维普中文期刊产品整合服务
88篇 您的检索式:作者名="Cloos"
    题名 作者 年代 出处 被引量
1How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?显示文摘P-glycoprotein(ABCB1),multidrug resistance protein-1(ABCC1)and breast cancer resistance protein(ABCG2)belong to the ATP-binding cassette(ABC)superfamily of proteins that play an important physiological role in protection of the body from toxic xenobiotics and endogenous metabolites.Beyond this,these transporters determine the toxicity profile of many drugs,and confer multidrug resistance(MDR)in cancer cells associated with a poor treatment outcome of cancer patients.It has long been hypothesized that inhibition of ABC drug efflux transporters will increase drug accumulation and thereby overcome MDR,but until now no approved inhibitor of these transporters is available in the clinic.In this review we present molecular strategies to overcome this type of drug resistance and discuss for each of these strategies their promising value or indicate underlying reasons for their limited success.Adrian C.Jaramillo Farah Al Saig Jacqueline Cloos Gerrit Jansen Godefridus J.Peters 2018Cancer Drug Resistance2018,1,1:3
2The putative onco- gene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3显示文摘Cloos PA Christensen J Agger K 2006Nature2006,442,710:1
3The urethra and its supporting structures in women with stress urinary incontinence:MR imaging using an endovaginal coil显示文摘Kim JK Kim YJ Cloo MS 0,,:1
4Molecular signature asso- ciated with bone marrow in human breast cancer显示文摘Woelfle U Cloos J Sauter G 2003Cancer Res2003,63,18:1
5The putative oncogene GASC1 demethylates tri-and dimethylated lysine 9 on histone H3显示文摘Cloos PA Christensen J Agger K 2006Nature2006,442,7100:1
6Mo- lecular signature as sociated with bone marrow micro metastasis in human breast cancer显示文摘WoeKle U Cloos J Sauter G 2003Cancer Res2003,63,18:1
7UTX and Jmjd3 are his-tone H3K27 demethylases involved in HOX gene regulation anddevelopment显示文摘Agger K Cloos PA Christensen J 2007Nature2007,449,7163:1
8Collagen fragments in urine derived from bone resorption are highlyracemized and isomerized:a biological clock of protein aging with clinical potential显示文摘Cloos PA Fledelius C 2000Biochem2000,345,3:1
9UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development显示文摘Agger K Cloos PA Christensen J 2007Nature2007,449,7163:1
10Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM)显示文摘Christgau S Tankó LB Cloos PA 2004Menopause2004,11,5:1
11Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments显示文摘Cloos PA Christgau S Lyubimova N 2003Breast Cancer Res2003,5,4:1
12Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease显示文摘Cloos PA Christensen J Agger K 2008Genes Dev2008,22,9:1
13Proteasome inhibitors in acute leukemia显示文摘Niewerth D Dingjan I Cloos J 2013Expert Rev Anticaneer Ther2013,13,:1
14The putative oncogene GASC1 demethylates tri-and dimethylated lysine 9 on histone H3显示文摘 CHRISTENSEN J AGGER K 2006Nature2006,442,7100:1
15RBP2 belongs to a family of demethylases, specific for tri-and dimethylatedlysine 4 on histone 3显示文摘Christensen J Agger K Cloos PA 2007Cell2007,128,6:1
16Zur experimentellen Tektonik 显示文摘Cloos H 1931Naturwissenschaften1931,19,11:1
17Bubbling magma chambers, cupolas, and porphyry copper deposits显示文摘Cloos M 2001International geology review2001,43,:1
18Current and future application of bone turnover markers显示文摘Christgau S Cloos PA 2003Clin Lab2003,49,910:1
19Cenozoic tectonics of New Guinea显示文摘Van Ufford A Q and Cloos M 2005AAPG Bulletin2005,89,1:1
20Proteasome inhibition as novel treatment strategy in leukemia 显示文摘Vink J Cloos J Kaspers GJL 2006Br J Haematol2006,134,3:1
返回顶部 每页显示:
共5页 首页 上一页 第1页 下一页 末页 /5 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费