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| 1 | How far is Lignin from being a biomedical material?显示文摘Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant,antibacterial,anti-UV,and good biocompatibility.Natural lignin can be processed through several chemical processes.The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials.Thus,lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery,biosensors,bioimaging,3D printing,tissue engineering,and dietary supplement additive.This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials.Thereafter,we also discuss on the challenges and outlook of utilizing lignin as a biomaterial. | Sigit Sugiarto Yihao Leow Chong Li Tan Guan Wang Dan Kai | 2022 | Bioactive Materials2022，7，2： | 9 |
| 2 | Expression patterns of cytokine,growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis显示文摘瞄准:在与影响肝新生的因素的关系在对部分肝切除术的正常和硬变肝的回答检验差别。方法:肝硬化被 thioacetamide 的管理在老鼠导致。未经治疗的老鼠被用作控制。象肝脏硬化症的老鼠一样的控制老鼠受到 70% 部分肝切除术。在在肝切除术以后的不同时间点,肝被收集, cytokines,生长因素和房间周期蛋白质的层次被分析。结果:在肝切除术以后,当与直到 72 的控制相比 h 张贴肝切除术,肝脏硬化症的残余显著地表示了 cyclin D1,它的激酶搭挡, cdk4,和 cyclin E 的底层。当时,显著地, cyclin A 和 cdk2 的底层也被观察 cdk 禁止者, p27 显著地更高。另外,有的更低的 IL-6 比控制铺平的肝脏硬化症的组根本组织时间点直到 72 h 追随者切除术。结论:从我们的学习的数据证明在肝脏硬化症的残余的那个损害的肝新生与 cyclins 和 cdks 的低表示被联系。这可能是在将接着影响调整在新生过程期间涉及房间增长和新陈代谢的动态平衡的基因的抄写因素的行动的硬变肝残余的低 IL-6 层次的后果。 | Shu Yang Chon Kar Leow Theresa May Chin Tan | 2006 | World Journal of Gastroenterology2006，12，7： | 8 |
| 3 | 中国患者内镜下括约肌切开术或胆管取石术后行胆囊切除术与保留胆囊术的比较显示文摘Background &Aims: In patients with stones in their bile ducts and gallbladders, cholecystectomy is generally recommended after endoscopic sphincterotomy and clearance of bile duct stones. However, only approximately 10%of patients with gallbladders left in situ will return with further biliary complications. Expectant management is alternately advocated. In this study, we compared the treatment strategies of laparoscopic cholecystectomy and gallbladders left in situ. Methods: We randomized patients (>60 years of age) after endoscopic sphincterotomy and clearance of their bile duct stones to receive early laparoscopic cholecystectomy or expectant management. The primary outcome was further biliary complications. Other outcome measures included adverse events after cholecystectomy and late deaths from all causes. Results: One hundred seventy-eight patients entered into the trial (89 in each group); 82 of 89 patients who were randomized to receive laparoscopic cholecystectomy underwent the procedure. Conversion to open surgery was needed in 16 of 82 patients (20%). Postoperative complications occurred in 8 patients (9%). Analysis was by intention to treat. With a median follow-up of approximately 5 years, 6 patients (7%) in the cholecystectomy group returned with further biliary events (cholangitis, n = 5; biliary pain, n = 1). Among those with gallbladders in situ, 21 (24%) returned with further biliary events (cholangitis, n = 13; acute cholecystitis, n = 5; biliary pain, n = 2; and jaundice, n = 1; log rank, P = .001). Late deaths were similar between groups (cholecystectomy, n = 19; gallbladder in situ, n = 11; P = .12). Conclusions: In the Chinese, cholecystectomy after endoscopic treatment of bile duct stones reduces recurrent biliary events and should be recommended. | Lau J. Y. W. Leow C. -K. Fung T. M. K. 成虹(译) 陈云茹(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 6 |
| 4 | 二十碳五烯酸对三种肝癌细胞系作用的实验研究显示文摘目的 探讨二十碳五烯酸 (eicosapentaenoicacid ,EPA)对 3种肝癌细胞系作用。方法EPA作用于HepG2 (携带有野生型p5 3基因 )、Huh7(携带有突变型p5 3基因 )和Hep3B(p5 3基因缺失 )这 3种肝癌细胞系 ,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这 3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长 ,而且这种抑制作用呈现出时间和剂量依赖的关系 ,而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制 ,而且p5 3基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 | 王蓬 陈孝平 PBS Lai CK leow Joseph W Y Lau | 2001 | 中华普通外科杂志2001，16，1： | 4 |
