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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Statin effects beyond lipid lowering are they clinically relevant显示文摘 | Bonetti PO Leman LO Napolic C | 2003 | Eur Heart J2003，24，3： | 1 |
| 3 | Effect of coping style andrelaxation on cancer chemotherapy side-effect and emotional respose显示文摘 | Leman C Rimer B | 1990 | Cancer Nursing1990，13，5： | 1 |
| 4 | Cerebral arterial fenes- trations associated with intraeranial saeeular aneurysms 显示文摘 | San Galli F Leman C Kien P | 1992 | Neurosurgery1992，30，： | 1 |
| 5 | Denoising of the Uterine EHG by an undeeimated wavelet transform显示文摘 | Carre P Leman H Fernandez-Maloigne C | 1998 | IEEE Transaction on Biomedical Engineering1998，45，9： | 1 |
| 6 | Per ceived and real barr iers formen ent ering nur sing: implications fo r gender div ersity显示文摘 | Roth J E Co leman C L | 2008 | J Cult Divers2008，15，3： | 1 |
| 7 | Nuclear Structrue as a Sourse of Canc- er Specific Biomarkers显示文摘 | Leman ES C etzenberg RH | 2007 | J cell Biochem2007，104，6： | 1 |
| 8 | The correlation between antixoidant en zyme activities and lipid peroxidation levels in Mentha pule gium organs grown in Ca^2+,Mg^2+,Cu^2+,Zn^2+and Mn^2+stress conditions 显示文摘 | Nilg n C Leman T | 2003 | Plant Science2003，165，： | 1 |
| 9 | Accurately and reliably extracting data from the web: a machine learning approach显示文摘 | KNOBLOCK C LEMAN K MINTOA S | 2000 | Data Engineering2000，23，4： | 1 |
| 10 | Coronary vascular remodeling in association with endothelial system dysfunction显示文摘 | Leman A Cannan C Higano S | 1998 | Am J Cardiol1998，81，9： | 1 |
| 11 | Statin effects be yond lipid lowering-are they clinically relevant?显示文摘 | Bonetti P O Leman L O Napoli C | 2003 | Eur Heart J2003，24，3： | 1 |
| 12 | Applica tion of in vitro anthemintic sensitivity assays to canine parasi tology: Detecting resistance to pyrantel in Ancylostoma cani hum 显示文摘 | KOPP S R C()LEMAN G T MCCARTHY J S et a l | 2008 | Vet Parasitol2008，152，34： | 1 |
| 13 | Statin effects be- yond lipid lowering:are they clinically relevant 显示文摘 | Bonetti PO Leman LO Napoli C | 2003 | Eur Heart J2003，24，： | 1 |
| 14 | Macrocyclic pep- toid-peptide hybrids as inhibitors of Class I histone deacetylases 显示文摘 | Olsen C A Montero A Leman L J | 2012 | ACS Med Chem Lett2012，3，9： | 1 |
| 15 | Human Timeless and Tipin stabilize replication forks and facilitate sister-chro- matid cohesion显示文摘 | Leman A R Noguchi C Lee C Y | 2010 | J Cell Sci2010，123，5： | 1 |
| 16 | Cerebral arterial fenestrations associated with intracranial saccular aneureysmas显示文摘 | Leman C Kien P | 1992 | Neurosurgery1992，30，： | 1 |
| 17 | Greenhouse gas emissions from Chinese cities 显示文摘 | Sugar L Kennedy C Leman E | 2012 | Journal of Industrial Ecology2012，16，4： | 1 |
| 18 | Denoising of the Uterine EHG by an Undecimated Wavelet transform显示文摘 | CARRE P LEMAN H FEMANDEZ C | 1998 | IEEE TransActions on Biomedical Engineering1998，45，9： | 1 |
| 19 | The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta- analysis of the published literature 显示文摘 | Langendijk J A Lemans C R Buter J | 2004 | J Clin Oncol2004，22，： | 1 |
| 20 | Large deletion of the GJB6 gene in deaf patients heterozygous for the GJB2 gene mutation:Genotypic and phenotypic analysis显示文摘 | Feldmann D Denoyelle F Chauvin P Garabedian E-N Coud-erc R Odent S Joannard A Schmerber S Delobel B Leman J Journel H Catros H Le Maréchal C Dollfus H Eliot MM Delau-noy JP David A Calais C Drouin-Garraud V Obstoy MF Bouc-cara D Strekers | | 0，，： | 1 |
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