technologies, soil erosion dynamics in Xingguo County of Jiangxi Province in South Chinawere analyzed on both temporal and spatial scales in soils of different parent materials, altitudes and slopes. The resultsshowed that from 1958 to 2000 severe soil erosion was coming under control with a decreasing percentage of the land undersevere erosion. It was also found that the soils developed from Quaternary red clay, granite and purple shale were moresusceptible to soil erosion and that areas sitting between 200 to 500 m in altitude with a slope less than 3° or between7° to 20° where human activities were frequent remained to be zones where soil erosion was most likely to occur. Theseareas deserve special attention in monitoring and controlling. | WANG Ku SHI Xue-Zheng YU Dong-Sheng SHI De-Ming CHEN Jing-Ming XU Bin-Bin LIANG Yin LI De-Cheng | 2005 | Pedosphere2005，15，5： | 12 |
| 5 | Paleotemperature changes over the past 3000 years in eastern Beijing, China: A reconstraction based on Mg/Sr records in a stalagmite显示文摘The Mg/Sr ratio in a stalagmite, which is di-rectly proportional to DMg/Ca, the solid-liquid distribution coefficient of Mg, is proposed as a geochemical thermometer to estimate paleotemperature changes. The paleotempera-ture change in eastern Beijing over the past 3000 years has been reconstructed by using this thermometer in the stalag-mite ZFFS-1 from Jingdong Cave. The records can be di-vided into two periods: 3000—2000 aBP, cool and wet, the air temperature averaging 9.8℃; and 2000 aBP—present, hot and dry, the air temperature being 1℃ higher than the mean value (11.7℃) of the past 3000 years. During 500—200 aBP, the air temperature was about 1.2℃ lower than that of the present, corresponding to the Little Ice Age in Europe. Like d 18O and d 13C, Mg/Sr (or DMg/Ca) reflects an obviously warming trend of the past 200 years. These results are sup-ported by historic records. | MA Zhibang1, LI Hongchun2, XIA Ming1, KU Tehlung2, PENG Zicheng3, CHEN Yushu4 & ZHANG Zhaofeng3 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth Sciences, University of Southern California, Los Angeles, CA90089-0740, USA 3. Department of Earth and Space Science, University of Science and Technology of China, Hefei 230026, China 4. Beijing Foshan Tourist Service Centre, Beijing 101201, China | 2003 | Chinese Science Bulletin2003，48，4： | 8 |
| 6 | Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high-and low-incidence areas显示文摘Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(P<0.001).Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China. | Lian-Qun Zhang Xin Song Xue-Ke Zhao Jia Huang Peng Zhang Lu-Wen Wang Hui Meng Jian-Wei Ku Guo-Qiang Kong Tao Jiang Xin-Min Li Xiao-Long Lv Teng Ma Guo Yuan Min-Jie Wu Shou-Jia Hu Shuang Lv Tang-Juan Zhang Ling-Fen Ji Zong-Min Fan Neng-Chao Wang Yao-Wen Zhang Fu-You Zhou Li-Dong Wang | 2017 | Cancer Biology & Medicine2017，14，1： | 7 |
| 7 | Abnormal energy metabolism and tau phosphorylation in the brains of middle-aged mice in response to atmospheric PM2.5 exposure显示文摘In light of the accelerated aging of the global population and the deterioration of the atmosphere pollution, we sought to clarify the potential mechanisms by which fine particulate matter(PM_(2.5)) can cause cognitive impairment and neurodegeneration through the alteration of mitochondrial structure and function. The results indicate that PM_(2.5) inhalation reduces ATP production by disrupting the aerobic tricarboxylic acid cycle and oxidative phosphorylation, thereby causing the hypophosphorylation of tau in the cortices of middle-aged mice. Furthermore, excessive reactive oxygen species generation was involved in the impairment. Interestingly, these alterations were partially reversed after exposure to PM_(2.5) ended. These findings clarify the mechanism involved in mitochondrial abnormality-related neuropathological dysfunction in response to atmospheric PM_(2.5) inhalation and provide an optimistic sight for alleviating the adverse health outcomes in polluted areas. | Rui Gao Tingting Ku Xiaotong Ji Yingying Zhang Guangke Li Nan Sang | 2017 | Journal of Environmental Sciences2017，29，12： | 7 |
