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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | 欧洲公益创投渐入佳境显示文摘随着政府和企业大量资金的注入,公益创投可能从利基转变为公益和社会责任投资不可分割的一部分。 | Leonora Bucklan Lisa Hehenberger Michael Hay 吕蓉 | 2015 | 中国社会组织2015，0，12： | 2 |
| 3 | An adapted multi-criteria approach to suppliers and products selection-An application oriented to lead-time reduction显示文摘 | LEONORA BOTTANI ANTONIO RIZZI | 2008 | International Journal of Production Economics2008，111，12： | 1 |
| 4 | Reserve carbohydrates in South African grasses显示文摘 | Weinmann H Leonora R | 1946 | Journal of South African Botany1946，12，： | 1 |
| 5 | Iron-mediated cardiotoxicity develops independently of extracellular hydroxyl radicals in isolated rat hearts 显示文摘 | Watts J A Ford M D Leonora E | 1999 | J Toxicol Clin Toxicol1999，37，1： | 1 |
| 6 | Effect of sink source manipulatin on the photosynthetic care and carbohydrate content of cucumber cotyledon显示文摘 | Maria L M Zuiplaut Leonora R | 1985 | Journal of Experimental Bocany1985，36，171： | 1 |
| 7 | Antioxidant capacity and sensory profiles of peanut skin infusions 显示文摘 | Francisco Maria Leonora dL Resurreccion A V A | 2012 | LWT - Food Science and Technology2012，47，1： | 1 |
| 8 | Effect of sink-source manipulation on the photosynthetic rate and carbohydrate content of cucumber cotyledon显示文摘 | Maria L J Mayoral Z S Leonora R W | 1985 | Journal of Experimental Botany1985，36，171： | 1 |
| 9 | A continuum of adaptive creative behaviors显示文摘 | Leonora M. Cohen | 1989 | Creativity Research Journal1989，，3： | 1 |
| 10 | CO2 CONCENTRATING MECHANISMS IN PHOTOSYNTHETIC MICROORGANISMS显示文摘 | Aaron Kaplan Leonora Reinhold | 1999 | Annual Review of Plant Physiology and Plant Molecular Biology1999，，： | 1 |
| 11 | Total phenolics and antioxidant capacity of heat-treated peanut skins显示文摘 | Maria Leonora Lotis D Francisco A V A | 2009 | Journal of Food Composition and Analysis2009，22，： | 1 |
| 12 | Effect of dietary earbamyl phosphate on dentine apposition in rat molars 显示文摘 | Leonora J Tjaderhane L Tieche JM | 2002 | Arch Oral Biol2002，47，： | 1 |
| 13 | Field investigations and laboratory simulation of clogging in Lixi tailings dam of Jinduieheng, China显示文摘 | Wu Jun Wu Yan-qing Lu Jian Leonora L | 2007 | Environmental Geology2007，53，2： | 1 |
| 14 | Effect of selected dietary addi-tives on the incidence of dental caries in the rat显示文摘 | Steinman RR John Leonora | 1975 | Journal of dental research1975，54，3： | 1 |
| 15 | Melatonin attenuates the decrement of dendritic protein MAP-2 immuno-staining in the hippocampal CA1 and CA3 fields of the aging male rat显示文摘 | Bertha Prieto-Gómez Mireya Velázquez-Paniagua Leonora Olivos Cisneros Cruz Reyes-Vázquez Francisco Jiménez-Trejo Miguel Esteban Reyes Julieta Mendoza-Torreblanca Gabriel Gutiérrez-Ospina | 2008 | Neuroscience Letters2008，，1： | 1 |
| 16 | In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma显示文摘 | Shahryar E. Mir Philip C. De Witt Hamer Przemek M. Krawczyk Leonora Balaj An Claes Johanna M. Niers Angela A.G. Van Tilborg Aeilko H. Zwinderman Dirk Geerts Gertjan J.L. Kaspers W. Peter Vandertop Jacqueline Cloos Bakhos A. Tannous Pieter Wesseling Jacob | 2010 | Cancer Cell2010，，3： | 1 |
| 17 | Immunostimulatory effects of Uncaria perrottetii (A. Rich.) Merr. (Rubiaceae) vinebark aqueous extract in Balb/C mice显示文摘 | Leonora P. Nudo Elena S. Catap | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 18 | Develop- ment of a reversed-phase high performance liquid chromatography (RP- HPLC) procedure for the simultaneous determination of phenolic com- pounds in peanut skin extracts显示文摘 | LEONORA D M FRANCISCO RESURRECCION A V A | 2009 | Food Chemistry2009，117，2： | 1 |
| 19 | Extruded rice noodles: Starch digestibility and glycemic re sponse of healthy and diabetic subjects with different habitual diets显示文摘 | Leonora N Panlasigui IJilian U Thompson Bienvenido () | 1992 | Nutrition Research1992，12，11： | 1 |
| 20 | Solving the homogene- ous probabilistic traveling salesman problem by the ACO metaheuristic显示文摘 | Leonora B C Luca M G Marco D | 2002 | Lecture Notes in Computer Science2002，2463，： | 1 |
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