| 5 | 谷歌与苹果对于开发移动AR技术的影响显示文摘2017年第三季度,苹果与谷歌分别发布了各自的增强现实SDK:ARKit与ARCore.本文概述了应用程序领导者在推出增强现实解决方案时需要加以考虑的主要事项,以确保所部署的增强现实应用程序顺利得到采用并获得成功. | Marty Resnick Adrian Leow Jason Wong | 2019 | 电子产品世界2019，26，7： | 4 |
| 6 | GENETIC PROGRAMMING TO PREDICT SKI-JUMP BUCKET SPILLWAY SCOUR显示文摘Researchers in the past had noticed that application of Artificial Neural Networks (ANN) in place of conventional statistics on the basis of data mining techniques predicts more accurate results in hydraulic predictions. Mostly these works pertained to applications of ANN. Recently, another tool of soft computing, namely, Genetic Programming (GP) has caught the attention of researchers in civil engineering computing. This article examines the usefulness of the GP based approach to predict the relative scour depth downstream of a common type of ski-jump bucket spillway. Actual field measurements were used to develop the GP model. The GP based estimations were found to be equally and more accurate than the ANN based ones, especially, when the underlying cause-effect relationship became more uncertain to model. | AZAMATHULLA H. MD GHANI A. AB ZAKARIA N. A LAI S. H CHANG C. K LEOW C. S ABUHASAN Z | 2008 | Journal of Hydrodynamics2008，20，4： | 4 |
| 7 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 8 | A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes显示文摘 | Asal Ataie-Jafari Seng-Cheong Loke Asmah B. Rahmat Bagher Larijani Farzaneh Abbasi Melvin K.S. Leow Zaitun Yassin | 2013 | Clinical Nutrition2013，，： | 2 |
| 9 | Hathl down-regulated in colon ade- nocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells 显示文摘 | Leow CC Romero MS Ross S | 2004 | Cancer Res2004，64，17： | 1 |
| 10 | The bioeffi- cacy of microemulsified natural pigments in egg yolk pigmentation 显示文摘 | CHOW P Y GUE S Z LEOW S K | 2014 | British Poultry Science2014，55，3： | 1 |
| 11 | A proteomic analysis ofthioacetamide induced hepatotoxi city and cirrhosis in rat livers 显示文摘 | Low TY Leow CK Saho-Tellez M | 2004 | Proteomics2004，4，12： | 1 |
| 12 | Dynamic study of an air cylinder forload positioning control显示文摘 | Fok S C Leow Y P | 1997 | American Society of Mecha-nical Engineers1997，4，： | 1 |
| 13 | Pituitary abscess:our experience with a case and a review of the literature显示文摘 | Dalan R Leow MK | 2008 | Pituitary2008，11，： | 1 |
| 14 | Cholecystectomy or gallbladder in situ after endoscopic sphincterotomy and bile duct stone removal in Chinese patients 显示文摘 | Lan JYW Leow CK Fung MK | 2006 | Castronenterology2006，130，3： | 1 |
| 15 | A review of in patients with adverse drug reactions to allopurinol显示文摘 | Khoo BP Leow YH | 2000 | Singapore Med J2000，41，4： | 1 |
| 16 | Screening for p-phenylenediamine (PPD) in hair-care products by thin-layer chromatography (TLC)显示文摘 | Koh D Tan C Ng S K Tan B T Leow Y H Goh C L | | 0，，： | 1 |
| 17 | Statistical properties of Jacobian maps and the realization of unbiased large- deformation nonlinear image registration 显示文摘 | LEOW A D YANOVSKY I CHIANG M-C | 2007 | IEEE Transactions on Image Processing2007，，： | 1 |
| 18 | Do Learners Notice Enhanced Forms while Interacting with the L27 : An Online and Offline Study of the Role of Written Input Enhancement in L2 Reading 显示文摘 | Leow R | 2001 | Hispania2001，，84： | 1 |
| 19 | Tracheobronchial stenting is safe and effective in relieving upper airway obstruction 显示文摘 | Pang YK Liam CK Leow CH | 2006 | Med J Malaysia2006，61，： | 1 |
| 20 | Applications of AnnAGNPS model for soil loss estimation and nutri- ent loading for Malaysian conditions显示文摘 | Shamshad A Leow C S Ramlah A | 2008 | International Journal of Applied Earth Observation and Geoinforma tion2008，10，3： | 1 |
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