| 8 | Reply to the comment of Cheng et al.显示文摘We thank Cheng et al. for their interest in our paper 'On linking climate to Chinese dynastic change: Spatial and temporal variations of of monsoonal rain' [1]. Our paper was written largely as a response to the suggestion made | ZHANG DeEr LI Hong-Chun KU Teh-Lung LU LongHua | 2010 | Chinese Science Bulletin2010，55，32： | 6 |
| 9 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 10 | Efficient oxygen reduction reaction by a highly porous,nitrogen-doped carbon sphere electrocatalyst through space confinement effect in nanopores显示文摘A highly porous nitrogen-doped carbon sphere(NPC)electrocatalyst was prepared through the carbonization of biomass carbon spheres mixed with urea and zinc chloride in N_(2) atmosphere.The sample carbonized at.1000℃ demonstrates a superior oxygen reduction reaction(ORR)performance over the Pt/C electrocatalyst,while its contents of pyridinic nitrogen and graphitic nitrogen are the lowest among samples synthesized at the same or lower carbonization temperatures.This unusual result is explained by a space confinement effect from the microporous and mesoporous structures in the microflakes,which induces the further reduction of peroxide ions or other oxygen species produced in the first step reduction to water to have the preferred overall four electron reduction ORR process.This work demonstrates that in addition to the amount or species of its aptive sites,the space confinement can be a new approach to enhance the ORR performance of precious-metal-free,nitrogen-doped carbon electrocatalysts. | Zheyang MO Weiyi YANG Shuang GAO Jian Ku SHANG Yajun DING Wuzhu SUN Qi LI | 2021 | Journal of Advanced Ceramics2021，10，4： | 3 |
| 11 | Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy model of depression in rats显示文摘 | Ying Xu Bao -Shan Ku Hai -Yan Yao Yan- Hua Lin Xing Ma Yong - He Zhang Xue - Jun Li | 2005 | 中国药理通讯2005，22，4： | 3 |
| 12 | Notch2‐induced COX‐2 expression enhancing gastric cancer progression显示文摘 | Yun‐Chien Tseng Yu‐Hui Tsai Min‐Jen Tseng Kai‐Wen Hsu Min‐Chieh Yang Kuo‐Hung Huang Anna Fen‐Yau Li Chin‐Wen Chi Rong‐Hong Hsieh Hung‐Hai Ku Tien‐Shun Yeh | 2011 | Mol Carcinog2011，，12： | 2 |
| 13 | Photosynthetic characteris-tics and tolerance to photo-oxidation of transgenic rice ex-pressing C4 photosynthesis enzymes显示文摘 | Jiao D.M Huang X.Q Li X Chi W Kuang T.Y Zhang Q.D Ku M.S.B and Cho D.H | | 0，，01： | 1 |
| 14 | Dynamic response characteristics of seismic isolation systems for building structures显示文摘 | Beom-Soo Kang Le Li Tae-Wan Ku | 2009 | Journal of Mechanical Science and Technology2009，，8： | 1 |
| 15 | Hole transport improvement in InGaN/GaN light-emitting diodes by graded-composition multiple quantum barriers显示文摘 | Wang C H Chang S P Ku P H Li J C Lan Y P Lin C C Yang H C Kuo H C Lu T C Wang S C Chang C Y | | 0，，17： | 1 |
| 16 | Introduction of genes encoding C4 photosynthesi enzymes into rice plants:Physiological Consequences显示文摘 | Ku M S Cho D Li X | 2001 | Novartis Foundation Symposium2001，236，： | 1 |
| 17 | Dynamic Response Characteristics of Seismic Isolation Systems for Building Structure 显示文摘 | Kang B S Li L Ku T W | 2009 | Journal of Mechanical Science and Technology2009，123，8： | 1 |
| 18 | Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs显示文摘 | Li S Ku CY Farmer AA | 1998 | J Biol Chem1998，273，11： | 1 |
| 19 | Small-Animal PET of Tumor Damage Induced by Photothermal Ablation with ^sup 64^Cu-Bis-DOTA-Hypericin显示文摘 | Song Shaoli Xiong Chiyi Zhou Min Lu Wei Huang Qian Ku Geng Zhao Jun Flores Leo G Ni Yicheng Li Chun | 2011 | The Journal of Nuclear Medicine2011，，5： | 1 |
| 20 | Photosynthetic characteristics and tolerance to photo-oxidation of transgenic rice expressing C4 photosynthesis enzymes显示文摘 | Demao Jiao Xueqing Huang Xia Li Wei Chi Tingyun Kuang Qide Zhang Maurice S. B. Ku Dongha Cho | 2002 | Photosynthesis Research2002，，1： | 1 |
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